escco, estimated Continuous Cardiac Output device DESEBBE OLIVIER SAUVEGARDE CLINIC, LYON, FRANCE
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1 escco, estimated Continuous Cardiac Output device DESEBBE OLIVIER SAUVEGARDE CLINIC, LYON, FRANCE
2 No conflict of interest
3 u Technology, based on Pulse Wave Transit Time u Limits of the technology u Precision and Accuracy of escco u escco in daily practice: Can escco follow changes in cardiac output?: during dynamic maneuvers (fluid challenge, change of PEEP, change of vasoconstrictors, Passive Leg Raising) u Potential causes of inacurracy
4 Technology THE PULSE WAVE TRANSIT TIME NON INVASIVE CALIBRATION
5 The Pulse Wave Transit Time (PWTT) Usual sensors: ECG synchronised with the pulse oximeter
6 Relationship between Stroke Volume and PWTT
7 Relationship between Stroke Volume and PWTT Yugo Conf Proc IEEE Eng Med Biol Soc. 2010:
8 Technology ECG Pulse Pressure u escco = K (a PWTT+ β) HR; u a = -0.3, experimental constant according to unpublished preliminary data. u Non invasive calibration: u The constants K and b are individualized for each patient according to the physical profile (age, weight, height) and the initial measurement of the Pulse Pressure, the Heart Rate and the PWTT Bataille BJA 2013, Tsuitsui, A&A 2013, Terada, JCMC 2014
9 Limits of the technology u ECG : u u u Confusion between R wave et S wave u Arrhythmias, pace maker (mixture of spontaneous and paced beat), OPCAB Pulse oximetry (SpO2) u Low perfusion index (vasoconstriction induced by drugs, hypothermia., body movement) Index of Quality Signal available u Aortic cross clamping: vein pulsation affects the pulse wave and therefore the PWTT u Intra Aortic Balloon Pumping: no detection of the pulse wave PWTT: u Severe diastolic dysfunction: flawing of the relationship between PWTT and SV u Aortic stenosis or insuffisiency Terada, JCMC 2014
10 Indications of escco u General monitoring u Hemodynamics monitoring after pulmonary artery catheter removal escco
11 Indications of escco escco u Intraoperative Hemodynamic optimization: u Major component of Enhanced Recovery After Surgery and the Perioperative Surgical Home model of care: u In Major surgery for low and intermediate risky patients JL Vincent, Crit Care 2015
12 Pearse JAMA 2014
13 Indications of escco escco u Intraoperative Hemodynamic optimization: u Major component of Enhanced Recovery After Surgery and the Perioperative Surgical Home model of care: u In Major surgery for low and medium risk patients JL Vincent, Crit Care 2015
14 Benefits of escco u u u u non-invasive calibration No special skills required Real time and continuous Low cost (alongside the familiar vital sign parameters of ECG and SpO2).?? technology? No additional sensors Vincent Crit Care 2011
15 Reliability: Reproducibility/Repeatability/Precision error of escco u acceptable: u reproducibility coefficient is 0.87 (P<0.05) during exercice (Stalter 2015) A CO variation value display of 3.1% can be due to the device and not to a true variation of CO Thonnerieux A&A 2015
16 Reliability: Reproducibility/Repeatability of escco u u acceptable: Repeatability along the time Ishihara JCMC 2004
17 Reliability: Reproducibility/Repeatability of escco u New Algorithm of escco (since 2012) with non invasive calibration u PWWT is averaged during 64 consecutive data of heart beats. u Exclusion of PWTT if Delta PWTT > 20 millisec or Pulse amplitude > 30% u If more than 16 PWTT are excluded: the calculation process is cancelled Tsuitsui A&A 2013
18 Precision and Accuracy echocardiography thermodilution Percentage of error LOA/meanCO Patients (n) Data points (n) Setting coronary unit ICU ICU labo ICU ICU ICU OR ICU ICU OR ICU/OR OR ICU OR/ICU OR
19 Precision and Accuracy PE (%) Meta analysis on totally non invasive CO monitoring escco, nipca, CO2r, Bioimpedance Versus bolus thermodilution escco: bias -0.2 L/mi,, LOA 2.76 L/min Mean PE 42%
20 Trending mean radial bias Radial LOA of the radial bias Concordance rate (%) acceptable < 5 < 30 > 85-90% Mean radial bias Exclusion zone if DCO < 0,5 L/min Saugel A&A 2015 Critchley A&A 2010
21 Trending Year Author dynamic maneuver angular bias angular LOA concordance rate (%) plot graph successive 2012 Bataille measurements polar 2014 Fischer PLR and FL 23 polar 2015 Feissel FL 100 four quadrant 2015 Biais PLR, FL, norepinephrine polar 2015 Thonnerieux PEEP polar 2012 Ishihara successive measurements polar escco underestimates changes of CO
22 Trending Mean angular bias Thonnerieux A&A 2015
23 Limits of escco u The constant alpha to calculate the PWTT has not been published and is based on 14 subjects only. u Averaging CO on 64 heart beats with exclusion of numerous PWTTs could impact the capacity of escco to detect acute changes of CO u Non invasive calibration algorythm based on japonese cohort different for other complexions?
24 Limits of escco: Relationship between PWTT and SV u Weak correlation between PWTT and SV Ishihara JCMC 2004
25 Limits of escco: Influence of Systemic Vascular Resistance Bataille 2012 Biais BJA 2015
26 Limits of escco: Influence of Systemic Vascular Resistance T2 Bataille 2012 Biais BJA 2015
27 Could escco be a promising tool? Repeatability is acceptable Most studies have been conducted in ICU and cardiac surgery (ECG and pulse wave can be affected), what about medium to high risk patients in OR?
28 Could escco be a promising tool? Feissel Study : Agreement: bias with LOA 1.42 L/min PE of 24% Concordance rate of 100% before and after FL Threshold 11% Se =83% Sp = 77% Feissel Plos One 2015
29 Conclusion u escco is a real time continuous non invasive CO monitoring u Most of studies show a wide LOA and an inability to follow CO changes u escco should be compare to a gold standard in animals (transonic flow probes) u Repeatability of the comparator (reference method) should also be assessed u escco should be tested in an outcome study
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