Didier Payen, MD, Ph D DAR Lariboisière Université Paris 7 Unité INSERM 1160
|
|
- Gary Bates
- 6 years ago
- Views:
Transcription
1 Assessing response to therapy: SvO 2, lactate, PCO 2 gap, others Didier Payen, MD, Ph D DAR Lariboisière Université Paris 7 Unité INSERM 1160 dpayen1234@orange.fr
2 How can we see the question? Some useful concept have to mentioned What means therapeutic response? SvO 2 :regional? Sup VCaval? Mixed SvO 2 Lactate: a marker or a mechanistic index or both? CO2 level within tissue
3 ALL IS LINKED!!! Glucose, lactate, inflammation, cellular metabolism, O 2 use and CO 2 production
4 Metabolic assessment can be seen as a part of inflammation
5 NADPH
6 glucose GLYCOLYSIS lactate LDH PDH pyruvate CYTOSOL pyruvate dehydrogenase MITOCHONDRION fatty acid oxidation acetyl CoA ATP synthase O 2 e - H + cytochrome oxidase IV ATP ADP H + RESPIRATORY CHAIN e - III H + II e - I e - NADH dehydrogenase NAD + NADH NAD + CITRIC ACID CYCLE
7 Energy consuming functions of immune cells Synthesis of macromolecule & ion transport; O 2 is mainly used by mitochondria, non-mitochondrial O 2 consumption is negligible 98% of VO 2 is related to Phos OX. In acute situation 20 to 40% is non mitochondrial ROS+++
8 Mitochondrial VO 2 becomes more decoupled after incubation in septic plasma.
9 Energy metabolism: interorgan cooperation Erythrocytes Glucose Recycling Glucose CO H 2 O 2 CO CO CO H 2 O Liver Glucose 6-P 1 Pyruvate ADP 2ATP 4 Lactate Glucose Pyruvate 4 The liver respires for anaerobic erythrocytes (Leverve 1998) 1 6ADP 6ATP O O 2 2 O 2 O 2 O 2 O 2 oxidation of fatty acids
10 Otto Warburg effect In oncology, the Warburg concept or effect is the observation that most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol, rather than by a comparatively low rate of glycolysis followed by oxidation of pyruvate in mitochondria as in normal cells. The latter process is aerobic. Malignant, rapidly growing tumor cells typically have glycolytic rates up to 200 times higher than those of their normal tissues of origin, even if oxygen is plentiful.
11 Neutro Macro Dend C Effector T Cell Memory T C Treg Cell Macro M2
12 The effect of systemic vascular tone changes on microcirculation. Arteriolar constriction and dilatation.
13 How can we see the question? Some useful concept have to mentioned What means therapeutic response? SvO 2 :regional? Sup VCaval? Mixed SvO 2 Lactate: a marker or a mechanistic index or both? CO2 level within tissue
14 What is tissue perfusion? How to asses it? - microvessels abnormalities : Microflow Index, MVDensity using (SDF/OPS imaging) - microcirculatory blood flow (Laser Doppler) - tissue micro-perfusion (PCO 2 gap) - micro-oxygenation? (StO 2 ) - all of them multimodal monitoring?
15 What is the problem? Is the systemic hemodynamic resuscitation able to change microcirculation? Is the regional blood flow related to microcirculatory flow? Is the tissue oxygenation well assessed by perfusion? What about the ICU clinical situations? SEPSIS THE EXAMPLE;
16 Macro-circulation responder vs non responders MacroR Increase in CO > 15% after fluid MacroNR Increase in CO < 15% after fluid
17 % variation 80 CO Variation RS Variation Macro-NR n=28 Macro-R n=21 Micro-R n=24 Micro-NR n=25
18 Coherence after fluid or «coherent» patients n=28 (57%) or «non coherent» patients n=21 (43%)
19 What is the problem? Is the systemic hemodynamic resuscitation able to change microcirculation? Is the regional blood flow related to microcirculatory flow? Is the tissue oxygenation well assessed by perfusion? What about the ICU clinical situations? SEPSIS THE EXAMPLE;
20
21 How to improve perfusion? by downstream dilatation (shear stress ) by upstream increase inflow pressure
22 How can we see the question? Some useful concept have to mentioned What means therapeutic response? SvO 2 :regional? Sup VCaval? Mixed SvO 2 Lactate: a marker or a mechanistic index or both? CO2 level within tissue
23 Rationale for monitoring SvjO 2 Cerebral tissue is highly susceptible to oxygen deficit Oxygen delivery is dependent on CBF+++ CBF and CMRO 2 are coupled: CBF has to match the demand. In brain injury, blood flow regulation could be lost SvjO 2 informs on: the ability of the brain to extract oxygen. the O 2 extraction adequacy CBF-CMRO 2 and may guide therapy. As long as Hb and SaO 2 remain constant SvjO 2 is THE KEY between CMRO 2 and CBF.
24
25 SEVERE HEAD TRAUMA Evolution of SvjO 2, ICP, MAP, MCA blood flow velocity after a fast i.v. bolus of Mannitol before ICP=33 mmhg MAP=89 mmhg CPP=56 mmhg SvjO2<60%
26 SEVERE HEAD TRAUMA Evolution of SvjO 2, ICP, MAP, MCA blood flow velocity after a fast i.v. bolus of Mannitol before ICP=33 mmhg MAP=89 mmhg CPP=56 mmhg SvjO2<60% Mannitol after ICP=20 mmhg MAP=89 mmhg CPP=69 mmhg SvJO2>60%
27 How can we see the question? Some useful concept have to mentioned What means therapeutic response? SvO 2 :regional? Sup VCaval? Mixed SvO 2 Lactate: a marker or a mechanistic index or both? CO2 level within tissue
28 Normal lactate turnover: 1300 mmol/day mostly RBC (1/3) Major sources: muscle, RBCs-WBCs, gut, (lung, eye, tumor cells), epinephrine, dysfunction of PDH: normal L/P hypoxia: increased L/P Clearance: liver (kidney, lung, heart, gut) 2/3 oxidized in citric acid cycle 1/3 gluconeogenesis (Cori cycle)
29 LACTATE & CATECHOLAMINES THE LANCET Vol 354 August 7, 1999 adrenaline AMPc + "glycolytic" Compartment glycogene glycogenolysis "oxydative" Compartment 2K 3Na Na/K pump + ADP ATP glucose 6-P glycolysis O 2 lactate lactate pyruvate mitochondria (James JH et al, Lancet 1999)
30 Sepsis: lactate clearance vs production 20 Lactate fluxes (mmol/h) LPS Control Release 10 0 Uptake -10 Lung Kidney Gut Liver Muscle (adapted from Bellomo, Chest 1996)
31 How can we see the question? Some useful concept have to mentioned What means therapeutic response? SvO 2 :regional? Sup VCaval? Mixed SvO 2 Lactate: a marker or a mechanistic index or both? CO2 level within tissue
32 Microvascular Blood Flow shunting & stagnant CO 2 in Severe Sepsis and/or high PvO 2 Arterial blood SO CO 2 40 SO CO 2 70 mmhg SO SO SO CO 2 60 SO CO 2 55 CO 2 70 mmhg SO Venous blood Increased SvO 2 from shunting area will enrich central SvO 2 Stagnant tissue kco 2 k CO 2 gradient with ETCO 2
33
34 From Vallée et al; Réanimation Schematic view for tissue PCO 2 Tonometry Normal conditions Shock with low systemic flow Resuscitated shock with Microcirculation failure
35
36 Gradient threshold: 16 mm d'hg for outcome; Spe 100%; Se 88% (AUC ROC: 0.97). Diagnostic tool 1- Patients in SShock at admission (n=30) : gradient P(tc-et) CO 2 patients vs controls (n=15) : 31±12 versus 11±4 mm Hg, p<
37 Pronostic value 2- Survivals increased P(tc-etCO 2 ) within the 1st 36 hrs after admission compared to NS: H0: 31±13 versus 29±12 mm Hg, NS; H36: 21±5 (S) vs 40±17 (NS), p<0.0001
38 Therapeutic test 3- D P(tc-et)CO 2 after fluid challenge (correlated negatively with cutaneous BF (Laser BF): R²= 0.68, p< 0.001): the more the Laser BF k the lower will be the P(tc-et)CO 2 gradient.
39 The Warming test Abnormal gradient questions: 1- is it related to macrocirculation abnormality? 2- is it related to microvessel disease?
40 Hypotheses Elevated tissue PCO 2 stagnant flow Vascular reactivity can be assessed by the heatinginduced vasodilatation Possible patterns Low flow but normal reactivity kpcco 2 & nl PIndex Low flow with abnormal microvessels kpcco 2 & abnl PIndex microvessel disease
41 Heat Challenge Δ HC PcCO 2 = PcCO 2 end - PcCO 2 start Δ HC PI max/min = PI max / PI min
42 To conclude No tool can be recommended for all situations A sufficient understanding of basic concepts and of pathologic situation is essential Metabolism is a witness more than a cause of organ dysfunction Metabolism is linked to all functions Lactate is a marker of «stress intensity» more than ischemic marker SvO 2 is interesting if it is lower than normal value; CO 2 gap is a marker of tissue perfusion; coupling with a vascular reactivity test it may help to make a decision and to assess the therapy.
43 Un example of acute inflammation in human beings: Liver transplantation
44 Day 4 after OLT
Mitochondria and ATP Synthesis
Mitochondria and ATP Synthesis Mitochondria and ATP Synthesis 1. Mitochondria are sites of ATP synthesis in cells. 2. ATP is used to do work; i.e. ATP is an energy source. 3. ATP hydrolysis releases energy
More informationUTILITY of ScvO 2 and LACTATE
UTILITY of ScvO 2 and LACTATE Professor Jeffrey Lipman Department of Intensive Care Medicine Royal Brisbane Hospital University of Queensland THIS TRIP SPONSORED AND PAID FOR BY STRUCTURE Physiology -
More information4. Which step shows a split of one molecule into two smaller molecules? a. 2. d. 5
1. Which of the following statements about NAD + is false? a. NAD + is reduced to NADH during both glycolysis and the citric acid cycle. b. NAD + has more chemical energy than NADH. c. NAD + is reduced
More informationRESPIRATION Worksheet
A.P. Bio L.C. RESPIRATION Worksheet 1. In the conversion of glucose and oxygen to carbon dioxide and water a) which molecule becomes reduced? b) which molecule becomes oxidized? c) what happens to the
More informationMULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.
Respiration Practice Name MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 1) Which of the following statements describes NAD+? A) NAD+ can donate
More informationChapter 7 Cellular Respiration and Fermentation*
Chapter 7 Cellular Respiration and Fermentation* *Lecture notes are to be used as a study guide only and do not represent the comprehensive information you will need to know for the exams. Life Is Work
More information7 Pathways That Harvest Chemical Energy
7 Pathways That Harvest Chemical Energy Pathways That Harvest Chemical Energy How Does Glucose Oxidation Release Chemical Energy? What Are the Aerobic Pathways of Glucose Metabolism? How Is Energy Harvested
More informationCellular Pathways That Harvest Chemical Energy. Cellular Pathways That Harvest Chemical Energy. Cellular Pathways In General
Cellular Pathways That Harvest Chemical Energy A. Obtaining Energy and Electrons from Glucose Lecture Series 12 Cellular Pathways That Harvest Chemical Energy B. An Overview: Releasing Energy from Glucose
More informationCellular Respiration
Cellular I can describe cellular respiration Cellular respiration is a series of metabolic pathways releasing energy from a foodstuff e.g. glucose. This yields energy in the form of ATP adenosine P i P
More informationChemical Energy. Valencia College
9 Pathways that Harvest Chemical Energy Valencia College 9 Pathways that Harvest Chemical Energy Chapter objectives: How Does Glucose Oxidation Release Chemical Energy? What Are the Aerobic Pathways of
More informationChapter 9: Cellular Respiration: Harvesting Chemical Energy
AP Biology Reading Guide Name: Date: Period Chapter 9: Cellular Respiration: Harvesting Chemical Energy Overview: Before getting involved with the details of cellular respiration and photosynthesis, take
More informationRespiration. Respiration. How Cells Harvest Energy. Chapter 7
How Cells Harvest Energy Chapter 7 Respiration Organisms can be classified based on how they obtain energy: autotrophs: are able to produce their own organic molecules through photosynthesis heterotrophs:
More informationMetabolism. Chapter 5. Catabolism Drives Anabolism 8/29/11. Complete Catabolism of Glucose
8/29/11 Metabolism Chapter 5 All of the reactions in the body that require energy transfer. Can be divided into: Cell Respiration and Metabolism Anabolism: requires the input of energy to synthesize large
More informationHarvesting energy: photosynthesis & cellular respiration
Harvesting energy: photosynthesis & cellular respiration Learning Objectives Know the relationship between photosynthesis & cellular respiration Know the formulae of the chemical reactions for photosynthesis
More informationCellular Respiration and Fermentation
Cellular Respiration and Fermentation How do plants and animals obtain the glucose they need? Plants: Animals: Cellular Respiration the process that releases energy from food in the presence of oxygen
More information2/4/17. Cellular Metabolism. Metabolism. Cellular Metabolism. Consists of all of the chemical reactions that take place in a cell.
Metabolism Cellular Metabolism Consists of all of the chemical reactions that take place in a cell. Can be reactions that break things down. (Catabolism) Or reactions that build things up. (Anabolism)
More informationHarvesting energy: photosynthesis & cellular respiration part 1I
Harvesting energy: photosynthesis & cellular respiration part 1I Agenda I. Overview (Big Pictures) of Photosynthesis & Cellular Respiration II. Making Glucose - Photosynthesis III. Making ATP - Cellular
More informationCellular Respiration and Fermentation
Name Class Date 9 Cellular Respiration and Fermentation Big idea Cellular Basis of Life Q: How do organisms obtain energy? WHAT I KNOW WHAT I LEARNED 9.1 Why do most organisms undergo the process of cellular
More informationVasopressors in septic shock
Vasopressors in septic shock Prof. Jean-Louis TEBOUL Medical ICU Bicetre hospital University Paris-South France Questions 1- Why do we use vasopressors in septic shock? 2- Which first-line agent? 3- When
More informationName Class Date. 1. Cellular respiration is the process by which the of "food"
Name Class Date Cell Respiration Introduction Cellular respiration is the process by which the chemical energy of "food" molecules is released and partially captured in the form of ATP. Carbohydrates,
More informationCellular Respiration Harvesting Chemical Energy ATP
Cellular Respiration Harvesting Chemical Energy ATP 2009-2010 Ch.8.3 Section Objectives: Compare and contrast cellular respiration and fermentation. Explain how cells obtain energy from cellular respiration.
More informationUPMC Critical Care
UPMC Critical Care www.ccm.pitt.edu Shock and Monitoring Samuel A. Tisherman, MD, FACS, FCCM Professor Departments of CCM and Surgery University of Pittsburgh Shock Anaerobic metabolism Lactic acidosis
More information3.7.1 Define cell respiration [Cell respiration is the controlled release of energy from organic compounds in cells to form ATP]
3.7 Cell respiration ( Chapter 9 in Campbell's book) 3.7.1 Define cell respiration [Cell respiration is the controlled release of energy from organic compounds in cells to form ATP] Organic compounds store
More informationCellular Metabolism. Biol 105 Lecture 6 Read Chapter 3 (pages 63 69)
Cellular Metabolism Biol 105 Lecture 6 Read Chapter 3 (pages 63 69) Metabolism Consists of all of the chemical reactions that take place in a cell Metabolism Animation Breaking Down Glucose For Energy
More informationUse of Blood Lactate Measurements in the Critical Care Setting
Use of Blood Lactate Measurements in the Critical Care Setting John G Toffaletti, PhD Director of Blood Gas and Clinical Pediatric Labs Professor of Pathology Duke University Medical Center Chief, VAMC
More informationBiol 219 Lec 7 Fall 2016
Cellular Respiration: Harvesting Energy to form ATP Cellular Respiration and Metabolism Glucose ATP Pyruvate Lactate Acetyl CoA NAD + Introducing The Players primary substrate for cellular respiration
More informationHell or High Lactate. Charles Bruen, MD. resusreview.com/regionsmar17
Hell or High Lactate Charles Bruen, MD resusreview.com/regionsmar17 No Disclosures No Off-label Use 3 Positive troponin? Inpatient or Observation? Lactate elevated? Goals What causes lactate production?
More informationBIOLOGY - CLUTCH CH.9 - RESPIRATION.
!! www.clutchprep.com CONCEPT: REDOX REACTIONS Redox reaction a chemical reaction that involves the transfer of electrons from one atom to another Oxidation loss of electrons Reduction gain of electrons
More informationCellular Metabolism 6/20/2015. Metabolism. Summary of Cellular Respiration. Consists of all the chemical reactions that take place in a cell!
Cellular Metabolism Biology 105 Lecture 6 Chapter 3 (pages 56-61) Metabolism Consists of all the chemical reactions that take place in a cell! Cellular metabolism: Aerobic cellular respiration requires
More informationCellular Respiration Checkup Quiz. 1. Of the following products, which is produced by both anaerobic respiration and aerobic respiration in humans?
1. Of the following products, which is produced by both anaerobic respiration and aerobic respiration in humans? I. Pyruvate II. III. ATP Lactate A. I only B. I and II only C. I, II and III D. II and III
More informationKEY CONCEPT The overall process of cellular respiration converts sugar into ATP using oxygen.
KEY CONCEPT The overall process of cellular respiration converts sugar into ATP using oxygen. ! Cellular respiration makes ATP by breaking down sugars. Cellular respiration is aerobic, or requires oxygen.
More informationCellular Metabolism 9/24/2013. Metabolism. Cellular Metabolism. Consists of all the chemical reactions that take place in a cell!
Cellular Metabolism Biology 105 Lecture 6 Chapter 3 (pages 56-61) Metabolism Consists of all the chemical reactions that take place in a cell! Cellular Metabolism Aerobic cellular respiration requires
More informationClass XI Chapter 14 Respiration in Plants Biology. 1. It is a biochemical process. 1. It is a physiochemical process.
Question 1: Differentiate between (a) Respiration and Combustion (b) Glycolysis and Krebs cycle (c) Aerobic respiration and Fermentation (a) Respiration and combustion Respiration Combustion 1. It is a
More informationCellular Respiration. How our body makes ATP, ENERGY!!
Cellular Respiration How our body makes ATP, ENERGY!! Useable Energy Adenosine Tri-Phosphate (ATP) Adenosine Ribose Sugar 3 Phosphates November 27, 2017 November 27, 2017 Where do our cells get energy?
More informationCellular Respiration. Unit 5: Plants, Photosynthesis, and Cellular Respiration
Cellular Respiration Unit 5: Plants, Photosynthesis, and Cellular Respiration Overview! Organisms obtain energy (ATP) by breaking down (catabolic pathway, exergonic reaction) organic molecules (glucose)
More information7 Cellular Respiration and Fermentation
CAMPBELL BIOLOGY IN FOCUS URRY CAIN WASSERMAN MINORSKY REECE 7 Cellular Respiration and Fermentation Lecture Presentations by Kathleen Fitzpatrick and Nicole Tunbridge, Simon Fraser University SECOND EDITION
More informationCellular Respiration
Cellular Respiration Cellular respiration is the process that releases energy by breaking down glucose and other food molecules in the presence of oxygen In biology and chemistry, energy is referred to
More informationCellular Metabolism. Biology 105 Lecture 6 Chapter 3 (pages 56-61)
Cellular Metabolism Biology 105 Lecture 6 Chapter 3 (pages 56-61) Metabolism Consists of all the chemical reactions that take place in a cell! Cellular Metabolism Aerobic cellular respiration requires
More information3. Distinguish between aerobic and anaerobic in terms of cell respiration. Outline the general process of both.
3.7 Cell Respiration 1. Define cell respiration. Cell respiration is the controlled release of energy from organic molecules in cells to form ATP. 2. State the equation for the process of cell respiration.
More informationMedical Biochemistry and Molecular Biology department
Medical Biochemistry and Molecular Biology department Cardiac Fuels [Sources of energy for the Cardiac muscle] Intended learning outcomes of the lecture: By the end of this lecture you would be able to:-
More informationBiology Kevin Dees. Chapter 9 Harvesting Chemical Energy: Cellular Respiration
Chapter 9 Harvesting Chemical Energy: Cellular Respiration Life is Work!!! Biology Kevin Dees Catabolic pathways and ATP production Catabolic pathways release energy by breaking down large molecules into
More information1 Which pathway for aerobic cellular respiration is located in the cytoplasm of the cell?
1 Which pathway for aerobic cellular respiration is located in the cytoplasm of the cell? glycolysis citric cycle 2 Which of the following statements is NOT correct regarding aerobic cellular respiration?
More informationQuestion 1: Differentiate between (a) Respiration and Combustion (b) Glycolysis and Krebs cycle (c) Aerobic respiration and Fermentation (a) Respiration and combustion Respiration Combustion 1. It is a
More informationCHY2026: General Biochemistry UNIT 7& 8: CARBOHYDRATE METABOLISM
CHY2026: General Biochemistry UNIT 7& 8: CARBOHYDRATE METABOLISM Metabolism Bioenergetics is the transfer and utilization of energy in biological systems The direction and extent to which a chemical reaction
More informationRespiration. Respiration. Respiration. How Cells Harvest Energy. Chapter 7
How Cells Harvest Energy Chapter 7 Organisms can be classified based on how they obtain energy: autotrophs: are able to produce their own organic molecules through photosynthesis heterotrophs: live on
More informationChapter 9 Cellular Respiration Overview: Life Is Work Living cells require energy from outside sources
Chapter 9 Cellular Respiration Overview: Life Is Work Living cells require energy from outside sources Some animals, such as the giant panda, obtain energy by eating plants, and some animals feed on other
More informationCh. 9 Cell Respiration. Title: Oct 15 3:24 PM (1 of 53)
Ch. 9 Cell Respiration Title: Oct 15 3:24 PM (1 of 53) Essential question: How do cells use stored chemical energy in organic molecules and to generate ATP? Title: Oct 15 3:28 PM (2 of 53) Title: Oct 19
More informationObjective: You will be able to construct an explanation for how each phase of respiration captures and stores free energy.
Objective: You will be able to construct an explanation for how each phase of respiration captures and stores free energy. Do Now: Compare and contrast the three black equations below ADP + P + Energy
More informationLesson Overview. Cellular Respiration: An Overview. 9.2 process of cell respiration
9.2 process of cell respiration Glycolysis During glycolysis, glucose is broken down into 2 molecules of the 3-carbon molecule pyruvic acid. Pyruvic acid is a reactant in the Krebs cycle. ATP and NADH
More informationOAT Biology - Problem Drill 03: Cell Processes - Metabolism and Cellular Respiration
OAT Biology - Problem Drill 03: Cell Processes - Metabolism and Cellular Respiration Question No. 1 of 10 1. What is the final electron acceptor in aerobic respiration? Question #01 (A) NADH (B) Mitochondria
More informationWhat is Respiration? The process of respiration is where organisms convert chemical energy into cellular energy, which is known as ATP. Adenine Ribose P P P Cellular Respiration high energy sugar low energy
More informationChapter Seven (Cellular Respiration)
Chapter Seven (Cellular Respiration) 1 SECTION ONE: GLYCOLYSIS AND FERMENTATION HARVESTING CHEMICAL ENERGY Cellular respiration is the process in which cells make adenosine triphosphate (ATP) by breaking
More informationChapter 4. Exercise Metabolism
Chapter 4 Exercise Metabolism Rest to Exercise Transition Step onto a treadmill at 6 mph In one step muscles increase ATP production What metabolic changes occur? From rest to light or moderate exercise
More informationBackground knowledge
Background knowledge This is the required background knowledge: State three uses of energy in living things Give an example of an energy conversion in a living organism State that fats and oils contain
More informationPyruvate + NADH + H + ==== Lactate + NAD +
1 UNIVERSITY OF PAPUA NEW GUINEA SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY PBL SEMINAR ANAEROBIC METABOLISM - An Overview
More informationLesson Overview. Cellular Respiration: An Overview. Lesson Overview. 9.1 Cellular Respiration: An Overview
9.1 Cellular Respiration: An Overview Chemical Energy and Food Food provides living things with the chemical building blocks they need to grow and reproduce. Food molecules contain chemical energy that
More informationGlycolysis Introduction to Metabolism Regulation of Metabolism Overview of Glycolysis Reactions of Glycolysis
Glycolysis Introduction to Metabolism Regulation of Metabolism Overview of Glycolysis Reactions of Glycolysis Suggested Reading: Lippincot s Ilustrated reviews: Biochemistry Glycolysis, an example of metabolic
More informationIntroduction to Carbohydrate metabolism
Introduction to Carbohydrate metabolism Some metabolic pathways of carbohydrates 1- Glycolysis 2- Krebs cycle 3- Glycogenesis 4- Glycogenolysis 5- Glyconeogenesis - Pentose Phosphate Pathway (PPP) - Curi
More informationNAME KEY ID # EXAM 3a BIOC 460. Wednesday April 10, Please include your name and ID# on each page. Limit your answers to the space provided!
EXAM 3a BIOC 460 Wednesday April 10, 2002 Please include your name and ID# on each page. Limit your answers to the space provided! 1 1. (5 pts.) Define the term energy charge: Energy charge refers to the
More informationHow Did Energy-Releasing Pathways Evolve? (cont d.)
How Did Energy-Releasing Pathways Evolve? (cont d.) 7.1 How Do Cells Access the Chemical Energy in Sugars? In order to use the energy stored in sugars, cells must first transfer it to ATP The energy transfer
More informationHow Cells Harvest Chemical Energy. Chapter 9
How Cells Harvest Chemical Energy Chapter 9 Cellular Respiration Releasing energy (ATP) from glucose (chemical energy) in the presence of O 2 Energy flows Matter cycles True or False Plants only perform
More informationCh 9: Cellular Respiration
Ch 9: Cellular Respiration Cellular Respiration An overview Exergonic reactions and catabolic pathway Energy stored in bonds of food molecules is transferred to ATP Cellular respiration provides the energy
More informationg) Cellular Respiration Higher Human Biology
g) Cellular Respiration Higher Human Biology What can you remember about respiration? 1. What is respiration? 2. What are the raw materials? 3. What are the products? 4. Where does it occur? 5. Why does
More informationCellular Respiration Notes. Biology - Mrs. Kaye
Cellular Respiration Notes Biology - Mrs. Kaye Energy Transfer In cellular respiration, chemical energy is converted into usable energy which is converted into heat energy. ATP and ADP ATP acts as an energy
More informationHow Cells Harvest Energy. Chapter 7. Respiration
How Cells Harvest Energy Chapter 7 Respiration Organisms classified on how they obtain energy: autotrophs: produce their own organic molecules through photosynthesis heterotrophs: live on organic compounds
More informationReview. Respiration. Glycolysis. Glycolysis is the decomposition (lysis) of glucose (glyco) to pyruvate (or pyruvic acid).
Review Photosynthesis is the process of incorporating energy from light into energy-rich molecules like glucose. Respiration is the opposite process extracting that stored energy from glucose to form ATP
More informationHow Cells Release Chemical Energy. Chapter 7
How Cells Release Chemical Energy Chapter 7 7.1 Overview of Carbohydrate Breakdown Pathways All organisms (including photoautotrophs) convert chemical energy of organic compounds to chemical energy of
More informationCellular Respiration Part V: Oxidative Phosphorylation
Cellular Respiration Part V: Oxidative Phosphorylation Figure 9.16 Electron shuttles span membrane 2 NADH or 2 FADH 2 MITOCHONDRION 2 NADH 2 NADH 6 NADH 2 FADH 2 Glucose Glycolysis 2 Pyruvate Pyruvate
More information10/25/2010 CHAPTER 9 CELLULAR RESPIRATION. Life is Work. Types of cellular respiration. Catabolic pathways = oxidizing fuels
CHAPTER 9 CELLULAR RESPIRATION Life is Work Living cells require transfusions of energy from outside sources to perform their many tasks: Chemical work Transport work Mechanical work Energy stored in the
More informationCARBOHYDRATE METABOLISM
Note (Study Glycolysis, fermentation and their regulation, Gluconeogenesis and glycogenolysis, Metabolism of galactose, TCA cycle and Amphibolic role of the cycle, and Glyoxalic acid cycle, HMP shunt in
More informationCollin County Community College BIOL Muscle Physiology. Muscle Length-Tension Relationship
Collin County Community College BIOL 2401 Muscle Physiology 1 Muscle Length-Tension Relationship The Length-Tension Relationship Another way that muscle cells can alter their force capability, is determined
More informationStructure of the Mitochondrion. Cell Respiration. Cellular Respiration. Catabolic Pathways. Photosynthesis vs. Cell Respiration ATP 10/14/2014
Structure of the Mitochondrion Cellular Respiration Chapter 9 Pgs. 163 183 Enclosed by a double membrane Outer membrane is smooth Inner, or cristae, membrane is folded - this divides the mitochondrion
More informationCellular Respiration. Objectives
Lecture 07 Objectives At the end of this series of lectures, you should be able to: Define terms. Compare the processes and locations of cellular respiration and photosynthesis. Explain how breathing and
More informationRESPIRATION: SYNTHESIS OF ATP. Clickers!
RESPIRATION: SYNTHESIS OF ATP Clickers! Respiration is a series of coupled reactions Carbon (in glucose) is oxidized ATP is formed from ADP plus phosphate O 2 ADP + Pi CO 2 + H 2 O ATP Synthesis of ATP
More informationChapter 9. Cellular Respiration: Harvesting Chemical Energy
Chapter 9 Cellular Respiration: Harvesting Chemical Energy Living cells require energy from outside sources Energy flows into an ecosystem as sunlight and leaves as heat Photosynthesis generates O 2 and
More informationCellular Respiration. Cellular Respiration. C 6 H 12 O 6 + 6O > 6CO 2 + 6H energy. Heat + ATP. You need to know this!
Cellular Respiration LISA Biology Cellular Respiration C 6 H 12 O 6 + 6O 2 - - - - - > 6CO 2 + 6H 2 0 + energy You need to know this! Heat + ATP 1 Did that equation look familiar? * The equation for cellular
More information9.2 The Process of Cellular Respiration
9.2 The Process of Cellular Respiration Oxygen Carbon 2 2 Dioxide 34 Water Glycolysis Glycolysis is the first stage of cellular respiration. During glycolysis, glucose is broken down into 2 molecules of
More informationIII. 6. Test. Respiració cel lular
III. 6. Test. Respiració cel lular Chapter Questions 1) What is the term for metabolic pathways that release stored energy by breaking down complex molecules? A) anabolic pathways B) catabolic pathways
More informationIntroduction. Living is work. To perform their many tasks, cells must bring in energy from outside sources.
Introduction Living is work. To perform their many tasks, cells must bring in energy from outside sources. In most ecosystems, energy enters as sunlight. Light energy trapped in organic molecules is available
More informationCellular Respiration Harvesting Chemical Energy ATP
Cellular Respiration Harvesting Chemical Energy ATP 2006-2007 What s the point? The point is to make ATP! ATP 2006-2007 Harvesting stored energy Energy is stored in organic molecules carbohydrates, fats,
More informationCellular Respiration: Harvesting Chemical Energy
Chapter 9 Cellular Respiration: Harvesting Chemical Energy PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with
More informationChapter 6 : How Cells Harvest Energy (B) Dr. Chris Doumen 10/28/14 CITRIC ACID CYCLE. Acetyl CoA CoA CoA CO 2 NAD + FADH 2 NADH FAD + 3 H + ADP + ATP
Chapter 6 : How Cells Harvest Energy (B) Dr. Chris Doumen Acetyl CoA CoA CoA Oxaloacetate Citrate CITRIC ACID CYCLE CO FADH 3 NAD + FAD 3 NADH ADP + P + 3 1 Pyruvate oxida.on and Citric Acid Cycle Thus
More informationBiology Ch 9 Cellular Respiration & Fermentation ( )
Name Class Date Biology Ch 9 Cellular Respiration & Fermentation (9.1-9.2) For Questions 1 10, complete each statement by writing the correct word or words. 1. A calorie is a unit of. 2. The Calorie used
More informationserves as a source of raw materials and energy for cellsslide
9-1 Chemical Pathways (Metabolism) refers to all of the chemical that take place in an organism or cell. Each reaction may handle materials or and is catalyzed by an enzyme. Metabolism has two parts: 1.
More informationChapter 9 Notes. Cellular Respiration and Fermentation
Chapter 9 Notes Cellular Respiration and Fermentation Objectives Distinguish between fermentation and anaerobic respiration. Name the three stages of cellular respiration and state the region of the cell
More informationEnergy Production In A Cell (Chapter 25 Metabolism)
Energy Production In A Cell (Chapter 25 Metabolism) Large food molecules contain a lot of potential energy in the form of chemical bonds but it requires a lot of work to liberate the energy. Cells need
More informationGeneral Biology 1004 Chapter 6 Lecture Handout, Summer 2005 Dr. Frisby
Slide 1 CHAPTER 6 Cellular Respiration: Harvesting Chemical Energy PowerPoint Lecture Slides for Essential Biology, Second Edition & Essential Biology with Physiology Presentation prepared by Chris C.
More informationElectron Transport and Oxidative. Phosphorylation
Electron Transport and Oxidative Phosphorylation Electron-transport chain electron- Definition: The set of proteins and small molecules involved in the orderly sequence of transfer to oxygen within the
More informationEnzymes and Metabolism
PowerPoint Lecture Slides prepared by Vince Austin, University of Kentucky Enzymes and Metabolism Human Anatomy & Physiology, Sixth Edition Elaine N. Marieb 1 Protein Macromolecules composed of combinations
More informationName: Block: Date: PACKET #8 Unit 3: Energy Transfer, Part II: Cellular Respiration
Name: Block: Date: PACKET #8 Unit 3: Energy Transfer, Part II: Cellular Respiration Reading: BSCS Text chapters 4, 5, and 2.8. Objectives: By the conclusion of this unit the student will be able to: Topic
More informationCELLULAR RESPIRATION: AEROBIC HARVESTING OF CELLULAR ENERGY Pearson Education, Inc.
CELLULAR RESPIRATION: AEROBIC HARVESTING OF CELLULAR ENERGY 2012 Pearson Education, Inc. Introduction In chemo heterotrophs, eukaryotes perform cellular respiration That harvests energy from food which
More informationNOTES: Ch 9, part & Fermentation & Regulation of Cellular Respiration
NOTES: Ch 9, part 4-9.5 & 9.6 - Fermentation & Regulation of Cellular Respiration 9.5 - Fermentation enables some cells to produce ATP without the use of oxygen Cellular respiration requires O 2 to produce
More informationCell Respiration Ch 7. Both autotrophs and heterotrophs use cellular respiration to make CO2 and water from
Cell Respiration Ch 7 Objectives: Identify the 2 major steps of cellular respiration Describe the major events in glycolysis Compare lactic acid fermentation with alcoholic fermentation Calculate the efficiency
More informationMULTIPLE CHOICE QUESTIONS
MULTIPLE CHOICE QUESTIONS 1. Which of the following statements concerning anabolic reactions is FALSE? A. They are generally endergonic. B. They usually require ATP. C. They are part of metabolism. D.
More informationElectron transport chain chapter 6 (page 73) BCH 340 lecture 6
Electron transport chain chapter 6 (page 73) BCH 340 lecture 6 The Metabolic Pathway of Cellular Respiration All of the reactions involved in cellular respiration can be grouped into three main stages
More information3.2 Aerobic Respiration
3.2 Aerobic Respiration Aerobic Cellular Respiration Catabolic pathways Breaks down energy-rich compounds to make ATP Requires oxygen Occurs in different parts of the cell C 6 H 12 O 6 (s) + 6O 2 (g) 6CO
More informationConsists of all of the chemical reactions that take place in a cell. Summary of Cellular Respiration. Electrons transferred. Cytoplasm Blood vessel
7/19/2014 Metabolism Cellular Metabolism Metabolism Consists of all of the chemical reactions that take place in a cell PLAY Animation Breaking Down Glucose For Energy Biol 105 Lecture Packet 6 Read Chapter
More informationUnit 2: Metabolic Processes
How is energy obtained biologically? Recall: Red Ox Reactions Unit 2: Metabolic Processes Oxidation Is the chief mechanism by which chemical potential energy is released This energy comes from reduced
More informationBiology Chapter-7 Cellular Respiration
Biology-1406 Chapter-7 Cellular Respiration Energy is stored in Chemicals Catabolism- the breaking down of complex molecules, such as glucose, to release their stored energy. Catabolism may or may not
More informationCellular Respiration
Cellular Respiration 1. To perform cell work, cells require energy. a. A cell does three main kinds of work: i. Mechanical work, such as the beating of cilia, contraction of muscle cells, and movement
More information