WHO International Biological Reference Preparations Held and distributed by the WHO International Laboratories for Biological Standards
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1 WHO International Biological Preparations Activin A, human, recombinant. Lyophilized. 5 units / Reagent, 1998 No th NIBSC 91/ Arginine vasopressin. Lyophilized. 8.2 IU / Standard, 1978 No. 638, 30th Hormone NIBSC 77/ Atrial natriuretic factor, human. Lyophilized. 2.5 IU / Standard, 1987 No. 771, 38th Peptide NIBSC 85/ Calcitonin, eel. Lyophilized. 88 IU / Standard, 1989 No. 800, 40th Hormone NIBSC 88/ Calcitonin, human. Lyophilized IU / Standard, 1991 No. 822, 42nd Hormone NIBSC 89/ Calcitonin, salmon. Lyophilized. 138 IU / 3rd-International Standard, 1999 No. 904, 50th Hormone NIBSC 98/ Chorionic gonadotrophin, alpha subunit, human, for immunoassay. Lyophilized. 70 IU / Preparation, 1974 No. 565, 26th Glycoprotein NIBSC 75/ Chorionic gonadotrophin, beta subunit, human, for immunoassay. Lyophilized. 70 IU / Preparation, 1974 No. 565, 26th Glycoprotein NIBSC 75/ Chorionic gonadotrophin, human. Lyophilized. 650 IU / 4th-International Standard, 1999 No. 904, 50th Glycoprotein NIBSC 75/ Corticotrophin (ACTH), porcine. Lyophilized. 5 IU / 3rd-International Standard, 1962 No. 259, 15th NIBSC 59/ Page 1 of 8
2 WHO International Biological Preparations Elcatonin (Calcitonin analogue). Lyophilized. 15 IU / No. 760, 37th Endocrinologic al products NIBSC 84/ Erythropoietin, human, urinary. Lyophilized. 10 IU / Preparation, 1970 No. 463, 23rd Urinary NIBSC 67/ Erythropoietin, rdna-derived. Lyophilized. 120 IU / Standard, 2003 No. 926, 53rd NIBSC 88/ Follicle stimulating, human, recombinant, for bioassay. Lyophilized. 138 IU / Standard, 1995 No. 872, 46th NIBSC 92/ Follicle stimulating, human, pituitary. Lyophilized. 80 IU / No. 760, 37th NIBSC 83/ Follicle stimulating, human, recombinant for immunoassay. Lyophilized. 60 IU / Standard, 1997 No. 889, 48th NIBSC 92/ Follicle stimulating, human, urinary (Urofollitropin), for bioassay. Lyophilized. 121 IU / Standard, 1995 No. 872, 46th Urinary NIBSC 92/ Follicle-stimulating and luteinising human, urinary for bioassay. Lyophilized. FSH 72 IU / LH 70 IU / 4th-International Standard, 2000 No. 910, 51st Urinary NIBSC 98/ Glucagon, porcine. Lyophilized IU / Standard, 1973 No. 530, 25th Gastrointestinal NIBSC 69/ Page 2 of 8
3 WHO International Biological Preparations Gonadotrophin, equine serum. Lyophilized. 1,600 IU / Standard, 1966 No. 361, 19th Horse serum NIBSC 62/ Human Chorionic Gonadotrophin for immunoassay of intact hcg. Lyophilized nmol / Hormone.Intact hcg: purified to remove nicked forms, and free subunits NIBSC 99/ alpha subunit hcg (hcg-alpha). Lyophilized nmol / Hormone. Purified alpha subunit of hcg NIBSC 99/ beta core fragment hcg (hcg-beta-cf). Lyophilized nmol / ampoule Hormone. hcg beta core fragment: residues beta 6-40 disulphide bonded to beta NIBSC 99/ hcg beta subunit (hcg-beta). Lyophilized nmol/ampoule Hormone. Beta subunit of hcg, purified to remove intact dimeric hcg, alpha subunit and nicked beta subunit NIBSC 99/ Page 3 of 8
4 WHO International Biological Preparations nicked hcg (hcg-n). Lyophilized nmol/ampoule Hormone. Nicked hcg: partially degraded hcg, missing bonds in the beta region NIBSC 99/ nicked hcg beta subunit (hcg-beta-n). Lyophilized nmol/ampoule Hormone. Nicked hcg beta subunit: partially degraded beta subunit, missing bonds in the beta region NIBSC 99/ Human growth, pituitary. Lyophilized. 4.4 IU / Standard, 1982 No. 687, 33rd NIBSC 80/ Inhibin A, human, recombinant. Lyophilized. 150,000 IU / Standard, 1994 No. 858, 45th ; No. 910, 51st NIBSC 91/ Inhibin B. Lyophilized. Immunoassay calibration 12 ng / Bioactivity: 12 units / Reagent, 2000 No. 910, 51st Immunoaffinity purified human inhibin NIBSC 96/ Page 4 of 8
5 WHO International Biological Preparations Inhibin, porcine. Lyophilized. 2,000 IU / Standard, 1990 No. 814, 41st Purified porcine NIBSC 86/ Insulin C-, human. Lyophilized. 10 µg / Reagent, 1986 No. 760, 37th Synthetic C- NIBSC 84/ Insulin, bovine. Hydrated crystals IU / mg. Approximately 50 mg / Insulin, human. Hydrated crystals. 26 IU / mg. Approximately 50 mg / Insulin, human, for immunoassay. Lyophilized. 3 IU / Insulin, porcine. Hydrated crystals. 26 IU / mg. Approximately 50 mg / Preparation, 1974 No. 760, 37th Insulin crystals NIBSC 83/ No. 760, 37th Insulin crystals NIBSC 83/ No. 565, 26th Human insulin NIBSC 66/ No. 760, 37th Insulin crystals NIBSC 83/ Insulin-like growth factor I for immunoassay. Lyophilized. 3.1 µg / Reagent, 2000 No. 910, 51st NIBSC 87/ Leptin, human. Lyophilized. 4,000 IU / Standard, 1999 No. 904, 50th / E.Coli NIBSC 97/ Leptin, mouse. Lyophilized. 4,000 IU / Standard, 1999 No. 904, 50th / E.Coli NIBSC 97/ Luteinizing, bovine, for immunoassay. Lyophilized IU / Standard, 1985 No. 745, 36th NIBSC 98/ Page 5 of 8
6 WHO International Biological Preparations Luteinizing, human, pituitary. Lyophilized. 35 IU / Standard, 1988 No. 786, 39th NIBSC 80/ Luteinizing, human, pituitary, alpha subunit. Lyophilized. 10 IU / Standard, 1984 No. 725, 35th NIBSC 78/ Luteinizing, human, pituitary, beta subunit. Lyophilized. 10 IU / Standard, 1984 No. 725, 35th NIBSC 78/ Lysine vasopressin. Lyophilized. 7.7 IU / Standard, 1978 No. 638, 30th Synthetic NIBSC 77/ Oxytocin. Lyophilized IU / 4th-International Standard, 1978 No. 638, 30th Synthetic oxytocin NIBSC 76/ Parathyroid, bovine. Lyophilized. 39 IU / Standard, 1985 No. 745, 36th Parathyroid NIBSC 82/ Parathyroid, human, for immunoassay. Lyophilized. 0.1 IU / Preparation, 1981 No.673, 32nd Parathyroid NIBSC 79/ Placental lactogen, human, for immunoassay. Lyophilized IU / Preparation, 1977 No. 626, 29th Purified placental protein NIBSC 73/ Proinsulin, bovine, for immunoassay. Lyophilized. 25 µg / No. 760, 37th Pancreatic enzyme NIBSC 84/ Page 6 of 8
7 WHO International Biological Preparations Proinsulin, human. Lyophilized. 6 µg / Reagent, 1986 No. 760, 37th proinsulin NIBSC 84/ Proinsulin, porcine, for immunoassay. Lyophilized. 20 µg / No. 760, 37th Pancreatic enzyme NIBSC 84/ Prolactin, human. Lyophilized IU / 3rd-International Standard, 1988 No. 786, 39th NIBSC 84/ Prolactin, recombinant human, for immunoassay. Lyophilized. Nominal content for immunization calibration: 24.5 µg / ampoule; for bioassay calibration: 1,400 mu / rdna derived prolactin NIBSC 97/ Prolactin, recombinant human, glycosylated form, for immunoassay. Lyophilized. Nominal content for immunization calibration: 5.5 µg / ampoule; for bioassay calibration: 88 mu / NIBSC 98/ Prolactin, recombinant human, non-glycosylated form, for immunoassay. Lyophilized µg / ampoule; for bioassay: 670 mu / rdna derived prolactin, nonglycosylated form NIBSC 98/ Renin, human. Lyophilized. 0.1 IU / Preparation, 1974 No. 565, 26th Kidney extract derived NIBSC 68/ Sex binding globulin (SHBG). Lyophilized. 107 IU / Standard, 1998 No. 897, 49th Human serum NIBSC 95/560 98/1884 Page 7 of 8
8 WHO International Biological Preparations Somatropin (rdna-derived human growth ). Lyophilized mg protein / Standard, 2000 No. 910, 51st / E.Coli NIBSC 98/ Tetracosactide. Lyophilized. 490 IU / Preparation, 1981 No. 673, 32nd Synthetic NIBSC 80/ Thyroid stimulating, human, for immunoassay. Lyophilized x -3 log 10 IU / 3rd-International Standard, 2003 In press NIBSC 81/ Thyroid-stimulating, human, recombinant. Lyophilized units / Reagent, 1996 No. 878, 47th, [Chinese Hamster Ovary cells (CHO)] NIBSC 94/ Thyroxine-binding globulin. Lyophilized. 30 IU / Standard, 1991 No. 822, 42nd Human serum derived NIBSC 88/ Page 8 of 8
PREPARATION STANDARD MATERIAL HELD AT CODE WHO/BS DOCUMENT. Native hormone purified from urine
WHO International Biological Reference Preparations Held and Distributed by the WHO International Laboratories for Biological Standards ENDOCRINOLOGICAL SUBSTANCES Activin A, human, recombinant, Lyophilized,
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