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1 1 IIT- JAM-BIOTECHNOLOGY SECTION-A 1. At what ph does poly-glu i a aqueous solutio form -helical structure? (a) 3 (b) 7 (c) 9 (d) 12 Aswer : 1. (a) 2. The techique that ivolves impactig samples with electros is. (a) NMR spectroscopy (b) ESI mass spectrometry (c) IR spectroscopy (d) UV-vis spectroscopy Aswer : 2. (b) 3. Let U {1, 2,3, 4,5}. A subset S is chose uiformly at radom from the o-empty subsets of U. What is the probability that S does NOT have two cosecutive elemets? (a) 9/31 (b) 10/31 (c) 11/31 (d) 12/31 Aswer : 3. (d) Which oe of the poits P,, Q,, R, ad 11 3 S, lies ABOVE the parabola 2 2 y x ad INSIDE the circle x y 4? (a) P (b) Q (c) R (d) S Aswer : 4. (b) 5. Which of the followig figures represets the correct sequece of phases i adult eukaryotic cell cycle? (a) (b) (c) (d) Aswer : 5. (b) 6. The glycosidic likages i cellulose ad amylose are, respectively. (a) 1-4 ad 1-4 (b) 1-4 ad 1-4 (c) 1-4 ad 1-6 (d) 1-4 ad 1-2 Aswer : 6. (b)

2 7. Match the etries i Group I with the etries i Group II Group I Group II P. Nylo (i) Isopree Q. Natural rubber (ii) Hexose R. Starch (iii) Amio acid S. Myoglobi (iv) Adipic acid (a) P-iv, Q-i, R-ii, S-iii (c) P-iv, Q-iii, R-ii, S-i Aswer : 7. (a) (b) P-iv, Q-i, R-iii, S-ii (d) P-ii, Q-iv, R-i, S-iii 8. A mutatio i the operator locus of lac opero that cofers costitutive expressio of -galactosidase is. (a) cis domiat (b) tras domiat (c) co-domiat (d) domiat egative Aswer : 8. (a) 9. The orbital agular mometum of hydroge atom i the groud state is. 2 (a) 0 Aswer : 9. (b) (b) h The dimesios of coefficiet of viscosity are. (c) 2 h (d) h (a) 1 1 ML T Aswer : 10. (a) (b) 1 2 (c) 2 2 (d) 2 1 ML T ML T ML T 11. A particle startig from rest is subjected to a costat force. The plot of distace traveled alog the directio of the force as a fuctio of time is a/a. (a) straight lie (b) circle (c) parabola (d) ellipse Aswer : 11. (c) 12. Accordig to the kietic theory of gases, the average eergy of a diatomic molecule i a ideal gas depeds o. (a) mass of each atom ad the temperature (b) mass of each atom ad the bod legth (c) mass of each atom, bod legth, ad temperature (d) temperature oly Aswer : 12. (d) 13. Which oe of the followig modificatios occurs both o DNA ad protei? (a) ADP-ribosylatio (b) Methylatio (c) Sumoylatio (d) Ubiquitiatio Aswer : 13. (b) 14. I a simple microscope,. (a) a les with egative power is used (b) the focal legth of the les is less tha the least distace for clear visio (c) the focal legth of the les is greater tha the least distace for clear visio (d) magificatio depeds oly o the focal legth of the les Aswer : 14. (b)

3 3 si A 1 cos A 15. Simplify. 1 cos A si A (a) 2 sec A (b) 2 cosec A (c) sec A (d) cosec A Aswer : 15. (b) 16. The evolutio of eyes i octopus ad i huma is a example of. (a) diverget evolutio (b) coverget evolutio (c) adaptive radiatio (d) geetic drift Aswer : 16. (b) 17. Idole acetic acid (IAA) is ivolved i. (a) gravitropism (b) flowerig (c) ripeig (d) seescece Aswer : 17. (a) 18. Let 5 1 a ad b a. The, lim 2 x a b b (a) is 1 (b) is 1/2 (c) is 0 (d) does ot exist Aswer : 18. (a) 19. Amog the followig species, the metal ceter that has the highest umber of upaired electros is (a) VCl 4 (b) Ni( CO ) 4 (c) [ AuCl4] (d) 2 4 [ CdBr ] Aswer : 19. (a) 20. Which oe of the followig statemets is a correct descriptio of modes of actio of taxol ad colchicie? (a) Taxol causes DNA damage ad colchicie prevets microtubule formatio (b) Taxol stabilizes microtubules ad colchicie ihibits protei sythesis (c) Taxol destabilizes microtubules ad colchicie promotes microtubule formatio (d) Taxol stabilizes microtubules ad colchicie prevets microtubule formatio Aswer : 20. (d) 21. The followig reactio is a example of. (a) eolizatio (b) racemizatio (c) isomerizatio (d) epimerizatio Aswer : 21. (c) 22. Which oe of the followig statemets is INCORRECT with respect to bacterial cojugatio? (a) It facilitates trasfer of geetic material (b) It requires flagellum (c) It ca spread atibiotic resistace (d) It ca trasfer virulece factors Aswer : 22. (b) 23. The free eergy required to sythesize a mixed ahydride bod of 1, 3-bisphosphoglycerate is geerated by the oxidatio of. (a) a aldehyde to acid (b) a alcohol to acid (c) a alcohol to aldehyde (d) NADH to NAD + Aswer : 23. (a)

4 24. Which oe of the followig remais uchaged whe light waves eter water from air? (a) Wavelegth (b) Waveumber (c) Frequecy (d) Itesity Aswer : 24. (c) 25. Solutios of the followig peptides are prepared separately at a cocetratio of 1mM. Amog these four, which oe has the highest A 280? (a) Ser-Val-Trp-Asp-Phe-Gly-Tyr-Trp-Ala (c) Met-Gly-Val-Ileu-Asp-Ser-Ala-Trp-His Aswer : 25. (a) 26. H 2 reacts with tras-(ph 3 P) 2 Ir(CO)Cl to primarily produce. (b) Gl-Leu-Glu-Phe-Thr-Leu-Asp-Gly-Tyr (d) His-Pro-Gly-Asp-Val-Ileu-Phe-Met-Leu 4 (a) (b) (c) (d) Aswer : 26. (d) 27. Which oe of the followig parameters chages upo doublig the ezyme cocetratio? (a) K M (b) V max (c) K cat (d) K eq Aswer : 27. (b) 28. I how may ways ca oe write the elemets 1, 2, 3, 4 i a sequece x 1, x 2, x 3, x 4 with xi (a) 9 (b) 10 (c) 11 (d) 12 Aswer : 28. (a) 29. Match the etries i Group I with etries i Group II Group I Group II P. Bacteria (i) Malaria Q. Virus (ii) Tuberculosis R. Protozoa (iii) Iflueza S. Autoatibodies (iv) Myastheia gravis (a) P-ii, Q-i, R-iii, S-iv (c) P-iv, Q-iii, R-i, S-ii Aswer : 29. (b) 30. pk a icreases i the order. (a) HN3 NH3OH N2H5 NH3 (b) P-ii, Q-iii, R-i, S-iv (d) P-i, Q-iv, R-ii, S-iii i i? (b) NH3OH N2H5 HN3 NH3 (c) NH3 NH3OH N2H5 HN3 Aswer : 30. (c) (d) HN3 N2H5 NN3 NH3OH

5 SECTION-B 5 1. The advatage(s) of storig chemical eergy i the form of starch ad ot as free glucose is/are that it. (a) miimizes diffusio (b) eables compact storage (c) reduces osmotic pressure (d) protects agaist chemical reactivity of aldehyde groups Aswer : 1. (a, b, c, d) 2. BF 3 reacts readily with. (a) C5H5N (b) SCl 2 (c) SO 3 (d) ( C5H5N) SCl2 Aswer : 2. (a, b, d) 3. Let U {1, 2,...,15}. Let P U cosists of all umbers, Q U cosists of all eve umbers ad R U cosist of all multiples of 3. Let T P Q. The, which of the followig is/are CORRECT? (a) T 5ad T R 9 (b) T 6ad T R 9 (c) T 5ad T R 1 (d) T 6ad T R 1 Aswer : 3. (a, c) 4. Electromagetic waves. (a) carry eergy (c) are trasverse i ature while travellig i vacuum Aswer : 4. (a, b, c, d) 5. Which of the followig statemet(s) is/are true? (b) carry mometum (d) do ot eed a material medium to travel (a) I itrisic semicoductors, the umber of electros is equal to the umber of holes at ay temperature (b) A itrisic semicoductor chages to a -type semicoductor upo additio of a trivalet elemet (c) The shape of the I-V characteristics of a p- diode is a straight lie (d) I the reverse bias coditio, the curret i a p- diode is due to the miority carriers Aswer : 5. (a, d) 6. The reactio of (R)-2-bromobutae with CN - proceeds by. (a) retetio of cofiguratio (c) formatio of CH2 CH ( CH2CH3) Aswer : 6. (b, d) (b) iversio of cofiguratio (d) formatio of (S)-2-methylbutaeitrile 7. Pick the correct statemet(s) with respect of the iter-coversio of the topoisomers of a circularly closed double straded DNA. (a) Oly oe strad eeds to be cut (c) No strad eeds to be cut Aswer : 7. (a, b, d) (b) Both strads have to be cut (d) ATP is required for iter-coversio

6 8. Let f ( x) ( x 1)( x 2)( x 3)( x 4) ad let is/are CORRECT? 3 5 f, f 2 2 ad 7 f. Which of the followig 2 (a) ad have the same sig (b) ad have the same sig (c) ad have the same sig (d) ad have the same sig Aswer : 8. (b, d) 9. Which of the followig cell types ca develop from myeloid lieage? (a) Macrophages (b) T lymphocytes (c) B lymphocytes (d) Erythrocytes Aswer : 9. (a, d) 10. The characteristic oxyge bidig profile of hemoglobi show below arises due to the. 6 (a) quaterary structure (c) cooperativity Aswer : 10. (a, b, c, d) (b) Subuit dissociatio (d) coformatioal chage SECTION-C 1. The total umber of multiplet peaks i the 1 H NMR spectrum of 1, 3, 5-tri-isopropylbezee i CDCl 3 is. Aswer : 1. (2) 2. Proisuli is a 84 residue polypeptide with six cysteies. How may differet disulfide combiatios are possible? Aswer : 2. (15) 3. Heterozygous female fruit flies with gray body ad purple eyes were mated with homozygous males with black body ad red eyes. The umber of offsprig obtaied ad their pheotypes are show below : Calculate the recombiatio frequecy. Aswer : 3. (15.2%) Number of offsprig Pheotype 300 Gray body purple eyes 347 Black body red eyes 61 Gray body red eyes 55 Black body purple eyes

7 4. The refractive idex of a liquid relative to air is 1.5. Calculate the ratio of the real depth to the apparet depth whe the liquid is take i a beaker. Aswer : 4. (1.5) 5. C 3 plats utilize 18 molecules of ATP to sythesize oe molecule of glucose from CO 2. How may molecules of ATP equivalets are used by C 4 plats to sythesize oe molecule of glucose from CO 2? Aswer : 5. (30) 6. A metallic wire of electrical resistace 40 is bet i the form of a square loop. The resistace betwee ay two diagoally opposite comers is. Aswer : 6. (10) 7. Let XYZ be a equilateral ad let P, Q, R be the mid poit of YZ, XZ ad XY, respectively. Let r Area( PQR). Area( XYZ ) The value of r is. Aswer : 7. (0.25) 8. Let N be the set of atural umber ad f : N N be defied by 7 x / 2, f ( x) 3x 1, x is eve x is odd Let f ( x ) deote the -fold compositio of f ( x ). What is the smallest iteger such that f (13) 1? Aswer : 8. (9) 9. The total umber of loe pairs of electros i NO2 F is. Aswer : 9. (8) 10. A 0.1% (w/v) solutio of a protei absorbs 20% of the icidet light. What fractio of light is trasmitted if the cocetratio is icreased to 0.4%? [Correct to two decimal places] Aswer : 10. (0.41) 11. The total umber of DNA molecules preset after 5 cycles of polymerase chai reactio (PRC) startig with 3 molecules of template DNA is. Aswer : 11. (96) 12. A ifiitely log soleoid of radius r ad umber of turs per uit legth carries a steady curret I. The ratio of the magetic fields at a poit o the axis of the soleoid to a poit r/2 from the axis is. Aswer : 12. (1) 13. I a bacterium, a mutatio resulted i a icrease of K s (substrate-specific costat) for ammoium from 50 M to 5000 M without affectig max. The specific growth rate ( ) of the mutat growig o 0.5 mm ammoium i the medium decreases by a factor of. Aswer : 13. (*) 14. The value of 2 x si xdx is. Aswer : 14. (1) 0

8 2 15. The stadard emf of a cell (i V) ivolvig the reactio, 2 Ag ( aq.) Ag( s) Ag ( aq.) at 298 K is. [Correct to two decimal places] o [Give : Ag ( aq.) e Ag( s); E 0.62V ad 2 o Ag ( aq.) e Ag ( aq.); E 0.12V ] Aswer : 15. (0.50) 16. Phosphoglucoisomerase catalyzes the followig reactio: Glu 6 P Fru 6 P If 0.05% of the origial cocetratio of Glu-6-P remais at equilibrium, the equilibrium costat of this reactio is. Aswer : 16. (1999) 17. Let a 4iˆ 2 ˆj 6kˆ ad b 7iˆ ˆj 12kˆ. If a b iˆ ˆj kˆ, the the value of equals. Aswer : 17. (126) 18. The cocetratio of NaCl (i mm) formed at the stoichiometric equivalece poit whe 10 ml of 0.1 M HCl solutio is titrated with 0.2 m NaOH solutio is. (as a iteger) Aswer : 18. (67mM) 19. Two idetical, ifiite coductig plates are kept parallel to each other ad are separated by a distace d. The uiform charge desities o the plates are ad. The electric field at a poit betwee the two plates, where is. 0 Aswer : 19. (2) 20. A schematic represetatio of restrictio fragmet legth polymorphism (RFLP) aalysis of a sample populatio is show below. The umber of people exhibitig a give patter is idicated above the laes. 8 Calculate the frequecy of 6.5 kb allele. [Correct to two decimal places] Aswer : 20. (0.21)

9 9 JAM IIT-BIOTECHNOLOGY-2019 ANSWER KEY SECTION-A 1. (a) 2. (b) 3. (d) 4. (b) 5. (b) 6. (b) 7. (a) 8. (a) 9. (b) 10. (a) 11. (c) 12. (d) 13. (b) 14. (b) 15. (b) 16. (b) 17. (a) 18. (a) 19. (a) 20. (d) 21. (c) 22. (b) 23. (a) 24. (c) 25. (a) 26. (d) 27. (b) 28. (a) 29. (b) 30. (c) SECTION-B 1. (a, b, c, d) 2. (a, b, d) 3. (a, c) 4. (a, b, c, d) 5. (a, d) 6. (b, d) 7. (a, b, d) 8. (b, d) 9. (a, d) 10. (a, b, c, d) SECTION-C 1. (2) 2. (15) 3. (15.2%) 4. (1.5) 5. (30) 6. (10) 7. (0.25) 8. (9) 9. (8) 10. (0.41) 11. (96) 12. (1) 13. (*) 14. (1) 15. (0.50) 16. (1999) 17. (126) 18. (67mM) 19. (2) 20. (0.21)