Exciting, health-promoting products from wood, bark and knots

Transcription

1 Exciting, health-promoting products from wood, bark and knots Bjarne Holmbom Åbo Akademi Process Chemistry Centre Turku/Åbo, Finland 15. Münchener Holzkolloquium

2 Sustainable material society Based on renewable resources: Biomass, not oil or coal Biodegradable, recyclable materials Gradual transformation from Petro to Bio- - - Forest resources are our hope 2

3 Forest Biorefineries Bioenergy Biofuels Wood Products Pulp and Paper High-value biomaterials and biochemicals Printing Packaging Tissue Chemical markets Food and Feed Health

4 Trees are plants --- very special ones Grow big Live long Bioactive defense chemicals Oleoresin Polyphenols High concentrations in bark, knots and heartwood 4

5 Health-promoting forest products Forest industries Pulp & Paper Wood prod. Berries Mushrooms Birch bark tar Wood tar Salicin (Aspirin) Resin chewing gum Wound-healing resin Taxol from yew (Taxus) bark Xylitol Sitosterol Bark Knots Lignans Flavonoids Stilbenes

6 Already during the Stone Age 3 cm Board of Antiquities Eastern Finland 7000 B.C. GC - MS Manufactured from birch outer bark Birch bark tar The first technochemical product (?) The first chewing gum Actually already the Neandertals years ago 6

7 Wood tar the most important product from Finland from the 16th to the 19th century For protection of wood products (ships and buildings), and health

8 "Jos ei sauna, terva ja viina auta, niin tauti on kuolemaksi." If sauna, tar and vodka do not cure your disease, then you will die But no use of tar in modern medicine

9 Forest industry by-products Tall Oil Turpentine Xylitol Sitosterol Chips Chem. pulping Chem.pulp Paper & Board

10 Xylitol Natural sweetener with a cool taste Inhibits tooth decay (Univ. of Turku 1970s) Also inhibits ear infections in children Production in Kotka, Finland since 1975 World production now more than 50,000 ton/a

11 HO Sitosterol H O Sitostanol Blood and heart HO Cholesterol

12 Today many sitosterol products Raisio Group Unilever: Becel pro-active Teriaka: Diminicol and other --- Raisio Group

13 1998 A crooked spruce tree was cut down A knot was sawn out

14 Knot Analysis: the knot contained 10% of lignans! The start for extensive research on knots

15 Lignans in Picea abies % 6-29% 0.1 % 0.0 % Stefan Willför PhD Thesis % of the lignans MeO O O HO HO OH OMe Hydroxymatairesinol (HMR)

16 Willför et al., 2003 a Knot in stem Outer branch Lignans, mg/g cm Upper w Compr. w cm

17 Much higher concentrations of lignans in the north Piispanen et al.,

18 The Norway spruce lignan Hydroxymatairesinol (HMR) Strong antioxidant Inhibits breast cancer growth (Univ. of Turku) Hormos Medical Corp., Turku, product development Clinical test on humans: no adverse effects New dietary ingredient clearance from US FDA 2004 License Hormos Linnea AS in 2005 Production of knots HMRlignan TM on the market in 2006 MeO HO HO OH O O OMe 14

19 The ChipSep process Eckerman - Holmbom patent Pulping Re-chipped over-thick chips Chip dryer Normal wood Sep. tank Warm air Knots to extraction

20 Farm production of knots Over-thick spruce chips from paper mill in Northern Finland 20

21 Recent research has shown that lignans have a positive influence on the development of breast, prostate and colon cancer Lignans also help to maintain good cardiovascular health and to moderate other oestrogen-dependent health problems such as menopause symptoms and osteoporosis

22 Nutritional supplements 22

23 Novel products containing spruce knot extract LUMENE 3-action Day Treatment / Night Recovery NATURAL With Arctic Beauty Blend Spruce knot extract Strong antioxidant that protects the skin against external factors causing ageing of the skin Tar shampoo Balances and pacifies the hair bottoms and decreases dandruff formation 23

24 Traditional chewing gum and wound healing salve from spruce resin Spruce resin Überwallungsharz has been chewed by people in the boreal region since ancient times Probably a positive effect on oral health Same resin used traditionally also for wound healing, mixed into butter

25 resin salve Manufactured from pure spruce resin collected in Lapland. Mixed into a fat-based salve, 10% resin. Pressure ulcers Burns Wound infections Surgical wounds Psoriasis Nail fungus Approved by the National Agency for Medicines in Finland Since 2008 sold in Finnish pharmacies 25

26 Lignans p-coumaric acid Pinoresinol Secoisolariciresinol Picea abies Callus resin Lignan esters Resin acids Oleoresin Holmbom, T. et al. Holzforschung 2008 Resin acids

27 Paclitaxel (Taxol ) A chemotherapy drug for treatment of ovarian, breast and lung cancer An alkaloid extracted from the bark and needles of yew trees, Taxus species Since 1995, now sold for over one billion USD per year

28 Extract from the bark of the maritime pine tree growing in southwest France A natural combination of procyanidins, bioflavonoids and organic acids. A powerful antioxidant A natural anti-inflammatory agent

29 5-10 % stilbenes in spruce bark OH OH OH HO HO OH HO OMe OH OH OH Resveratrol Also in red wine Piceatannol Me-Piceatannol Resveratrol can extend the life-span of yeasts, banana flies, mice, etc. Humans too?

30 Health-promoting compounds from forests Xylitol Sitosterol Pulping Papermaking Paper Board Knots Bark Lignans Flavonoids Stilbenes Stilbenes Tannins Taxol Pycnogenol Dietary supplements Health-prom. foods Cosmetics Pharmaceuticals

31 Forests a rich source of Health-promoting substances Even in our boreal and temperate forests in addition to various other sustainable, natural materials

32 We are just in the beginning of a new bio-based era where forests and wood science will play a key role