Intestinal Microbial Overgrowth
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1 Patient Age: 4 Time of Collection: 08:00 AM Patient Sex: F Print Date: 08/02/2012 Intestinal Microbial Overgrowth Yeast and Fungal Markers 1 Citramalic Hydroxymethyl-2-furoic Oxoglutaric Furan-2,5-dicarboxylic Furancarbonylglycine Tartaric 3.9 H Arabinose 56 H Carboxycitric Tricarballylic Malabsorption and Bacterial Markers 10 2-Hydroxyphenylacetic Hydroxyphenylacetic Hydroxybenzoic Hydroxyhippuric Hippuric Indoleacetic Succinic 15 H HPHPA (Clostridia Marker) Cresol (C. difficile) DHPPA (Beneficial Bacteria) Testing performed by, Lenexa, Kansas. The Great Plains Laboratory has developed and determined the performance characteristics of this test. This test has not been evaluated by the U.S. FDA; the FDA does not currently regulate such testing. Organic Acids Test - Nutritional and Metabolic Profile Page 1 of 9
2 Oxalate Metabolites 20 Glyceric Glycolic Oxalic Glycolytic Cycle Metabolites 23 Lactic H Pyruvic Hydroxybutyric Krebs Cycle Metabolites 26 Succinic 15 H Fumaric Malic Oxoglutaric Aconitic Citric H Neurotransmitter Metabolites 32 Homovanillic (HVA) (dopamine) Vanillylmandelic (VMA) (norepinephrine, epinephrine) 34 HVA / VMA Ratio Hydroxyindoleacetic (5-HIAA) (serotonin) 36 Quinolinic H Kynurenic Quinolinic / 5-HIAA Ratio H Pyrimidine Metabolites - Folate Metabolism 39 Uracil Thymine Organic Acids Test - Nutritional and Metabolic Profile Page 2 of 9
3 Ketone and Fatty Acid Oxidation 41 3-Hydroxybutyric Acetoacetic Hydroxybutyric Ethylmalonic Methylsuccinic 4.3 H Adipic Suberic Sebacic Nutritional Markers Vitamin B12 49 Methylmalonic ä Vitamin B6 50 Pyridoxic (B6) Vitamin B5 51 Pantothenic (B5) Vitamin B2 (Riboflavin) 52 Glutaric ä Vitamin C 53 Ascorbic L Vitamin Q10 (CoQ10) 54 3-Hydroxy-3-methylglutaric ä Glutathione Precursor and Chelating Agent 55 N-Acetylcysteine (NAC) Biotin (Vitamin H) 56 Methylcitric ä ä A high value for this marker may indicate a deficiency of this vitamin. Organic Acids Test - Nutritional and Metabolic Profile Page 3 of 9
4 Indicators of Detoxification 57 Pyroglutamic Orotic Hydroxyhippuric 1.2 H Amino Acid Metabolites 60 2-Hydroxyisovaleric Oxoisovaleric L Methyl-2-oxovaleric Hydroxyisocaproic Oxoisocaproic Oxo-4-methiolbutyric Mandelic 0.28 H Phenyllactic Phenylpyruvic L Homogentisic Hydroxyphenyllactic N-Acetylaspartic Malonic Methylglutaric H Hydroxyglutaric 11 H Methylglutaconic Bone Metabolites 76 Phosphoric Organic Acids Test - Nutritional and Metabolic Profile Page 4 of 9
5 Indicator of Fluid Intake 77 *Creatinine 72 mg/dl *The creatinine test is performed to adjust metabolic marker results for differences in fluid intake. Urinary creatinine has limited diagnostic value due to variability as a result of recent fluid intake. Samples are rejected if creatinine is below 20 mg/dl unless the client requests results knowing of our rejection criteria. Explanation of Report Format The reference ranges for organic acids were established using samples collected from typical individuals of all ages with no known physiological or psychological disorders. The ranges were determined by calculating the mean and standard deviation (SD) and are defined as + 2SD of the mean. Reference ranges are age and gender specific, consisting of Male Adult (>13 years), Female Adult (>13 years), Male Child (<13 years), and Female Child (<13 years). There are two types of graphical representations of patient values found in the new report format of both the standard Organic Acids Test and the Microbial Organic Acids Test. The first graph will occur when the value of the patient is within the reference (normal) range, defined as the mean plus or minus two standard deviations. The second graph will occur when the value of the patient exceeds the upper limit of normal. In such cases, the graphical reference range is shrunk so that the degree of abnormality can be appreciated at a glance. In this case, the lower limits of normal are not shown, only the upper limit of normal is shown. In both cases, the value of the patient is given to the left of the graph and is repeated on the graph inside a diamond. If the value is within the normal range, the diamond will be outlined in black. If the value is high or low, the diamond will be outlined in red. Example of Value Within Reference Range Example of Elevated Value Organic Acids Test - Nutritional and Metabolic Profile Page 5 of 9
6 7.4H H Organic Acids Test - Nutritional and Metabolic Profile Page 6 of 9
Intestinal Microbial Overgrowth
Patient Age: 5 Time of Collection: 08:00 AM Patient Sex: M Print Date: 10/04/2012 Metabolic Markers in Urine Reference Range Patient Reference Population - Males Under Age 13 (mmol/mol creatinine) Intestinal
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Accession #: Order #: Reference #: Patient: G1234567 Date Collected: Date Received: Date of Report: 04/03/2012 Date of Birth: 02/05/1962 Telephone: 7704464583 Ordering Physician: Age: Sex: 50 Female Fax:
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