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1 Streamline Automation, LLC Non-Invasive Cardiac Output Measurement Based on Pulse Oximetry Streamline Automation, LLC 3100 Fresh Way SW Huntsville, AL Phone: Prepared by: Alton Reich, MS, PE Date: July Copyright 2013, Streamline Automation, LLC All rights reserved.
2 Value Proposition Non-invasive measurement with minimal risk Extracts information contained in the pulse oximeter output signal to measure cardiac stroke volume and cardiac output Leverages a well known base technology with good market penetration The technology will enable the reliable use of cardiac stroke volume information for: Supporting patient assessment and diagnosis Determination of fluid responsiveness Detection of traumatic blood loss 2
3 Market Cardiac output measurements are currently performed with invasive procedures Swan-Ganz catheterization Transesophageal echocardiography There are about 2.7 million Swan-Ganz procedures performed annually at a cost of about $5B Pulse oximetry market is about $1B annually 3
4 Motivation This would be great data to adjust treatment for a patient in heart failure. This would allow the physician to treat any hemodynamic event. This technology would minimize the time in the hospital and discomfort for the patient. Dr. Alex Vasquez, Cardiologist at the Heart Center With the workload that nurses have, asking them to use a new piece of equipment is often difficult; whereas using a conventional pulse oximeter to detect cardiac stroke volume would be easy for a nurse since we use a pulse oximeter as a matter of routine. Lisa Walker, Nurse at Huntsville Hospital 4
5 Cardiac Output Measurement (1) Patient Output: Blood Volume and Oxygen Time-Varying Signals (2) Pulse Oximeter Output: Pulse Rate and Percutaneous Oxygen Saturation Signals (3) Streamline Automation's IDEA Probabilistic Inference Package (4) Output of Time-Averaged Circulatory Parameters: Stroke Volume, Cardiac Output, and Percutaneous Oxygen Saturation (1) Patient Pulse Oximeter SV, CO, HR, SpO2 (4) (2) IDEA Package (3) Feature Extraction Algorithms for Integrated Cardiac Function Parameters 5
6 Initial Validation MIMIC Data Data set from the MIMIC database (a database of anonymous patient data) that contains the PLETH waveform and measured cardiac output Data is processed to compute the stroke volume 38 year old male - Respiratory failure Stroke Volume (ml), Blood Pressure (mmhg) + Predicted Aortic Pressure Observed Aortic Pressure Predicted Stroke Volume Observed Stroke Volume 6
7 Heart Center Validation Collected PPG waveform data from patients at the Heart Center in Huntsville, AL Swan-Ganz invasive measurements were performed on these patients to provide a baseline for comparison Stroke Volume (ml) 7
8 Comparison With Swan-Ganz The invasive Swan-Ganz cardiac output measurement generally involves 3 or 4 raw measurements that are averaged to get the final measurement The plot compares our non-invasive measurement (X) with the final, average Swan-Ganz measurement The raw Swan-Ganz measurements ( ) are shown for comparison The lines on the plot: Solid: Exact correlation Dotted: ±10% from Swan-Ganz Dashed: ±20% from Swan-Ganz 8
9 Comparison With Swan-Ganz Comparison of Non-Invasive Cardiac Output Measurements with Swan-Ganz Measurements 9 Non-Invasive Cardiac Output (liters/minute) Swan-Ganz Average Cardiac Output (liters/minute) Non-invasive measurement compares favorably with the invasive Swan-Ganz measurements 9
10 Difference Between Non-Invasive and Invasive Cardiac Output Measurements Bland-Altman Plot Evaluates agreement between measurement methods Mean difference and 95% confidence interval (±1.96SD) are shown 30% 20% 10% 0% % -20% -30% Difference Between the Non-Invasive and Invasive Cardiac Output Measurements Difference (%) Mean Difference ±1.96SD Average of Non-Invasive and Invasive Cardiac Output Measurements (LPM) 10
11 Current Status Commitment for private investment funding has been received from several investors Seeking additional investment funding from individuals and corporate partners Currently 1 patent allowed on the technology 6 additional US patents pending European (EPO) patent pending Additional patent applications are likely 11
12 Summary Received National Science Foundation SBIR Phase II award in 2010 to develop and test a prototype of the algorithm and software to enhance pulse oximetry Testing indicates that our non-invasive measurement compares favorably with the invasive Swan-Ganz measurements with significantly less risk to the patient First patent on the technology has been allowed 12
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