LIPIDS. Biomolecules soluble in organic solvents but not water (hydrophobic). Important in: n Cell membranes. n Storage for energy.

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1 LIPIDS Biomolecules soluble i orgaic solvets but ot water (hydrophobic). Importat i: Cell membraes Storage for eergy Vitamis (Steroid) hormoes Classified ito: i. Simple lipids (oils/fats, wax) ii. Complex lipids (phospholipids) iii. Derived lipid (cholesterol, PG, vitami D) Subdivided ito family of lipids with specific features, icludig wax, steroids, glycolipids, ad phospholipids.

2 Classes of Lipids LIPID COMPOSITION Waxes Triglycerides Phospholipids a. Glycerophospholipids Fatty acid + log-chai alcohol Fatty acid + glycerol Fatty acid + glycerol + phosphate + amio alcohol (serie, ethaolamie, cholie, iositol) b. Sphigolipids Fatty acid + sphigosie + phosphate + amio alcohol c. Glycolipids Fatty acid + glycerol/sphigosie + moo or disaccharides Steroids Fused structure of 3 cyclohexaes ad oe cyclopetae

3 FATTY ACIDS Log-chai hydrophobic carboxylic acids Fatty acids typically have eve umber of carbo atoms, ad carry out a umber of biologic fuctios. Subdivided ito: Saturated fatty acids: carbos sigle bods betwee Moo-usaturated fatty acids: oe double-bod i the carbo chai. Poly-usaturated fatty acids: 2 or more double bods.

4 Structure of Fatty Acids

5 Properties of Fatty Acids Saturated fatty acids: regular shape strog attractio betwee carbo chais high eergy eeded to separate fatty acids (meltig). Usaturated fatty acids: irregular shape (cis-double bod) fewer iteractios betwee carbo chais lower meltig poit most are liquid at room temperature.

6 Saturated vs. Usaturated Fatty Acids

7 Fatty Acids

8 Fatty Acids No-essetial Fatty Acids: Sythesized i the body. Essetial fatty acids: Not made i sufficiet quatities by the body. Need to be provided by the diet.

9 Usaturated Fatty Acids Four importat usaturated fatty acids: Palmitoleic acid (palmitic acid) Oleic acid, lioleic acid, lioleic acid (stearic acid) Arragemet of hydrocarbo tail aroud the C=C bod: cis-bods: o the same side tras-bod: o opposite sides.

10 Arachidoic Acid A 20-carbo usaturated fatty acid. Preset i the membrae of mammalia cells. Geerates importat iflammatory mediators: Cyclooxygease pathway: prostagladis (PGs) ad thromboxaes (Tx) Lipooxygease Pathway: Leukotriees (LTs) Target of ati-iflammatory therapy: No-steroidal ati-iflammatory drugs (NSAIDs), block PG sythesis Corticosteroids, suppress arachidoic acid metabolism

11 Arachidoic Acid Metabolism

12 Fats ad Oils Most commo form of lipids. Esters of glycerol ad 3 fatty acids: simple (same FA) ad mixed (differet FA). Reactios of triglycerides: Hydrogeatio: coversio of carbo-carbo double bods to sigle bods. Oxidatio: carbo-carbo double bod. Hydrolysis: ester bods. Sapoificatio: coversio of fats/oils to glycerol ad soaps i presece of base.

13 Fats vs. Oils Fats are solid, oils liquid at room temperature. Physical state depeds o presece or absece of usaturated fatty acids. Meltig poit icreases (fats) or decreases (oils) as legth of carbo chai icreases.

14 Triacylglycerols (triglycerides)

15 Triglycerides

16 Phospholipids Cotai glycerol, fatty acids ad a phosphate group. Have 2 regios: polar: the head regio, ad o-polar: tail regio. Major compoets i the cell membrae structure. Precursors of importat biological molecules/mediators.

17 Phospholipids Amphipathic: cosist of a hydrophilic head ad hydophobic tail. Mai lipids foud i the cell membrae. Arraged as a bilayer i the membrae, ad cotrol cellular permeability. Subdivided ito 3 groups: a. Glycerophospholipids b. Sphigophospholipids c. Glycosphigolipids

18 a. Glycerophospholipids

19 Other Phospholipids B. Sphigophospholipids: Sphigosie (18-C alcohol) backboe (istead of glycerol) Abudat i ervous system, white matter e.g. Sphigomyeli (myeli shealth). C. Glycosphigolipids: Similar to (B) but do ot cotai a phosphate group Cotai a sugar (moo- or di-saccharide), e.g.. Cerebrosides: cosist of sphigosie + fatty acid + galactose/glucose. Gagliosides: Cotai 2 or more moosaccharide

20 CHOLESTEROL Ch foud i cell membrae ad modulates its fluidity. It is very hydrophobic molecule. Composed of four rigs (A,B,C,D) Precursor for: Steroid hormoes: Sex steroids: adroges ad estroges Adreal corticosteroids: glucocorticoids ad mieralocorticoids Vitami D Bile Salts. High levels leads to atherosclerosis

21 Bile Salts Polar derivatives of cholesterol. Effective detergets: have both polar ad opolar regios. Sythesized i the liver, stored ad cocetrated i the gallbladder, ad released ito small itesties. Major bile salts: Primary, cholic acid & cheodeoxycholic acid Secodary, (formed by actio of itestial bacteria: deoxycholic ad lithocholic acids) Both are cojugated by amio acids: glycie or taurie (from cysteie)

22 Steroid Hormoes Importat for maitaiig proper body fuctio Sythesized ad secreted ito bloodstream by edocrie glads. Characterized by the steroid ucleus: Glucocorticoids Mieralocorticoids Sex steroids (estroges, adroges, progestis)

23 Lipoproteis Clusters of proteis ad lipids. Fuctio i trasportig lipids i the blood. All lipoprtoteis cotai: Core of eutral lipids (TG, Ch-ester) Surface coat: polar lipids (Ch, PL), & Apolipoproteis.

24 Lipoproteis Very-low Desity Lipoproteis (VLDL) [triglyceride-rich] Low i protei, phospholipids ad choesterol High i triglycerides Low-desity Lipoproteis (LDL) High levels of isoluble cholesterol Trasport Ch from liver to tissue High levels leads to atherosclerosis (Bad Ch) High-desity Lipoproteis (HDL) More dese/compact tha LDL High protei ad phospholipid cotet Good cholesterol: trasport cholesterol out of the bloodstream.

LIPIDS. Biomolecules soluble in organic solvents but not water (hydrophobic). Important in: n Cell membranes. n Storage for energy.

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