WHO International Biological Reference Preparations Held and distributed by the WHO International Laboratories for Biological Standards

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1 WHO International Biological Preparations PREPARATION STANDARD WHO TRS Activin A, human, recombinant. Lyophilized. 5 units / ampoule. 1st- Reagent, 1998 Alphafoetoprotein, human. Lyophilized. 100,000 IU / ampoule. Standard, 1975 Amphotericin B. Lyophilized. 940 IU / mg. Approximately 50 mg of Amphotericin B. Standard, 1963 Ancrod. Lyophilized. 55 IU / ampoule. Anthrax spore vaccine. Lyophilized spore suspension of Bacillus anthracis strain 34 F2. 1 IU / ampoule. Preparation, 1976 Preparation, 1978 Anti-A blood typing serum, human. Lyophilized. 470 IU / ampoule. 2nd-International Standard, 1981 Anti-B blood-typing serum, human. Lyophilized. 860 IU / ampoule. 3rd-International Standard, 1981 Anti-brucella abortus serum, bovine. Lyophilized. 1,000 IU / ampoule of agglutinating; 1,000 IU / ampoule of complement-fixing activity. 2nd-International Standard, 1975 Anti-brucella ovis serum, ovine. Lyophilized. 1,000 IU / ampoule. Standard, 1985 Anti-C complete blood-typing serum, human. Lyophilized. 100 IU / ampoule. Standard, 1984 Anti-c incomplete blood-typing serum, human. Lyophilized. 64 IU / ampoule. Standard, 1976 No th Report No. 594, 27th Report Human cord serum 91/ AFP No. 274, 16th Report Antibiotic 60/ No. 626, 29th Report Enzyme 74/ No. 638, 30th Report Antigen AxV No. 673, 32nd Report Human serum Sanquin W No. 673, 32nd Report Human serum Sanquin W No. 594, 27th Report Bovine serum BaDS No. 745, 36th Report Bovine serum BovisDs No. 725, 35th Report Human serum Sanquin W No. 610, 28th Report Human serum Sanquin W , Page 1 of 33

2 WHO International Biological Preparations Anti-canine distemper serum. Lyophilized. 1,000 IU / ampoule. Standard, 1967 Anti-canine hepatitis serum. Lyophilized. 1,000 IU / ampoule. Standard, 1967 Anti-D (anti-rh0) complete blood-typing reagent. Liquid. No assigned value Minimum Potency Reagent, 2004 Anti-D (anti-rh0) incomplete blood-typing serum, human. Lyophilized. 32 IU / ampoule. Standard, 1966 Anti-D immunoglobulin, human. Lyophilized. 300 IU (60 ug) / ampoule. Preparation, 1977 Anti-double-stranded DNA serum, human. Lyophilized. 100 IU / ampoule. Standard, 1985 Anti-dysentery serum (Shiga), equine. 1 IU equivalent to 0.05 mg of dried standard serum. Standard, 1928 Anti-E complete blood-typing serum, human. Lyophilized. 100 IU / ampoule. Standard, 1983 Anti-echinococcus serum, human. Lyophilized mg human serum / ampoule. Reagent, 1975 Anti-hepatitis A immunoglobulin, human. Lyophilized. 49 IU / ampoule. 2nd-International Standard, 1998 No. 384, 20th Report Horse serum CDS , Add. 1 No. 384, 20th Report Horse serum CHS , Add. 1 Monoclonal IgM (mouse) 99/ Rev. 1 No. 361, 19th Report Human serum Sanquin W No. 626, 29th Report Human immunoglobulin 68/ , No. 745, 36th Report Human serum Sanquin Wo/ See Bull. Health Org. document Horse serum DY Bull. Health Org. 4, 1935 No. 700, 34th Report Human serum Sanquin W No. 594, 27th Report Human serum ECHS No. 897, 49th Report Human immunoglobulin Sanquin 97/ , Add.1 Page 2 of 33

3 WHO International Biological Preparations Anti-hepatitis B immunoglobulin, human. Lyophilized. 50 IU / ampoule. Preparation, 1977 Anti-hepatitis E serum, human. Lyophilized. 50 units / ampoule. 1st- Reagent, 1997 Anti-human platelet antigen-1a. Lyophilized. No unitage assigned. 1st- Reagent, 1997 Anti-interferon alpha serum, human. Lyophilized. 8,000 neutralising units / ampoule. Reagent, 1994 Anti-interferon beta serum, human. Lyophilized. 1,500 neutralising units / ampoule. Reagent, 1994 Anti-measles serum, human. Lyophilized. 5 IU / ampoule. 2nd-International Anti-mycoplasma gallisepticum serum. Lyophilized. 1,000 IU / ampoule of agglutinating activity and 1,000 IU / ampoule of haemagglutination-inhibiting activity. Standard, 1990 Preparation, 1969 Anti-newcastle-disease serum. Lyophilized. 320 IU / ampoule. Preparation, 1968 Anti-nuclear ribonucleoprotein serum. Lyophilized. No unitage assigned. Reagent, 1983 No. 626, 29th Report Human immunoglobulin Sanquin W No. 889, 48th Report Human serum 95/ No. 889, 48th Report Human serum 93/ No. 858, 45th Report Human serum NIAID G No. 858, 45th Report Human serum NIAID G No. 814, 41st Report Human serum 66/ No. 444, 22nd Report Chicken serum MgDS No. 413, 21st Report Chicken serum NDS , No.700, 34th Report Human serum Sanquin W Page 3 of 33

4 WHO International Biological Preparations Anti-nuclear-factor (homogeneous) serum. Lyophilized. 100 IU / ampoule. Preparation, 1970 Anti-parvovirus B19 (IgG) serum. Lyophilized. 100 IU / ampoule. Anti-pertussis serum, mouse. 17 units / vial of anti-pertussis toxin. 143 units / vial of antifilamentous haemagglutinin. 30 units / vial of anti-pertactin. 32 units / vial of anti-fimbria types 2/3. Anti-poliovirus serum (Types 1, 2, 3). Lyophilized. 25 IU / ampoule (Type 1), 50 IU / ampoule (Type 2), 5 Standard, st- Reagent, nd-International Standard, 1991 IU / ampoule (Type 3). Anti-Q-fever serum, bovine. Lyophilized. 1,000 IU / ampoule. Standard, 1954 Anti-rabies immunoglobulin, human. Lyophilized. 30 IU / ampoule. 2nd-International Standard, 1993 Anti-rubella immunoglobulin, human. Lyophilized. 1,600 IU / vial. Standard, 1996 Anti-salmonella pullorum serum (Standard Form S). Lyophilized. 1,000 IU / ampoule. Standard, 1973 Anti-salmonella pullorum serum (Variant Form V). Lyophilized. 1,000 IU / ampoule. Standard, 1973 Anti-smooth muscle serum. Lyophilized. No unitage assigned. Reagent, 1983 No. 463, 23rd Report Human serum Sanquin 66/ No. 872, 46th Report Human serum 93/ Mouse serum 97/ No. 822, 42nd Report Human serum 66/ No. 96, 8th Report Bovine serum QF , No. 848, 44th Report Human immunoglobulin Human immunoglobulin RAI , Add 1 RUBI No. 530, 25th Report Goat serum SpDS-S No. 530, 25th Report Goat serum SpDS-V , corr 1 No. 700, 34th Report Human serum Sanquin W Page 4 of 33

5 WHO International Biological Preparations Anti-staphylococcal P-V leucocidin serum, equine. Lyophilized. 150 IU / ampoule. Standard, 1965 Anti-swine fever serum. Lyophilized. 1,000 IU / ampoule. Standard, 1963 Anti-syphilitic serum, human. Lyophilized. 49 IU / ampoule. Standard, 1958 Anti-tetanus immunoglobulin, human. Lyophilized. 120 IU / ampoule. Standard, 1992 Anti-tetanus serum, equine. Lyophilized. 1,400 IU / ampoule. 2nd-International Standard, 1969 Antithrombin, concentrate, human. Lyophilized. Functional potency IU / ampoule. Antigenic potency IU / ampoule. 2nd-International Standard, 1997 Antithrombin, plasma, human. Lyophilized IU / ampoule. 2nd-International Standard, 1994 Anti-thyroglobulin serum, human. Lyophilized. 1,000 IU / ampoule. Preparation, 1978 Anti-tick borne encephalitis serum (louping ill (Moredun) virus). Lyophilized. No unitage assigned. Reagent, 1964 Anti-tick borne encephalitis serum (Russian spring-summer (sophyn and absettarov) virus). Lyophilized. No unitage assigned. Reagent, 1964 No. 329, 18th Report Horse serum SPLS , No. 274, 16th Report Pig serum SFS , , Add. 1 No. 172, 12th Report Human serum HS No. 840, 43rd Report Human immunoglobulin TE , Add. 1 No. 444, 22nd Report Horse serum TE No. 889, 48th Report Purified plasma protein 96/ No. 848, 44th Report Human plasma 93/ No. 638, 30th Report Human serum 65/ , No. 293, 17th Report Sheep serum TILI , , corr. 1 No. 293, 17th Report Sheep serum TISA , , corr.1 Page 5 of 33

6 WHO International Biological Preparations Anti-toxoplasma serum. Lyophilized. 1,000 IU / ampoule. 3rd-International Standard, 1994 Anti-toxoplasma serum (IgG), human. Lyophilized. 20 IU / ampoule. Standard, 2003 Anti-typhoid serum, equine. Lyophilized. 5 ml of freeze dried horse serum per ampoule. Preparation, 1957 Anti-varicella zoster immunoglobulin, human. Lyophilized. 50 IU / ampoule. Standard, 1987 Anti-yellow fever serum, monkey. Lyophilized. 143 IU / ampoule. Standard, 1962 Apolipoprotein A-1. Lyophilized mg / vial. Reagent, 1992 Apolipoprotein B. Frozen g / l. Vials, 1 ml. Reagent, 1993 Arginine vasopressin. Lyophilized. 8.2 IU / ampoule. Standard, 1978 Atrial natriuretic factor, human. Lyophilized. 2.5 IU / ampoule. Standard, 1987 Bacitracin. Lyophilized. Approximately 100 mg of zinc bacitracin (74 IU / mg). 2nd-International Standard, 1964 No. 858, 45th Report Human serum TOXM Human serum 01/ No. 68, 6th Report Horse serum TYS No. 771, 38th Report Human immunoglobulin Sanquin W No. 259, 15th Report Monkey serum YF , corr.1 No. 840, 43rd Report Human serum CDC SP No. 848, 44th Report Human serum CDC SP No. 638, 30th Report Hormone 77/ No. 771, 38th Report Peptide 85/ No. 293, 17th Report Antibiotic 62/ Page 6 of 33

7 WHO International Biological Preparations Basic fibroblast growth factor (bfgf, FGF-2). Lyophilized. 1,600 IU / ampoule. Standard, 1993 BCG vaccine. Lyophilized. 2.5 mg of semi-dry bacillary mass / 5-ml ampoule. Preparation, 1965 Beta-2 microglobulin. Lyophilized. 100 IU / ampoule. Standard, 1985 Beta-thromboglobulin, human. Lyophilized. 500 IU / ampoule. Standard, 1984 Birch pollen extract (Betula verrucosa). Lyophilized. 100,000 IU / ampoule. Standard, 1986 Bleomycin complex A2/B2. Lyophilized. 8,910 IU / ampoule. Preparation, 1980 Blood coagulation factor IX concentrate, human. Lyophilized IU / vial. 3rd-International Standard, 1996 Blood coagulation factor IXa, concentrate, human. Lyophilized IU / ampoule. Blood Coagulation Factor V Leiden (G1691A), human gdna (three samples: FV wild type; FVL homozygote; FVL heterozygote). Lyophilized. No assigned value Genetic Panel, 2004 Blood coagulation factor VII concentrate, human. Lyophilized. 6.3 IU / ampoule. Standard, 1998 No. 848, 44th Report growth factor 90/ No. 329, 18th Report Antigen BCG , , No. 745, 36th Report Human serum B2M No. 725, 35th Report Purified plasma protein 83/ No. 760, 37th Report Allergen 84/ No. 658, 31st Report Antibiotic 78/ , Add.1 No. 897, 49th Report Purified plasma protein protein Genetic material Purified plasma protein 96/ / /254; 03/260; 03/ / Page 7 of 33

8 WHO International Biological Preparations Blood coagulation factor VIIa concentrate, human. Lyophilized. 5,130 IU / ampoule. Standard, 1993 Blood coagulation factor VIII and von Willebrand factor, plasma, human. Lyophilized IU / ampoule Factor VIII:C; 0.94 IU/ampoule factor VIII. Antigen; 0.91 IU/ampoule VWF:antigen; 0.78 IU/ampoule VWF:ristocetin cofactor; 0.94 IU/ampoule VWF:collagen binding 5th-International Standard, 2003 Blood coagulation factor VIII concentrate, human. Lyophilized IU / ampoule. 7th-International Standard, 2003 Blood Coagulation Factor XIII, plasma, human. Lyophilized. 091 IU/ampoule Standard, 2004 Blood coagulation factors II, VII, IX, X, plasma, human. Lyophilized IU (factor II), 1.00 IU (factor VII), 0.86 IU (factor IX), 0.93 IU (factor X) / ampoule. 3rd-International Standard, 2001 Blood coagulation factors, II and X concentrate, human. Lyophilized IU (factor II), 10.2 IU (factor X) / ampoule. 3rd-International Bone morphogenic protein-2. Lyophilized. 5,000 units / ampoule. 1st- Reagent, 1997 Brain derived neurotrophic factor. Lyophilized. 16,000 units / ampoule. 1st- Reagent, 1997 Calcitonin, eel. Lyophilized. 88 IU / ampoule. Standard, 1989 Calcitonin, human. Lyophilized IU / ampoule. 2nd-International Standard, 1991 Calcitonin, salmon. Lyophilized. 138 IU / ampoule. 3rd-International No. 848, 44th Report protein 89/ Human plasma 02/ protein 99/ Human plasma 02/ Rev.1 No. 924, 52nd Report Human plasma 99/ No. 889, 48th Report No. 889, 48th Report Purified plasma proteins growth factor 98/ / / No. 800, 40th Report Hormone 88/ No. 822, 42nd Report Hormone 89/ Hormone 98/ , Add1 Page 8 of 33

9 WHO International Biological Preparations Carcinoembryonic antigen (CEA), human. Lyophilized. 100 IU / ampoule. Preparation, 1975 Cholera antitoxin, goat. Lyophilized. 2,200 IU / ampoule. Standard, 1984 Cholera vaccine (Inaba). Lyophilized. 40,000,000,000 organisms / ampoule. 2nd-International Preparation, 1971 Cholera vaccine (Ogawa). Lyophilized. 40,000,000,000 organisms / ampoule. 2nd-International Preparation, 1971 Chorionic gonadotrophin, alpha subunit, human, for immunoassay. Lyophilized. 70 IU / ampoule. Preparation, 1974 Chorionic gonadotrophin, beta subunit, human, for immunoassay. Lyophilized. 70 IU / ampoule. Preparation, 1974 Chorionic gonadotrophin, human. Lyophilized. 650 IU / ampoule. 4th-International Ciliary Neurotrophic Factor for the bioassay of human CNTF. Lyophilized. For bioassay: 8,000 units / ampoule; for immunoassay: 6.5 ug / ampoule. 1st- Reagent, 2001 Clostridium botulinum Type B antitoxin, equine. Lyophilized IU / ampoule. 2nd-International Standard, 1985 Clostridium botulinum Type E antitoxin, equine. Lyophilized. 1,000 IU / ampoule. Standard, 1962 No. 594, 27th Report Human carcinoma derived 73/ , No. 725, 35th Report Goat serum CHAN No. 486, 24th Report Antigen INV Rev. 1 No. 486, 24th Report Antigen OGV No. 565, 26th Report No. 565, 26th Report No. 897, 49th Report No. 924, 52nd Report Glycoprotein Glycoprotein Glycoprotein growth factor 75/ / / / No. 745, 36th Report Horse serum BUSB No. 259, 15th Report Horse serum BTUSE Page 9 of 33

10 WHO International Biological Preparations Clostridium novyi alpha toxoid. Lyophilized. No unitage assigned. Preparation, 1966 Clostridium perfringens beta antitoxin, equine. Lyophilized. 4,770 IU / ampoule. 2nd-International Standard, 1998 Clostridium perfringens beta toxoid. Lyophilized. No unitage assigned. Preparation, 1975 Clostridium perfringens epsilon antitoxin, equine. Lyophilized. 1,020 IU / ampoule. 2nd-International Standard, 1985 Clostridium perfringens epsilon toxoid. Lyophilized. No unitage assigned. Preparation, 1975 Colistin. Lyophilized. 20,500 IU / mg. Approximatley 75 mg of colistin sulfate. Colistin methane sulfonate. Lyophilized. 12,700 IU / mg. Approximately 75 mg of colistin methane sulfonate. Standard, 1968 Preparation, 1968 Corticotrophin (ACTH), porcine. Lyophilized. 5 IU / ampoule. 3rd-International Standard, 1962 C-reactive protein, human. Lyophilized IU / ampoule. Standard, 1986 Dihydrostreptomycin. Lyophilized. 820 IU / mg. Approximately 200 mg of dihydrostreptomycin sulfate. 2nd-International Standard, 1966 No. 361, 19th Report Toxoid CoT , No. 897, 49th Report Horse serum 2Cp BetaAt No. 594, 27th Report Toxoid CWBetatd No. 745, 36th Report Horse serum 2Cp Epsilon At No. 594, 27th Report Antigen CW Epsilontd No. 413, 21st Report Antibiotic 65/ No. 413, 21st Report Antibiotic 66/ No. 259, 15th Report Pituitary 59/ No. 760, 37th Report Human plasma 85/ No. 361, 19th Report Antibiotic 62/ Page 10 of 33

11 WHO International Biological Preparations Diphtheria (schick) test toxin. Lyophilized. 900 IU / ampoule. Standard, 1954 Diphtheria antitoxin, equine. Lyophilized. Bottles in the form of 10 ml of a solution of dried serum in 66% v/v of glycerol. 10 IU / ml. Standard, 1934 Diphtheria toxoid, adsorbed. Lyophilized. 160 IU / ampoule. 3rd-International Diphtheria toxoid, for flocculation tests. Lyophilized. 900 Lf IU / ampoule. Reagent, 1988 Dog hair and dander extract (Canis domesticus). Lyophilized. 100,000 IU / ampoule. Standard, 1986 Elcatonin. Lyophilized. 15 IU / ampoule. Standard, 1986 Endotoxin for Limulus Amoebocyte Lysate (LAL) gelation tests. Lyophilized. 10,000 IU / ampoule. 2nd-International Standard, 1996 Epidermal growth factor (1-52), human, recombinant. Lyophilized ug / ampoule. No unitage assigned. Reagent, 1994 Epidermal growth factor, human, recombinant. Lyophilized. 2,000 IU / ampoule. Standard, 1994 Erythromycin. Lyophilized. 920 IU / mg. Approximately 75 mg of erythromycin A base. 2nd-International Standard, 1978 No. 96, 8th Report Toxin STT , , Add. 1, Add. 2 See Bull. Health Org. document Horse serum 97/762 Bull. Health Org. 5, 1936 Adsorbed toxoid 98/ , Add.1 No. 786, 39th Report Toxoid DIFT No. 760, 37th Report Allergen 84/ , No. 760, 37th Report Endocrinologic al products 84/ , Toxin 94/ Rev. 1 No. 858, 45th Report No. 858, 45th Report growth factor growth factor 91/ / No. 638, 30th Report Antibiotic 76/ Page 11 of 33

12 WHO International Biological Preparations Erythropoietin, human, urinary. Lyophilized. 10 IU / ampoule. 2nd-International Preparation, 1970 Erythropoietin, rdna-derived. Lyophilized. 86 IU / ampoule. Standard, 1990 Ferritin, human, recombinant. Lyophilized. 6.3 ug / ampoule. 3rd-International Standard, 1996 Fibrinogen concentrate human. Lyophilized. Total protein 15 mg / ampoule. Clottable protein 10.5 mg / ampoule. Standard, 2000 Fibrinogen, plasma, human. Lyophilized. 2.2 mg / ampoule. 2nd-International FMS-like tyrosine kinase 3 ligand. Lyophilized. 1,000 units / ampoule. 1st- Reagent, 1997 Follicle stimulating, human, recombinant, for bioassay. Lyophilized. 138 IU / ampoule. Standard, 1995 Follicle stimulating, human, pituitary. Lyophilized. 80 IU / ampoule. Standard, 1986 Follicle stimulating, human, recombinant for immunoassay. Lyophilized. 60 IU / ampoule. Standard, 1997 Follicle stimulating, human, urinary (Urofollitropin), for bioassay. Lyophilized. 121 IU / ampoule. Standard, 1995 No. 463, 23rd Report No. 814, 41st Report No. 910, 51st Report Urinary protein diluted in plasma Purified plasma protein 67/ / / , / Human plasma 98/ No. 889, 48th Report No. 872, 46th Report No. 760, 37th Report No. 889, 48th Report No. 872, 46th Report Pituitary Urinary 96/ / / / / Page 12 of 33

13 WHO International Biological Preparations Follicle-stimulating and luteinising human, urinary for bioassay. Lyophilized. FSH 72 IU / ampoule. LH 70 IU / ampoule. 4th-International Standard, 2000 Gas-gangrene antitoxin (Clostridium histolyticum), equine. Lyophilized. 50 IU / ampoule. 3rd-International Standard, 1971 Gas-gangrene antitoxin (Clostridium perfringens), equine. Lyophilized. 270 IU / ampoule. 5th-International Standard, 1962 Gas-gangrene antitoxin (Clostridium sordellii), equine. Liquid. 7,500 IU / ampoule. Bottles in the form of 10 ml of a solution of dried serum in 66% v/v of glycerol. 20 IU / ml. Standard, 1938 Gas-gangrene antitoxin, (Clostridium novyi), equine. Lyophilized. 1,100 IU / ampoule. 3rd-International Standard, 1966 Gas-gangrene antitoxin, (Clostridium septicum), equine. Lyophilized. 500 IU / ampoule. 3rd-International Standard, 1957 Gentamicin. Lyophilized. 31,020 IU / ampoule. 2nd-International Standard, 1995 Glucagon, porcine. Lyophilized IU / ampoule. Standard, 1973 Gonadotrophin, equine serum. Lyophilized. 1,600 IU / ampoule. 2nd-International Standard, 1966 Gramicidin. Lyophilized. 1,000 IU / mg. Approximately 55 mg of gramicidin. Preparation, 1966 Granulocyte colony stimulating factor, human, recombinant. Lyophilized. 10,000 IU / ampoule. Standard, 1992 No. 910, 51st Report Urinary 98/ No. 486, 24th Report Horse serum HI No. 259, 15th Report Horse serum PE Rev. 1 See Bull. Health Org. document Horse serum 97/764 Bull. Health Org. 8, 1939 No. 361, 19th Report Horse serum OE No. 147, 11th Report Horse serum VI No. 872, 46th Report Antibiotic 92/ No. 530, 25th Report Gastrointestinal peptide 69/ , No. 361, 19th Report Horse serum 62/ No. 361, 19th Report Antibiotic 64/ No. 840, 43rd Report growth factor 88/ Page 13 of 33

14 WHO International Biological Preparations Granulocyte-macrophage colony stimulating factor, human, recombinant. Lyophilized. 10,000 IU / ampoule. Standard, 1992 Haemoglobin A2, raised. Lyophilized. 5.3 % (w/w) of total haemoglobin. Reagent, 1993 Haemoglobin F, raised. Lyophilized. 3.4% (w/w) of total haemoglobin. Reagent, 1993 Haemoglobincyanide. Liquid umol / l. 6th-International Standard, 1998 Heparin, low molecular weight. Liquid IU / ampoule (anti-xa), 326 IU / ampoule (anti-iia). 2nd-International Standard, 2003 Heparin, low molecular weight (calibrant for molecular weight distribution). Lyophilized. No unitage assigned. Reagent, 1993 Heparin, unfractionated. Lyophilized. 2,031 IU / ampoule. 5th-International Standard, 1998 Hepatitis A RNA. Lyophilized. 50,000 IU / vial. Standard, 2003 Hepatitis A vaccine, inactivated. Frozen. 100 IU / ml of immunogenic activity; 100 IU / ml of antigen content. No. 840, 43rd Report No. 848, 44th Report No. 848, 44th Report No. 897, 49th Report No. 848, 44th Report No. 897, 49th Report growth factor Betathalassemia haemolysate derived Cyanmethaemo globin, haemolysate derived Bovine hemoglobin Porcine mucosal derived Porcine mucosal derived Porcine mucosal derived Nucleic acid preparation 88/ / / / / / / / Antigen 95/ Page 14 of 33

15 WHO International Biological Preparations Hepatitis B surface antigen, subtype adw2, genotype A. Lyophilized. Dilutional panel (IU/vial: 8.25; 2.06; 0.52; 0.13) Panel, 2003 Hepatitis B surface antigen, subtype adw2, genotype A. Lyophilized. 33 IU / vial. 2nd-International Standard, 2003 Hepatitis B virus DNA. Lyophilized. 500,000 IU / vial. Hepatitis C virus RNA. Lyophilized. 50,000 IU / vial. 2nd-International Standard, 2003 Hepatocyte growth factor/scatter factor (precursor), human. Lyophilized. 2,000 IU / ampoule. Hepatocyte growth factor/scatter factor, human. Lyophilized. 4,000 IU / ampoule. HIV-1 p24 antigen. Lyophilized. 1,000 IU / ampoule. Reagent, 1992 HIV-1 RNA. Lyophilized. 100,000 IU / vial. HIV-1 RNA genotypes (set of 10 genotypes). Liquid. 1,1 ml/vial. No assigned value Panel, 2003 Horseradish peroxidase-conjugated sheep anti-human IgG (H and L chains). Lyophilized. No unitage assigned. Preparation, 1982 No. 840, 43rd Report Recalcified human plasma Recalcified human plasma Nucleic acid preparation Nucleic acid preparation growth factor growth factor Peptide in human serum Nucleic acid preparation Nucleic acid preparation 03/ / / / ; / / / / / No. 687, 33rd Report Sheep serum Sanquin W Page 15 of 33

16 WHO International Biological Preparations House-dust mite extract (Dermatophagoides pteronyssinus). Lyophilized. 10,000 IU / ampoule. Standard, 1983 Human Chorionic Gonadotrophin for immunoassay of intact hcg. Lyophilized nmol / ampoule. 1st- Reagent, 2001 Human Chorionic Gonadotrophin, for immunoassay of alpha subunit hcg (hcg-alpha). Lyophilized nmol / ampoule. Human Chorionic Gonadotrophin, for immunoassay of beta core fragment hcg (hcg-beta-cf). Lyophilized nmol / ampoule Human Chorionic Gonadotrophin, for immunoassay of hcg beta subunit (hcg-beta). Lyophilized nmol/ampoule 1st- Reagent, st- Reagent, st- Reagent, 2001 No. 700, 34th Report Allergen 82/ No. 924, 52nd Report No. 924, 52nd Report No. 924, 52nd Report No. 924, 52nd Report Hormone.Intact hcg: purified to remove nicked forms, and free subunits Hormone. Purified alpha subunit of hcg Hormone. hcg beta core fragment: residues beta 6-40 disulphide bonded to beta Hormone. Beta subunit of hcg, purified to remove intact dimeric hcg, alpha subunit and nicked beta subunit 99/ / / / Page 16 of 33

17 WHO International Biological Preparations Human Chorionic Gonadotrophin, for immunoassay of nicked hcg (hcg-n). Lyophilized nmol/ampoule Human Chorionic Gonadotrophin, for immunoassay of nicked hcg beta subunit (hcg-beta-n). Lyophilized nmol/ampoule 1st- Reagent, st- Reagent, 2001 Human growth, pituitary. Lyophilized. 4.4 IU / ampoule. Standard, 1982 Human serum complement components C1q, C4, C5, factor B, and whole functional complement CH50. Lyophilized. C1q : 100 IU / ampoule, C4 : 100 IU / ampoule, Factor B : 100 IU / ampoule, Whole functional complement CH50 : 100 IU / ampoule. Preparation, 1980 Human serum immunoglobulin E. Lyophilized. 5,000 IU / ampoule. 2nd-International Preparation, 1980 No. 924, 52nd Report No. 924, 52nd Report No. 687, 33rd Report Hormone. Nicked hcg: partially degraded hcg, missing peptide bonds in the beta region Hormone. Nicked hcg beta subunit: partially degraded beta subunit, missing peptide bonds in the beta region Pituitary 99/ / / No. 658, 31st Report Human serum Sanquin W No. 658, 31st Report Human serum 75/ , Page 17 of 33

18 WHO International Biological Preparations Human serum immunoglobulins G, A, and M (IgG, IgA and IgM). Lyophilized. 100 IU IgG, 100 IU IgA and 100 IU IgM / ampoule. Preparation, 1970 Human serum proteins, for immunoassay: albumin; alpha-1-antitrypsin; alpha-2-macroglobulin; ceruloplasmin; complement C3; transferrin. Lyophilized. 100 IU of each protein / ampoule. Preparation, 1977 Immunoglobulin, intravenous: anti-d negative control. Lyophilized. No assigned value 1st- Reagent, 2004 Immunoglobulin, intravenous: anti-d positive control. Lyophilized. No assigned value 1st- Reagent, 2004 Inhibin A, human, recombinant. Lyophilized. 150,000 IU / ampoule. Standard, 1994 Inhibin B. Lyophilized. Immunoassay calibration 12 ng / ampoule. Bioactivity: 12 units / ampoule. 1st- Reagent, 2000 Inhibin, porcine. Lyophilized. 2,000 IU / ampoule. Standard, 1990 Insulin C-peptide, human. Lyophilized. 10 ug / ampoule. Reagent, 1986 Insulin, bovine. Hydrated crystals IU / mg. Approximately 50 mg / ampoule. Standard, 1986 Insulin, human. Hydrated crystals. 26 IU / mg. Approximately 50 mg / ampoule. Standard, 1986 No. 463, 23rd Report Human serum 67/ No. 626, 29th Report Human serum Sanquin W In Press In Press No. 858, 45th Report; No. 910, 51st Report No. 910, 51st Report No. 814, 41st Report Human immunoglobulin Human immunoglobulin Immunoaffinity purified human inhibin Purified porcine No. 760, 37th Report Synthetic C- peptide 02/ / / / / / No. 760, 37th Report Insulin crystals 83/ No. 760, 37th Report Insulin crystals 83/ Page 18 of 33

19 WHO International Biological Preparations Insulin, human, for immunoassay. Lyophilized. 3 IU / ampoule. Preparation, 1974 Insulin, porcine. Hydrated crystals. 26 IU / mg. Approximately 50 mg / ampoule. Standard, 1986 Insulin-like growth factor I for bioassay. Lyophilized. 150 IU / ampoule. Standard, 1994 Insulin-like growth factor I for immunoassay. Lyophilized. 3.1 µg / ampoule. 1st- Reagent, 2000 Insulin-like growth factor II, human, recombinant. Lyophilized. 5,000 units / ampoule. 1st- Reagent, 1999 Interferon alpha, human, leukocyte N3. Lyophilized. 60,000 IU / ampoule. Interferon alpha 1/8, human. Lyophilized. 27,000 IU / ampoule. Interferon alpha 2c, human, recombinant. Lyophilized. 40,000 IU / ampoule. Interferon alpha consensus, human, recombinant. Lyophilized. 100,000 IU / ampoule. Interferon alpha, human, leukocyte (HulFN-a(Le)). Lyophilized. 11,000 IU / ampoule. 2nd-International No. 565, 26th Report Human insulin 66/ No. 760, 37th Report Insulin crystals 83/ No. 858, 45th Report; No. 910, 51st Report No. 910, 51st Report growth factor growth Factor Human cells leukocyte derived Human cells leukocyte derived 91/ / ; ; / / / / / / Page 19 of 33

20 WHO International Biological Preparations Interferon alpha, human, lymphoblastoid N1 (HuIFN-alpha(Ly)). Lyophilized. 38,000 IU / ampoule. 2nd-International Interferon alpha2a, human, recombinant (rhulfn-alpha2 (alpha-a)). Lyophilized. 63,000 IU / ampoule. 2nd-International Interferon alpha2b, human, recombinant, (rhulfn-alpha2 (alpha-2b)). Lyophilized. 70,000 IU / ampoule. 2nd-International Interferon beta ser-17, human, recombinant (rhulfn-beta(ser17)). Lyophilized. 6,000 IU / ampoule. Reagent, 1987 Interferon beta, human, fibroblast (HulFN-beta). Lyophilized. 40,000 IU / ampoule. 3rd-International Standard, 2003 Interferon gamma, human, recombinant. Lyophilized. 80,000 IU / ampoule. Standard, 1994 Interferon omega, human, recombinant. 20,000 IU / ampoule. Interferon, chick. Lyophilized. 80 IU / ampoule. Preparation, 1978 Interferon, murine, alpha (MulFN-alpha). Lyophilized. 16,000 IU / ampoule. 2nd-International Standard, 1987 No. 771, 38th Report No. 771, 38th Report No. 858, 45th Report No. 897, 49th Report No. 638, 30th Report Human cells lymphoblastoid derived Human cells fibroblast derived Chick embryo 95/ / / / NIAID Interferon alpha-1 (alpha-d), human, recombinant, (rhuifnalpha1(alphad)). Lyophilized. 8,000 IU / ampoule. Gxb NIAID 00/ NIAID Gxg / / No. 771, 38th Report Murine NIAID Ga Page 20 of 33

21 WHO International Biological Preparations Interferon, murine, beta (MulFN-beta). Lyophilized. 15,000 IU / ampoule. 2nd-International Standard, 1987 Interferon, murine, gamma (MulFN-gamma). Lyophilized. 1,000 IU / ampoule. Reagent, 1987 Interferon, rabbit. Lyophilized. 10,000 IU / ampoule. Standard, 1978 Interleukin-1 alpha, human. Lyophilized. 117,000 IU / ampoule. Standard, 1989 Interleukin-1 beta, human. Lyophilized. 100,000 IU / ampoule. Standard, 1989 Interleukin-10, human. Lyophilized. 5,000 units / ampoule. 1st- Reagent, 1997 Interleukin-11, human. Lyophilized. 5,000 units / ampoule. 1st- Reagent, 1996 Interleukin-12, human. Lyophilized. 10,000 units / ampoule. 1st- Reagent, 1996 Interleukin-13, human. Lyophilized. 1,000 units / ampoule. 1st- Reagent, 1996 Interleukin-15, human. Lyophilized. 1,0000 units / ampoule. 1st- Reagent, 1996 Interleukin-2, human. Lyophilized. 100 IU / ampoule. Standard, 1987 No. 771, 38th Report No. 771, 38th Report No.638, 30 th Report No. 800, 40th Report No. 800, 40th Report No. 889, 48th Report No. 771, 38th Report T-Cell line (Jurkat) derived NIAID NIAID Gb Gg NIAID G /632 TRS 800, /680 TRS 800, / / / / / / Page 21 of 33

22 WHO International Biological Preparations Interleukin-3, human. Lyophilized. 1,700 IU / ampoule. Standard, 1994 Interleukin-4, human. Lyophilized. 1,000 IU / ampoule. Standard, 1994 Interleukin-5, human. Lyophilized. 5,000 units / ampoule. 1st- Reagent, 1996 Interleukin-6, human. Lyophilized. 100,000 IU / ampoule. Standard, 1992 Interleukin-7, human. Lyophilized. 100,000 units / ampoule. 1st- Reagent, 1996 Interleukin-8, human. Lyophilized. 1,000 IU / ampoule. Standard, 1995 Interleukin-9, human. Lyophilized. 1,000 units / ampoule. 1st- Reagent, 1996 Islet cell antibodies. Lyophilized. 20 units / ampoule of islet cell antibodies; 100 units / ampoule of anti-gad65; 100 units / ampoule of anti-ia-2. 1st- Reagent, 1999 Kanamycin. Lyophilized. 10,345 IU / ampoule. Standard, 1986 Leptin, human. Lyophilized. 4,000 IU / ampoule. Leptin, mouse. Lyophilized. 4,000 IU / ampoule. No. 848, 44th Report No. 858, 45th Report No. 840, 43rd Report No. 872, 46th Report 91/ / / / / / / Human serum 97/ No. 760, 37th Report Antibiotic 83/ / E.Coli / E.Coli 97/ / Page 22 of 33

23 WHO International Biological Preparations Leukaemia inhibitory factor. Lyophilized. 10,000 units / ampoule. 1st- Reagent, 1996 Lipoprotein (a). Lyophilized nanomoles/vial 1st- Reagent, 2003 Luteinizing, bovine, for immunoassay. Lyophilized IU / ampoule. Standard, 1985 Luteinizing, human, pituitary. Lyophilized. 35 IU / ampoule. 2nd-International Standard, 1988 Luteinizing, human, pituitary, alpha subunit. Lyophilized. 10 IU / ampoule. Standard, 1984 Luteinizing, human, pituitary, beta subunit. Lyophilized. 10 IU / ampoule. Standard, 1984 Lysine vasopressin. Lyophilized. 7.7 IU / ampoule. Standard, 1978 Macrophage colony stimulating factor, human, recombinant. Lyophilized. 60,000 IU / ampoule. Standard, 1992 MAPREC analysis of poliovirus type 3 (Sabin). Lyophilized. 0.9% 472-C nucleotide / vial. Standard, 1996 MAPREC analysis of poliovirus type 3 (Sabin), high virus reference. Lyophilized. 1.1% 472-C nucleotide / vial. 1st- Reagent, / Human serum CDC IFCC SRM 2B No. 745, 36th Report No. 786, 39th Report No. 725, 35th Report No. 725, 35th Report No. 638, 30th Report No. 840, 43rd Report No. 889, 48th Report Pituitary Pituitary Pituitary Pituitary Synthetic growth factor Chemically synthesized DNA Chemically synthesized DNA / / / / / / / / Page 23 of 33

24 WHO International Biological Preparations MAPREC analysis of poliovirus types 3 (Sabin), low virus reference. Lyophilized. 0.7% 472-C nucleotide / vial. 1st- Reagent, 1997 Measles vaccine (live). Lyophilized. 4.3 log10 (20 000) infectious units / vial. 2nd-International Reagent, 1994 Mumps vaccine (live). Lyophilized. 4.6 log10 (40000) infectious units / vial. Neomycin. Lyophilized. 775 IU / mg. Ampoules containing approximately 50 mg of neomycin sulfate. Neomycin B. Lyophilized. 670 IU / mg. Ampoules containing approximately 25 mg of neomycin B sulfate. Reagent, nd-International Preparation, 1975 Preparation, 1975 Nerve growth factor. Lyophilized. 10,000 units / ampoule. 1st- Reagent, 1996 Netilmicin. Lyophilized. 4,810 IU / ampoule. Standard, 1989 Newcastle (Hitchner B1 strain) disease vaccine, live. Lyophilized. No unitage assigned. Preparation, 1967 Newcastle disease vaccine (inactivated). Lyophilized. 525 IU / ampoule. Standard, 1963 Nystatin. Lyophilized. 4,855 IU / mg. Approximately 100 mg. 2nd-International Standard, 1982 No. 889, 48th Report No. 858, 45th Report No. 858, 45th Report Chemically synthesized DNA Attenuated measles virus Attenuated mumps virus 96/ / / No. 594, 27th Report Antibiotic 72/ No. 594, 27th Report Antibiotic 68/ growth factor 93/ No. 800, 40th Report Antibiotic 83/ No. 384, 20th Report Attenuated newcastle virus NV No. 274, 16th Report Antigen NVIA , No. 687, 33rd Report Antibiotic 80/ Page 24 of 33

25 WHO International Biological Preparations Oncostatin M. Lyophilized. 25,000 units / ampoule. 1st- Reagent, 1996 Opacity. 10 IU of opacity. 5th-International Standard, 1975 Oxytocin. Lyophilized IU / ampoule. 4th-International Standard, 1978 Parathyroid, bovine. Lyophilized. 39 IU / ampoule. Standard, 1985 Parathyroid, human, for immunoassay. Lyophilized. 0.1 IU / ampoule. Preparation, 1981 Parvovirus B19 DNA human. Lyophilized IU / ampoule. Standard, 2000 Pertussis serotype 2, typing serum. No assigned value 1st- Reagent, 2004 Pertussis serotype 3 (fimbriae), typing serum. No assigned value 1st- Reagent, 2004 Pertussis Toxin. Liquid IU / ampoule. Standard, 2003 Pertussis vaccine. Lyophilized. 46 IU / ampoule. 3rd-International Standard, / No. 594, 27th Report Miscellaneous 76/ No. 638, 30th Report No. 745, 36th Report No.673, 32nd Report Synthetic oxytocin peptide Parathyroid peptide Parathyroid peptide 76/ / / No. 910, 51st Report Human plasma 99/ Blood typing serum Blood typing serum 04/ / Toxin JNIH No. 897, 49th Report Inactivated bordetella pertussis 66/ Page 25 of 33

26 WHO International Biological Preparations Placental lactogen, human, for immunoassay. Lyophilized IU / ampoule. Preparation, 1977 Plasmin, human. Lyophilized. 5.3 IU / ampoule. 3rd-International Plasminogen-Activator Inhibitor 1 (PAI-1), human. Lyophilized. Tissue-plasminogen-activator: 27.5 IU of neutralising activity / ampoule. Urinary-plasminogen-activator: 7 IU of neutralising activity / ampoule. Standard, 1998 Standard, 1995 Platelet derived growth factor-bb isoform. Lyophilized. 3,000 IU / ampoule. Standard, 1997 Platelet factor 4. Lyophilized. 400 IU / ampoule. Poliomyelitis vaccine (inactivated). Lyophilized. Type 1 antigen: 430 D-antigen units / ml, Type 2 antigen: 95 D-antigen units / ml, Type 3 antigen: 285 D-antigen units / ml. Poliomyelitis vaccine, oral log10 TCID 50/ml poliovirus type log10 TCID 50/ml poliovirus type log10 TCID 50/ml poliovirus type log10 TCID 50/ml total poliovirus content Poliovirus (Sabin) live attenuated. Lyophilized. Type 1: 6.6 log10 CCID50 / ml ;Type 2: 5.6 log10 CCID50 / ml ;Type 3: 6.2 log10 CCID50 / ml ;Total virus content: 6.8 log10 CCID50 / ml. Standard, 1984 Reagent, nd-International Standard, 2004 Reagent, 1995 No. 626, 29th Report No. 897, 49th Report No. 872, 46th Report No. 889, 48th Report No. 725, 35th Report No. 858, 45th Report Purified placental protein Human plasma protein protein [Chinese Hamster Ovary cells (CHO)], spiked in plasma growth factor Human platelet protein Inactivated polioviruses 73/ / / / / / , Corr.1, Antigen 02/ No. 872, 46th Report Attenuated polio viruses 85/ Page 26 of 33

27 WHO International Biological Preparations Polymyxin B. 8,403 IU / mg. Approximately 75 mg of purified polymyxin B sulfate. 2nd-International Standard, 1969 Prekallikrein activator. Lyophilized. 29 IU / ampoule. 2nd-International Standard, 2003 Proinsulin, bovine, for immunoassay. Lyophilized. 25 ug / ampoule. Standard, 1986 Proinsulin, human. Lyophilized. 6 ug / ampoule. Reagent, 1986 Proinsulin, porcine, for immunoassay. Lyophilized. 20 ug / ampoule. Standard, 1986 Prolactin, human. Lyophilized IU / ampoule. 3rd-International Standard, 1988 Prolactin, recombinant human, for immunoassay. Lyophilized. Nominal content for immunization calibration: 24.5 ug / ampoule; for bioassay calibration: 1,400 mu / ampoule. Prolactin, recombinant human, glycosylated form, for immunoassay. Lyophilized. Nominal content for immunization calibration: 5.5 ug / 1st- Reagent, st- Reagent, 2001 ampoule; for bioassay calibration: 88 mu / ampoule. Prolactin, recombinant human, non-glycosylated form, for immunoassay. Lyophilized ug / ampoule; for bioassay: 670 mu / ampoule. 1st- Reagent, 2001 Prostate specific antigen. Lyophilized. 1 ug total PSA per vial. 1st- Reagent, 1999 No. 444, 22nd Report Antibiotic 67/ No. 760, 37th Report No. 760, 37th Report No. 760, 37th Report No. 786, 39th Report No. 924, 52nd Report No. 924, 52nd Report No. 924, 52nd Report Purified from human plasma Pancreatic enzyme proinsulin Pancreatic enzyme Pituitary rdna derived prolactin rdna derived prolactin, nonglycosylated form Purified plasma protein 82/ / / / / , Add 1, / / / / Page 27 of 33

28 WHO International Biological Preparations Prostate specific antigen (90:10). Lyophilized. 1 ug total PSA per vial. 1st- Reagent, 1999 Protein C, plasma, human. Lyophilized IU / ampoule. Standard, 1987 Protein S, plasma, human. Lyophilized IU / ampoule. Standard, 1995 Pyrogen. Lyophilized. Approximately 2 mg / vial. Preparation, 1957 Rabies vaccine. Lyophilized. 16 IU / ampoule (PM-glycoprotein: 10 IU / ampoule. PM-ribonucleoprotein 135 IU / ampoule in addition to the 16 IU of rabies vaccine). 5th-International Standard, 1991 Human Luteinizing Hormone. 189 IU / ampoule. Standard, 2003 Renin, human. Lyophilized. 0.1 IU / ampoule. Preparation, 1974 Rheumatoid arthritis serum. Lyophilized. 100 IU / ampoule. Preparation, 1973 Rifamycin SV. Lyophilized. 887 IU / mg. Approximately 100 mg of sodium Rifamycin SV. Preparation, 1967 Purified plasma protein 96/ No. 771, 38th Report Human plasma 86/ No. 872, 46th Report Human plasma 93/ No.147, 11th Report No. 822, 42nd Report No. 565, 26th Report "O" somatic antigen of shigella dysenteriae Rabies inactivated virus Kidney extract derived 57/ , RAV , , / / No. 530, 25th Report Human serum Sanquin W No. 384, 20th Report Antibiotic 66/ Page 28 of 33

29 WHO International Biological Preparations Rubella vaccine (live). Lyophilized. 3.9 log10 (8 000) infectious units / vial. Reagent, 1994 Scarlet fever streptococcus antitoxin, equine. Lyophilized. 10,000 IU / ampoule. Standard, 1952 Serum amyloid A protein. Lyophilized IU / ampoule. Standard, 1997 Sex binding globulin (SHBG). Lyophilized. 107 IU / ampoule. Standard, 1998 Short ragweed pollen extract (Ambrosia elatior). Lyophilized. 100,000 IU / ampoule. Standard, 1983 Sisomicin. Lyophilized. 35,200 IU / ampoule. Standard, 1984 Smallpox vaccine. Lyophilized. 14 mg / ampoule. No unitage assigned. Preparation, 1962 Somatropin (rdna-derived human growth ). Lyophilized mg protein / ampoule. 2nd-International Standard, 2000 Spiramycin. Lyophilized. 3,200 IU / mg. Approximately 50 mg. Preparation, 1964 Staphylococcus-alpha antitoxin, equine. Lyophilized. 220 IU / ampoule. 3rd-International Standard, 1982 No. 858, 45th Report Attenuated rubella virus 91/ No. 68, 6th Report Horse serum SC , No. 889, 48th Report Human serum 92/ No. 897, 49th Report Human serum 95/560 98/1884 No. 700, 34th Report Defatted short ragweed pollen 84/ No. 725, 35th Report Antibiotic 80/ No. 259, 15th Report Antigen SMV , No. 910, 51st Report / E.Coli 98/ No. 293, 17th Report Antibiotic 62/ No. 687, 33rd Report Horse serum STA Page 29 of 33

30 WHO International Biological Preparations Stem cell factor. Lyophilized. 1,000 units / ampoule. 1st- Reagent, 1997 Streptokinase. Lyophilized. 1,030 IU / ampoule. 3rd-International Standard, 2001 Streptomycin. Lyophilized. 78,500 IU / ampoule. 3rd-International Standard, 1980 Swine erysipelas serum (anti-n). Lyophilized. 628 IU / ampoule. Standard, 1954 Teicoplanin. Lyophilized. 51,550 IU / ampoule. Standard, 1990 Tetanus toxoid (adsorbed). Lyophilized. 469 IU / ampoule. 3rd-International Standard, 2000 Tetanus toxoid, for flocculation tests. Lyophilized. 1,000 Lf / ampoule. Reagent, 1988 Tetracosactrin. Lyophilized. 490 IU / ampoule. Preparation, 1981 Thrombin, alpha, human. Lyophilized. 100 IU / ampoule. Standard, 1991 Thromboplastin, bovine, combined. Lyophilized. International Sensitivity Index: nd-International Preparation, 1983 No. 889, 48th Report No. 924, 52nd Report Purified from streptococcus hemolyticus culture 91/ / No. 658, 31st Report Antibiotic 76/ No. 96, 8th Report Horse serum SES , No. 814, 41st Report Antibiotic 90/ No. 910, 51st Report Toxoid 98/ No. 786, 39th Report Toxoid TEFT No. 673, 32nd Report No. 822, 42nd Report Synthetic peptide Purified plasma protein 80/ / No. 700, 34th Report Brain derived Sanquin OBT/ Page 30 of 33

31 WHO International Biological Preparations Thromboplastin, human, recombinant, plain. Lyophilized. International Sensitivity Index: rd-International Preparation, 1996 Thromboplastin, rabbit, plain. Lyophilized. International Sensitivity Index: rd-International Reagent, 1995 Thyroid stimulating, human, for immunoassay. Lyophilized x -3 log 10 IU / ampoule. 3rd-International Standard, 2003 Thyroid-stimulating antibody. Lyophilized. 0.1 IU / ampoule. Preparation, 1995 Thyroid-stimulating, human, recombinant. Lyophilized units / ampoule. 1st- Reagent, 1996 Thyroxine-binding globulin. Lyophilized. 30 IU / ampoule. Standard, 1991 Timothy (Phleum pratense) pollen extract. Lyophilized. 100,000 IU / ampoule. Standard, 1983 Tissue Plasminogen Activator (t-pa), human, recombinant. Lyophilized. 10,000 IU / ampoule. 3rd-International Tobramycin. Lyophilized. 9,800 IU / ampoule. 2nd-International Standard, 1985 protein Sanquin rtf/ Rev.1 No. 872, 46th Report Brain derived Sanquin RBT/ Pituitary 81/ No. 872, 46th Report Human serum 90/ No. 822, 42nd Report No. 700, 34th Report Nos. 897; 904 & 910: 49th, 50th & 51st Reports, [Chinese Hamster Ovary cells (CHO)] Human serum derived Phleum pratense allergenic extract r-tpa. [Chinese Hamster Ovary cells (CHO)] 94/ / / / No. 745, 36th Report Antibiotic 82/ Page 31 of 33

32 WHO International Biological Preparations Tuberculin, old. Liquid. 90,000 IU / ml. 3rd-International Standard, 1965 Tuberculin, purified protein derivative (PPD), avian. Lyophilized. 500,000 IU / ampoule. Standard, 1954 Tuberculin, purified protein derivative (PPD), bovine. Lyophilized. 58,500 IU / ampoule. Standard, 1986 Tuberculin, purified protein derivative (PPD), mammalian. Lyophilized. 5,000 IU / ampoule. Standard, 1951 Tumor necrosis factor, alpha, human. Lyophilized IU / ampoule. 2nd-International Standard, 2003 Tumor necrosis factor, beta, human. Lyophilized. 150,000 units / ampoule. 1st- Reagent, 1996 Typhoid vaccine (acetone-inactivated). Lyophilized. No unitage assigned. Preparation, 1960 Typhoid vaccine (heat-phenol-inactivated). Lyophilized. No unitage assigned. Preparation, 1960 Urokinase, high molecular weight. Lyophilized. 4,300 IU / ampoule. Standard, 1989 No. 329, 18th Report No. 96, 8th Report No. 760, 37th Report No. 56, 5th Report No. 222, 14th Report No. 222, 14th Report No. 800, 40th Report Mycobacterium tuberculosis culture derived Mycobacterium avium culture derived Mycobacterium bovis culture derived Mycobacterium tuberculosis culture derived Inactivated salmonella typhi Inactivated salmonella typhi Two chain urine derived TU PPDA , PPD BOV PPDT , / / TYVK , TYVL , / Page 32 of 33

33 WHO International Biological Preparations Vancomycin. Lyophilized. 1,007 IU / mg. Approximately 50 mg of vancomycin sulfate. Standard, 1963 Vitamin B12, in human serum. Lyophilized. 320 pg / ampoule. Reagent, 1992 Whole blood folate. Lyophilized. 13 ng / ampoule. Standard, 1996 Yellow fever vaccine. Lyophilized. 4.5 log 10 IU / ampoule. Standard, 2003 No. 274, 16th Report Antibiotic 59/ No. 840, 43rd Report Human serum 81/ Hemolysed blood Attenuated yellow fever virus 95/ , / Rev.1; Page 33 of 33