WHO International Biological Reference Preparations Held and Distributed by the WHO International Laboratories for Biological Standards

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1 WHO International Biological Reference Preparations Held and Distributed by the WHO International Laboratories for Biological Standards PREPARATION Activin A, human, recombinant, Lyophilized., 5 units / 1st Reference Reagent, 1998 No th Report Recombinant hormone 91/ Alpha-1-antitrypsin,, In press Alphafoetoprotein, human, Lyophilized., 100,000 IU / 1st International Standard, 1975 No. 594, 27th Report Human cord serum AFP Amphotericin B, Lyophilized., 940 IU / mg. Approximately 50 mg of Amphotericin B. 1st International Standard, 1963 No. 274, 16th Report Antibiotic 60/ Ancrod, Lyophilized., 55 IU / No. 626, 29th Report Enzyme 74/ Preparation, 1976 Anthrax spore vaccine, Lyophilized spore suspension of Bacillus anthracis strain 34 F2., 1 IU / Preparation, 1978 No. 638, 30th Report Antigen AxV Anti-A Blood Grouping minimum potency reagent, Lyophilized., No assigned activity. However a 1 in 8 dilution should define the recommended minimum potency specification for anti-a glood grouping reagents. 1st International Standard, 2005 To be published Blood grouping serum 03/ Anti-A blood typing serum, human, Lyophilized., 470 IU / 2nd International Standard, 1981 No. 673, 32nd Report Human serum Sanquin W Anti-B Blood Grouping minimum potency reagent, Lyophilized., No assigned activity. However a 1 in 4 dilution should define the recommended minimum potency specification for anti-b blood grouping reagents 1st International Standard, 2005 To be published Blood grouping serum 03/ Anti-B blood-typing serum, human, Lyophilized., 860 IU / 3rd International Standard, 1981 No. 673, 32nd Report Human serum Sanquin W Anti-brucella abortus serum, bovine, Lyophilized., 1,000 IU / ampoule of agglutinating; 1,000 IU / ampoule of complementfixing activity. 2nd International Standard, 1975 No. 594, 27th Report Bovine serum BaDS Anti-brucella ovis serum, ovine, Lyophilized., 1,000 IU / 1st International Standard, 1985 No. 745, 36th Report Bovine serum BovisDs Anti-C complete blood-typing serum, human, Lyophilized., 100 IU / Anti-c incomplete blood-typing serum, human, Lyophilized., 64 IU / 1st International Standard, 1984 No. 725, 35th Report Human serum Sanquin W st International Standard, 1976 No. 610, 28th Report Human serum Sanquin W Anti-canine distemper serum, Lyophilized., 1,000 IU / 1st International Standard, 1967 No. 384, 20th Report Horse serum CDS Anti-canine hepatitis serum, Lyophilized., 1,000 IU / 1st International Standard, 1967 No. 384, 20th Report Horse serum CHS Anti-D (anti-rh0) blood-grouping reagent, complete, Lyophilized., 1 in 3 dilution recommended 1st International Minimum Potency Standard, 2004 In press Monoclonal IgM (human) 99/ Rev. 1 Anti-D (anti-rh0) incomplete blood-typing serum, human, Lyophilized., 32 IU / Anti-D immunoglobulin, human, Lyophilized., 285 IU (57 μg) / 1st International Standard, 1966 No. 361, 19th Report Human serum Sanquin W nd International Standard, 2003 No. 926, 53rd Report Human immunoglobulin 01/ Page 1 of 17

2 Anti-dengue virus type 1,2,3 and 4 serum, Freeze-dried, 100 units per serotype per ampoule To be published Human plasma 02/ Anti-double-stranded DNA serum, human, Lyophilized., 100 IU / 1st International Standard, 1985 No. 745, 36th Report Human serum Sanquin Wo/80 (W1065) Anti-dysentery serum (Shiga), equine,, 1 IU equivalent to 0.05 mg of dried standard serum. Anti-E complete blood-typing serum, human, Lyophilized., 100 IU / 1st International Standard, 1928 See Bull. Health Org. docume Horse serum DY Bull. Health Org. 4, st International Standard, 1983 No. 700, 34th Report Human serum Sanquin W Anti-echinococcus serum, human, Lyophilized., mg human serum / Reagent, 1975 No. 594, 27th Report Human serum ECHS Anti-hepatitis A immunoglobulin, human, Lyophilized., 49 IU / 2nd International Standard, 1998 No. 897, 49th Report Human immunoglobulin Sanquin W / Anti-hepatitis B immunoglobulin, human, Lyophilized., 50 IU / Preparation, 1977 No. 626, 29th Report Human immunoglobulin Sanquin W Anti-hepatitis E serum, human, Lyophilized., 50 units / 1st Reference Reagent, 1997 No. 889, 48th Report Human serum 95/ Anti-HIV antibodies (set of 6 subtypes), Lyophilized., No unitage assigned Panel, 2006 To be published Human plasma 02/ Anti-human platelet antigen-1a, Lyophilized., No unitage assigned. 1st Reference Reagent, 1997 No. 889, 48th Report Human serum 93/ Anti-human platelet antigen-5b, Lyophilized., No assigned unitage 1st Reference Reagent, 2003 No. 926, 53rd Report Human serum 99/666 Verbal Anti-interferon alpha serum, human, Lyophilized., 8,000 neutralising units / Reagent, 1994 No. 858, 45th Report Human serum NIAID G Anti-interferon beta serum, human, Lyophilized., 1,500 neutralising units / Reagent, 1994 No. 858, 45th Report Human serum NIAID G Anti-measles serum, human, Lyophilized., 5 IU / 2nd International Standard, 1990 No. 814, 41st Report Human serum 66/ Anti-mycoplasma gallisepticum serum, Lyophilized., 1,000 IU / ampoule of agglutinating activity and 1,000 IU / ampoule of haemagglutination-inhibiting activity. Preparation, 1969 No. 444, 22nd Report Chicken serum MgDS Anti-newcastle-disease serum, Lyophilized., 320 IU / No. 413, 21st Report Chicken serum NDS Preparation, 1968 Anti-nuclear ribonucleoprotein serum, Lyophilized., No unitage assigned. Reagent, 1983 No.700, 34th Report Human serum Sanquin W Anti-nuclear-factor (homogeneous) serum, Lyophilized., 100 IU / Preparation, 1970 No. 463, 23rd Report Human serum Sanquin 66/233 (W1064) Anti-parvovirus B19 (IgG) serum, Lyophilized., 77 IU / 2nd International Standard, 2003 No. 926, 53rd Report: Human serum 01/ Anti-pertussis serum, mouse,, 17 units / vial of anti-pertussis toxin. 143 units / vial of anti-filamentous haemagglutinin. 30 units / vial of anti-pertactin. 32 units / vial of anti-fimbria types 2/3. 1st Reference Reagent, 1999 No. 904, 50th Report Mouse serum 97/ Page 2 of 17

3 Anti-poliovirus serum (Types 1, 2, 3), Lyophilized., 25 IU / ampoule (Type 1), 50 IU / ampoule (Type 2), 5 IU / ampoule (Type 3). 2nd International Standard, 1991 No. 822, 42nd Report Human serum 66/ Anti-Q-fever serum, bovine, Lyophilized., 1,000 IU / 1st International Standard, 1954 No. 96, 8th Report Bovine serum QF Anti-rabies immunoglobulin, human, Lyophilized., 30 IU / 2nd International Standard, 1993 No. 848, 44th Report Human immunoglobulin RAI Anti-rubella immunoglobulin, human, Lyophilized., 1,600 IU / vial. 1st International Standard, 1996 No. 878, 47th Report Human immunoglobulin RUBI Anti-salmonella pullorum serum (Standard Form S), Lyophilized., 1,000 IU / Anti-salmonella pullorum serum (Variant Form V), Lyophilized., 1,000 IU / 1st International Standard, 1973 No. 530, 25th Report Goat serum SpDS-S st International Standard, 1973 No. 530, 25th Report Goat serum SpDS-V Anti-smooth muscle serum, Lyophilized., No unitage assigned. No. 700, 34th Report Human serum Sanquin W Reagent, 1983 Anti-staphylococcal P-V leucocidin serum, equine, Lyophilized., 150 IU / 1st International Standard, 1965 No. 329, 18th Report Horse serum SPLS Anti-swine fever serum, Lyophilized., 1,000 IU / 1st International Standard, 1963 No. 274, 16th Report Pig serum SFS Anti-syphilitic serum, human, Lyophilized., 49 IU / 1st International Standard, 1958 No. 172, 12th Report Human serum HS Anti-tetanus immunoglobulin, human, Lyophilized., 120 IU / Antithrombin, concentrate, human, Lyophilized., Functional potency IU / Antigenic potency IU / 1st International Standard, 1992 No. 840, 43rd Report Human immunoglobulin TE nd International Standard, 1997 No. 889, 48th Report Purified plasma protein 96/ Antithrombin, plasma, human, Lyophilized., 0.85 IU / 2nd International Standard, 1994 No. 848, 44th Report Human plasma 93/ Anti-thyroglobulin serum, human, Lyophilized., 1,000 IU / No. 638, 30th Report Human serum 65/ Preparation, 1978 Anti-tick borne encephalitis serum (louping ill (Moredun) virus), Lyophilized., No unitage assigned. Reagent, 1964 No. 293, 17th Report Sheep serum TILI Anti-tick borne encephalitis serum (Russian spring-summer (sophyn and absettarov) virus), Lyophilized., No unitage assigned. Reagent, 1964 No. 293, 17th Report Sheep serum TISA Anti-toxoplasma serum, Lyophilized., 1,000 IU / 3rd International Standard, 1994 No. 858, 45th Report Human serum TOXM Anti-toxoplasma serum (IgG), human, Lyophilized., 20 IU / 1st International Standard, 2003 In press Human serum 01/ Anti-typhoid serum, equine, Lyophilized., 5 ml of freeze dried horse serum per Preparation, 1952 No. 68, 6th Report Horse serum TYS Anti-varicella zoster immunoglobulin, human, Lyophilized., 50 IU / 1st International Standard, 1987 No. 771, 38th Report Human immunoglobulin Sanquin W Anti-yellow fever serum, monkey, Lyophilized., 143 IU / 1st International Standard, 1962 No. 259, 15th Report Monkey serum YF Page 3 of 17

4 Apolipoprotein A-1, Lyophilized., 1.5 mg / vial. No. 840, 43rd Report Human serum CDC SP Reagent, 1992 Apolipoprotein B, Frozen., 1.22 mg / vial. No. 848, 44th Report Human serum CDC SP Reagent, 1993 Arginine vasopressin, Lyophilized., 8.2 IU / 1st International Standard, 1978 No. 638, 30th Report Hormone 77/ Atrial natriuretic factor, human, Lyophilized., 2.5 IU / 1st International Standard, 1987 No. 771, 38th Report Peptide hormone 85/ Bacitracin, Lyophilized., Approximately 100 mg of zinc bacitracin (74 IU / mg). Basic fibroblast growth factor (bfgf, FGF-2), human, rdna derived, Lyophilized., 1,600 IU / 2nd International Standard, 1964 No. 293, 17th Report Antibiotic 62/ st International Standard, 1993 No. 848, 44th Report Recombinant growth factor 90/ BCG vaccine, Lyophilized., 2.5 mg of semi-dry bacillary mass / 5- ml Preparation, 1965 No. 329, 18th Report Antigen BCG Beta-2 microglobulin, Lyophilized., 100 IU / 1st International Standard, 1985 No. 745, 36th Report Human serum B2M Beta-thromboglobulin, human, Lyophilized., 500 IU / 1st International Standard, 1984 No. 725, 35th Report Purified plasma protein 83/ Birch pollen extract (Betula verrucosa), Lyophilized., 100,000 IU / 1st International Standard, 1986 No. 760, 37th Report Allergen 84/ Bleomycin complex A2/B2, Lyophilized., 8,910 IU / No. 658, 31st Report Antibiotic 78/ Preparation, 1980 Blood coagulation factor IX concentrate, human, Lyophilized., 10.7 IU / vial. Blood coagulation factor IXa, concentrate, human, Lyophilized., 11.0 IU / 3rd International Standard, 1996 No. 878, 47th Report Purified plasma protein 96/ st International Standard, 1999 No. 904, 50th Report Recombinant protein 97/ Blood Coagulation Factor V Leiden (G1691A), human gdna (three samples: FV wild type; FVL homozygote; FVL heterozygote), Lyophilized., No assigned value 1st International Genetic Reference Panel, 2004 In press Genetic material 04/ Blood Coagulation Factor V, plasma, human, Lyophilized., 0.74 International Units of Factor V:C per ampoule Blood coagulation factor VII concentrate, human, Lyophilized., 6.3 IU / Blood coagulation factor VIIa concentrate, human, Lyophilized., 5,130 IU / Blood coagulation factor VIII and von Willebrand factor, plasma, human, Lyophilized., 0.68 IU / ampoule Factor VIII:C; 0.94 IU/ampoule factor VIII. Antigen; 0.91 IU/ampoule VWF:antigen; 0.78 IU/ampoule VWF:ristocetin cofactor; 0.94 IU/ampoule VWF:collagen binding Blood coagulation factor VIII concentrate, human, Lyophilized., 11.0 IU / 1st International Standard, 2005 To be published Human plasma 03/ st International Standard, 1998 No. 897, 49th Report Purified plasma protein 97/ st International Standard, 1993 No. 848, 44th Report Recombinant protein 89/ th International Standard, 2003 In press Human plasma 02/ th International Standard, 2003 In press Recombinant protein 99/ Page 4 of 17

5 Blood Coagulation factor XI, plasma human, Lyophilized., 0.86 International Units per ampoule Blood Coagulation Factor XIII, plasma, human, Lyophilized., 091 IU/ampoule Blood coagulation factors II, VII, IX, X, plasma, human, Lyophilized., 0.91 IU (factor II), 1.00 IU (factor VII), 0.86 IU (factor IX), 0.93 IU (factor X) / Blood coagulation factors, II and X concentrate, human, Lyophilized., 11.2 IU (factor II), 10.2 IU (factor X) / Bone morphogenic protein-2, human, rdna derived, Lyophilized., 5,000 units / Brain derived neurotrophic factor, human, rdna derived, Lyophilized., 16,000 units / 1st International Standard, 2005 To be published Human plasma 04/ st International Standard, 2004 In press Human plasma 02/ Rev.1 3rd International Standard, 2001 No. 924, 52nd Report Human plasma 99/ rd International Standard, 1999 No. 904, 50th Report Purified plasma proteins 98/ st Reference Reagent, 1997 No. 889, 48th Report Recombinant cytokine 93/ st Reference Reagent, 1997 No. 889, 48th Report Recombinant growth factor 96/ Calcitonin, eel, Lyophilized., 88 IU / 1st International Standard, 1989 No. 800, 40th Report Hormone 88/ Calcitonin, human, Lyophilized., 17.5 IU / 2nd International Standard, 1991 No. 822, 42nd Report Hormone 89/ Calcitonin, salmon, Lyophilized., 138 IU / 3rd International Standard, 1999 No. 904, 50th Report Hormone 98/ Carcinoembryonic antigen (CEA), human, Lyophilized., 100 IU / Preparation, 1975 No. 594, 27th Report Human carcinoma derived 73/ Cholera antitoxin, goat, Lyophilized., 2,200 IU / 1st International Standard, 1984 No. 725, 35th Report Goat serum CHAN Cholera vaccine (Inaba), Lyophilized., 40,000,000,000 organisms / 2nd International Reference Preparation, 1971 No. 486, 24th Report Antigen INV Rev. 1 Cholera vaccine (Ogawa), Lyophilized., 40,000,000,000 organisms / 2nd International Reference Preparation, 1971 No. 486, 24th Report Antigen OGV Chorionic gonadotrophin, alpha subunit, human, for immunoassay, Lyophilized., 70 IU / Preparation, 1974 No. 565, 26th Report Glycoprotein hormone 75/ Chorionic gonadotrophin, beta subunit, human, for immunoassay, Lyophilized., 70 IU / Preparation, 1974 No. 565, 26th Report Glycoprotein hormone 75/ Chorionic gonadotrophin, human, Lyophilized., 650 IU / 4th International Standard, 1999 No. 904, 50th Report Glycoprotein hormone 75/ Ciliary Neurotrophic Factor for the bioassay of human CNTF, human, rdna derived, Lyophilized., For bioassay: 8,000 units / ampoule; for immunoassay: 6.5 μg / Clostridium botulinum Type B antitoxin, equine, Lyophilized., 30.7 IU / 1st Reference Reagent, 2001 No. 924, 52nd Report Recombinant growth factor 94/ nd International Standard, 1985 No. 745, 36th Report Horse serum BUSB Clostridium botulinum Type D antitoxin, equine, Lyophilized., 1,000 IU / 1st International Standard, 1962 No. 259, 15th Report Horse serum 61/001 (BUSD) Clostridium novyi alpha toxoid, Lyophilized., No unitage assigned. No. 361, 19th Report Toxoid CoT Preparation, 1966 Page 5 of 17

6 Clostridium perfringens beta antitoxin, equine, Lyophilized., 4,770 IU / 2nd International Standard, 1998 No. 897, 49th Report Horse serum 2Cp BetaAt Clostridium perfringens beta toxoid, Lyophilized., No unitage assigned. Preparation, 1975 No. 594, 27th Report Toxoid CWBetatd Clostridium perfringens epsilon antitoxin, equine, Lyophilized., 1,020 IU / 2nd International Standard, 1985 No. 745, 36th Report Horse serum 2Cp Epsilon At Clostridium perfringens epsilon toxoid, Lyophilized., No unitage assigned. Preparation, 1975 No. 594, 27th Report Antigen CW Epsilontd Colistin, Lyophilized., 20,500 IU / mg. Approximatley 75 mg of colistin sulfate. 1st International Standard, 1968 No. 413, 21st Report Antibiotic 65/ Colistin methane sulfonate, Lyophilized., 12,700 IU / mg. Approximately 75 mg of colistin methane sulfonate. Preparation, 1968 No. 413, 21st Report Antibiotic 66/ Corticotrophin (ACTH), porcine, Lyophilized., 5 IU / 3rd International Standard, 1962 No. 259, 15th Report Pituitary hormone 59/ C-reactive protein, human, Lyophilized., IU / 1st International Standard, 1986 No. 760, 37th Report Human plasma 85/ Dihydrostreptomycin, Lyophilized., 820 IU / mg. Approximately 200 mg of dihydrostreptomycin sulfate. 2nd International Standard, 1966 No. 361, 19th Report Antibiotic 62/ Diphtheria (schick) test toxin, Lyophilized., 900 IU / 1st International Standard, 1954 No. 96, 8th Report Toxin STT Diphtheria antitoxin, equine, Lyophilized., Bottles in the form of 10 ml of a solution of dried serum in 66% v/v of glycerol. 10 IU / ml. 1st International Standard, 1934 See Bull. Health Org. docume Horse serum 03/214 Bull. Health Org. 5, 1936 Diphtheria toxoid, adsorbed, Lyophilized., 160 IU / 3rd International Standard, 1999 No. 904, 50th Report Adsorbed toxoid 98/ Diphtheria toxoid, for flocculation tests, Lyophilized., 900 Lf IU / Reagent, 1988 No. 786, 39th Report Toxoid DIFT Dog hair and dander extract (Canis domesticus), Lyophilized., 100,000 IU / 1st International Standard, 1986 No. 760, 37th Report Allergen 84/ Elcatonin (Calcitonin analogue), Lyophilized., 15 IU / 1st International Standard, 1986 No. 760, 37th Report Endocrinological products 84/ Endotoxin for Limulus Amoebocyte Lysate (LAL) gelation tests, Lyophilized., 10,000 IU / 2nd International Standard, 1996 No. 878, 47th Report Toxin 94/ Rev. 1 Epidermal growth factor (1-52), human, recombinant, Lyophilized., 1.75 μg / No unitage assigned. Reagent, 1994 No. 858, 45th Report Recombinant growth factor 91/ Epidermal growth factor, human, recombinant, Lyophilized., 2,000 IU / Erythromycin, Lyophilized., 920 IU / mg. Approximately 75 mg of erythromycin A base. 1st International Standard, 1994 No. 858, 45th Report Recombinant growth factor 91/ nd International Standard, 1978 No. 638, 30th Report Antibiotic 76/ Erythropoietin, human, urinary, Lyophilized., 10 IU / 2nd International Reference No. 463, 23rd Report Urinary hormone 67/ Preparation, 1970 Erythropoietin, rdna-derived, Lyophilized., 120 IU / 2nd International Standard, 2003 No. 926, 53rd Report Recombinant hormone 88/ Page 6 of 17

7 Ferritin, human, recombinant, Lyophilized., 6.3 μg / 3rd International Standard, 1996 No. 878, 47th Report Recombinant protein diluted in plasma 94/ Fibrinogen concentrate human, Lyophilized., Total protein 15 mg / Clottable protein 10.5 mg / 1st International Standard, 2000 No. 910, 51st Report Purified plasma protein 98/ Fibrinogen, plasma, human, Lyophilized., 2.2 mg / 2nd International Standard, 1999 No. 904, 50th Report Human plasma 98/ FMS-like tyrosine kinase 3 ligand, human, rdna derived, Lyophilized., 1,000 units / Follicle stimulating hormone, human, recombinant, for bioassay, Lyophilized., 138 IU / Follicle stimulating hormone, human, pituitary, Lyophilized., 80 IU / Follicle stimulating hormone, human, recombinant for immunoassay, Lyophilized., 60 IU / Follicle stimulating hormone, human, urinary (Urofollitropin), for bioassay, Lyophilized., 121 IU / Follicle-stimulating hormone and luteinising hormone human, urinary for bioassay, Lyophilized., FSH 72 IU / LH 70 IU / Gas-gangrene antitoxin (Clostridium histolyticum), equine, Lyophilized., 50 IU / Gas-gangrene antitoxin (Clostridium perfringens), equine, Lyophilized., 270 IU / Gas-gangrene antitoxin (Clostridium sordellii), equine, Liquid., 7,500 IU / Bottles in the form of 10 ml of a solution of dried serum in 66% v/v of glycerol. 20 IU / ml. Gas-gangrene antitoxin, (Clostridium novyi), equine, Lyophilized., 1,100 IU / Gas-gangrene antitoxin, (Clostridium septicum), equine, Lyophilized., 500 IU / 1st Reference Reagent, 1997 No. 889, 48th Report Recombinant cytokine 96/ st International Standard, 1995 No. 872, 46th Report Recombinant hormone 92/ st International Standard, 1986 No. 760, 37th Report Pituitary hormone 83/ st International Standard, 1997 No. 889, 48th Report Recombinant hormone 92/ st International Standard, 1995 No. 872, 46th Report Urinary hormone 92/ th International Standard, 2000 No. 910, 51st Report Urinary hormone 98/ rd International Standard, 1971 No. 486, 24th Report Horse serum HI th International Standard, 1962 No. 259, 15th Report Horse serum PE Rev. 1 1st International Standard, 1938 See Bull. Health Org. docume Horse serum 97/764 Bull. Health Org. 8, rd International Standard, 1966 No. 361, 19th Report Horse serum OE rd International Standard, 1957 No. 147, 11th Report Horse serum VI Gentamicin, Lyophilized., 31,020 IU / 2nd International Standard, 1995 No. 872, 46th Report Antibiotic 92/ Glucagon, porcine, Lyophilized., 1.49 IU / 1st International Standard, 1973 No. 530, 25th Report Gastrointestinal peptide 69/ Gonadotrophin, equine serum, Lyophilized., 1,600 IU / 2nd International Standard, 1966 No. 361, 19th Report Horse serum 62/ Gramicidin, Lyophilized., 1,000 IU / mg. Approximately 55 mg of gramicidin. Preparation, 1966 No. 361, 19th Report Antibiotic 64/ Granulocyte colony stimulating factor, human, recombinant, Lyophilized., 10,000 IU / Granulocyte-macrophage colony stimulating factor, human, recombinant, Lyophilized., 10,000 IU / 1st International Standard, 1992 No. 840, 43rd Report Recombinant growth factor 88/ st International Standard, 1992 No. 840, 43rd Report Recombinant growth factor 88/ Page 7 of 17

8 Haemoglobin A2, raised, Lyophilized., 5.3 % (w/w) of total haemoglobin. Reagent, 1993 No. 848, 44th Report Beta-thalassemia haemolysate derived 89/ Haemoglobin F, raised, Lyophilized., 3.4% (w/w) of total haemoglobin. Reagent, 1993 No. 848, 44th Report Cyanmethaemoglobin, haemolysate derived 85/ Haemoglobincyanide, Liquid., μmol / l. 6th International Standard, 1998 No. 897, 49th Report Bovine hemoglobin 98/ Haemophilus influenza type b capsular polysaccharide, Lyophilized., 4.933± mg/ampoule of polyribosyl ribitol phosphate (PRP) Heparin, low molecular weight, Liquid., 1097 IU / ampoule (anti- Xa), 326 IU / ampoule (anti-iia). 1st International Standard, 2005 To be published Antigen 02/ nd International Standard, 2003 In press Porcine mucosal derived 01/ Heparin, low molecular weight (calibrant for molecular weight distribution), Lyophilized., No unitage assigned. Reagent, 1993 No. 848, 44th Report Porcine mucosal derived 90/ Heparin, unfractionated, Lyophilized., 2,031 IU / 5th International Standard, 1998 No. 897, 49th Report Porcine mucosal derived 97/ Hepatitis A vaccine, inactivated, Frozen., 100 IU / ml of immunogenic activity; 100 IU / ml of antigen content. 1st International Standard, 1999 No. 904, 50th Report Antigen 95/ Hepatitis A virus RNA, Lyophilized., 50,000 IU / vial. 1st International Standard, 2003 No. 926, 53rd Report Human plasma 00/ Hepatitis B surface antigen, subtype adw2, genotype A, Lyophilized., Dilutional panel (IU/vial: 8.25; 2.06; 0.52; 0.13) Panel, 2003 In press Recalcified human plasma 03/ Hepatitis B surface antigen, subtype adw2, genotype A, Lyophilized., 33 IU / vial. 2nd International Standard, 2003 In press Recalcified human plasma 00/ Hepatitis B virus DNA, Lyophilized., 500,000 IU / vial. 2nd International Standard, 2006 To be published Human plasma 97/ Hepatitis C virus RNA, Lyophilized., 50,000 IU / vial. 2nd International Standard, 2003 No. 926, 53rd Report Human plasma 96/ Hepatocyte growth factor/scatter factor (precursor), human, Lyophilized., 2,000 IU / Hepatocyte growth factor/scatter factor, human, Lyophilized., 4,000 IU / 1st International Standard, 1999 No. 904, 50th Report Recombinant growth factor 96/ st International Standard, 1999 No. 904, 50th Report Recombinant growth factor 96/ HIV-1 p24 antigen, Lyophilized., 1,000 IU / No. 840, 43rd Report Peptide in human serum 90/ Reagent, 1992 HIV-1 RNA, Lyophilized., 556,000 IU / vial 2nd International Standard, 2005 To be published HIV-1 genotype B isolate diluted in human plasma 97/ HIV-1 RNA genotypes (set of 10 genotypes), Liquid., No assigned value Panel, 2003 No. 926, 53rd Report HIV-1 isolates diluted in human plasma 01/ Horseradish peroxidase-conjugated sheep anti-human IgG (H and L chains), Lyophilized., No unitage assigned. Preparation, 1982 No. 687, 33rd Report Sheep serum Sanquin W House-dust mite extract (Dermatophagoides pteronyssinus), Lyophilized., 10,000 IU / 1st International Standard, 1983 No. 700, 34th Report Allergen 82/ Page 8 of 17

9 Human brain, CJD control, Lyophilized., No assignment No. 926, 53rd Report Brain homogenate NHBZ0/ Rev.1 Reagent, 2003 Human brain, sporadic CJD, preparation 1, Lyophilized., No assignment 1st Reference Reagent, 2003 No. 926, 53rd Report Brain homogenate NHBX0/ Rev. 1 Human brain, sporadic CJD, preparation 2, Lyophilized., No assignment 1st Reference Reagent, 2003 No. 926, 53rd Report Brain homogenate NHBX0/ Rev. 1 Human brain, variant CJD, Lyophilized., No assignment 1st Reference Reagent, 2003 No. 926, 53rd Report Brain homogenate NHBY0/ Rev.1 Human Chorionic Gonadotrophin for immunoassay of intact hcg, Lyophilized., 1.88 nmol / Human Chorionic Gonadotrophin, for immunoassay of alpha subunit hcg (hcg-alpha), Lyophilized., 0.84 nmol / Human Chorionic Gonadotrophin, for immunoassay of beta core fragment hcg (hcg-beta-cf), Lyophilized., 1.02 nmol / ampoule Human Chorionic Gonadotrophin, for immunoassay of hcg beta subunit (hcg-beta), Lyophilized., 0.88 nmol/ampoule Human Chorionic Gonadotrophin, for immunoassay of nicked hcg (hcg-n), Lyophilized., 0.78 nmol/ampoule Human Chorionic Gonadotrophin, for immunoassay of nicked hcg beta subunit (hcg-beta-n), Lyophilized., 0.33 nmol/ampoule 1st Reference Reagent, 2001 No. 924, 52nd Report Hormone.Intact hcg: purified to remove nicked forms, and free subunits 1st Reference Reagent, 2001 No. 924, 52nd Report Hormone. Purified alpha subunit of hcg 1st Reference Reagent, 2001 No. 924, 52nd Report Hormone. hcg beta core fragment: residues beta 6-40 disulphide bonded to beta st Reference Reagent, 2001 No. 924, 52nd Report Hormone. Beta subunit of hcg, purified to remove intact dimeric hcg, alpha subunit and nicked beta subunit 1st Reference Reagent, 2001 No. 924, 52nd Report Hormone. Nicked hcg: partially degraded hcg, missing peptide bonds in the beta region 1st Reference Reagent, 2001 No. 924, 52nd Report Hormone. Nicked hcg beta subunit: partially degraded beta subunit, missing peptide bonds in the beta region 99/ / / / / / Human growth hormone, pituitary, Lyophilized., 4.4 IU / 1st International Standard, 1982 No. 687, 33rd Report Pituitary hormone 80/ Human serum complement components C1q, C4, C5, factor B, and whole functional complement CH50, Lyophilized., C1q : 100 IU / ampoule, C4 : 100 IU / ampoule, Factor B : 100 IU / ampoule, Whole functional complement CH50 : 100 IU / Preparation, 1980 No. 658, 31st Report Human serum Sanquin W Human serum immunoglobulin E, Lyophilized., 5,000 IU / 2nd International Reference Preparation, 1980 No. 658, 31st Report Human serum 75/ Human serum immunoglobulins G, A, and M (IgG, IgA and IgM), Lyophilized., 100 IU IgG, 100 IU IgA and 100 IU IgM / Preparation, 1970 No. 463, 23rd Report Human serum 67/ Human serum proteins, for immunoassay: albumin; alpha-1- antitrypsin; alpha-2-macroglobulin; ceruloplasmin; complement C3; transferrin, Lyophilized., 100 IU of each protein / Preparation, 1977 No. 626, 29th Report Human serum Sanquin W Page 9 of 17

10 Immunoglobulin, intravenous: anti-d negative control, Lyophilized., No assigned value Immunoglobulin, intravenous: anti-d positive control, Lyophilized., No assigned value Inhibin A, human, recombinant, Lyophilized., 150,000 IU / 1st Reference Reagent, 2004 In Press Human immunoglobulin 02/ st Reference Reagent, 2004 In Press Human immunoglobulin 02/ st International Standard, 1994 No. 858, 45th Report; No. 91 Recombinant hormone 91/ Inhibin B, Lyophilized., Immunoassay calibration 12 ng / Bioactivity: 12 units / 1st Reference Reagent, 2000 No. 910, 51st Report Immunoaffinity purified human inhibin hormone 96/ Inhibin, porcine, Lyophilized., 2,000 IU / 1st International Standard, 1990 No. 814, 41st Report Purified porcine hormone 86/ Insulin C-peptide, human, Lyophilized., 10 μg / No. 760, 37th Report Synthetic C-peptide 84/ Reagent, 1986 Insulin, bovine, Hydrated crystals., 25.7 IU / mg. Approximately 50 mg / Insulin, human, Hydrated crystals., 26 IU / mg. Approximately 50 mg / 1st International Standard, 1986 No. 760, 37th Report Insulin crystals 83/ st International Standard, 1986 No. 760, 37th Report Insulin crystals 83/ Insulin, human, for immunoassay, Lyophilized., 3 IU / No. 565, 26th Report Human insulin 66/ Preparation, 1974 Insulin, porcine, Hydrated crystals., 26 IU / mg. Approximately 50 mg / Insulin-like growth factor I for bioassay, Lyophilized., 150 IU / Insulin-like growth factor I for immunoassay, Lyophilized., 3.1 µg / Insulin-like growth factor II, human, recombinant, Lyophilized., 5,000 units / Interferon alpha, human, leukocyte N3, Lyophilized., 60,000 IU / 1st International Standard, 1986 No. 760, 37th Report Insulin crystals 83/ st International Standard, 1994 No. 858, 45th Report; No. 91 Recombinant growth factor 91/ st Reference Reagent, 2000 No. 910, 51st Report Recombinant hormone 87/ st Reference Reagent, 1999 No. 904, 50th Report Recombinant growth Factor 96/ st International Standard, 1999 No. 904, 50th Report Human cells leukocyte derived 95/ Interferon alpha 1/8, human, Lyophilized., 27,000 IU / 1st International Standard, 1999 No. 904, 50th Report Recombinant cytokine 95/ Interferon alpha 2c, human, recombinant, Lyophilized., 40,000 IU / Interferon alpha consensus, human, recombinant, Lyophilized., 100,000 IU / Interferon alpha, human, leukocyte (HulFN-a(Le)), Lyophilized., 11,000 IU / 1st International Standard, 1999 No. 904, 50th Report Recombinant cytokine 95/ st International Standard, 1999 No. 904, 50th Report Recombinant cytokine 94/ nd International Standard, 1999 No. 904, 50th Report Human cells leukocyte derived 94/ Interferon alpha, human, lymphoblastoid N1 (HuIFN-alpha(Ly)), Lyophilized., 38,000 IU / 2nd International Standard, 1999 No. 904, 50th Report Human cells lymphoblastoid derived 95/ Interferon alpha-1 (alpha-d), human, recombinant, (rhuifnalpha1(alphad)), Lyophilized., 8,000 IU / 1st International Standard, 1987 No. 771, 38th Report Recombinant cytokine 83/ Page 10 of 17

11 Interferon alpha2a, human, recombinant (rhulfn-alpha2 (alpha- A)), Lyophilized., 63,000 IU / Interferon alpha2b, human, recombinant, (rhulfn-alpha2 (alpha- 2b)), Lyophilized., 70,000 IU / 2nd International Standard, 1999 No. 904, 50th Report Recombinant cytokine 95/ nd International Standard, 1999 No. 904, 50th Report Recombinant cytokine 95/ Interferon beta ser-17, human, recombinant (rhulfn-beta(ser17)), Lyophilized., 6,000 IU / Reagent, 1987 No. 771, 38th Report Recombinant cytokine NIAID Gxb Interferon beta, human, fibroblast (HulFN-beta), Lyophilized., 40,000 IU / 3rd International Standard, 2003 In press Human cells fibroblast derived 00/ Interferon gamma, human, recombinant, Lyophilized., 80,000 IU / 1st International Standard, 1994 No. 858, 45th Report Recombinant cytokine NIAID Gxg Interferon omega, human, recombinant,, 20,000 IU / 1st International Standard, 1999 No. 897, 49th Report Recombinant cytokine 94/ Interferon, chick, Lyophilized., 80 IU / No. 638, 30th Report Chick embryo cytokine 67/ Preparation, 1978 Interferon, murine, alpha (MulFN-alpha), Lyophilized., 16,000 IU / 2nd International Standard, 1987 No. 771, 38th Report Murine cytokine NIAID Ga Interferon, murine, beta (MulFN-beta), Lyophilized., 15,000 IU / 2nd International Standard, 1987 No. 771, 38th Report Recombinant cytokine NIAID Gb Interferon, murine, gamma (MulFN-gamma), Lyophilized., 1,000 IU / Reagent, 1987 No. 771, 38th Report Recombinant cytokine NIAID Gg Interferon, rabbit, Lyophilized., 10,000 IU / 1st International Standard, 1978 No.638, 30 th Report Recombinant cytokine NIAID G Interleukin-1 alpha, human, Lyophilized., 117,000 IU / 1st International Standard, 1989 No. 800, 40th Report Recombinant cytokine 86/632 TRS 800, 1990 Interleukin-1 beta, human, Lyophilized., 100,000 IU / 1st International Standard, 1989 No. 800, 40th Report Recombinant cytokine 86/680 TRS 800, 1990 Interleukin-10, human, Lyophilized., 5,000 units / 1st Reference Reagent, 1997 No. 889, 48th Report Recombinant cytokine 93/ Interleukin-11, human, Lyophilized., 5,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 92/ Interleukin-12, human, Lyophilized., 10,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 95/ Interleukin-13, human, Lyophilized., 1,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 94/ Interleukin-15, human, Lyophilized., 1,0000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 95/ Interleukin-2, human, Lyophilized., 100 IU / 1st International Standard, 1987 No. 771, 38th Report T-Cell line (Jurkat) derived 86/ Interleukin-3, human, Lyophilized., 1,700 IU / 1st International Standard, 1994 No. 848, 44th Report Recombinant cytokine 91/ Interleukin-4, human, Lyophilized., 1,000 IU / 1st International Standard, 1994 No. 858, 45th Report Recombinant cytokine 88/ Interleukin-5, human, Lyophilized., 5,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 90/ Interleukin-6, human, Lyophilized., 100,000 IU / 1st International Standard, 1992 No. 840, 43rd Report Recombinant cytokine 89/ Interleukin-7, human, Lyophilized., 100,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 90/ Page 11 of 17

12 Interleukin-8, human, Lyophilized., 1,000 IU / 1st International Standard, 1995 No. 872, 46th Report Recombinant cytokine 89/ Interleukin-9, human, Lyophilized., 1,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 91/ Islet cell antibodies, Lyophilized., 20 units / ampoule of islet cell antibodies; 100 units / ampoule of anti-gad65; 100 units / ampoule of anti-ia-2. 1st Reference Reagent, 1999 No. 904, 50th Report Human serum 97/ Kanamycin, Lyophilized., 10,345 IU / 1st International Standard, 1986 No. 760, 37th Report Antibiotic 83/ Keratinocyte growth factor, human, Lyophilized., 4000 units of KGF per ampoule Keratinocyte growth factor, human (24-163), Lyophilized., 9000 units of KGF per ampoule 1st Reference Reagent, 2005 To be published Recombinant growth factor 03/ st Reference Reagent, 2005 To be published Recombinant growth factor 03/ Leptin, human, Lyophilized., 4,000 IU / 1st International Standard, 1999 No. 904, 50th Report Recombinant/ E.Coli 97/ Leptin, mouse, Lyophilized., 4,000 IU / 1st International Standard, 1999 No. 904, 50th Report Recombinant/ E.Coli 97/ Leukaemia inhibitory factor, human, Lyophilized., 10,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 93/ Lipoprotein (a), Lyophilized., nanomoles/vial 1st Reference Reagent, 2003 In press Human serum CDC IFCC SRM 2B Luteinizing hormone, bovine, for immunoassay, Lyophilized., IU / Luteinizing hormone, human, pituitary, Lyophilized., 35 IU / Luteinizing hormone, human, pituitary, alpha subunit, Lyophilized., 10 IU / Luteinizing hormone, human, pituitary, beta subunit, Lyophilized., 10 IU / 1st International Standard, 1985 No. 745, 36th Report Pituitary hormone 98/ nd International Standard, 1988 No. 786, 39th Report Pituitary hormone 80/ st International Standard, 1984 No. 725, 35th Report Pituitary hormone 78/ st International Standard, 1984 No. 725, 35th Report Pituitary hormone 78/ Lysine vasopressin, Lyophilized., 7.7 IU / 1st International Standard, 1978 No. 638, 30th Report Synthetic hormone 77/ Macrophage colony stimulating factor, human (CSF-1), Lyophilized., 60,000 IU / MAPREC analysis of poliovirus type 3 (Sabin), Lyophilized., 0.9% 472-C nucleotide / vial. MAPREC analysis of poliovirus type 3 (Sabin), high virus reference, Lyophilized., 1.1% 472-C nucleotide / vial. MAPREC analysis of poliovirus types 3 (Sabin), low virus reference, Lyophilized., 0.7% 472-C nucleotide / vial. MAPREC assay for poliovirus type 2, Lyophilized., 0.67% 481-G per ampoule MAPREC assay of poliovirus type 2 (481-G control), Lyophilized., 93.5% 481-G per ampoule 1st International Standard, 1992 No. 840, 43rd Report Recombinant growth factor 89/ st International Standard, 1996 No. 878, 47th Report Chemically synthesized DNA 95/ st Reference Reagent, 1997 No. 889, 48th Report Chemically synthesized DNA 96/ st Reference Reagent, 1997 No. 889, 48th Report Chemically synthesized DNA 96/ st International Standard, 2003 No. 926, 53rd Report Chemically synthesized DNA 97/ st Reference Reagent, 2003 No. 926, 53rd Report Chemically synthesized DNA 98/ Page 12 of 17

13 MAPREC assay of poliovirus type 2 (high mutant virus), Lyophilized., 1.21% 481-G per ampoule MAPREC assay of poliovirus type 2 (low mutant virus), Lyophilized., 0.65% 481-G per ampoule 1st Reference Reagent, 2003 No. 926, 53rd Report Chemically synthesized DNA 98/ st Reference Reagent, 2003 No. 926, 53rd Report Chemically synthesized DNA 97/ Measles vaccine (live), Lyophilized., 4.3 log10 (20 000) infectious units / vial. 2nd International Reference Reagent, 1994 No. 858, 45th Report Attenuated measles virus 92/ Mumps vaccine (live), Lyophilized., 4.6 log10 (40000) infectious units / vial. Reagent, 1994 No. 858, 45th Report Attenuated mumps virus 90/ Neomycin, Lyophilized., 775 IU / mg. Ampoules containing approximately 50 mg of neomycin sulfate. 2nd International Reference Preparation, 1975 No. 594, 27th Report Antibiotic 72/ Neomycin B, Lyophilized., 670 IU / mg. Ampoules containing approximately 25 mg of neomycin B sulfate. Preparation, 1975 No. 594, 27th Report Antibiotic 68/ Nerve growth factor, human, Lyophilized., 10,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant growth factor 93/ Netilmicin, Lyophilized., 4,810 IU / 1st International Standard, 1989 No. 800, 40th Report Antibiotic 83/ Newcastle (Hitchner B1 strain) disease vaccine, live, Lyophilized., No unitage assigned. Preparation, 1967 No. 384, 20th Report Attenuated newcastle virus NV Newcastle disease vaccine (inactivated), Lyophilized., 525 IU / 1st International Standard, 1963 No. 274, 16th Report Antigen NVIA Nystatin, Lyophilized., 4,855 IU / mg. Approximately 100 mg. 2nd International Standard, 1982 No. 687, 33rd Report Antibiotic 80/ Oncostatin M, human, Lyophilized., 25,000 units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant cytokine 93/ Opacity,, 10 IU of opacity. 5th International Standard, 1975 No. 594, 27th Report Miscellaneous 76/ Oxytocin, Lyophilized., 12.5 IU / 4th International Standard, 1978 No. 638, 30th Report Synthetic oxytocin peptide 76/ Parathyroid hormone, bovine, Lyophilized., 39 IU / 1st International Standard, 1985 No. 745, 36th Report Parathyroid peptide hormone 82/ Parathyroid hormone, human, for immunoassay, Lyophilized., 0.1 IU / Preparation, 1981 No.673, 32nd Report Parathyroid peptide hormone 79/ Parvovirus B19 DNA human, Lyophilized., 500,000 IU / vial. 1st International Standard, 2000 No. 910, 51st Report Parvovirus B19 positive donation diluted in human plasma 99/ Pertussis serotype 2, typing serum (anti-bordetella pertussis fimbriae),, No assigned value Pertussis serotype 3, typing serum (anti-bordetella pertussis fimbriae),, No assigned value 1st Reference Reagent, 2004 In press Monoclonal IgG (mouse) 04/ st Reference Reagent, 2004 In press Monoclonal IgG (mouse) 04/ Pertussis Toxin, purified, Liquid., IU / 1st International Standard, 2003 In press Toxin JNIH Pertussis vaccine, Lyophilized., 46 IU / 3rd International Standard, 1998 No. 897, 49th Report Inactivated bordetella pertussis 66/ Page 13 of 17

14 Placental lactogen, human, for immunoassay, Lyophilized., IU / Preparation, 1977 No. 626, 29th Report Purified placental protein 73/ Plasmin, human, Lyophilized., 5.3 IU / 3rd International Standard, 1998 No. 897, 49th Report Human plasma protein 97/ Plasminogen-Activator Inhibitor 1 (PAI-1), human, Lyophilized., Tissue-plasminogen-activator: 27.5 IU of neutralising activity / Urinary-plasminogen-activator: 7 IU of neutralising activity / Plasmodium falciparum DNA, Lyophilized., 500,000,000 IU/vial 1st International Standard, 1995 No. 872, 46th Report Recombinant protein [Chinese Hamster Ovary cells (CHO)], spiked in plasma 1st International Standard, 2006 To be published P.falciparum infected human blood 92/ / Platelet derived growth factor-bb isoform, human, Lyophilized., 3,000 IU / 1st International Standard, 1997 No. 889, 48th Report Recombinant growth factor 94/ Platelet factor 4, Lyophilized., 400 IU / 1st International Standard, 1984 No. 725, 35th Report Human platelet protein 83/ Poliomyelitis vaccine (inactivated), Lyophilized., Type 1 antigen: 430 D-antigen units / ml, Type 2 antigen: 95 D-antigen units / ml, Type 3 antigen: 285 D-antigen units / ml. Reagent, 1994 No. 858, 45th Report Inactivated polioviruses 91/ Poliomyelitis vaccine, oral,, 7.51 log10 TCID 50/ml poliovirus type log10 TCID 50/ml poliovirus type log10 TCID 50/ml poliovirus type log10 TCID 50/ml total poliovirus content 2nd International Standard for potency testing, 2004 In press Antigen 02/ Polymyxin B,, 8,403 IU / mg. Approximately 75 mg of purified polymyxin B sulfate. 2nd International Standard, 1969 No. 444, 22nd Report Antibiotic 67/ Prekallikrein activator, Lyophilized., 29 IU / 2nd International Standard, 2003 In press Purified from human plasma 02/ Proinsulin, bovine, for immunoassay, Lyophilized., 25 μg / 1st International Standard, 1986 No. 760, 37th Report Pancreatic enzyme 84/ Proinsulin, human, Lyophilized., 6 μg / No. 760, 37th Report Recombinant proinsulin 84/ Reagent, 1986 Proinsulin, porcine, for immunoassay, Lyophilized., 20 μg / 1st International Standard, 1986 No. 760, 37th Report Pancreatic enzyme 84/ Prolactin, human, Lyophilized., IU / 3rd International Standard, 1988 No. 786, 39th Report Pituitary hormone 84/ Prolactin, recombinant human, for immunoassay, Lyophilized., Nominal content for immunization calibration: 24.5 μg / ampoule; for bioassay calibration: 1,400 mu / Prolactin, recombinant human, glycosylated form, for immunoassay, Lyophilized., Nominal content for immunization calibration: 5.5 μg / ampoule; for bioassay calibration: 88 mu / 1st Reference Reagent, 2001 No. 924, 52nd Report rdna derived prolactin 97/ st Reference Reagent, 2001 No. 924, 52nd Report Recombinant hormone 98/ Prolactin, recombinant human, non-glycosylated form, for immunoassay, Lyophilized., 10.5 μg / ampoule; for bioassay: 670 mu / 1st Reference Reagent, 2001 No. 924, 52nd Report rdna derived prolactin, nonglycosylated form 98/ Prostate specific antigen, Lyophilized., 1 μg total PSA per vial. 1st Reference Reagent, 1999 No. 904, 50th Report Purified plasma protein 96/ Page 14 of 17

15 Prostate specific antigen (90:10), Lyophilized., 1 μg total PSA per vial. 1st Reference Reagent, 1999 No. 904, 50th Report Purified plasma protein 96/ Protein C, plasma, human, Lyophilized., 0.82 IU / 1st International Standard, 1987 No. 771, 38th Report Human plasma 86/ Protein S, plasma, human, Lyophilized., 0.90 IU / 1st International Standard, 1995 No. 872, 46th Report Human plasma 93/ Prothrombin Mutation G20210A, Lyophilized., No assigned activity 1st International Genetic Reference To be published Purified plasma protein 05/ Panel, 2005 Rabies vaccine, Lyophilized., 16 IU / ampoule (PM-glycoprotein: 10 IU / PM-ribonucleoprotein 135 IU / ampoule in addition to the 16 IU of rabies vaccine). Recombinant Human Luteinizing Hormone,, 189 IU / 5th International Standard, 1991 No. 822, 42nd Report Rabies inactivated virus RAV st International Standard, 2003 In press Recombinant hormone 96/ Renin, human, Lyophilized., 0.1 IU / No. 565, 26th Report Kidney extract derived 68/ Preparation, 1974 Rheumatoid arthritis serum, Lyophilized., 100 IU / Preparation, 1973 No. 530, 25th Report Human serum Sanquin W Rifamycin SV, Lyophilized., 887 IU / mg. Approximately 100 mg of sodium Rifamycin SV. Preparation, 1967 No. 384, 20th Report Antibiotic 66/ Rubella vaccine (live), Lyophilized., 3.9 log10 (8 000) infectious units / vial. Reagent, 1994 No. 858, 45th Report Attenuated rubella virus 91/ Scarlet fever streptococcus antitoxin, equine, Lyophilized., 10,000 IU / 1st International Standard, 1952 No. 68, 6th Report Horse serum SC Serum amyloid A protein, Lyophilized., 0.15 IU / 1st International Standard, 1997 No. 889, 48th Report Human serum 92/ Sex hormone binding globulin (SHBG), Lyophilized., 107 IU / Short ragweed pollen extract (Ambrosia elatior), Lyophilized., 100,000 IU / 1st International Standard, 1998 No. 897, 49th Report Human serum 95/560 98/1884 1st International Standard, 1983 No. 700, 34th Report Defatted short ragweed pollen 84/ Sisomicin, Lyophilized., 35,200 IU / 1st International Standard, 1984 No. 725, 35th Report Antibiotic 80/ Smallpox vaccine, Lyophilized., 14 mg / No unitage assigned. Preparation, 1962 No. 259, 15th Report Antigen SMV Somatropin (rdna-derived human growth hormone), Lyophilized., 1.95 mg protein / 2nd International Standard, 2000 No. 910, 51st Report Recombinant hormone / E.Coli 98/ Spiramycin, Lyophilized., 3,200 IU / mg. Approximately 50 mg. No. 293, 17th Report Antibiotic 62/ Preparation, 1964 Staphylococcus-alpha antitoxin, equine, Lyophilized., 220 IU / 3rd International Standard, 1982 No. 687, 33rd Report Horse serum STA Stem cell factor, human, Lyophilized., 1,000 units / 1st Reference Reagent, 1997 No. 889, 48th Report Recombinant cytokine 91/ Page 15 of 17

16 Streptokinase, Lyophilized., 1,030 IU / 3rd International Standard, 2001 No. 924, 52nd Report Purified from streptococcus hemolyticus culture 00/ Streptokinase and Streptodornase, Freeze-dried, 3100 IU of streptokinase and 2400 IU of streptodornase per ampoule 1st International Standard, , 17th Report Enzyme 62/007 BS/716 Streptomycin, Lyophilized., 78,500 IU / 3rd International Standard, 1980 No. 658, 31st Report Antibiotic 76/ Swine erysipelas serum (anti-n), Lyophilized., 628 IU / 1st International Standard, 1954 No. 96, 8th Report Horse serum SES Teicoplanin, Lyophilized., 51,550 IU / 1st International Standard, 1990 No. 814, 41st Report Antibiotic 90/ Tetanus toxoid (adsorbed), Lyophilized., 469 IU / 3rd International Standard, 2000 No. 910, 51st Report Toxoid 98/ Tetanus toxoid, for flocculation tests, Lyophilized., 1,000 Lf / Reagent, 1988 No. 786, 39th Report Toxoid TEFT Tetracosactide, Lyophilized., 490 IU / No. 673, 32nd Report Synthetic peptide 80/ Preparation, 1981 Thrombin, human, Lyophilized., 110 IU / 2nd International Standard, 2003 No. 926, 53rd Report Purified plasma protein 01/ Thromboplastin, bovine, combined, Lyophilized., International Sensitivity Index: nd International Reference Preparation, 1983 No. 700, 34th Report Brain derived Sanquin OBT/79 (W1053) Thromboplastin, human, recombinant, plain, Lyophilized., International Sensitivity Index: rd International Reference Preparation, 1996 No. 878, 47th Report Recombinant protein Sanquin rtf/95 (W1054) Rev.1 Thromboplastin, rabbit, plain, Lyophilized., International Sensitivity Index (ISI) value of th International Standard, 2005 To be published Brain-derived 04/ Thyroid stimulating hormone, human, for immunoassay, Lyophilized., 11.5 x -3 log 10 IU / 3rd International Standard, 2003 In press Pituitary hormone 81/ Thyroid-stimulating antibody, Lyophilized., 0.1 IU / No. 872, 46th Report Human serum 90/ Preparation, 1995 Thyroid-stimulating hormone, human, recombinant, Lyophilized., units / 1st Reference Reagent, 1996 No. 878, 47th Report Recombinant hormone, [Chinese Hamster Ovary cells (CHO)] 94/ Thyroxine-binding globulin, Lyophilized., 30 IU / 1st International Standard, 1991 No. 822, 42nd Report Human serum derived 88/ Timothy (Phleum pratense) pollen extract, Lyophilized., 100,000 IU / Tissue Plasminogen Activator (t-pa), human, recombinant, Lyophilized., 10,000 IU / 1st International Standard, 1983 No. 700, 34th Report Phleum pratense allergenic extract 3rd International Standard, 1999 Nos. 897; 904 & 910: 49th, 5 r-tpa. [Chinese Hamster Ovary cells (CHO)] 82/ / Tobramycin, Lyophilized., 9,800 IU / 2nd International Standard, 1985 No. 745, 36th Report Antibiotic 82/ Tuberculin, old, Liquid., 90,000 IU / ml. Tuberculin, purified protein derivative (PPD), avian, Lyophilized., 500,000 IU / 3rd International Standard, 1965 No. 329, 18th Report Mycobacterium tuberculosis culture derived 1st International Standard, 1954 No. 96, 8th Report Mycobacterium avium culture derived TU PPDA Page 16 of 17