High Precision Dose Delivery from Electron & X-ray Beam Lines
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1 High Precision Dose Delivery from Electron & X-ray Beam Lines J.Mittendorfer F. Gratzl I. Hirschmueller Mediscan GmbH & CoKG, Austria AccApp09, IAEA Vienna May 4th 8th,
2 Industrial Irradiation Product treatment using ionizing radiation electrons (β) of different energy Gamma (γ)- radiation from radioactive decay (Co-60) X-rays from conversion of electrons in a target AccApp09, IAEA Vienna May 4th 8th,
3 Sterilisation SAL (Sterility Assurance Level) 10-6 Sterilisation D 10 -Wert Effects on microorganisms Deposition of ionising radiation (Energy Dose D = de/dm) measurend in Gy = [J/kg] AccApp09, IAEA Vienna May 4th 8th,
4 Radiation Sources Electrons of different energy X-rays (from Bremsstrahlung) Power [kw] 80 kev 1.6 kw X-Rays 7 MeV 700 kw 10 MeV 35 kw Energy Penetration Power Throughput 5 10 Energy [MeV] AccApp09, IAEA Vienna May 4th 8th,
5 Customer Requirements for doses: Electron Beam Routine doses (doses set to sterilizes products) Repeatability, very tight Small D max D min Value Trend to lower doses 25 kgy -> 15 kgy Verification Dose Audits Very low doses ( because of low bioburden) Precise dose delivery (within 10%) AccApp09, IAEA Vienna May 4th 8th,
6 Mediscan, Austria: Irradiation Service Provider Consultancy in Radiation Processing Established TT MeV 35 kw Second Unit: Additional 6.6 MeV X-ray AccApp09, IAEA Vienna May 4th 8th,
7 Electron beam Surface Dose Dose defining parameter: D = k. I/v.s k process constant AccApp09, IAEA Vienna May 4th 8th,
8 Electron beam Dose in Product Depth-Dose Curve Build-Up Steep Slope Source : ISO/ASTM AccApp09, IAEA Vienna May 4th 8th,
9 Electron beam Dose in Product DUR Dose Uniformity Ratio DUR = Dmax/Dmin AccApp09, IAEA Vienna May 4th 8th,
10 Electron beam Use of special product carriers (build-up plates) to shape dose distribution DUR = 1.1 achievable for some products Careful Product Qualification reduces process uncertainty and facilitates product release D ref D min D max Tight Release Window [D refmin, D refmax ] AccApp09, IAEA Vienna May 4th 8th,
11 Electron beam AccApp09, IAEA Vienna May 4th 8th,
12 Combination: Electron/Gamma High Penetration No Isotope! shorter dwell time AccApp09, IAEA Vienna May 4th 8th,
13 X-Ray System: Generation of high energetic (X-rays) by stopping of electrons in a target (Converter): Tungsten, Tantalum High Z-Material Very low yield: 5 MeV 8% 7.5 MeV 10 % AccApp09, IAEA Vienna May 4th 8th,
14 25 X-Ray Spectrum: 20 Fraction [%] ,2 1 1,8 2,6 3,4 4,2 5 5,8 6,6 Energy [MeV] AccApp09, IAEA Vienna May 4th 8th,
15 X-Ray Dose Modelling AccApp09, IAEA Vienna May 4th 8th,
16 Iso-Dose Distribution High Surface Dose Maximum Utilisation of the radiation field AccApp09, IAEA Vienna May 4th 8th,
17 Sterigenics X-Ray Facility TT MeV Elektrons 5 MeV X-Ray 7.5 MeV X-Ray Source : IBA AccApp09, IAEA Vienna May 4th 8th,
18 Modelling Dose Calculation through mathematical modelling (mostly Monte Carlo method) AccApp09, IAEA Vienna May 4th 8th,
19 9 FWT DosimeterStack 1 Alanine Strip Intercomparison of models Reproducability of experiments Test models agains experiment Simple Design - yet tests real world phaenomena which are core to any product validation in detail AccApp09, IAEA Vienna May 4th 8th,
20 Stack AccApp09, IAEA Vienna May 4th 8th,
21 Very Low DUR AccApp09, IAEA Vienna May 4th 8th,
22 Alanine Dosimetrie Now Referencedosimeter Future: Routinedosimeter? AccApp09, IAEA Vienna May 4th 8th,
23 Conclusions Precise Dose Delivery is not due to a single action It is a sum of actions to strive for quality IQ of the radiation source OQ to validate processes PQ to validate products Reliable measurement tools Maintainence and training of personnel AccApp09, IAEA Vienna May 4th 8th,
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