Live life, less complicated. InPen MOBILE APP. Healthcare Provider INSTRUCTIONS FOR USE. CompanionMedical.com
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1 InPen MOBILE APP Healthcare Provider INSTRUCTIONS FOR USE
2 TABLE OF CONTENTS Introduction...3 InPen Mobile App...3 Intended Use...3 Indications for Use...3 Contraindications...3 Start Orders...4 General Notes...4 Definitions...5 Dose Calculator Algorithm... 6 Basic Setup...7 Calculate a Dose... 9 Using the Dose Calculator with Blood Glucose Data... 9 Low Blood Glucose...10 Logging Doses without Using the Dose Calculator...11 Using the Dose Calculator without Blood Glucose Data...12 Split Doses...12 Additional Dose Calculator Settings Time of Day Settings Dose Reminders Insights by InPen Reports Patient Stats...16 Daily Reports
3 INTRODUCTION InPen Mobile App The InPen Application (App) is a diabetes management tool that tracks insulin doses from the InPen, calculates insulin doses, and shares therapy details with healthcare professionals and family members. This guide provides important information for the safe use of the InPen. To learn more visit: or download our free app Intended Use The InPen App is intended for use by people with diabetes to view, calculate, track, trend, and share data to support diabetes management. The App is available for use on ios and Android mobile devices, and is designed to work with the InPen smart injector pen. Indications for Use The InPen dose calculator, a component of the InPen App, is indicated for the management of diabetes by people with diabetes age 12 and older by calculating an insulin dose or carbohydrate intake based on user entered data. Prior to use, a healthcare professional must provide the patient-specific target blood glucose, insulin-to-carbohydrate ratio, insulin sensitivity parameters, duration of insulin action, and maximum dose to be entered into the App. Contraindications The InPen System is not intended for anyone unable or unwilling to: Check blood glucose (BG) levels as recommended by a healthcare provider Demonstrate adequate carbohydrate-counting skills Maintain sufficient diabetes self-care skills Visit a healthcare provider regularly 3
4 CONTINUED InPen Prescription/Start Orders InPen is a prescription-use only device. Whenever you prescribe InPen be sure to include the required and optional settings for customizing the dose calculator. These can be found on our website at: The patient may enter their settings into the InPen app at home once they have an InPen. General Notes Note: Refer to the Mobile App User Guide for instructions on how to pair the InPen to the mobile device. If the InPen is out of range of the mobile device the dose calculator may not have all recent doses logged which could result in unsafe recommendations, including hyperglycemia, hypoglycemia, or injury. To receive Alarms or Alerts the patient must: Make sure notifications are turned on in the settings menu. Check that the App hasn t been shut down by the mobile device. Make sure to turn on Bluetooth. Turn off the Do Not Disturb feature on the mobile device (if available). After the mobile device is restarted, make sure the InPen App is running. You may need to start the app by touching the InPen App icon. Set the volume on the mobile device at a level the patient can hear. Do not close the app. Keep it running in the background when you move on to other apps. Unplug headphones when not in use; Alarms and Alerts from the App cannot be heard through the mobile device if headphones are plugged in. It is recommended to allow the mobile device to set the date and time automatically. Medical device apps, like the InPen App, do not have any special priorities over the device s features. You cannot determine if an alarm/alert is a notification from the InPen App or another app without looking at the screen of the mobile device. 4
5 DEFINITIONS Active Insulin Also known as IOB (Insulin On Board), is an estimate of the insulin from recent doses that is still being used in the body. It is derived from the recent doses taken and the Duration of Insulin Action parameter. Maximum Calculated Dose This is the largest dose a patient should normally take. When using the dose calculator, the calculator never recommends a dose that is greater than this setting. Further, if the total of dose recommendation plus the doses taken in the last two hours exceeds this, a warning will be displayed.. Duration of Insulin Action This is the amount of time that insulin is actively lowering blood glucose. It is used to calculate Active Insulin and the blue circles on the history arc of the Home Screen. The bubbles are filled with blue immediately after dosing, and gradually turn grey as insulin metabolizes. Time of Day Settings Found in Insulin Settings, by default, this is disabled and Target Blood Glucose, Carbohydrate Factor, and Correction Factor are constant throughout the day. Time of Day (If Time of Day Settings are enabled) Each day at the time selected, the parameters in the column beneath it will be active until the next column s time is reached. Target Blood Glucose This is the blood glucose value the patient is trying to achieve. When entering a BG value into the Dose Calculator, it will recommend insulin or carbohydrates to return to this target value. Insulin Sensitivity Factor This is the amount blood glucose is lowered by 1 unit of insulin. Insulin to Carb Ratio This is the number of grams of carbohydrate covered by 1 unit of insulin. Last Glucose and Last Dose These are displays of the last glucose entered or measured with a connected BGM or CGM and the last insulin dose taken with an InPen or manually logged in the Logbook. How long ago is displayed in hours and minutes. If the value is older than 24 hours it is displayed as the number of days ago. 5
6 DOSE CALCULATOR ALGORITHM The insulin dose calculations provided by the App are meant for patients undergoing subcutaneous multiple daily injection (MDI) therapy. Dose calculators also track residual bolus insulin to mitigate insulin stacking. 1 The dose calculator utilizes the current blood glucose measurement, carbohydrate consumption, active insulin, carbohydrate factor, correction factor, and target blood glucose to calculate the estimated dose. 1 Adapted from Mudaliar et al, Diabetes Care, Volume 22, Number 9, Sept. 1999, page The basic equation is as follows: Dose Recommendation = Carbs Entered Carb Factor + BG Target BG Correction Factor Active Insulin If the calculated value is less than 0, then an Eat recommendation is given using the following equation: Suggested Carbs = - (Dose Recommendation) x Carb Factor If BG is not entered, Active Insulin (IOB) is not included in the calculation, and only a carb dose is calculated: Dose Recommendation = Carbs Entered Carb Factor 6
7 HOME SCREEN Time and value of last glucose measurement Time and size of last rapid acting insulin dose Daily Timeline Current Insulin-on-Board (Active Insulin) Dose Calculator Notification icons: Rapid Acting Reminder Low InPen Battery Insulin Temperature Insulin Age Long Acting Reminder 7
8 BASIC SETUP 1. Provide a complete InPen Start Order to the patient. Note: Insulin settings must be accurate and correct. If you are unfamiliar with insulin dosing or how to determine insulin settings, then do not prescribe the InPen System. 2. Download and install the InPen App from the mobile device app store. 3. Prepare the InPen for pairing (see quick start guide for instructions). 4. Launch the App by tapping the InPen icon. 5. Open the Settings page by tapping Settings. Open Insulin Settings by tapping on Insulin Settings. 6. Insulin setting values are entered from the InPen Start Order. 7. Review the settings and tap Home to return to the Home screen. 7. Setup is complete. 8
9 CALCULATE A DOSE Using the Dose Calculator with Blood Glucose Data 1. Launch the App by tapping the InPen icon. 2.. Open the dose calculator by tapping the icon. 3. Enter the current blood glucose as measured by BGM or CGM. Note: If a connected BGM is used and shared through Apple Health, blood glucose will be pre-populated. 4. Enter the number of grams of carbohydrates to be eaten. The dose recommendation is displayed. Low Blood Glucose If a low Blood Glucose value is entered, regardless of Active Insulin or Carbohydrates entered, a recommendation will be made to eat fast acting carbohydrates. 5. The math used to calculate the dose may be displayed by tapping the recommendation. 6. Tap Save to return to the Home screen. 7. Use the InPen to prime and then dial and dispense the recommended dose. 8. The Home Screen is updated with the time since last dose and current IOB. Note: It s recommended that the user not enter blood glucose if they dosed within the last two hours. 9
10 CALCULATE A DOSE Logging doses without using the Dose Calculator Note: If a fast-acting insulin source other than the InPen is used it must be logged as a manual dose. 1. Launch the App by tapping the icon. 2. Open the Logbook by tapping the icon and tap Log Dose. 3. Choose rapid-acting or long-acting insulin and enter the time and size of the dose taken. Note: If the patient has traveled across a time zone, adjust and enter thedose time as though it was taken in the current time zone. 4. Tap Save to return to the Logbook. 5. Tap Home to return to the Home Screen. 6. The Home Screen is updated with the time since last dose and current IOB. 10
11 CALCULATE A DOSE Using the Dose Calculator without Blood Glucose Data 1. Launch the App by tapping the icon. 2. Open the dose calculator by tapping the icon. 3. Enter the number of grams of carbohydrates to be eaten. The dose recommendation is displayed. 4. Use the InPen to dial and dispense the recommended dose. 5. Tap Save to return to the Home Screen. 6. The Home Screen is updated with the time since last dose and current IOB. Dose recommendations greater than maximum calculated dose The dose calculator has a maximum calculated dose setting that is set by the healthcare provider. If a single dose recommendation or the total of recent doses plus the recommendation exceeds the maximum calculated dose setting, a message will be displayed. The calculator caps the recommendation at the specified value and the calculator warns the user if the sum of the recommendation and the rapid-acting doses in the last two hours exceeds this value. The patient should refer to the instructions given by their healthcare provider. Prime InPen automatically determines if a dose was a Prime or a Therapeutic dose. If you need to adjust whether a dose was a Therapeutic dose or a Prime, tap the entry in the Logbook. A Dose or Prime selector will appear, and you can select the correct dose type. Split Doses The InPen can deliver a maximum of 30 units per injection. For doses greater than 30 units the dose must be split into multiple doses. If for any reason a dose is split into multiple doses, each dose that is delivered will be logged separately. To ensure that insulin is tracked correctly, the patient should always take the larger dose first. If the patient forgets how much insulin was recommended, they may use the dose calculator again to calculate the remaining dose required. 11
12 ADDITIONAL DOSE CALCULATOR SETTINGS Note: Use these steps to program customized time of day settings and dose reminders. Time of Day Settings When enabled, up to four time settings may be programmed for a 24 hour period. Target Blood Glucose, Carbohydrate Factor, and Correction Factor may be customized for each time setting. Each time setting ends when the next one begins. 1. Launch the App and open Insulin Settings. 2. Slide the Time of Day Settings switch 3. Tap each Time of Day to enter settings for that period. 4. Tap Back to return to the Home screen. Note: Time of Day settings are not affected by time zone changes. Instruct patients to always consult their healthcare provider about actions they should take when using multiple Time of Day settings and traveling to different time zones. Only the patient s healthcare provider can determine if differences due to time zone changes are clinically important so as to require the patient to adjust Time of Day settings while traveling. 12
13 ADDITIONAL DOSE CALCULATOR SETTINGS Missed Dose Reminders When enabled, up to four rapid-acting dose reminders may be programmed for a 24 hour period. If no dose has been logged by the end of the time period then the App will notify the patient. 1. Launch the App and open Insulin Settings. 2. Open Reminders 3. To enable a reminder, tap the corresponding cell and customize the start and end times of the period as needed. 4. Tap the green checkmark to save the change, or the red X to cancel. 5. Tap Back to return to the Settings screen. Note: Time periods cannot overlap, so you may need to adjust another time period start or end time to prevent overlap. 13
14 ADDITIONAL DOSE CALCULATOR SETTINGS Long-Acting Reminders When enabled, up to two long-acting dose reminders may be programmed for a 24 hour period. If no dose has been logged by the end of the time period then the App will notify the patient. 1. Launch the App and open Insulin Settings. 2. Open Reminders. 3. Tap Long-Acting Reminder. 4. To enable a reminder, slide the corresponding switch and tap the cell to select the long acting insulin type and the number of doses per day. 5. Tap the cell to enter the usual amount of long acting insulin to take. 6. To adjust the reminder time, tap the cell and select the reminder time. 7. To disable reminders, slide the switch to the left. 8. Tap Save to return to the Reminders screen. 14
15 INSIGHTS BY INPEN REPORTS IMPORTANT: The Insights by InPen report should be used by healthcare professionals familiar with the management of diabetes. The following is intended to supplement, not replace, medical expertise in the selfadministration of insulin for the treatment of diabetes. The report provides information that can be used to identify trends to inform treatment decisions. Reports are not intended to produce medical advice and should not be relied upon for such purpose. 15
16 INSIGHTS - PATIENT STATS Glucose Overview Use this chart to understand: Average and standard deviation of blood glucose over the report period Percentage of time spent in and out of the target blood glucose range: Very Low (< 54 mg/dl) Low (54 69mg/dL) Target (70 180mg/dL) High ( mg/dL) Very High (> 250 mg/dl) Insulin Overview Use this chart to understand: Average total daily insulin dose (TDD) over the report period for days with at least one insulin dose and standard deviation of rapid acting doses only Percentages of basal and bolus insulin within TDD Missed Doses Use this chart to understand: How many doses were missed, or meals skipped, over the report period If a rapid-acting dose is not logged within the time range configured in meal dose reminders then it is considered a missed dose. If dose reminders are not enabled missed doses will still be reported. If a long-acting dose is not logged within three hours before or after the long acting reminder time then it is considered a missed dose. Missed long acting doses are calculated only when the long acting reminder is enabled. Dose Calculator Usage Use this chart to understand: Percentage of doses in which the dose calculator was used within 10 min prior to the dose Percentage of doses taken within ± 0.5 U of the advised dose Percentage of doses taken 1 U over or under the advised dose 16
17 INSIGHTS - DAILY REPORTS General Each vertical bar represents a 30-minute period. The black line is the median value for the period. The dark color shows the interquartile range (middle 50%). The light color shows the range of values from the 10th percentile to the 90th percentile. Modal Day Glucose Use this chart to visualize and assess patterns in blood glucose over 24 hours. This chart may help identify: Variability in blood glucose by time of day Hyperglycemia trends Hypoglycemia trends Modal Day Insulin Use this chart to visualize and assess patterns in insulin dosing over 24 hours. This chart may help identify: Variability in timing of doses Variability in dose size If correction doses are being given 17
18 INSIGHTS - DAILY REPORTS CONTINUED Modal Day Carbohydrate Use this chart to visualize and assess patterns in carbohydrates over 24 hours. This chart may help identify: Variability in timing of meals Correlations between meals and doses Daily Charts Use the daily charts to visualize and assess patterns in glucose, insulin, insulin on board (IOB), and carbohydrates on a daily basis for the last 7 or 14 days of the report period. Daily charts may help identify: Effects of individual dosing decisions Causes of individual episodes of hypoglycemia or hyperglycemia Daily charts may help verify: Insulin action time Insulin sensitivity factor Insulin to carbohydrate ratio 18
19 Why InPen? Notes / Questions: InPen automatically tracks insulin therapy, reports last dose and active insulin, and helps people with diabetes calculate mealtime and correction doses. This eases the burden of memorizing doses and improves the reliability of the insulin logbook. Contact your InPen Representative today! 19
20 For information contact: To learn more visit: or download our free app Companion Medical, Inc Via Frontera, Suite D. San Diego, CA USA Companion Medical, Inc. LBL AF
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