Main cariogenic microorganisms: a Meta-analysis. doi: /j.issn

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1 Chinese Journal of Tissue Engineering Research August 20, 2015 Vol.19, No.34 Meta ( ) Meta Meta Meta ( {2012]16 ) 6 Cochrane EMBASE PubMed A ( A )( A ) Meta 8 OR > 1 < 1 Meta OR=2.41 OR=1.68 OR=2.75 OR=1.98 OR=2.38 OR= :R318 :B : (2015) Meta [J] (34): doi: /j.issn Main cariogenic microorganisms: a Meta-analysis Ye Yi-liao 1, 2, Jia Yu-huan 1, 3, Huang Wen-ming 1, 3, Zheng Yu-qi 2, 3 ( 1 Stomatological Hospital of Chongqing Medical University, Chongqing , China; 2 Chongqing Key Laboratory of Oral Diseases and Biomedicine, Chongqing , China; 3 Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing , China) Abstract BACKGROUND: Scholars have carried out a lot of research on the main cariogenic microorganisms, but there is still no comprehensive and systematic evaluation. OBJECTIVE: To perform an evidence-based medicine analysis on the six main cariogenic microorganisms. METHODS: Literature about microbial factors and age factors of caries disease etiology were retrieved, which were published from 2011 to 2014 in the Cochrane Library, EMBASE, PubMed, Wanfang, China Biology Medicine disc (CBMdisc), Chinese Journal Full-text Database (CJFD) and VIP. Eligible studies were divided into two groups according to absorbance values: observation group (higher absorbance value) and control group (lower absorbance value). The probability of dental caries under the impact of Streptococcus mutans, Lactobacillus microbe, Prevotella, Selenomonas, Capnocytophaga, Veillonella were statistically analyzed using Meta-analysis. RESULTS AND CONCLUSION: Eight articles were included in result analysis. Odds ratio (OR) values refer to the statistical difference in the probability of dental caries under same pathogenic factors between two groups: OR > 1 indicates the incidence of dental caries is higher in the observation group than the control group, and OR < 1 suggests the incidence of dental caries is lower in the observation group than the control group. Meta-analysis results show Streptococcus mutans (OR=2.41), Lactobacillus microbe (OR=1.68), Prevotella (OR=2.75), Ye Yi-liao, Studying for master s degree, Stomatological Hospital of Chongqing Medical University, Chongqing , China; Chongqing Key Laboratory of Oral Diseases and Biomedicine, Chongqing , China Accepted: ISSN CN /R CODEN: ZLKHAH 5559

2 . Meta Capnocytophaga (OR=1.98), Selenomonas (OR=2.38), indicating that the probability of dental caries is higher in the observation group than the control group, and these microorganisms are greatly correlated with the occurrence and development of dental caries; Veillonella (OR=0.45), indicating the probability of dental caries is lower in the observation group than the control group, and Veillonella has small correlation with dental caries and only plays an important role in a certain development stage of dental caries. Subject headings: Dental Caries Susceptibility; Streptococcus; Meta-Analysis Funding: the Plan Research Projects of the Science and Technology in Chongqing, No. [2012]16 Ye YL, Jia YH, Huang WM, Zheng YQ. Main cariogenic microorganisms: a Meta-analysis. Zhongguo Zuzhi Gongcheng Yanjiu. 2015;19(34): Introduction ( ) [1-3] ph 1994 Marsh Marsh 2006 ( ) ( ) (ph ) Meta Meta 6 1 Data and methods 1.1 CochraneEMBASE PubMed Dental caries dental caries Streptococcus mutans Lactobacillus microbe Capnocytophaga Selenomonas Prevotella Veillonella Google Scholar Cochrane 5.1 [4] 1.2 ( > 1) 20 40, 3 [ ] Meta 6 A1 1 (A ) Table 1 Experimental grouping according to different contents of microorganisms P.O. Box 10002, Shenyang

3 . Meta 1.3 [10] Meta [11] [12] 2 3 Cochrane A B C 3 Cochrane % 3 A B 1 1 C Cochrane RevMan 5.0 MetaRR (WMD) (SMD) 95% [13] 2 (Fixed effect model) [14] 2 Results Table 2 Quality evaluation of included studies / (n) (%) Kumar YS 2014 [1] 193/ A Do LG 2014 [2] 166/ A Rother M 2014 [3] 269/ A Prabhakar AR 2014 [5] 172/184 (n=2) 96.4 B Mei ML 2014 [6] 239/ A Soni S 2014 [7] 245/194 (n=2) 95.3 B Makhija SK 2014 [8] 223/186 (n=1) 98.7 B Gaudilliere D 2014 [9] 221/ A 2.2 Meta 6 P=0.99 P=1 P=1 P=0.72 P=1 P=0.8 P > 0.1 I 2 0 OR OR >1 OR < 1 OR=2.41(95% ) P< OR=1.68(95% ) P < OR=2.75(95% ) P < OR=2.38(95% ) P < OR=1.98(95% ) P < OR=0.45(95% ) P < ( ) OR 95% 1 (OR > 1) ( ) OR 95% 0.45(OR < 1) Revman5.0 7 ISSN CN /R CODEN: ZLKHAH 5561

4 . Meta 1 Meta Figure 1 Forest map of Streptococcus mutans effect on dental caries OR=2.41(95% ) P < Meta Figure 2 Forest map of Lactobacillus microbe effect on dental caries OR=1.68(95% ), P < Meta Figure 3 Forest map of Prevotella effect on dental caries OR=2.75(95% ), P < P.O. Box 10002, Shenyang

5 . Meta 4 Meta Figure 4 Forest map of Selenomonas effect on dental caries OR=2.38(95% ), P < Meta Figure 5 Forest map of Capnocytophaga effect on dental caries OR=1.98(95% ), P < Meta Figure 6 Forest map of Veillonella effect on dental caries OR=0.45(95% ), P < 0.05 ISSN CN /R CODEN: ZLKHAH 5563

6 100. Meta , 8 3 Discussion Meta Meta (X ) (Y ) 6 (Meta )Meta (n < 2) 1 10 [17] Beighton [16] 7 Figure 7 Funnel plot of literature bias concerning the six main cariogenic microorganisms 0.01% 1% [17] Chhour [18] PCR ph [19] [20] Bradshaw [21] ph [22] (HOMIM) 454 [23-25] 6 ( ) 5564 P.O. Box 10002, Shenyang

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