ERYTHRODERMA CAUSED DRUG ALLERGIES
|
|
- Camron Barton
- 5 years ago
- Views:
Transcription
1 CASE REPORT ERYTHRODERMA CAUSED DRUG ALLERGIES Asrawati Sofyan, Sitti Nur Rahmah, Asnawi Madjid Department of Dermatovenereology Medical Faculty of Hasanuddin University / Wahidin Sudirohusodo Hospital Makassar ABSTRACT Erythroderma is inflammation skin disease characterized by erythema and scales almost or all over the body. Erythroderma is Caused by many etiologies such as extended skin diseases, allergic drug, systemic diseases and idiopathic. About 5-40% erythordermic caused by allergic drug. Regardless of the underlying disease, eryhtrodermic patient should be hospitalized. Erythroderma due to allergic drug has a good prognosis, if the offending drug could be established and withdrawn. We reported a case of erythroderma due to drug eruption in a 56 year old woman. The management of this patient include withdrawn the offending drugs, intravenous dexamethasone. Topical corticosteroids as a dexosimethasone 0.025% ointment and hydrocortisone 2.5% cream, have given a satisfying result. Keywords: erythroderma, allergic drug, dexamethasone iv, hydrocortisone 2.5% cream, desoximethasone 0.25% ointment 27
2 Asrawati Sofyan Erythroderma Caused Drug Allergies INTRODUCTION Erythroderma is a skin disorder that belongs to a group papulosquamous eruption, characterized by erythema and squama which extends more than 90% body surface area. (1-4) Another name for this disease is exfoliative dermatitis, pityriasis rubra (Hebra), erythroderma ( Wilson- Brocq), and erythema scarlatiniform. 1.5 Erythroderma can be caused by the expansion of skin and systemic disease, psoriasis 23%, spongiotic dermatitis 20%, drug hypersensitivity reactions 15%, CTCL (cutaneous T-cell lymphoma) or Sezary syndrome 5%, seborrheic dermatitis idiopathic 4%. (4) The incidence of erythroderma varied, ranging from 0.9 to 71 cases per 100,000 people. (1) From the data of a study from 1981 to 2000, obtained results which men are more often affected than females with a ratio of 2.2: 1. ( 6) The average age of patients with this disease between years old, in which children are the exclusion criteria in this disease in previous studies (1). The pathogenesis of the erythroderma is unclear. In general it can be said that the pathophysiology of erythroderma is almost the same regard-less of the underlying disease. (4) In ery-throderma turnover increased epidermal cells (epidermal turn over), so that the transit time required keratinocytes through the epidermis becomes shorter. Because rapid succession, the stratum corneum, there are a number of components that are normally absorbed or metabolized. (7) In addition, the increased circulation erythroderma epidermis and dermis, and vascular permeability. (8) The presence of cytokines in dermal infiltration can vary depending on the basis of erythroderma disease. Mild erythroderma showed the presence of T helper-1 cytokines, whereas Sezary syndrome showed a T helper-2 cytokine by different pathophysiological mechanisms. (1) Interleukin (IL) - 1, IL-2, IL-8 cellular adhesion molecule (ICAM) - 1, tumor necrosis factor and interferon gamma is a cytokine that plays a role in erythroderma. Increased expression of adhesion molecules increased epidermal proliferation and production of inflammatory mediators. (7) Erythroderma management in general is based on the etiology of erythroderma itself. Hospitalization, where dermatological care available, as well as supporting facilities and adequate laboratory, generally can be a treatment option for patients with erythroderma. Erythroderma can be a serious medical cases and endanger the patient, and requires hospitalization. (1,4,9) This case reported a case erythroderma caused by drug eruption, in a woman, 56 years old. Patient respond well to systemic and topical corticosteroids. CASE REPORTS A woman, 56 years, came to Bhayangkara Hospital Makassar, with complaints of reddish spots on the entire body experienced since 6 days ago. Originally itching felt on both hands, 11 days ago, the patient went to Sungguminasa hospital and treated with cefadroxil, loratadine, and desoximethasone ointments. But there is no improve-ment, itching and redness accompanied by swelling widespread. Redness was originally found in mouth and face and then the rest of the body. Fine scales showed up all over the body and extremities later. Patient complaint pain of eye and pain during urination.patient complained of nausea. No fever. History of fever 2 days 28
3 IJDV Vol.1 No before entering hospital and patient took paracetamol. Based on history, pasient had consumption of drugs / herbs before itching and redness raised up. History of drug allergies and food allergies were denied. History of suffering with the same complaint is denied. No previous skin disease. A family history of similar complaints denied. History of diabetes and erythematous macular and fine scales. And on face area is found erythematous, squama and crusting. From the results of laboratory tests found a leukocytosis (28.700/µl), and other laboratory tests in normal. The results of histopathological examination showed psoriasiform hyperplasia epidermal, hyperkeratosis, parakeratosis, many neutrophil hypertension is denied, the patient had a history of suffering from sinusitis and polip nasal. On physical examination found the patient's general state of ill being, consciousness composmentis, sufficient nutrition. Vital signs within normal limits. Dermatology examination on the entire surface of the body (generalized) is found 29 accumulation in this area, focal hypogranulosis, spongiosis, papillary dermal blood vessels dilate, containing erythrocytes. Upper dermis contained dense infiltrates of inflammatory lymphocytes, eosinophils, neutrophils perivasculer. In conclusion : chronic spongiotic dermatitis drug eruption.
4 Asrawati Sofyan Erythroderma Caused Drug Allergies Patients diagnosed with erythroderma due to drug eruption, erythroderma d ue to psoriasis vulgaris. Based on history, physical examination and histopathological examination, the diagnosis is established erythrodermi ec drug eruptions. Treatment was given with cessation of the suspected drugs, infusion of Ringer's lactate (20 drops per minute), intravenous injection dexamethasone 1 ampoule (5mg/ml) per 12 hours, ranitidine 1 ampoule per 12 hours, mebhidrolin naphadisilate 50mg twice a day. Topical treatment desoximethasone 0.025% ointment, and hydrocortisone 2.5% cream for face area. Treatment for post-biopsy given erythromycin 500 mg 3 times a day, and sodium diclofenac tablet 3x1. The second day of treatment patient was consulted to the eye s doctor with a diagnosed as dry eye and was given cendo teen eye drops, patient was also consulted to internist for chest pain. Fourth day of treatment, itching was obtained, and erythema and squama reduced, treatment was continued. Sixth day of treatment, sometimes itchy. Erythema and skin squama greatly reduced. Because the lesions began to improve, dexamethasone replaced with oral medication methylprednisolone 20 mg per day. Seventh day of treatment, the patient was allowed to go home, and results dermatology examination showed fine scales on the body, and only minimal erythema in the region of vertebral and recommended for visite an outpatient clinic Bhayangkara hospital. Patient was diagnosed erythroderma caused by drug allergies. Treatment was continued methylprednisolone 20 mg per day, mebhydrolin naphadisilat 2x 50 mg daily (if itchy) and topical treatment desoximethasone ointment. DISCUSSION From the history and physical examination was found erythematous and squama on almost the entire body, which according to the existing literature on the presence of symptoms of an erythematous erythroderma and squama in the whole body or most of the body. Erythroderma classified into two, namely, primary erythrodermic / idiopathic (20%) the cause 30
5 IJDV Vol.1 No is unknown and secondary erythroderma (80%) with a known cause, such as the expansion of skin disease that has been there before, medicines, basic disorders or other systemic diseases In this case, erythroderma is caused by an allergic reaction of medication. Prevalence of erythroderma induced by different drugs in various populations. In a study conducted by E. Euch D et al on 127 cases of erythroderma in Tunisia, 13 percent of the cause is obscure. Meanwhile, from the other literature mentioned that the prevalence of drug-induced erythroderma is about 5 to 40 percent of all cases of erythroderma. 10th There are many drugs that can cause erythroderma. From various literature mentioned that drugs that often cause erythroderma include calcium channel blockers, antiepileptic, antimicrobial (cephalosporin, goals. Penicillin, sulfonamides, vancomycin), allopurinol, gold, lithium, quinidine, cimetidine, NSAIDs and dapsone. (1, 11.12). Drugs most suspected as the cause of erythroderma in these patients is cefadroxil and did not rule out with an unknown medication medicine names, paracetamol and herbs. However, in order to diagnose the type of drug suspects, one of them to do patch test. Squama formed in erythroderma varied, depending on the stage of erythroderma and underlying disease. In erythroderma due to an allergic reaction drugs, squamas were found to be thinner. (13) In this case, initially redness of the lips and face, and then spreads throughout the body, within a few days. Redness of the skin is also followed by the formation of a thin squama. Laboratory findings in erythrodermic generally does not help to establish a specific diagnosis. Abnormalities are often found were anemia, leukocytosis with eosinophilia, erythrocyte sedimentation rate (ESR) increased, hypoalbuminemia, increased levels of uric acid. (13) In the case of laboratory results showed leukocytosis (28.700/µl). In this case, the results of histopathological examination a chronic spongiotic dermatitis because drug eruption. In the literature it is said that a skin biopsy of erytroderma due to drugs showed parakeratosis, the disappearance of the granular cell layer and psoriasiform hyperplasia. Histopathological examination can not distinguish with certainty the cause of erythroderma. Biopsy specimens of erythroderma tend to exhibit nonspecific description such as hyperkeratosis, parakeratosis, acanthosis and chronic inflammatory infiltration. This discovery is often covered histological of the underlying disease. One third of the biopsy specimen failed to demonstrate basic disease erythroderma diagnosis. Accurate diagnosis of 50% established by dermatopathologist without obvious clinical information. Therefore, multiple biopsies recommended to increase the likelihood of a histopathologic diagnosis. 1,4,14,15 Differential diagnosis of erythroderma due to psoriasis removed because based on history, the rash appeared after patients taking the drug and no family who suffered the same skin diseases. This is contrast with psoriasis have a genetic predisposition. (1) Erythrodermic psoriasis begins with a typical psoriatic plaque on the area of predilection of psoriasis. In the clinical picture of this case showed fine scale, in psoriasis scales are thick and layered. (1.13) Apart from various causes, erythroderma treatment should be performed in a hospital. The principle of treatment is to 31
6 Asrawati Sofyan Erythroderma Caused Drug Allergies keep the skin moist, avoid scratching, avoiding trigger factors, providing topical steroids, treat basic of disease, and deal with complications that arise. That need to be monitored are the nutrients, protein and electrolyte balance, circulatory status, and body temperature. (2.7) In erythroderma due to allergic drug eruption is most important to stop the drugs suspected to be the cause of erythroderma as soon as possible and avoid unnecessary medication. (8.14) In this case, patient was hospitalized and withdrawn the suspected drugs. Control of fluid and electrolytes balances. For prevention of infections after biopsy was given erythromycin 1500 mg daily in three divided doses. In erythroderma, oral sedative antihistamines can help reduce pruritus experienced by patients. (14) In case, the patient is given mebhidrolin napadisilate 50 mg twice daily. In erythroderma due to allergic drug eruption, required systemic corticosteroids. The dosage was given is 1-2 mg / kg per day. (1) In the case of patients treated with dexametasone 1 ampoule / 12 hours intravenously, and on the sixth day was replaced with methylprednisolone 20 mg. Prognosis in erythroderma depends on the basis of existing disease. Erythroderma caused by allergic drug eruptions have relatively better prognosis, when the suspected drug is known and its use discontinued. (7) In cases patient experienced allergic reactions caused by drugs. Once known suspected drug of causing the emergence of drug eruption and dismissed. Where to find patients respond well to treatment and could be argued that in this case of erythrodermic patient had a good prognosis. REFERENCES 1. Margaret J, Bernstein ML, Rothe MJ. Exfoliative dermatitis. In: Wolff K, Goldsmith LA, Katz SI, editors. Fitzpatrick's Dermatology in General Medicine. 7 th ed. New Yo rk: Mc. Graw Hill Medical; P Burton JL, Holden AC. Eczema, lichenification, Prurigo and Erythroderma. In; Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. 7 th ed. London: Blackwell Science; P : Habif TP. Exfoliative Er y throderma In: Habif TP. Dermat Clinical ology: AC olour G uide to D iagnosis and T herapy. 4 th ed. Edinburg: Mosby; p Richard AF, Clark TH. Papulosquamous eruptions and Exfoliative Dermatitis. In: Moachella SL, Hurley HJ, Editors. Dermatology. 3 rd ed. Philadel phia: WB Saunders Company; P Arnold HR, Odam RB, James WD. Rosea, pityriasis rubra pilaris, and Other Papulosquamous. In: James WD, Berger TG, Elston DM, editors. Andrews' Diseases of the Skin Clinical Dermatology. tenth ed. Philadelphia: Elsevier; p Rym BM, Mourad M, Bechir Z. Erythroderma in adults: a report of 80 cases. International Journal od Dermatology March; 44 (9) : Karakayli G, Beckham G, Orengo I et al. Exfoliative dermatitis. A American Family Physician 1999; Murphy FG. Non Infectious Diseases Vesicobullous and Vesiculopustular. 32
7 IJDV Vol.1 No In: Elder ED, Elenitsas R, Johnson LB, Murphy FG, editors. Lever's histopathology of the skin. 9 th ed. Philadelphia: Lipincott William & Wilkins; p Sterry W, Münche M, Erythroderma. In: Bolognia LJ, LJ Jorizzo, Rapini PR, editors. Dermatology. London: Mosby; P Euch El D, Zeglaoui F, Benmously M et al. Erythroderma: A Clinical Study of 127 Cases and Review of the Literature. Exog J Dermatol 2003; 2: Dwiprahasto I. Epidemiology and Drug Side Effects Monitoring. Scientific Seminar set text & E Dermatology; Yogyakarta; White MG, Cox HN. Patterns of Drug eruptions. In: White MG, Cox HN, editors. Diseases of the Skin. 2 nd ed. Philadelphia: Elsevier Inc; p Sterry W, Muche M. Erythroderma. In: Bolognia LJ, LJ Jorizzo, Rapini PR, editors. Dermatology. London: Mosby; p EL ownership. Drug eruptions. In: Moschella LS, Hurley JH, editors. Dermatology. 3 rd ed. Philadelphia: WB Saunders C; p Neil Crowson, Brown J T. Progress in the Understanding of the pathology and pathogenesis of Cutaneous Drug Eruption, Implications for Management.Am J Clin Dermatol 2003; 4 (6):
Psoriasiform pemphigus foliaceus: a report of two cases
J Cutan Pathol 2012: 39: 549 553 doi: 10.1111/j.1600-0560.2012.01866.x John Wiley & Sons. Printed in Singapore Copyright 2012 John Wiley & Sons A/S Journal of Cutaneous Pathology Psoriasiform pemphigus
More informationRetrospective 10 years review of 100 patients with psoriasis in the Kingdom of Saudi Arabia (KSA)
Retrospective 10 years review of 100 patients with psoriasis in the Kingdom of Saudi Arabia (KSA) Ahmed Abdullah Alhumidi King saud university, Riyadh, kingdom of Saudi Arabia Abstract Background: This
More informationSupplementary Online Content
Supplementary Online Content Ross NA, Chung H-J, Li Q, Andrews JP, Keller MS, Uitto J. Pityriasis rubra pilaris: a case series of patients. Published online March 9, 26. JAMA Dermatol. doi:./jamadermatol.26.9.
More informationErythroderma: A clinico-etiological study of 58 cases in a tertiary hospital of North India
ORIGINAL ARTICLE ASIAN JOURNAL OF MEDICAL SCIENCES Erythroderma: A clinico-etiological study of 58 cases in a tertiary hospital of North India Nadia Shirazi 1, Rashmi Jindal 2, Akanksha Jain 2, Kanika
More informationA Pilot Study. Name of investigational product:
An Open Label, Multi Center Clinical Study to Evaluate the Efficacy and Safety of a New Topical Cosmeceutical in Relieving the Redness, Scaling and Flaking Associated with Severe Skin Conditions A Pilot
More informationERYTHRODERMA. ASAPA 2018 Fall Conference Tucson, AZ 10/12/2018. Andrew Newman, DO Pgy-3, Affiliated Dermatology/Honor Health
ERYTHRODERMA ASAPA 2018 Fall Conference Tucson, AZ 10/12/2018 Andrew Newman, DO Pgy-3, Affiliated Dermatology/Honor Health OBJECTIVES Define Erythroderma Name common diseases and medications that cause
More informationPsoriasis Case presentation 2 Ahmad is 50 years old male came to the on call dermatologist with a 3 day history of feeling generally unwell and
Psoriasis Case presentation 2 Ahmad is 50 years old male came to the on call dermatologist with a 3 day history of feeling generally unwell and redness of all skin associated with de-sequamation scaling.
More informationName the condition: Canine sterile neutrophilic dermatosis (Sweet s syndrome)
5-year-old male miniature Schnauzer dog with acute onset of severe macular erythema and multiple tender violaceus plaques all over the body. Which of the following is the most likely diagnosis? 1. Canine
More informationOriginal Article. Palmoplantar Psoriasis versus Eczema: Major Histopathologic Clues for Diagnosis
Iranian Journal of Pathology (2014) 9 (4), 251-256 251 Original Article Palmoplantar Psoriasis versus Eczema: Major Histopathologic Clues for Diagnosis Kambiz Kamyab Hesari, Zahra Safaei Naraghi, Azita
More informationRecalcitrant Warty Erythroderma With Severe Pruritus. Gil Yosipovitch Professor & Chair Department of Dermatology & Itch Center Temple University
Recalcitrant Warty Erythroderma With Severe Pruritus Gil Yosipovitch Professor & Chair Department of Dermatology & Itch Center Temple University DISCLOSURE OF RELEVANT RELATIONSHIPS WITH INDUSTRY Gil Yosipovitch,
More informationCase Report Breast Cancer Presenting as Paraneoplastic Erythroderma: An Extremely Rare Case
Case Reports in Medicine, Article ID 351065, 4 pages http://dx.doi.org/10.1155/2014/351065 Case Report Breast Cancer Presenting as Paraneoplastic Erythroderma: An Extremely Rare Case Ioannis Protopsaltis,
More informationClinical, Histopathological and Immunohistochemical Study of Cases Presenting with Erythroderma
Clinical, Histopathological and Immunohistochemical Study of Cases Presenting with Erythroderma A Thesis Submitted For Partial Fulfillment of Master Degree in Dermatology By Suzan Mohamed Ameen Shalaby
More informationA. Erythema multiforme and related diseases
Go Back to the Top To Order, Visit the Purchasing Page for Details Chapter Erythema, Erythroderma (Exfoliative Dermatitis) Erythema is caused by telangiectasia or hyperemia in the papillary and reticular
More informationEmergency Dermatology Dr Melissa Barkham
Emergency Dermatology Dr Melissa Barkham Spotlight Seminar 30 th September 2010 Why is this important? Urgent recognition and treatment of dermatologic emergencies can be life saving and prevent long term
More informationComparative microanatomy of the normal skin with that of immunobullous condition
Original article: Comparative microanatomy of the normal skin with that of immunobullous condition 1Dr BananiKundu, 2 DrAnirban Sadhu, 3 DrRudradev Meyur, 4 Dr SauravKundu, 5 Dr Alpana De, 6Dr SatabdiSarkar
More informationHistopathological spectrum of non-infectious erythematous, papulo-squamous lesions
Histopathological spectrum of non-infectious erythematous, papulo-squamous lesions B. Rajasekhar Reddy 1*, Nalini Krishna.M 2 1 Associate Professor, Department of Pathology, Mediciti Institute of Medical
More informationMECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB. Friday, February 12, :30 am 11:00 am
MECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB Friday, February 12, 2012 9:30 am 11:00 am FACULTY COPY GOALS: Describe the basic clinical and morphologic features of various
More informationEczema & Dermatitis Clinical features: Histopathological features: Classification:
Eczema & Dermatitis Eczema is an inflammatory reactive pattern of skin to many and different stimuli characterized by itching, redness, scaling and clustered papulovesicles. Eczema and dermatitis are synonymous
More informationA Histopathologic Study of Papulosquamous Lesions of Skin
Original 404 Article Indian Journal of Pathology: Research and Practice Volume 6 Number 2, April - June 2017 (Part 2) DOI: http://dx.doi.org/10.21088/ijprp.2278.148x.6217.11 A Histopathologic Study of
More informationDermatology elective for yr. 5. Natta Rajatanavin, MD. Div. of dermatology Dep. Of Medicine, Ramathibodi Hospital Mahidol University 23 rd Feb 2015
Dermatology elective for yr. 5 Natta Rajatanavin, MD. Div. of dermatology Dep. Of Medicine, Ramathibodi Hospital Mahidol University 23 rd Feb 2015 How to diagnosis and manage eczema and psoriasis. Objectives
More informationPathology of the skin. Dr Fónyad László, 1sz. Patológiai és Kísérleti Rákkutató Intézet, SE
Pathology of the skin Dr Fónyad László, 1sz. Patológiai és Kísérleti Rákkutató Intézet, SE The skin Biggest organ Kb. 1.8 nm Kb. 10 kg Most frequent site for tumor development (BCC) Pathology of the skin
More informationAllergic versus Contact
Allergic versus Contact Dermatitis Julie Sterbank, DO Assistant Clinical Professor Allergy/Immunology MetroHealth Medical Center/Case Western Reserve University Disclosure I have no financial disclosures
More informationActinic keratosis (AK): Dr Sarma s simple guide
Actinic keratosis (AK): Dr Sarma s simple guide Actinic keratosis is a very common lesion that you will see in your day-to-day practice. First, let me explain the name Actinic keratosis. It means keratosis
More informationMucinoses Diverse group of disorders which have in common deposition of basophilic, finely granular and stringy material in the connective tissues of
Cutaneous Mucinoses Nathan C. Walk, M.D. Mucinoses Diverse group of disorders which have in common deposition of basophilic, finely granular and stringy material in the connective tissues of the dermis.
More informationNaphthalene in the Treatment of Patients with Atopic Dermatitis
2007;15(1):15-19 SHORT SCIENTIFIC COMMUNICATION Naphthalene in the Treatment of Patients with Atopic Dermatitis Ankica Smeh-Skrbin 1, Ivan Dobrić 2, Gordana Krnjević-Pezić 1, Pero Vržogić 1 1 Naftalan
More informationAzithromycin Therapy for Multiple Eruptive Milia: A Report of a Case, New Treatment Option, and Review of the Literature
ISPUB.COM The Internet Journal of Dermatology Volume 7 Number 1 Azithromycin Therapy for Multiple Eruptive Milia: A Report of a Case, New Treatment Option, and Review of the Literature E McCarley O'Shea,
More informationClinico-Pathologic Study of Exfoliative Dermatitis in Patients Visiting a Tertiary Care Centre in South India
Original Article DOI: 10.17354/ijss/2016/69 Clinico-Pathologic Study of Exfoliative Dermatitis in Patients Visiting a Tertiary Care Centre in South India G Mahabaleshwar 1, Kashinath Nayak 2, Maria Kuruvila
More informationTHERE IS A GROUP OF PAtients. Defining Urticarial Dermatitis. A Subset of Dermal Hypersensitivity Reaction Pattern
STUDY Defining Urticarial Dermatitis A Subset of Dermal Hypersensitivity Reaction Pattern Steven Kossard, FACD; Ian Hamann, FACD; Barbara Wilkinson, BSc Background: Urticarial dermatitis may represent
More informationDepartment of Dermatology, Christian Medical College and Hospital, Ludhiana, Punjab, India.
Bullous pemphigoid mimicking granulomatous inflammation Abhilasha Williams, Emy Abi Thomas. Department of Dermatology, Christian Medical College and Hospital, Ludhiana, Punjab, India. Egyptian Dermatology
More informationEverant.in/index.php/jmpr. Journal of Medical Practice and Review
Everant.in/index.php/jmpr Journal of Medical Practice and Review Real world Efficacy and Tolerance of Bepotastine, a new 2 nd generation antihistamine, in Pruritis and other symptoms associated with cutaneous
More informationDrug Allergy A Guide to Diagnosis and Management
Drug Allergy A Guide to Diagnosis and Management (Version 1 April 2015 updated April 2018) Author: Jed Hewitt Chief Pharmacist, Governance & Professional Practice Date of Preparation: April 2015 Updated:
More informationInflammatory skin disease I Jade Wititsuwannakul, MD Chulalongkorn University, Thailand
Inflammatory skin disease I Jade Wititsuwannakul, MD Chulalongkorn University, Thailand Superficial Perivascular Dermatitis Interface Dermatitis Vacuolar Dermatitis Lichenoid Dermatitis Barnhill Textbook
More information1.1. Lenalidomide and (aggravation of) psoriasis
20-4-2012 1.1. Lenalidomide and (aggravation of) psoriasis Introduction Lenalidomide (Revlimid ), was registered on the Dutch market in June 2007 and is indicated for the treatment of multiple myeloma
More information2004 Health Press Ltd.
Eczema and Contact Dermatitis John Berth-Jones Consultant Dermatologist University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK Eunice Tan Specialist Registrar in Dermatology Norfolk and
More informationDrug allergy and Skin Disorders. Timothy Craig, DO, FACOI Professor of Medicine and Pediatrics Distinguished Educator Penn State University, Hershey
Drug allergy and Skin Disorders Timothy Craig, DO, FACOI Professor of Medicine and Pediatrics Distinguished Educator Penn State University, Hershey The best screening test for anaphylaxis is? A. histamine
More informationMECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB. Friday, February 13, :30 am 11:00 am
MECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB Friday, February 13, 2009 9:30 am 11:00 am FACULTY COPY GOALS: Describe the basic clinical and morphologic features of various
More informationOXCARBAZEPINE-INDUCED STEVENS-JOHNSON SYNDROME: A CASE REPORT
OXCARBAZEPINE-INDUCED STEVENS-JOHNSON SYNDROME: A CASE REPORT Lung-Chang Lin, 1,2 Ping-Chin Lai, 3 Sheau-Fang Yang, 4 and Rei-Cheng Yang 1,5 Departments of 1 Pediatrics and 4 Pathology, Kaohsiung Medical
More informationA Retrospective Study of Correlation Between Clinical And Histopathological Diagnosis In Erythroderma.
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 16, Issue 10 Ver. II (Oct. 2017), PP 60-64 www.iosrjournals.org A Retrospective Study of Correlation
More informationEmergency Dermatology. Emergency Dermatology
Emergency Dermatology These are rapidly progressive skin conditions and some are potentially lifethreatening. Early recognition is important to implement prompt supportive care and therapy. Some are drug
More informationSubject Outline: Dermatology II
Subject Outline: Dermatology II Course: Master of Dermatology (Coursework) Subject: Dermatology II (An introduction to clinical dermatology) Credit Points: 3 Year/Semester Delivered: 1/2 Subject Outline:
More informationEczema. By:- Dr. Naif Al-Shahrani Salman bin Abdazziz University
Eczema By:- Dr. Naif Al-Shahrani Salman bin Abdazziz University Dermatitis= Eczema =Spongiosis Eczema Atopic Seborrheic Contact Allergic Irritant Nummular Asteatotic Stasis Neurodermatitis/Lichen Simplex
More informationPsoriasis. What is Psoriasis? What causes psoriasis? Medical Topics Psoriasis
1 Psoriasis What is Psoriasis? Psoriasis is a long standing inflammatory non-contagious skin disease which waxes and wanes with triggering factors. There is a genetic predisposition in psoriasis. Internationally,
More informationBreast Pathway Group EC x 4 Docetaxel x 4: Epirubicin & Cyclophosphamide followed by Docetaxel in Early Breast Cancer
Breast Pathway Group EC x 4 Docetaxel x 4: Epirubicin & Cyclophosphamide followed by Docetaxel in Early Breast Indication: Neoadjuvant therapy for high risk and fit breast cancer patients suitable for
More informationA Descriptive Study on Patients of Papulosquamous Lesion at Tertiary Care Institute
MVP Journal of Medical Sciences, Vol 1(1), 30 35, January 2014 A Descriptive Study on Patients of Papulosquamous Lesion at Tertiary Care Institute S. D. Chavhan 1*, S. V. Mahajan 2 and A. J. Vankudre 3
More informationالاكزيماتيد= Eczematid
1 / 7 2 / 7 Pityriasis Debate confusing of hypopigmentation characterized increasing surrounded differ hypomelanotic "progressive exists alba misnomer extensive a to observed term the applied term derived
More informationComparative efficacy of topical mometasone furoate 0.1% cream vs topical tacrolimus 0.03% ointment in the treatment of atopic dermatitis
Original Article Comparative efficacy of topical mometasone furoate 0.1% cream vs topical tacrolimus 0.03% ointment in the treatment of atopic dermatitis Md Alauddin Khan *, Lubna Khondker **, Dilshad
More informationCutaneous Adverse Drug Reactions in Domestic Animals. Katherine Doerr, DVM, Dip. ACVD. Veterinary Dermatology Center
Cutaneous Adverse Drug Reactions in Domestic Animals Katherine Doerr, DVM, Dip. ACVD Veterinary Dermatology Center Maitland, Rockledge, Waterford Lakes, FL Not highly studied in veterinary medicine Unknown
More informationINTRA LESIONAL TRIAMCINOLONE ACETONIDE INJECTION IN THE TREATMENT OF CHRONIC RECALCITRANT PLAQUE PSORIASIS
I.J.A.B.R., VOL. 2(4) 2012: 750-755 ISSN 2250-3579 INTRA LESIONAL TRIAMCINOLONE ACETONIDE INJECTION IN THE TREATMENT OF CHRONIC RECALCITRANT PLAQUE PSORIASIS a Galawish A. Abdullah, b Ammar T. Aliwe &
More informationDifference Between Seborrheic Dermatitis and Psoriasis
Difference Between Seborrheic Dermatitis and Psoriasis www.differencebetween.com Key Difference Seborrheic Dermatitis vs Psoriasis Dermatological conditions are perhaps the most worrisome diseases in the
More informationA case of Sweet's syndrome with marked facial swelling and fluid collection
Hong Kong J. Dermatol. Venereol. (2017) 25, 128-132 Case Report A case of Sweet's syndrome with marked facial swelling and fluid collection JE Seol, SH Park, DH Kim, JN Kang, H Kim A 43-year-old woman
More informationCPC. Chutika Srisuttiyakorn, M.D. Kobkul Aunhachoke, M.D. Phramongkutklao Hospital Bangkok, Thailand
CPC Chutika Srisuttiyakorn, M.D. Kobkul Aunhachoke, M.D. Phramongkutklao Hospital Bangkok, Thailand A 53 year-old woman with fever, facial swelling and rashes on face, trunk and upper extremities for 3
More informationKeywords: Psoriasis vulgaris Zinc pyrithione Betamethasone dipropionate
CLINICAL EFFICACY AND SAFETY OF A COMBINED FORMULATION OF ZINC PYRITHIONE 0.25% AND BETAMETHASONE DIPROPIONATE MICRONIZED 0.05% IN THE TREATMENT OF MILD TO MODERATE PLAQUE PSORIASIS. Abstract Background
More informationGrover s disease: A case report.
320 Case report Thai J Dermatol, October-December 2011 ABSTRACT: Grover s disease: A case report. Supicha Chavanich MD, Praneet Sajjachareonpong MD. CHAVANICH C, SAJJACHAREONPONG P. GROVER S DISEASE: A
More informationCase No. 5; Slide No. B13/8956/2
Interface diseases Case No. 5; Slide No. B13/8956/2 Histological findings Severe hydropic vacuolation of epidermal and follicular basal cells/ interface dermatitis Multifocally apoptotic keratinocytes
More informationGuttate psoriasis =ﻒدﺼﻠا ﻲﻄﻘﻨﻠا
1 / 69 Psoriasis Psoriasis may be divided into psoriasis vulgaris, generalized pustular psoriasis, and localized pustular ps Psoriasis Vulgaris Clinical Features 2 / 69 Psoriasis vulgaris is a common chronic
More informationPsoraisis = ﻒدﺼﻠا 1 / 84
1 / 84 2 / 84 3 / 84 4 / 84 5 / 84 6 / 84 Psoriasis Psoriasis may be divided into psoriasis vulgaris, generalized pustular psoriasis, and localized pustular ps Psoriasis Vulgaris Clinical Features 7 /
More informationBreast Pathway Group Docetaxel in Advanced Breast Cancer
Breast Pathway Group Docetaxel in Advanced Breast Cancer Indication: First-line palliative treatment, with or without trastuzumab, for advanced breast cancer in patients for whom an anthracycline is not
More informationFIT Board Review Corner April 2017
FIT Board Review Corner April 2017 Welcome to the FIT Board Review Corner, prepared by Tammy Peng, MD, and Amar Dixit, MD, senior and junior representatives of ACAAI's Fellows-In-Training (FITs) to the
More informationIt is estimated that about 26,000 new cases of
Focus on CME at Dalhousie University Set On Soothing Psoriasis A. H. Murray, MD, FRCP(C) Presented at the 76th Annual Dalhousie Refresher Course It is estimated that about 26,000 new cases of psoriasis
More informationSuccessful treatment of lichen planus with sulfasalazine in 20 patients
Successful treatment of lichen planus with sulfasalazine in 20 patients A. Bauzá, MD, A. España, MD, P. Gil, MD, P. Lloret, MD, and F. J. Vázquez Doval, MD From the Department of Dermatology, University
More informationDiagnosis and Management of Common and Infective Skin Diseases in Children at primary care level
Diagnosis and Management of Common and Infective Skin Diseases in Children at primary care level Dr Ng Su Yuen Paediatrician and Paediatric Dermatologist Hospital Pulau Pinang Outline Common inflammatory
More informationMicroscopic study of the normal skin in cases of mycosis fungoides
Microscopic study of the normal skin in cases of mycosis fungoides M. El Darouti, S. Marzook, M. Bosseila, O. Abu Zeid, O. El- Safouri, A. Zayed, A. El-Ramly Egyptian Dermatology Online Journal 2 (1):
More informationPackage leaflet: Information for the user. Piperacillin/Tazobactam Actavis 4 g / 0.5 g powder for solution for infusion. piperacillin / tazobactam
Package leaflet: Information for the user Piperacillin/Tazobactam Actavis 2 g / 0.25 g powder for solution for infusion Piperacillin/Tazobactam Actavis 4 g / 0.5 g powder for solution for infusion piperacillin
More informationCUTANEOUS DRUG REACTIONS OR I WOULDN T HAVE SEEN IT, IF I HADN T BELIEVED IT Edmund J. Rosser Jr., DVM, DACVD
CUTANEOUS DRUG REACTIONS OR I WOULDN T HAVE SEEN IT, IF I HADN T BELIEVED IT Edmund J. Rosser Jr., DVM, DACVD DERMATOLOGY Pathogenesis Immunologic: can involve Type I, II, III, IV hypersensitivity reactions.
More informationThe Identification Malassezia Species and Sebum Content on Seborrheic Dermatitis Patients
International Journal of Sciences: Basic and Applied Research (IJSBAR) ISSN 237-4531 (Print & Online) http://gssrr.org/index.php?journal=journalofbasicandapplied ---------------------------------------------------------------------------------------------------------------------------
More informationCommonly Coded Conditions in Dermatology
Commonly Coded Conditions in Dermatology No part of this presentation may be reproduced or transmitted in any form or by any means (graphically, electronically, or mechanically, including photocopying,
More informationDose of prednisone for allergic reaction
Dose of prednisone for allergic reaction Medical uses. Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic.
More informationA Case of Erythrodermic Dermatomyositis Associated with Gastric Cancer
Ann Dermatol Vol. 21, No. 4, 2009 CASE REPORT A Case of Erythrodermic Dermatomyositis Associated with Gastric Cancer Sung Woo Kim, M.D., Yoo Seok Kang, M.D., Sang Hoon Park, M.D., Un Ha Lee, M.D., Hyun
More information50 microgram/g Calcipotriol and 500 microgram/g betamethasone (as dipropionate).
DUPISOR Composition Gel 50 microgram/g Calcipotriol and 500 microgram/g betamethasone (as dipropionate). Action Calcipotriol is a non-steroidal antipsoriatic agent, derived from vitamin D. Calcipotriol
More informationEndocarditis. By : Mehrnoush. dianatkhah
Endocarditis By : Mehrnoush. dianatkhah Case 5.31, 31 years old woman CC : Fever, dyspnea, 3 days postpartum PMH : Mitral prolapse Fever 38.5 WBC : 8900 ESR : 84 CRP : 10.4 Cr : 0.6 NT Pro BNP: 5469 Physical
More informationGROUP 15 TOPICAL PREPARATIONS
- 105 - GROUP 15 15.1 DERMATOLOGICAL PREPARATIONS 15.1.1 TOPICAL ANTIFUNGALS CLOTRIMAZOLE Indication: Treatment of susceptible fungal infections, dermatophytoses, superficial mycoses, and cutaneous candidiasis
More informationClinical profile, etiology and histopathology of patients with erythroderma in South India
International Journal of Research in Dermatology Snigdha O et al. Int J Res Dermatol. 2017 Sep;3(3):384-388 http://www.ijord.com Original Research Article DOI: http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20173919
More informationPACKAGE LEAFLET: INFORMATION FOR THE USER. Flutarzole 0,05% w/w cream, Fluticasone propionate
PACKAGE LEAFLET: INFORMATION FOR THE USER Flutarzole 0,05% w/w cream, Fluticasone propionate 1. IDENTIFICATION OF THE MEDICINAL PRODUCT 1.1. Trade name Flutarzole 1.2. Composition Active substance: Fluticasone
More informationProgressive symmetrical Erythrokeratoderma: A case report and literature review.
214 Case report Thai J Dermatol, October-December 2010 Progressive symmetrical Erythrokeratoderma: A case report and literature review. Pasu Piamphongsant MD, Kowit Kampirapap MD. ABSTRACT: PIAMPHONGSANT
More informationEgyptian Dermatology Online Journal Vol. 6 No 1: 14, June 2010
Wells Syndrome H. Gammaz, H. Amer, A. Adly and S. Mahmoud Egyptian Dermatology Online Journal 6 (1): 14 Al-Haud Al-Marsoud Hospital, Cairo, Egypt e-mail: hananderma@hotmail.com Submitted: April 15, 2010
More informationFAMILIAL LICHEN AMYLOIDOSIS
CASE REPORT FAMILIAL LICHEN AMYLOIDOSIS Lisa Yuniati, Farida Tabri, Dirmawati Kadir Department of Dermatovenereology Medical Faculty of Hasanuddin University / Wahidin Sudirohusodo Hospital Makassar ABSTRACT
More informationDERMATOLOGICAL EMERGENCIES. DR. Ian Hoyle MBBS DIP IMC RCS (Ed), DA (UK),FRACGP,FACRRM,DIP DERM(Wales) TASMANIAN SKIN AND BODY CENTRE
DERMATOLOGICAL EMERGENCIES DR. Ian Hoyle MBBS DIP IMC RCS (Ed), DA (UK),FRACGP,FACRRM,DIP DERM(Wales) TASMANIAN SKIN AND BODY CENTRE Dermatological Emergencies INFECTIONS ERYTHRODERMA DRUG ERUPTIONS STEVENS-JOHNSON
More informationPhototherapy and Photochemotherapy Treatment (Ultraviolet A [PUVA] and B [UBV])
Origination: 09/27/07 Revised: 08/2/17 Annual Review: 11/2/17 Purpose: To provide Phototherapy and Photochemotherapy Treatment (PUVA and UBV) guidelines for the Medical Department staff to reference when
More informationTHE THERAPY OF THE REBEL SEVERE PSORIAZIS WITH BIOLOGICAL PREPARATS
Bulletin of the Transilvania University of Braşov Series VI: Medical Sciences Vol. 5 (54) No. 2-2012 THE THERAPY OF THE REBEL SEVERE PSORIAZIS WITH BIOLOGICAL PREPARATS Mădălina FRÎNCU 1 Abstract: Biological
More informationUrticarial Dermatitis: Clinical Characteristics of Itch and Therapeutic Response to Cyclosporine
Itch and Cyclosporine in Urticarial Dermatitis pissn 1013-9087ㆍeISSN 2005-3894 Ann Dermatol Vol. 29, No. 2, 2017 https://doi.org/10.5021/ad.2017.29.2.143 ORIGINAL ARTICLE Urticarial Dermatitis: Clinical
More informationSkin lesions & Abrasions
Skin lesions & Abrasions What Are Skin Lesions? A skin lesion is a part of the skin that has an abnormal growth or appearance compared to the skin around it Types of Skin Lesions Two types of skin lesions
More informationPapulosquamous: clinicopathological
International Journal of Research in Medical Sciences Narayankar SL et al. Int J Res Med Sci. 2018 Jan;6(1):309-316 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Original Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20175740
More information1 / 5. الابط في الحبيبي التقرن نظير=- parakeratosis Axillary granular
1 / 5 الابط في الحبيبي التقرن نظير=- parakeratosis Axillary granular Axillary Granular manifesting cutaneous parakeratosis antiperspirants agents. sweating, granular Granular parakeratosis, and, folds.
More informationAnimal Models of Atopic Dermatitis
Skin Diseases Animal Models of Atopic Dermatitis JMAJ 47(11): 51 57, 24 Hitoshi MIZUTANI*, Takeshi NISHIGUCHI**, and Takaaki MURAKAMI*** *** Professor, Department of Dermatology, Mie University, Faculty
More informationOriginal Research Article
CLINICOPATHOLOGICAL STUDY OF PAPULOSQUAMOUS SKIN LESIONS Chowdari Balaji 1, Metta Parvathi 2, Seeram Satish Kumar 3, Gunta Divya Lekha 4, Latchupatula Lavanya 5, Mantripragada Vidya Soundarya Lahari 6,
More informationA Case Report on Amoxicillin Induced Stevens- Johnson Syndrome
Open Journal of Clinical & Medical Case Reports Volume 2 (2016) Issue 11 A Case Report on Amoxicillin Induced Stevens- Johnson Syndrome Rajendra Singh Airee*; Aastha Rawal; Binu Mathew; H. Doddayya Abstract
More informationCutaneous Drug Reactions
Cutaneous Drug Reactions Andrei Metelitsa, MD, FRCPC, FAAD Co-Director, Institute for Skin Advancement Clinical Associate Professor, Dermatology University of Calgary, Canada Copyright 2017 by Sea Courses
More informationMy Algorithm. Questions to ask. Do you or your family have a history of?... Allergic rhinitis, Sensitive skin, Asthma Skin Cancer
Tracey C. Vlahovic, DPM Associate Professor, Temple University School of Podiatric Medicine My Algorithm Inflammatory Skin Disorder on Feet Family hx, clinical exam, look at hands! Defined plaques: Psoriasis
More informationThe Role of Low-Potency Topical Steroids in Day-to-Day Practice
Supplement to the December 2009 & AGING Series: Relevance of Low-Potency Topical Steroids in Dermatology The Role of Low-Potency Topical Steroids in Day-to-Day Practice Supplement supported by HMP COMMUNICATIONS
More informationATOPIC DERMATITIS: PATHOPHYSIOLOGY AND PHARMACOLOGY OF MANAGEMENT PEGGY VERNON, RN, MA, C-PNP, DCNP, FAANP
ATOPIC DERMATITIS: PATHOPHYSIOLOGY AND PHARMACOLOGY OF MANAGEMENT PEGGY VERNON, RN, MA, C-PNP, DCNP, FAANP Disclosures Promotional Speaker for Pfizer, Inc. Any unlabeled/unapproved uses of drugs or products
More informationDisorders of the vulva
Vulval lesions Disorders of the vulva Terminology standardised by the International Society for the Study of Vulvovaginal Disease(ISSVD) Classification 1.Nonneoplastic epithelial disorders of vulva Lichen
More informationBenign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more
Benign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more common on the trunk; but extremities, head and neck are
More informationPsoriasis Penis - A Two Case Report
Article ID: WMC003176 ISSN 2046-1690 Psoriasis Penis - A Two Case Report Corresponding Author: Dr. Ilko Bakardzhiev, MD, PhD, Medical College, Medical University of Varna, 9000 - Bulgaria Submitting Author:
More informationLow-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis
Open Access Case Report DOI: 10.7759/cureus.3943 Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis Eduardo P. Beltran Monasterio 1 1. Dermatology, Universidade Gama Filho (instituto
More informationWhat is Psoriasis? Common Areas Affected. Type Who Does it Affect Characteristics
What is? is a term derived from the Greek word psōra which means itch and is a common, long lasting, inflammatory skin condition which affects 1-3% of the UK population and about 80 million people worldwide.
More informationIf looking for a book Psoriasis Cure: Treatments, Natural Remedies and Best Home Managements (Skin Disease, Skin Problems, Skin Diseases and
Psoriasis Cure: Treatments, Natural Remedies And Best Home Managements (Skin Disease, Skin Problems, Skin Diseases And Disorders Book 1) By Jeff Kennedy READ ONLINE If looking for a book Psoriasis Cure:
More informationPsoriasiform Dermatitis in Children: Calling in the Troops
Psoriasiform Dermatitis in Children: Calling in the Troops Markus Boos, MD PhD Attending Physician, Dermatology Seattle Children s Hospital Assistant Professor of Pediatrics, University of Washington School
More informationRecognizing common Dermatologic conditions. Case presentations. CAPA 2015 Annual Conference. Tanya Nino, MD St. Joseph Heritage Medical Group
Recognizing common Dermatologic conditions Tanya Nino, MD St. Joseph Heritage Medical Group Case presentations 65 year old female referred for rule out melanoma a lesion on back 30 year old female has
More informationSkin Disease in the Elderly
Special Issue Skin Disease in the Elderly DoWon Kim, M.D. Department of Dermatology Kyungpook National University School of Medicine & Hospital Email : kimdw@knu.ac.kr Abstract With the advance of socioeconomy
More informationFrequency of skin diseases among sea fishermen in Basrah
ISPUB.COM The Internet Journal of Dermatology Volume 7 Number 1 Frequency of skin diseases among sea fishermen in Basrah K Al Hamdi, M Al-Malikey Citation K Al Hamdi, M Al-Malikey.. The Internet Journal
More information