COMPOUNDED PRESCRIPTION DRUG PRODUCTS
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1 COMPOUNDED PRESCRIPTION DRUG PRODUCTS UTILIZATION MANAGEMENT CRITERIA COVERAGE AUTHORIZATION CRITERIA Compounded drug products whose total prescription ingredient cost is $200 or more are covered only when ALL of the following conditions are met: 1. The compounded product contains at least one prescription ingredient; AND 2. Each prescription drug ingredient in the compounded product is approved by the Food & Drug Administration (FDA) for medical use in the United States; AND 3. The active prescription medication component(s) are in therapeutic amounts, based on scientific literature or national compendia*; AND 4. The compounded product is not a copy of any commercially available FDA-approved drug product; AND 5. The use for which the compounded product is being prescribed is supported by FDA approval of the active ingredient(s), or is supported by adequate medical and scientific evidence in the medical literature* for that diagnosis and for the method or route of delivery; AND 6. If any prescription ingredient in the compounded product is on BCBSNC s prior review list, the patient must meet the criteria designated for that prescription ingredient; AND 7. The compound does not contain over the counter medications. Coverage will NOT be provided for compounds under the following circumstances: 1. Any compound that does not contain a prescription ingredient otherwise covered by the plan; OR 2. Compounded formulations are being used for cosmetic purposes; OR 3. Compounded formulations are using prescription ingredients for non-fda approved indications or purposes; OR 4. Compounded formulations that include investigational or experimental drugs as defined in the BCBSNC Corporate Medical Policy Investigational (Experimental) Services; OR 5. Compounded formulations that use drugs withdrawn or removed from the market for safety reasons; OR 6. Prescription ingredient(s) compounded for the purpose of convenience only. a. Exceptions include: i. For those patients that cannot swallow or have trouble swallowing and require administration with an oral liquid, or administration by topical, rectal or other appropriate non-oral routes; ii. For those patients who have sensitivity to dyes, preservatives, or fillers in commercial products and require allergy-free medications as documented in the medical record; iii. For children who require prescription medications for which there are no liquid formulations available Last Reviewed: February 2017 Page 1
2 *Please note: Medical and scientific evidence is defined as any ONE of the following: 1. Peer-reviewed scientific studies published in or accepted for publication by medical journals that meet nationally recognized requirements for scientific manuscripts and that submit most of their published articles for review by experts who are not part of the editorial staff; OR 2. Peer-reviewed literature, biomedical compendia, and other medical literature that meet the criteria of the National Institute of Health s Nations Library of Medicine for indexing in index Medicus, Excerpta Medicus (EMBASE), Medline, or MEDLARS database Health Services Technology Assessment Research (STAR).; OR 3. Medical journals recognized by the Secretary of Health and Human Services, under Section 1861(t)(2) of the Social Security Act (42 U.S.C. 1395x).; OR 4. The following standard reference compendia: a. The American Hospital Formulary Service Drug Information (AHFS-DI) b. Micromedex s DrugDex c. National Comprehensive Cancer Network (NCCN) Drug & Biological Compendia; OR 5. Findings, studies, or research conducted by or under the auspices of federal government agencies and nationally recognized federal research institutes including the: a. Agency for Healthcare Research and Quality, b. National Institutes of Health, c. National Cancer Institute, d. National Academy of Sciences, e. Center for Medicare and Medicaid Services, and f. Any national board recognized by the National Institutes of Health for the purpose of evaluating the medical value of health services; BCBSNC Off-Label Requirements The FDA is responsible for approving medications for use based on clinical data proving the medication is safe and effective for that specific use. BCBSNC s prior review and quantity limitations programs follow FDA-approved uses for these drugs. However, BCBSNC recognizes that in many cases, off-label (non- FDA approved) uses of prescription drugs may be acceptable. In determining the acceptability of off-label uses, BCBSNC utilizes several sources of clinical information including but not limited to 1) nationally recognized clinical references including American Hospital Formulary Service Drug Information and Micromedex; 2) the results of at least two randomized controlled clinical studies that support a specific offlabel use, and that are published in peer-reviewed professional medical journals; and 3) consultations with internal and external physician experts regarding community standards. Additional searches for current supporting medical literature may be performed utilizing standard electronic databases. POLICY IMPLEMENTATION/UPDATE INFORMATION February 2017: Clarification added on over the counter products. Over the counter medications are a benefit exclusion outlined in the members benefit booklet and therefore excluded from coverage in a compound. September 2012: Policy Originated REFERENCES U.S. Food and Drug Administration. Pharmacy Compounding: Guidance, Compliance and Regulatory Information; 43.htm (accessed 31 July, 2012) BCBSNC Corporate Medical Policy: Hormone Pellet Implantation for Hormone Replacement Last Reviewed: February 2017 Page 2
3 Therapy in Women. one_replacement_therapy_in_women.pdf BCBSNC Corporate Medical Policy: Progesterone therapy in high risk pregnancies. gnancies.pdf Non-Discrimination and Accessibility Notice Discrimination is Against the Law Blue Cross and Blue Shield of North Carolina ( BCBSNC ) complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex. BCBSNC does not exclude people or treat them differently because of race, color, national origin, age, disability, or sex. BCBSNC: Provides free aids and services to people with disabilities to communicate effectively with us, such as: - Qualified interpreters - Written information in other formats (large print, audio, accessible electronic formats, other formats) Provides free language services to people whose primary language is not English, such as: - Qualified interpreters - Information written in other languages If you need these services, contact Customer Service , TTY and TDD, call If you believe that BCBSNC has failed to provide these services or discriminated in another way on the basis of race, color, national origin, age, disability, or sex, you can file a grievance with: BCBSNC, PO Box 2291, Durham, NC 27702, Attention: Civil Rights Coordinator- Privacy, Ethics & Corporate Policy Office, Telephone , Fax , TTY civilrightscoordinator@bcbsnc.com You can file a grievance in person or by mail, fax, or . If you need help filing a grievance, Civil Rights Coordinator - Privacy, Ethics & Corporate Policy Office is available to help you. You can also file a civil rights complaint with the U.S. Department of Health and Human Services, Office for Civil Rights, electronically through the Office for Civil Rights Complaint Portal, available at or by mail or phone at: U.S. Department of Health and Human Services 200 Independence Avenue, SW Room 509F, HHH Building Washington, D.C , (TDD). Complaint forms are available at Last Reviewed: February 2017 Page 3
4 This Notice and/or attachments may have important information about your application or coverage through BCBSNC. Look for key dates. You may need to take action by certain deadlines to keep your health coverage or help with costs. You have the right to get this information and help in your language at no cost. Call Customer Service ATTENTION: If you speak another language, language assistance services, free of charge, are available to you. Call ATENCIÓN: Si habla español, tiene a su disposición servicios gratuitos de asistencia lingüística. Llame al (TTY: ). 注意 : 如果您講廣東話或普通話, 您可以免費獲得語言援助服務 請致電 (TTY: ) CHÚ Ý: Nếu bạn nói Tiếng Việt, có các dịch vụ hỗ trợ ngôn ngữ miễn phí dành cho bạn. Gọi số 주의 : 한국어를사용하시는경우, 언어지원서비스를무료로이용하실수있습니다 (TTY: ) 번으로전화해주십시오. ATTENTION : Si vous parlez français, des services d'aide linguistique vous sont proposés gratuitement. Appelez le (ATS : ). ملحوظة: إذا كنت تتحدث اللغة العربية فإن خدمات المساعدة اللغوية تتوافر لك بالمجان. اتصل برقم المبرقة الكاتبة: LUS CEEV: Yog tias koj hais lus Hmoob, cov kev pab txog lus, muaj kev pab dawb rau koj. Hu rau ВНИМАНИЕ: Если вы говорите на русском языке, то вам доступны бесплатные услуги перевода. Звоните (телетайп: ). PAUNAWA: Kung nagsasalita ka ng Tagalog, maaari kang gumamit ng mga serbisyo ng tulong sa wika nang walang bayad. Tumawag sa સ ચન : જ તમ ગ જર ત બ લત હ, ત નન:સ લ ક ભ ષ સહ ય સ વ ઓ તમ ર મ ટ ઉપલબ ધ છ. ફ ન કર ច ណ ប រស នបរ ប កអ នកន យ យជ ភ ស ខ ម រ បសវ កម ជ ន យខ នកភ ស ម ននតល ជ នសប ម រ ប កអ នកប យម នគ តថ ល ស ម ទ ន ក ទ នងត ម រយ បលម (TTY: ) ACHTUNG: Wenn Sie Deutsch sprechen, stehen Ihnen kostenlos sprachliche Hilfsdienstleistungen zur Verfügung. Rufnummer: ध य न द : यदद आप द न द ब लत त आपक दलए म फ त म भ ष स यत स व ए उपलब ध (TTY: ) पर क ल कर Last Reviewed: February 2017 Page 4
5 ໂປດຊາບ: ຖ າວ າ ທ ານເວ າພາສາ ລາວ, ການບ ລການຊ ວຍເຫອດ ານພາສາ, ໂດຍບ ເສ ຽຄ າ, ແມ ນມ ພ ອມໃຫ ທ ານ. ໂທຣ 注意事項 : 日本語を話される場合 無料の言語支援をご利用いただけます (TTY: ) まで お電話にてご連絡ください Last Reviewed: February 2017 Page 5
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