Open fracture repair: wound infection, implant selection and evaluation of prognosis doi: /j.issn

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1 Chinese Journal of Tissue Engineering Research June 25, 2015 Vol.19, No.26 ( ) 1 2 3D PubMed Open fractureevaluation and prognosis of injuryantibioticsdebirdement Treatment of fracturewound repair D /PEEK :R318 :A : (2015) [J] (26): doi: /j.issn Open fracture repair: wound infection, implant selection and evaluation of prognosis Ma Xiang-yu, Wang Dong (the Second Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China) Abstract BACKGROUND: Open fractures often present soft-tissue defects, high-risk infection, and fracture with bone defect, often lead to more postoperative complication, defect of limb function, and bring great difficulties to clinical treatment. There is some controversy in the treatment of such fracture. Relevant animal experiment and clinical study become the hotspot in recent years. OBJECTIVE: To review some controversy about open fracture treatment and latest research. METHODS: A computer-based online search of China National Knowledge Infrastructure database and PubMed was performed for articles published from January 2005 to January Key words included Open fracture, Evaluation and prognosis of injury, Antibiotics, Debirdement, Treatment of fracture, Wound repair. More than 100 literatures were retrieved, and 47 articles met the inclusion criteria. RESULTS AND CONCLUSION: After a large number of animal experiments and clinical application, open fracture debridement, prevention of infection, implant selection and evaluation of prognosis had been deeply studied, especially the study of implant treatment of bone defects. Metal three-dimensional printer has changed the traditional concept of implant. Nano titanium dioxide /PEEK bioactive composite materials have become a hot research in recent years. Subject headings: Fractures, Open; Prostheses and Implants; Debridement Ma Xiang-yu, Studying for master s degree, the Second Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China Corresponding author: Wang Dong, M.D., Chief physician, Doctoral supervisor, the Second Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China Accepted: P.O. Box 10002, Shenyang

2 . Ma XY, Wang D. Open fracture repair: wound infection, implant selection and evaluation of prognosis. Zhongguo Zuzhi Gongcheng Yanjiu. 2015;19(26): Introduction [1] 1Data and methods PubMed ( gov/pubmed)( Open fracture Evaluation and prognosis of injury Antibiotics DebirdementTreatment of fracturewound repair [1-7] [8-24] [25-30] [31-39] [40-47] (1) PubMed [1-7] [8-24] [25-30] [31-39] [40-47] 1 2Results GustiloAnderson1976 Gustilo 3 < 1 cm > 1 cm 3A BA C ISSN CN /R CODEN: ZLKHAH 4259

3 . 3 < 3 cm 315 cm 15 cm [2] Gustilo [3-4] % 2%5%A5%10%B1050% C25%50%Bowen [5] 3 31% [6] Rajasekaran [7] GangaMESS JBJS % [8] Zalavras [9] 8% 7%25% Nanchahal [10] 4260 [11] [12] Baliga [13] 3 d 3 d 1 d 1 d5 d Fletcher [14] 3 h 4.7%3 h7.4%collinge [15] 1 h AO Gustilo 12 1 d3 5 d 3 [16] Okike [17] 8 h1 g 24 h [18] Ostermann [19] % 3.7%Murray [20] (PMMA) [21] AB 2011(Expert Tibial Nail PROtect) P.O. Box 10002, Shenyang

4 . [22-23] Penn-Barwell [24] h 6 h Kindsfater [25] 5 h 7%5 h38% 6 h [26] 6 hal-arabi [27] h7.8%9.6% Weber [28] 736 [29] 3 LAnglen [30] Gustilo [3-4] 1 (3 L)2(6 L)3(9 L) 2.4 ( ) Keating [31] [32] Esan [33] 514 d [34] Alsan [35] (15 d) 2 6Gustilo [3-4] ISSN CN /R CODEN: ZLKHAH 4261

5 . 36X 12 3D(Additive Manufacturing) (23) D 3 3D [36] /PEEK 21 PEEK [37] Mason [38] 3 3 [39] 2 3D 3 3D Llizarov Garg [40] 18 [41] Franken [42] B Rajasekaran [43] 12 h (4) [44] [45] [46] Alet [47] 4262 P.O. Box 10002, Shenyang

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