ATYPICAL ANTIPSYCHOTICS
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1 ATYPICAL ANTIPSYCHOTICS UTILIZATION MANAGEMENT CRITERIA DRUG CLASSES: Second Generation (Atypical) Antipsychotics BRAND (generic) NAMES: Restricted Access Agents: Abilify Discmelt (aripiprazole), Fanapt (iioperidone), Latuda (lurasidone), Rexulti (brexpiprazole), Saphris (asenapine), Vraylar (cariprazine), Quantity Limits: Abilify(aripiprazole), Abilify Discmelt (aripiprazole), Clozaril (clozapine), FazaClo (clozapine), Fanapt (iioperidone), Geodon (ziprasidone), Invega (paliperidone), Latuda (lurasidone), Rexulti (brexpiprazole), Risperdal (risperidone), Risperdal M-Tab (risperidone ODT), Saphris (asenapine), Seroquel (quetiapine), Seroquel XR (quetiapine XR), Versacloz (clozapine), Vraylar (cariprazine), Zyprexa (olanzapine), Zyprexa Zydis (olanzapine ODT) COVERAGE AUTHORIZATION CRITERIA: Restricted Access Atypical Antipsychotics listed in this policy may be eligible for coverage when the following criteria are met: 1. The patient is currently taking one of the restricted access atypical antipsychotics; AND 2. The prescribing provider must certify to BCBSNC that the patient cannot be safely transitioned to a non-restricted access agent from a restricted access agent. Non-restricted access agents include the following generic antipsychotics: aripiprazole, clozapine, olanzapine, quetiapine, paliperidone, risperidone, ziprasidone. For members on the Enhanced Formulary, before approval of a restricted access agent is given, one non-restricted access agent must be tried. For members on the Essential and ASO Net Results Formularies, before approval of a restricted access agent is given, two non-restricted access agents must be tried. Non-formulary medications included in this criteria may be considered for exception approval if the formulary specific criteria is satisfied (see Non-Formulary Exception criteria for details). QUANTITY LIMIT EXCEPTION CRITERIA: Last Revision Date: May 2017 Page 1
2 Quantities above the program set limit (see pages 2-4) may be eligible for coverage when: 1. The quantity (dose) requested is for documented titration purposes at the initiation of therapy (authorization for a 90 day titration period); AND 2. The prescribed dose cannot be achieved using a lesser quantity of a higher strength; AND 3. The quantity (dose) requested does not exceed the maximum FDA labeled dose, when specified, or to the safest studied dose per the manufacturer s product insert; OR 4. If the quantity (dose) requested exceeds the maximum FDA labeled dose, when specified, or to the safest studied dose per the manufacturer s product insert, then the prescriber must submit documentation in support of therapy with a higher dose for the intended diagnosis (submitted documentation may include medical records OR fax form which reflects medical record documentation that shows the length of time the requested dose has been used, and what other medications and doses have been tried and failed). QUANTITY LIMITS Medication Name Dosage/Strength Quantity Limit per Day *unless otherwise noted Abilify (aripiprazole) 2 mg tablet 1 tablet Abilify (aripiprazole) 5 mg tablet 1 tablet Abilify (aripiprazole) 10 mg tablet 1 tablet Abilify (aripiprazole) 15 mg tablet 1 tablet Abilify (aripiprazole) 20 mg tablet 1 tablet Abilify (aripiprazole) 30 mg tablet 1 tablet Abilify (aripiprazole) 1 mg/ml oral solution 25 ml Abilify Discmelt (aripiprazole) 10 mg disintegrating tablet 2 tablets Abilify Discmelt (aripiprazole) 15 mg disintegrating tablet 2 tablets Clozaril (clozapine) 25 mg tablet 3 tablets Clozaril (clozapine) 50 mg tablet 3 tablets Clozaril (clozapine) 100 mg tablet 9 tablets Clozaril (clozapine) 200 mg tablet 4 tablets Fanapt (iloperidone) 1 mg tablet 2 tablets Fanapt (iloperidone) 2 mg tablet 2 tablets Fanapt (iloperidone) 4 mg tablet 2 tablets Fanapt (iloperidone) 6 mg tablet 2 tablets Fanapt (iloperidone) 8 mg tablet 2 tablets Fanapt (iloperidone) 10 mg tablet 2 tablets Fanapt (iloperidone) 12 mg tablet 2 tablets Fanapt (iloperidone) Titration pak 1 pak (8 tablets)/4 days FazaClo (clozapine) 12.5 mg tablet 3 tablets FazaClo (clozapine) 25 mg tablet 9 tablets FazaClo (clozapine) 100 mg tablet 3 tablets FazaClo (clozapine) 150 mg tablet 6 tablets FazaClo (clozapine) 200 mg tablet 4 tablets Geodon (ziprasidone) 20 mg capsule 2 capsules Last Revision Date: May 2017 Page 2
3 Geodon (ziprasidone) 40 mg capsule 2 capsules Geodon (ziprasidone) 60 mg capsule 2 capsules Geodon (ziprasidone) 80 mg capsule 2 capsules Invega (paliperidone) 1.5 mg tablet 1 tablet Invega (paliperidone) 3 mg tablet 1 tablet Invega (paliperidone) 6 mg tablet 2 tablets Invega (paliperidone) 9 mg tablet 1 tablet Latuda (lurasidone) 20 mg tablet 1 tablet Latuda (lurasidone) 40 mg tablet 1 tablet Latuda (lurasidone) 60 mg tablet 1 tablet Latuda (lurasidone) 80 mg tablet 2 tablets Latuda (lurasidone) 120 mg tablet 1 tablet Rexulti (brexpiprazole) 0.25 mg tablet 1 tablet Rexulti (brexpiprazole) 0.5 mg tablet 1 tablet Rexulti (brexpiprazole) 1 mg tablet 1 tablet Rexulti (brexpiprazole) 2 mg tablet 1 tablet Rexulti (brexpiprazole) 3 mg tablet 1 tablet Rexulti (brexpiprazole) 4 mg tablet 1 tablet Risperdal (risperidone) 0.25 mg tablet 2 tablets Risperdal (risperidone) 0.5 mg tablet 2 tablets Risperdal (risperidone) 1 mg tablet 2 tablets Risperdal (risperidone) 2 mg tablet 2 tablets Risperdal (risperidone) 3 mg tablet 2 tablets Risperdal (risperidone) 4 mg tablet 4 tablets Risperdal (risperidone) 1 mg/ml oral solution 16 ml Risperdal M-Tab (risperidone ODT ) 0.25 mg tablet 2 tablets Risperdal M-Tab (risperidone ODT ) 0.5 mg tablet 2 tablets Risperdal M-Tab (risperidone ODT ) 1 mg tablet 2 tablets Risperdal M-Tab (risperidone ODT ) 2 mg tablet 2 tablets Risperdal M-Tab (risperidone ODT ) 3 mg tablet 2 tablets Risperdal M-Tab (risperidone ODT ) 4 mg tablet 4 tablets Saphris (asenapine) 2.5 mg sublingual tablet 2 tablets Saphris (asenapine) 5 mg sublingual tablet 2 tablets Saphris (asenapine) 10 mg sublingual tablet 2 tablets Seroquel (quetiapine) 25 mg tablet 3 tablets Seroquel (quetiapine) 50 mg tablet 3 tablets Seroquel (quetiapine) 100 mg tablet 3 tablets Seroquel (quetiapine) 200 mg tablet 3 tablets Seroquel (quetiapine) 300 mg tablet 2 tablets Seroquel (quetiapine) 400 mg tablet 2 tablets Seroquel XR (quetiapine) 50 mg extended-release tablet 2 tablets Seroquel XR (quetiapine) 150 mg extended-release tablet 1 tablet Seroquel XR (quetiapine) 200 mg extended-release tablet 1 tablet Seroquel XR (quetiapine) 300 mg extended-release tablet 2 tablets Last Revision Date: May 2017 Page 3
4 Seroquel XR (quetiapine) 400 mg extended-release tablet 2 tablets Versacloz (clozapine) 50 mg/ml oral suspension 18 ml Vraylar (cariprazine) 1.5 mg capsule 1 capsule Vraylar (cariprazine) 3 mg capsule 1 capsule Vraylar (cariprazine) 4.5 mg capsule 1 capsule Vraylar (cariprazine) 6 mg capsule 1 capsule Vraylar Therapy Pack 1.5 mg (1) and 3 mg (6) 1 box per 180 days Zyprexa (olanzapine) 2.5 mg tablet 1 tablet Zyprexa (olanzapine) 5 mg tablet 1 tablet Zyprexa (olanzapine) 7.5 mg tablet 1 tablet Zyprexa (olanzapine) 10 mg tablet 1 tablet Zyprexa (olanzapine) 15 mg tablet 1 tablet Zyprexa (olanzapine) 20 mg tablet 1 tablet Zyprexa Zydis (olanzapine ODT) 5 mg tablet 1 tablet Zyprexa Zydis (olanzapine ODT) 10 mg tablet 1 tablet Zyprexa Zydis (olanzapine ODT) 15 mg tablet 1 tablet Zyprexa Zydis (olanzapine ODT) 20 mg tablet 1 tablet NOTE: quantity limits apply to both brand and generic formulations POLICY IMPLEMENTATION/UPDATE INFORMATION March 2018: Removed reference to the Basic Open Formulary May 2017: Removed Seroquel XR from restriction as well as the co-liscensed generic in due to market change and release of generic. November 2016: Reviewed for ASO Net Results and Essential formularies; non-formulary verbiage added; added quetiapine fumarate ER to restriction in conjunction with the launch of the authorized generic. June 2016: Corrected QL on Rexulti 0.25 to 1 daily based on original intention of the program. March 2016: Added new to market drug, Vraylar, to the policy. January 2016: Original utilization management criteria issued. Last Revision Date: May 2017 Page 4
5 Non-Discrimination and Accessibility Notice Discrimination is Against the Law Blue Cross and Blue Shield of North Carolina ( BCBSNC ) complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex. BCBSNC does not exclude people or treat them differently because of race, color, national origin, age, disability, or sex. BCBSNC: Provides free aids and services to people with disabilities to communicate effectively with us, such as: - Qualified interpreters - Written information in other formats (large print, audio, accessible electronic formats, other formats) Provides free language services to people whose primary language is not English, such as: - Qualified interpreters - Information written in other languages If you need these services, contact Customer Service , TTY and TDD, call If you believe that BCBSNC has failed to provide these services or discriminated in another way on the basis of race, color, national origin, age, disability, or sex, you can file a grievance with: BCBSNC, PO Box 2291, Durham, NC 27702, Attention: Civil Rights Coordinator- Privacy, Ethics & Corporate Policy Office, Telephone , Fax , TTY civilrightscoordinator@bcbsnc.com You can file a grievance in person or by mail, fax, or . If you need help filing a grievance, Civil Rights Coordinator - Privacy, Ethics & Corporate Policy Office is available to help you. You can also file a civil rights complaint with the U.S. Department of Health and Human Services, Office for Civil Rights, electronically through the Office for Civil Rights Complaint Portal, available at or by mail or phone at: U.S. Department of Health and Human Services 200 Independence Avenue, SW Room 509F, HHH Building Washington, D.C , (TDD). Complaint forms are available at Last Revision Date: May 2017 Page 5
6 This Notice and/or attachments may have important information about your application or coverage through BCBSNC. Look for key dates. You may need to take action by certain deadlines to keep your health coverage or help with costs. You have the right to get this information and help in your language at no cost. Call Customer Service ATTENTION: If you speak another language, language assistance services, free of charge, are available to you. Call ATENCIÓN: Si habla español, tiene a su disposición servicios gratuitos de asistencia lingüística. Llame al 注意 : 如果您講廣東話或普通話, 您可以免費獲得語言援助服務 請致電 (TTY: ) CHÚ Ý: Nếu bạn nói Tiếng Việt, có các dịch vụ hỗ trợ ngôn ngữ miễn phí dành cho bạn. Gọi số 주의 : 한국어를사용하시는경우, 언어지원서비스를무료로이용하실수있습니다 (TTY: ) 번으로전화해주십시오. ATTENTION : Si vous parlez français, des services d'aide linguistique vous sont proposés gratuitement. Appelez le (ATS : ). ملحوظة: إذا كنت تتحدث اللغة العربیة فا ن خدمات المساعدة اللغویة تتوافر لك بالمجان. اتصل برقم المبرقة الكاتبة: LUS CEEV: Yog tias koj hais lus Hmoob, cov kev pab txog lus, muaj kev pab dawb rau koj. Hu rau ВНИМАНИЕ: Если вы говорите на русском языке, то вам доступны бесплатные услуги перевода. Звоните (телетайп: ). PAUNAWA: Kung nagsasalita ka ng Tagalog, maaari kang gumamit ng mga serbisyo ng tulong sa wika nang walang bayad. Tumawag sa ચન : જ તમ જર ત બ લત હ, ત ન: લ ભ ષ સહ ય સ વ ઓ તમ ર મ ટ ઉપલબ ધ છ. ફ ન કર ច ណ របស ន ប ល កអ កន យយជភ ស ខ រ សវកម ជ ន យ ផ កភ ស ម នផ ល ជ នស រម ប ល កអ ក ដយម នគ ត ថ ស មទ នក ទ នងត មរយ លខ (TTY: ) ACHTUNG: Wenn Sie Deutsch sprechen, stehen Ihnen kostenlos sprachliche Hilfsdienstleistungen zur Verfügung. Rufnummer: ध य न द : य द आप हन द ब लत ह त आपक लए म फ त म भ ष सह यत स व ए उपलब ध ह (TTY: ) पर क ल कर Last Revision Date: May 2017 Page 6
7 ໂປດຊາບ: ຖ າວ າ ທ ານເວ າພາສາ ລາວ, ການບ ລການຊ ວຍເຫ ອດ ານພາສາ, ໂດຍບ ເສ ຽຄ າ, ແມ ນມ ພ ອມໃຫ ທ ານ. ໂທຣ 注意事項 : 日本語を話される場合 無料の言語支援をご利用いただけます (TTY: ) まで お電話にてご連絡ください Last Revision Date: May 2017 Page 7
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