SECOND BMP SYMPOSIUM ADVANCE PROGRAM

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1 ADVANCE PROGRAM SECOND BMP SYMPOSIUM APRIL 16 18, 2011 PHILADELPHIA MARRIOTT DOWNTOWN HOTEL FEATURING Extended Clinical Applications of Recombinant Human Bone Morphogenetic Protein 2 (rhbmp-2) PROGRAM CHAIR Robert E. Marx, DDS DISTINGUISHED SPEAKERS Joel S. Berger, DDS, MD David L. Cochran, DDS, PhD Alan S. Herford, DDS, MD Ole T. Jensen, DDS, MS Sascha A. Jovanovic, DDS, MS Jay P. Malmquist, DMD Robert E. Marx, DDS Craig M. Misch, DDS, MDS Peter K. Moy, DMD Daniel B. Spagnoli, DDS, PhD William K. Tom, DDS, MS Presented by

2 INVITATION Dear Colleagues: It is with great enthusiasm and pleasure that I invite you to attend the Second BMP Symposium on the Extended Clinical Applications of Recombinant Human Bone Morphogenetic Protein-2 (rhbmp-2) in Philadelphia. The strong attendance and overwhelming success of the First BMP Symposium in San Diego last February underscores the interest and expanding applications of this remarkable biotechnology. By now, most oral and maxillofacial surgeons, periodontists, and craniofacial surgeons are aware of rhbmp-2 and its potential. This symposium will present both clinical outcome data and a how to technique-oriented approach to the extended applications of rhbmp-2, such as horizontal and vertical ridge augmentations, sinus augmentations, periodontal and peri-implant bone regeneration, alveolar cleft grafts, ridge split grafts, orthognathic surgery, continuity defect grafts, and rescue grafts, among others. This symposium is designed to provide you with specifi c indications, doses, use of co-materials, and placement principles, as well as an understanding of the pitfalls to avoid, drawbacks, and a discussion of complications so that the best results in bone regeneration can be achieved. The faculty for this symposium consists of the clinicians and researchers with the most thorough scientifi c and clinical experience using rhbmp-2 so that everyone will receive the most up-to-date information and see case-specifi c examples to assess their own patients as to the applications and limitations of rhbmp-2 for their own practice. I am confi dent that this meeting will deliver the same extraordinary learning opportunities that participants experienced during the First BMP Symposium last year. I look forward to welcoming you to Philadelphia. Sincerely, Robert E. Marx, DDS Program Chairman ABOUT THIS COURSE After numerous animal and human research studies that fi rst began in 1965, the Food and Drug Administration (FDA) cleared recombinant human Bone Morphogenetic Protein-2/ACS (rhbmp-2/acs) for two dental and oral and maxillofacial surgery indications (socket grafting and sinus augmentation) in March of In just three short years, it has met and even exceeded its clinical promise of bone regeneration without using the patient s own bone. Extended applications into horizontal and vertical ridge augmentations, ridge splitting, implant salvage, alveolar clefts, orthognathic surgery, continuity defects, and salvaging inadequate grafts have shown that rhbmp-2/acs can replace autogenous grafting in many other applications thereby providing a reduced complication potential and morbidity for such patients. This course is designed to present the specifi cs of indications, techniques to be used, doses, co-materials, costs, and outcomes for these extended applications, by the researchers and clinicians with the most thorough scientifi c and clinical experience using rhbmp-2/acs. This course should provide the necessary information and examples so that attendees can assess each of their own patients as to the potential use and limitations in using rhbmp-2/acs.

3 GENERAL INFORMATION REGISTRATION Your registration fee includes admission to all symposium sessions and exhibits, daily morning coffee breaks, breakfast Saturday through Monday, lunch Saturday and Sunday, and the symposium reception on Saturday evening. Take advantage of specially reduced fees by registering in advance. REGISTRATION FEES By January 31, 2011 On or After February 1, 2011 Regular rate $750 $850 Resident rate* $400 $400 *Please submit verifi cation of resident status with the registration form. HOW TO REGISTER Complete the enclosed registration form and do one of the following: Register online at OR Mail your form and check (payable to Quintessence Publishing Co Inc) for the registration fee to Quintessence Publishing at the address indicated on the reverse, OR Fax your form with credit card information to Quintessence at On-site registration will be accepted only on the basis of space availability and thus cannot be guaranteed. Early advance registration is strongly recommended. The deadline for registering for the symposium is April 1, CANCELLATIONS/REFUNDS Cancellations made in writing and received by Quintessence before April 1, 2011, will be refunded in full. For cancellations received on or after April 1, 2011, but before the start of the meeting, a cancellation fee of US $50 will be charged. No refunds will be made after the symposium begins on April 16, LOST BADGES Your badge represents your ticket of admittance to all lectures. If you lose or misplace your badge, you will be charged a replacement fee of US $400; there are no exceptions to this policy. You must wear your badge each time you wish to enter the lecture halls. CONTINUING EDUCATION CREDITS One hour of continuing education (CE) credit is offered for every hour of program attendance. CE credit awarded for participation in a course may not apply toward licensing renewal in all states. It is the responsibility of each participant to verify the requirements of his or her state licensing board. Meeting attendees are responsible for ensuring that their education credits are current and on fi le with their respective state board or other licensing/regulatory agency. Attendees of the symposium may receive up to hours of CE credit. If you have any questions regarding CE credit, contact Carol Thomas, cthomas@quintbook.com. Quintessence Publishing Co Inc is an ADA CERP Recognized Provider. REGISTRATION DESK Your symposium packet will await you at the symposium registration desk. The desk will be open from 1:00 PM to 6:00 PM on Friday, April 15, and from 6:30 AM on Saturday through Monday. Please note that on-site registrations will be accepted only if room capacity allows. HOTEL RESERVATION A block of hotel rooms has been held for symposium participants at the Philadelphia Marriott Downtown Hotel. Reservations at the special symposium rate will be accepted until the cut-off date, April 6, 2011, or until the room block is sold out, whichever comes first. Call the hotel reservation desk direct at or Make sure to indicate the name of the symposium to receive the special meeting rate. You can also fi nd a link to the hotel reservation site on our webpage at TECHNICAL EXHIBITS Technical exhibits will be held on Saturday and Sunday during the symposium. Visit the exhibits to observe the latest developments in dental products offered by the leading manufacturers. Exhibit hours are: Saturday, April 16, :00 AM 6:00 PM Sunday, April 17, :00 AM 6:00 PM SYMPOSIUM RECEPTION A Welcome Reception will be held on Saturday, April 16, 2011, from 6:00 PM to 8:00 PM in the Liberty Ballroom. Meet your colleagues and the distinguished speakers; renew old friendships and begin new ones.

COURSE GOALS & OBJECTIVES Course Goals 1.

recombinant human bone morphogenetic protein in jaw reconstructions 2.

morphogenetic protein is indicated in their individual patients.

Participants will learn the appropriate dose of recombinant human bone

Participants will understand the role of scaffolds and tenting devices to

morphogenetic protein through hands-on practice, lectures, and seminar

PROGRAM SCHEDULE SATURDAY, APRIL 16, 2011 SPEAKER(S) TIME Breakfast with

Marx 8:00 8:15 AM The Science and History of BMP from Marshall Urist to

Marx 8:15 8:30 AM Sinus Augmentation Using rhbmp-2: Dosing, Space

Moy 8:30 9:30 AM 9:30 10:30 AM Break and Refreshments with Exhibitors

Augmentation Lunch with Exhibitors C. Misch S.

4 COURSE GOALS & OBJECTIVES Course Goals 1. Participants will be able to understand the expanding utility of recombinant human bone morphogenetic protein in jaw reconstructions 2. Participants will learn specifi c procedures for the regeneration of bone in defects of the jaws 3. Participants will be able to determine whether recombinant human bone morphogenetic protein is indicated in their individual patients. Objectives 1. Participants will learn the appropriate dose of recombinant human bone morphogenetic protein for each indication 2. Participants will understand the role of scaffolds and tenting devices to achieve the best outcome when using recombinant human bone morphogenetic protein 3. Participants will learn the correct application of recombinant human bone morphogenetic protein through hands-on practice, lectures, and seminar formats. PROGRAM SCHEDULE SATURDAY, APRIL 16, 2011 SPEAKER(S) TIME Breakfast with Exhibitors 7:00 8:00 AM Welcome and Introduction R. Marx 8:00 8:15 AM The Science and History of BMP from Marshall Urist to the Clinical Arena R. Marx 8:15 8:30 AM Sinus Augmentation Using rhbmp-2: Dosing, Space Maintainers, and Scaffolds J. Malmquist P. Moy 8:30 9:30 AM 9:30 10:30 AM Break and Refreshments with Exhibitors Ridge Preservation and Localized Horizontal and Vertical Ridge Augmentation Lunch with Exhibitors C. Misch S. Jovanovic 10:30 11:00 AM 11:00 12:00 PM 12:00 1:00 PM 1:00 2:30 PM Use of rhbmp-2 in Periodontal and Peri-Implant Defects D. Cochran 2:30 3:30 PM Use of rhbmp-2 for Interpositional Maxillary Ridge Split Grafts and Buccopalatal Wall Defects Case Discussion with Speakers Session A: Sinus Augmentation O. Jensen 3:30 4:30 PM J. Malmquist P. Moy Session B: Ridge Augmentation Session C: Ridge Split Grafts/Periodontal and Implant Defects C. Misch S. Jovanovic O. Jensen D. Cochran 4:30 6:00 PM Welcome Reception for All Participants and Faculty 6:00 8:00 PM

5 SUNDAY, APRIL 17, 2011 SPEAKER(S) TIME Breakfast With Exhibitors Bone Regeneration in Maxillary Alveolar Clefts and Craniofacial Defects Break and Refreshments with Exhibitors Use of rhbmp-2 in Local Ridge Augmentations Jaw Defects Lunch with Exhibitors W. Tom A. Herford J. Berger 7:00 7:30 AM 7:30 8:30 AM 8:30 9:30 AM 9:30 10:00 AM 10:00 11:00 AM 11:00 12:00 PM 12:00 1:30 PM Extended and Total Vertical Ridge Augmentations of the Maxilla and Mandible Using rhbmp-2 R. Marx 1:30 2:30 PM Reconstruction of Mandibular Continuity Defects Using rhbmp Case Discussion with Speakers Session A: Alveolar Clefts and Craniofacial Defects R. Marx W. Tom A. Herford 2:30 3:15 PM 3:15 4:30 PM Session B: Local Ridge Augmentation and Jaw Defects Session C: Mandibular Continuity Defects J. Berger O. Jensen R. Marx 4:30 6:00 PM MONDAY, APRIL 18, 2011 SPEAKER(S) TIME Breakfast 7:00 8:00 AM Applications of rhbmp-2 in Orthognathic Surgery P. Moy 8:00 9:00 AM Salvaging Defi cient Graft Outcomes Using rhbmp-2 R. Marx 9:00 10:00 AM 10:00 11:00 AM

6 SPEAKERS Joel S. Berger, DDS, MD, is chief of surgery at Sharp Memorial Hospital in San Diego, California, where he supervises all surgical subspecialties as well as general surgery, neurosurgery, and orthopedic surgery. He has served as a member of the San Diego Cleft and Craniofacial Group; chief of dental surgery at Rady Children s Hospital; chief of oral surgery at the University of California, San Diego, in the Department of Plastic Surgery; and a senior staff member at Scripps Mercy Hospital. He also maintains a private practice in oral and maxillofacial surgery in San Diego. David L. Cochran, DDS, PhD, is currently chairman of the Department of Periodontics at the University of Texas Health Science Center at San Antonio s Dental School. Prior to his appointment at San Antonio, he was director of postgraduate periodontics at the Medical College of Virginia, where he received his DDS and PhD in biochemistry before being trained in periodontology at the Harvard School of Dental Medicine. Dr Cochran is the former president of the American Academy of Periodontology. He has published numerous scientific articles on various periodontal biochemistry and implant topics and has received awards for his research work at both the national and international levels. Alan S. Herford, DDS, MD, is the chairman and residency program director of the Department of Oral and Maxillofacial Surgery at Loma Linda University School of Dentistry. He is the author of more than 20 peer-reviewed scientific publications on topics ranging from reconstructing skin cancer defects to distraction osteogenesis. He has also written book chapters on treatment of mandibular fractures, facial flaps, and treatment of soft tissue injuries. Dr Herford has presented his original research at both national and international meetings. His clinical interests are reconstructive surgery, maxillofacial trauma, and esthetic surgery. Ole T. Jensen, DDS, MS, has a private practice in oral and maxillofacial surgery that focuses on implants and bone graft reconstruction in Greenwood Village, Colorado. He is the author and/or editor of many publications, including the new multiauthored book The Osteoperiosteal Flap: A Simplifi ed Approach to Alveolar Bone Reconstruction (Quintessence, 2010) and lectures widely throughout the world. He was president of the Academy of Osseointegration Foundation in Sascha A. Jovanovic, DDS, MS, is a course director in implant dentistry at the UCLA School of Dentistry and is chairman and founder of the gide Insititute, an online dental education company. He was formally trained in periodontics, implant dentistry, and prosthodontics at the UCLA School of Dentistry, Loma Linda University, and University of Aachen, Germany, respectively, and he holds an MS degree in oral biology from UCLA. Dr Jovanovic is the former president of the European Association for Osseointegration (EAO). He has published 63 articles and book chapters and was a contributing author to Implantology: Color Atlas of Dental Medicine (Thieme, 1995). His research focuses on bone regeneration, rhbmp-2 growth factors and barrier membranes, and the biology of soft tissue around teeth and implants. Jay P. Malmquist, DMD, is an associate professor of oral and general pathology and oral and maxillofacial surgery at Oregon Health Sciences University in Portland, Oregon, where he also maintains a private practice limited to oral and maxillofacial surgery. He is a diplomate of the American Board of Oral and Maxillofacial Surgery, the National Dental Board of Anesthesiology, and the International Congress of Oral Implantologists.

7 Robert E. Marx, DDS, is professor of surgery and chief of the Division of Oral and Maxillofacial Surgery at the University of Miami Miller School of Medicine. His areas of research include the use of hyperbaric oxygen following radiation therapy, the development of platelet-rich plasma, and the relationship between smoking and carcinogenesis. Dr Marx has received numerous awards, including the Harry S. Archer Award, the William J. Gies Award, the Paul Bert Award, and the Donald B. Osbon Award. His fi rst textbook, Oral and Maxillofacial Pathology: A Rationale for Diagnosis and Treatment (Quintessence, 2002), won the American Medical Writers Association s Medical Book of the Year Award for Craig M. Misch, DDS, MDS, received postgraduate certificates in prosthodontics and oral implantology and an MS degree from the University of Pittsburgh. He completed specialty training in oral and maxillofacial surgery at St Francis Medical Center in Pittsburgh and is a diplomate of the American Board of Oral and Maxillofacial Surgery. He currently practices as a dual specialist in Sarasota, Florida. Dr Misch is a clinical associate professor at New York University in the Department of Implant Dentistry and at the University of Florida in the Department of Prosthodontics. He serves on the Board of Directors of the Academy of Osseointegration and on the editorial board of The International Journal of Oral & Maxillofacial Implants. Peter K. Moy, DMD, is an associate professor of clinical dentistry in the Department of Oral and Maxillofacial Surgery as well as the director of the Nobel Biocare Surgical Fellowship Training Program in Implant Dentistry at the University of California Los Angeles. He also maintains a private practice limited to oral and maxillofacial surgery, primarily in the areas of osseointegrated dental implants and the reconstruction of severely atrophic ridges. Dr Moy has lectured nationally and internationally, has written numerous articles on implant dentistry and osseointegration, and serves as an associate editor for The International Journal of Oral & Maxillofacial Implants. Daniel B. Spagnoli, DDS, PhD, works in private practice as an oral and maxillofacial surgeon with offi ces in Concord, Denver, and Charlotte, North Carolina. He recently completed four research projects, three of which concerned the use of rhbmp-2 in grafts for maxillofacial bone defects. His interests include all aspects of temporomandibular joint treatment and surgery as well as reconstructive procedures of the oral and maxillofacial region, including bone grafting, distraction osteogenesis, dental implants, and orthognathic surgery. Dr Spagnoli has published numerous book chapters and research articles related to oral and maxillofacial surgery and basic science. He has also been a section editor of the American Association of Oral and Maxillofacial Surgeons Knowledge Update textbook since 1992 and editor of the oral and maxillofacial surgery section of the Cleft Palate Journal since William K. Tom, DDS, MS, is an oral and maxillofacial surgeon dedicated to treating patients with congenital and facial deformities. In addition to his private practice, he is a member of the craniofacial team at Children s Hospital and Research Center in Oakland, California. Currently, he is involved in the study of new tissue engineering materials, which he believes may reinvent surgical techniques used worldwide to treat congenital defects. Dr Tom is a diplomate of the American Board of Oral and Maxillofacial Surgery.

BMP SYMPOSIUM Extended Clinical Applications of Recombinant Human Bone Morphogenetic Protein 2 (rhbmp-2) Robert E. Marx, DDS FEATURING CHAIRMAN

BMP SYMPOSIUM Extended Clinical Applications of Recombinant Human Bone Morphogenetic Protein 2 (rhbmp-2) Robert E. Marx, DDS FEATURING CHAIRMAN BMP SYMPOSIUM 2010 FEBRUARY 12 13, 2010 SHERATON SAN DIEGO HOTEL AND MARINA FEATURING Extended Clinical Applications of Recombinant Human Bone Morphogenetic Protein 2 (rhbmp-2) CHAIRMAN Robert E. Marx,