Essential Amino Acids
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1 3425 Corporate Way Duluth, GA ION Profile with Amino Acids 40 - Blood/Urine Amino Acids 40 Profile - Plasma Methodology: High Performance Liquid Chromotography s: Ages 13 and over. Limiting Amino Acids Branched Chain Amino Acids Other Essential Amino Acids Conditionally Essential Amino Acids μmol/l Essential Amino Acids Lysine Methionine Tryptophan Isoleucine Leucine Valine Phenylalanine Histidine Threonine Arginine Taurine Glycine Serine C0490.1
2 Page 2 Amino Acids 40 Profile - Plasma Methodology: High Performance Liquid Chromotography s: Ages 13 and over. Vitamin B6 Status Markers Vascular Function Neurotransmitters and Precursors Sulfur Amino Acids (Glutathione - related) α-aminoadipic acid α-amino-n-butyric acid (α-anb) γ-aminobutyric acid (GABA) μmol/l Functional Categories <= <= <= 1.5 Cystathionine 0.3 <= 0.3 Arginine Taurine α-aminoadipic acid <= Phenylalanine Tyrosine Tryptophan Glutamic Acid Taurine Methionine Cystathionine 0.3 <= Homocystine 0.6 <= Cystine Taurine C0490
3 Page 3 Amino Acids 40 Profile - Plasma Methodology: High Performance Liquid Chromotography s: Ages 13 and over. Urea Cycle and Ammonia Detoxification Glycine, Serine and Related Amino Acids Collagen - Related Amino Acids μmol/l Functional Categories Arginine Citrulline Ornithine Glutamine Asparagine Aspartic Acid Alanine Glycine Sarcosine 5.0 <= Serine Phosphoserine 0.5 <= Ethanolamine 5.0 <= Phosphoethanolamine 5.0 <= Proline Hydroxyproline 5 <= Lysine Hydroxylysine 0.6 <= 0.6 C0490
4 Page 4 Amino Acids 40 Profile - Plasma Methodology: High Performance Liquid Chromotography s: Ages 13 and over. β -Amino Acids and Derivatives β-alanine DNA (Thymine) Degradation μmol/l Functional Categories <= Histidine Carnosine 5.0 <= Methylhistidine 5.0 <= Anserine 10 <= β-aminoisobutyric Acid <= 3.2 Muscle-Specific Amino Acids Methylhistidine 5 <= 52 Ratios Phenylalanine/Tyrosine 1.00 <= Glutamic Acid/Glutamine Hydroxyproline/Proline <= α-anb/leucine 0.04 <= Tryptophan/LNAA* *Large neutral amino acids (Leu+Ile+Val+Phe+Tyr) NR = Not Reportable C0490
5 Page 5 Methodology: Enzymatic Assay s: Ages 13 and over. Homocysteine Assay - Plasma Homocysteine nmol/ml Nutrient & Toxic Elements Profile - Blood Methodology: Inductively Coupled Plasma/Mass Spectrometry Erythrocytes (packed cells) Plasma Nutrient Elements 2,672 Potassium 2,985 2,303-3,374 ppm 44 Magnesium ppm 44 Calcium* ppm 815 Zinc 1, ,594 ppb 929 Copper 1, ,920 ppb Whole Blood Selenium ppm Whole Blood Toxic Elements Aluminum 10 <= 113 ppb 5.1 Arsenic 10.0 <= 10.0 ppb 0.60 Cadmium 1.00 <= 1.10 ppb 18 Lead 10 <= 29 ppb 4.3 Mercury 5.0 <= 9.8 ppb 45 *Relevant to membrane permeability, not nutritional status. for whole blood toxic elements that are within normal limits do not rule out metal accumulation in other tissues. NR = Not Reportable C0490
6 Page 6 Methodology: High Performance Liquid Chromotography s: Ages 13 and over. Coenzyme Q10 Plus Vitamins Profile - Serum Coenzyme Q alpha-tocopherol gamma-tocopherol Vitamin A (Retinol) β-carotene mg/l Methodology: High Performance Liquid Chromotography nmol/ml Lipid Peroxides Assay - Serum Lipid Peroxides 1.00 <= Methodology: LC/Tandem Mass Spectrometry, Colorimetric s: Ages 13 and over. ng/mg creatinine 7. DNA/Oxidative Stress Marker (8-OHdG) Assay - Urine 8-Hydroxy-2-deoxyguanosine 1.4 <= Vitamin D Profile - Serum Methodology: Chemiluminescent Reference ng/ml Hydroxyvitamin D ng/ml Deficiency: Insufficiency: Sufficient: Recommended: Excessive: <20 ng/ml ng/ml ng/ml ng/ml >100 ng/ml There is no consensus in the literature regarding optimal levels of 25-Hydroxyvitamin D. Higher levels of 25-Hydroxyvitamin D may be concerning in some patient populations, such as renal failure. Levels below 30 ng/ml are considered insufficient by most medical associations.treatment is at the discretion of the treating clinician. Holick MF, et al. J Clin Endocrinol Metab. 2011;96(7): Vitamin D Council: <DL = less than detection limit NR = Not Reportable 25-Hydroxyvitamin D testing performed by Genova Diagnostics, Inc. 63 Zillicoa St., Asheville, NC A. L. Peace-Brewer, PhD, D(ABMLI), Lab Director - CLIA Lic. #34D Medicare Lic. # C0490.7
7 Page 7 Fatty Acids Profile - Plasma Methodology: Capillary Gas Chromatography/Mass Spectrometry s: Ages 13 and over μmol/l Polyunsaturated Omega-3 20 Alpha Linolenic (18:3n3) Eicosapentaenoic (20:5n3) Docosapentaenoic (22:5n3) Docosahexaenoic (22:6n3) Polyunsaturated Omega ,669 Linoleic (18:2n6) 1, , Gamma Linolenic (18:3n6) Eicosadienoic (20:2n6) Dihomogamma Linolenic (20:3n6) Arachidonic (20:4n6) Docosadienoic (22:2n6) 1.0 <= Docosatetraenoic (22:4n6) Polyunsaturated Omega Mead (20:3n9) 7.0 <= 8.3 Monounsaturated Myristoleic (14:1n5) Palmitoleic (16:1n7) Vaccenic (18:1n7) ,182 Oleic (18:1n9) 1, , Eicosenoic (20:1n9) Nervonic (24:1n9) C0490.9
8 Page 8 Fatty Acids Profile - Plasma Methodology: Capillary Gas ChromatographyMass Spectrometry s: Ages 13 and over μmol/l Saturated Capric (10:0) Lauric (12:0) Myristic (14:0) ,794 Palmitic (16:0) , Stearic (18:0) Arachidic (20:0) Behenic (22:0) Lignoceric (24:0) Hexacosanoic (26:0) 0.30 <= 0.43 Odd Chain 14.5 Pentadecanoic (15:0) 15.0 <= Heptadecanoic (17:0) 20.0 <= Nonadecanoic (19:0) 1.00 <= Heneicosanoic (21:0) 0.50 <= Tricosanoic (23:0) 0.50 <= Trans 0.4 Palmitelaidic (16:1n7t) 1.0 <= Total C:18 Trans 50 <= 59 Ratios LA/DGLA EPA/DGLA AA/EPA Triene/Tetraene <= NR = Not Reportable C
9 Page 9 Organix Comprehensive Profile - Urine Methodology: LC/Tandem Mass Spectrometry, Colorimetric This report is not intended for the diagnosis of neonatal inborn errors of metabolism. s: Ages 13 and over Fatty Acid Metabolism (Carnitine & B2) Nutrient Markers Adipate 2.9 <= 11.1 Suberate 0.6 <= 4.6 Ethylmalonate 2.9 <= 6.3 Carbohydrate Metabolism (B1, B3, Cr, Lipoic Acid, CoQ10) Pyruvate 2.9 <= 6.4 L-Lactate <DL L Energy Production (Citric Acid Cycle) (B comp., CoQ10, Amino Acids, Mg) Citrate Cis-Aconitate 10 L Isocitrate 29 L Succinate 2.9 <= 20.9 Fumarate 0.57 <= 1.35 Malate 0.6 <= 3.1 Hydroxymethylglutarate 0.6 <= 5.1 B-Complex Vitamin Markers (B1, B2, B3, B5, B6, Biotin) β-hydroxybutyrate α-ketoglutarate α-ketoisovalerate α-ketoisocaproate α-keto-β-methylvalerate mcg/mg creatinine <= <= <= 1.10 Xanthurenate 0.23 <= β-hydroxyisovalerate 0.2 <= <= <= C
10 Page 10 Organix Comprehensive Profile - Urine Methodology: LC/Tandem Mass Spectrometry, Colorimetric This report is not intended for the diagnosis of neonatal inborn errors of metabolism. s: Ages 13 and over Methylation Cofactor Markers (B12, Folate) Neurotransmitter Metabolism Markers (Tyrosine, Tryptophan, B6, Antioxidants) Cell Regulation Markers Vanilmandelate Homovanillate Hydroxyindoleacetate Kynurenate 0.6 <= 1.5 Quinolinate 2.9 <= 5.8 Picolinate Oxidative Damage and Antioxidant Markers (Vitamin C and Other Antioxidants) mcg/mg creatinine p-hydroxyphenyllactate 0.04 <= Hydroxy-2-deoxyguanosine 1.4 <= 7.6 (Units for 8-hydroxy-2-dexoyguanosine are ng/mg creatinine) Nutrient Markers Methylmalonate 0.6 <= 2.3 Formiminoglutamate 0.1 <= Detoxification Indicators (Arg, NAC, Met, Mg, Antioxidants) Toxicants and Detoxification 2-Methylhippurate <= Orotate 0.57 <= 1.01 Glucarate 0.6 <= 10.7 α-hydroxybutyrate 0.3 <= Pyroglutamate 21 L Sulfate 10 L 690-2, ,347 C
11 Organix Comprehensive Profile - Urine Methodology: LC/Tandem Mass Spectrometry, Colorimetric This report is not intended for the diagnosis of neonatal inborn errors of metabolism. s: Ages 13 and over mcg/mg creatinine Page 11 Compounds of Bacterial or Yeast/Fungal Origin Bacterial - General Benzoate 0.6 <= Hippurate 3 <= 1,070 Phenylacetate 0.06 <= 0.18 Phenylpropionate 0.03 <= 0.06 p-hydroxybenzoate 0.6 <= 1.8 p-hydroxyphenylacetate 1 <= 34 Indican 3 <= Tricarballylate 0.57 <= 1.41 L. acidophilus / General Bacterial 44. D-Lactate <DL <= 4.1 Clostridial Species ,4-Dihydroxyphenylpropionate <DL <= 0.05 Yeast / Fungal 46. D-Arabinitol <DL <= Creatinine = 175 mg/dl <DL = less than detection limit >UL = greater than upper linearity limit NR = Not Reportable C
12 Page 12 Commentary The Diasorin Liaison 25-Hydroxyvitamin D Total Assay is certified by the CDC Vitamin D Standardization-Certification Program (CDC VDSCP). The performance characteristics of all assays have been verified by Genova Diagnostics, Inc. Unless otherwise noted with, the assay has not been cleared by the U.S. Food and Drug Administration. COVAT
13 Page ION Profile with Amino Acids 40 - Blood/Urine Arginine Coenzyme Q10 8-OHdG* Homocysteine alpha-tocopherol AA/EPA ION Analyte Pattern Analysis A multi-analyte report can provide greater insight about health risks and special nutrient needs. Patterns of abnormalities can reinforce the degree of significance indicated by a single measurement. Analytes from the various profiles in the ION report are combined below into categories associated with clinical/metabolic conditions. The categories included cover the most common areas of concern relevant to these profiles. Above each thermometer are listed the or appears when the patient result is outside the fourth quintile of the analytes used to calculate the degree of significance. An population. The thermometer advances to the right as the number and severity of relevant abnormalities increases. The longer the filled bar, the greater the degree of significance or likelihood that a health threat may exist in that category. The preceeding laboratory results provide the detail upon which these thermometers are based. Cardiovascular System Calcium gamma-tocopherol Magnesium Lipid Peroxides Fatigue Isoleucine Magnesium α-ketoglutarate Leucine Coenzyme Q10 Succinate Phenylalanine Adipate Malate Valine Suberate Xanthurenate Methylmalonate Formiminoglutamate Metabolic Syndrome (Syndrome X) Magnesium β-hydroxybutyrate Palmitic (16:0) β-hydroxyisovalerate Stearic (18:0) α-hydroxybutyrate *8-OHdG = 8-Hydroxy-2-deoxyguanosine C
14 Page ION Profile with Amino Acids 40 - Blood/Urine Tryptophan Tyrosine Mental/Emotional Magnesium Eicosapentanoic Docosahexaenoic Vanilmandelate Xanthurenate 5-Hydroxyindoleacetate Methylmalonate Formiminoglutamate Intestinal/Bacterial Metabolites Phenylacetate Phenylpropionate p-hydroxybenzoate p-hydroxyphenylacetate Indican Tricarballylate D-Lactate 3,4-DHPP* Intestinal Yeasts/FungalMetabolites D-Arabinitol Digestion/Absorption Arginine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Threonine Tryptophan Valine Selenium *3,4-DHPP = 3,4-Dihydroxyphenylpropionate C
15 Page ION Profile with Amino Acids 40 - Blood/Urine Aluminum Mercury Cis-Aconitate Orotate Arsenic Palmitelaidic (16:1n7t) Isocitrate Glucarate Toxic Exposure Cadmium Total C:18 Trans Lead Citrate Quinolinate 2-Methylhippurate Detoxification Impairment Methionine Glutamine Glycine Pyroglutamate Serine Sulfate Taurine Benzoate Taurine alpha-tocopherol Lipid Peroxides Oxidative Stress/Antioxidant Insufficiency Selenium Lead Mercury gamma-tocopherol Vitamin A (Retinol) β-carotene 8-OHdG* p-hydroxyphenyllactate Sulfate Magnesium Ethylmalonate Mitochondrial Functional Impairment Coenzyme Q10 Adipate Pyruvate L-Lactate Suberate α-hydroxybutyrate β-hydroxybutyrate Succinate Fumarate Malate *8-OHdG = 8-Hydroxy-2-deoxyguanosine C
16 Page ION Profile with Amino Acids 40 - Blood/Urine Amino Acid Insufficiency Arginine Histidine Isoleucine Leucine Lysine Tryptophan Methionine Valine Phenylalanine Sulfate Threonine Essential Fatty Acid Insufficiency Arachidonic Alpha Linoleic Eicosapentaenoic Docosahexaenoic Linoleic Gamma Linolenic Dihomogamma Linolenic Palmitoleic Triene/Tetraene Homocysteine Tricosanoic Kynurenate Disordered Methyl Group (Single Carbon) Transfer Pentadecanoic Heptadecanoic Nonadecanoic Xanthurenate Methylmalonate Formiminoglutamate Tryptophan Quinolinate Disordered Tryptophan Metabolism Xanthurenate 5-Hydroxyindoleacetate Indican Kynurenate C
17 Page ION Profile with Amino Acids 40 - Blood/Urine Additional Considerations This page is provided as a starting point that may guide decisions about medical treatment based on the test results. It is derived only from the laboratory results included in this report. Final recommendations should be based on consideration of the patient's medical history and current clinical condition. Nutrient Vitamin D N-Acetylcysteine Nutrient Need Moderate Low Various conditionally essential nurients and other potentially beneficial interventions appear in this section only if relevant abnormalities are present. C
18 Page ION Profile with Amino Acids 40 - Blood/Urine General Supplement s These supplement ranges are not adjusted for age, sex, or gender. Nutrient supplementation is at the discretion of the treating clinician. The supplement dose ranges provided below are meant for educational purposes only. These dosage ranges relate to findings commonly found on Genova's nutritional panels and do not apply to specific disease conditions where different dosages may be warranted. Nutrient Vitamin A Vitamin C Vitamin D Vitamin E (mixed tocopherols) Vitamin B-1 (Thiamin) Vitamin B-2 (Riboflavin) Vitamin B-3 (Niacin) Vitamin B-5 (Pantothenic Acid) Vitamin B-6 (Pyridoxine) Vitamin B-12 (Cobalamin) Folic Acid Biotin Magnesium Zinc Selenium Omega-3 Carnitine Coenzyme Q10 Lipoic Acid N-Acetylcysteine L-Arginine Glycine L-Glutamine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine Taurine L-Tyrosine L-Threonine L-Tryptophan L-Valine Adult Dosage * IU mg IU IU 0-50 mg 0-50 mg 0-50 mg mg 0-50 mg mcg mcg mcg mg 0-25 mg mcg 0-3 gms mg mg mg mg mg mg mg mg mg mg mg mg mg mg mg mg mg 1 *Dosage ranges are adapted from the textbook Nutritional Medicine by Alan Gaby, M.D. 1. Gaby AR. Nutritional Medicine. Vol 265: Fritz Perlberg Publishing; C
Essential Amino Acids
3425 Corporate Way Duluth, GA 30096 Patient: SAMPLE PATIENT DOB: Sex: MRN: 3100 ION Profile - Blood / Urine Amino Acids 20 Profile - Plasma Methodology: High Performance Liquid Chromatography s: Ages 13
0490 ION with Amino Acids 40 Profile
Accession Number: Order Number: Number: Patient: Age: Sex: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: 0490 ION with Amino Acids 40 Profile Amino Acids 40 Profile -
0091 Organix Comprehensive Profile - Urine
3425 Corporate Way Duluth GA 30096 USA 770.446.5483 Fax: 770.441.2237 www.gdx.net/www.metametrix.com Ordering Physician: Accession #: Reference #: Patient: Date of Birth: Age: Sex: Reprinted: 07/04/2001
0091 Organix Comprehensive Profile - Urine
Accession #: Order #: Reference #: Patient: Date of Birth: Age: Sex: Date Collected: Date Received: Telephone: Fax: Organix Interpretation Organix Interpretive Guide is downloadable at: www.metametrix.com/files/test-menu/interpretive-guides/organix-ig.pdf
0490 ION with Amino Acids 40 Profile
Metametrix 1234 Main St. Anywhere, GA 30096 Accession Number: Order Number: G1234567 Number: Patient: Age: 51 Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: Sex: 4/3/13 Date Received:
0490 ION with Amino Acids 40 Profile
Accession Number: Order Number: Number: Patient: Age: Sex: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: 0490 ION with Amino Acids 40 Profile Amino Acids 40 Profile -
0091 Organix Comprehensive Profile Summary of abnormal results:
Ordering Physician: 255252-279741 Via Borin 48 31100 Treviso Number: Age: 43 Sex: F Date of Birth: 03/01/1964 Date Collected: 12/12/07 Date Received: 12/17/07 Telephone: Fax: Summary of abnormal results:
0291 Organix Basic Profile - Urine
Accession #: Order #: Reference #: Patient: G1234567 Date Collected: Date Received: Date of Report: 04/03/2012 Date of Birth: 02/05/1962 Telephone: 7704464583 Ordering Physician: Age: Sex: 50 Female Fax:
0290 Cardio/ION Profile
Accession Number: Order Number: Reference Number: Patient: Age: Sex: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: 0290 Cardio/ION Profile Date Reported: Cardiovascular
0410 Triad Bloodspot Profile
Accession Number: Order Number: Reference Number: Patient: Age: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: 0410 Triad Bloodspot Profile This report contains the following:
Target. Effective Tools. for complex chronic illnesses. personalized patient recommendations
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0290 Cardio/ION Profile
3425 Corporate Way Duluth GA 30096 USA 770.446.5483 Fax: 770.441.2237 www.gdx.net/www.metametrix.com Accession Number: Number: Patient: Age: Date of Birth: Date Collected: Report Date: Telephone: Fax:
0291 Organix Basic Profile Summary of abnormal results:
Ordering Physician: 250200-274226 Reference Number: Age: 57 Sex: F Date of Birth: 12/25/1949 Date Collected: 11/18/07 Date Received: 11/18/07 Report Date: Telephone: Fax: Reprinted: 12/5/07 7704465483
4146 Women's Health Profile
Ordering Physician: Metametrix 1234 Main St. Anywhere, GA 30096 Reference Number: Age: 50 Sex: Female Date of Birth: 02/05/1962 Date Collected: 6/12/12 Date Received: 6/13/12 Report Date: Telephone: Fax:
0010 Amino Acids 40 Profile - Plasma
Accession #: Order #: G1234567 Date Collected: Date Received: 01/22/2013 Reference #: Patient: Date of Birth: 02/05/1962 Date of Report: Telephone: 7704464583 Ordering Physician: 1234 Main St. Anywhere,
4315 NY Designs for Health Metabolic Profile
Ordering Physician: Metametrix Staff & Family 3425 Corporate Way Duluth, NY 30096 Accession Number:A0909030008 Reference Number: Age: 47 Sex: Female Date of Birth: 02/05/1962 Date Collected: 9/2/09 Date
4320 Designs for Health Metabolic Profile plus FA
Ordering Physician: Metametrix 3425 Corporate Way Duluth, GA 30096 Accession Number:A0909030010 Reference Number: Age: 47 Sex: Female Date of Birth: 02/05/1962 Date Collected: 9/2/09 Date Received: 9/3/09
0400 Triad Profile. Accession Number: Order Number: Reference Number: Patient: Age:
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0010 Amino Acid Analysis - 40 Plasma
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