Target audience. Jorge Correale Department of Neurology Raúl Carrea Institute for Neurological Research (FLENI) Buenos Aires, Argentina

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1 EXCEMED Blended Education Immune and clinical profiling in multiple sclerosis: laying groundwork for advanced approaches to treatment Live intervention in PRELIMINARY PROGRAMME

2 Immune and clinical profiling in multiple sclerosis: laying groundwork for advanced approaches to treatment Overview Over the past year, steps have been taken to understand the immunopathogenic mechanisms underlying multiple sclerosis (MS), leading to the discovery of new treatment targets and the development of innovative treatments. Today, there is an extensive therapeutic armamentarium for those with the relapsing remitting form of the disease and new treatment options are also available for progressive MS. Early and accurate diagnosis is crucial in order to prevent disability, but it is still unclear how to select the right treatment for each patient and which is the safest and more effective sequence of therapies. New risks, in fact, have emerged making treatment choices challenging. Complex patients require a comprehensive management programme addressing and managing comorbidities and preventing treatment risks. An EXCEMED Learning Journey EXCEMED offers to learners a complete blended Learning Journey to strengthen knowledge in the main immunological, clinical and therapeutic dynamics characterizing modern MS. We address competence in everyday management of patients as well as confidence in decision making. A multistep approach will be used, encompassing web-based and live activities; all activities in person and online will involve the full interactivity of learners. Educational content will be delivered by international and local speakers with extensive expertise in the MS field. Learning objectives By attending this programme, you will be able to: Interpret genetic, immunological and clinical elements featuring individual multiple sclerosis profile Quantify treatment risks and benefits in different clinical conditions (i.e. pregnancy, comorbidities, paediatric and elderly patients) Specify the unmet needs of patients and doctors in terms of treatment management and quality of life Target audience This programme is designed for neurologists involved in MS management from the Latin American region. Chairs Jorge Correale Raúl Carrea Institute for Neurological Research (FLENI) Edgardo Cristiano Italian Hospital of Buenos Aires 2 3

3 CME Provider EXCEMED is a non profit foundation dedicated, since the last four decades, to the development of highquality medical education programmes all over the world. EXCEMED adheres to the guidelines and standards of the European Accreditation Council for Continuing Medical Education (EACCME ) which states that continuing medical education must be balanced, independent, objective and scientifically rigorous. EXCEMED - Excellence in Medical Education Senior Programme Manager: Alessia Addessi T F alessia.addessi@excemed.org Medical Advisor: Doriana Landi doriana.landi@gmail.com EXCEMED adheres to the principles of the Good CME Practice group (gcmep). Register now and receive the EXCEMED invitation to start your Learning Journey! VIDEO LECTURE The first exclusive tutorial is a video lecture with Prof. C. Navas (Colombia) that discusses the patientdoctor relationship and highlights past and future unmet needs in MS. Learning objectives: Contemplate past and future unmet needs of MS patients Consider future unmet needs of MS neurologists Understand expectations and challenges of old and new treatments INTERACTIVE LIBRARY The second exclusive tutorial helps illuminate the content of the upcoming live intervention with the help of the Interactive Library. Get the head start you need to be fully engaged during the in-person learning. Take the opportunity to share your research and publications with the rest of the community using the Library Platform, and submit questions directly to faculty ahead of the live intervention; your question will be addressed by faculty during the live Q&A sessions. Features of the Interactive Library: Literature corner: summarises the key points and related publications for each of the lectures being presented during the live intervention in Buenos Aires Publication exchange: a space for learners to share their research and publications related to the Learning Journey Question time: a chance for leaners to submit a question for the faculty to answer during the live intervention 4 5

4 The live component of the Learning Journey is a combination of frontal lectures followed by Q&A slots, interactive case studies and parallel working groups. LEARNING OBJECTIVES By attending this live educational workshop you will be able to: Recognize the emerging immunological targets for MS treatments Illustrate new diagnostic criteria for MS Quantify risks of new MS treatments Adapt treatment strategies to common challenging clinical conditions Venue This live educational workshop will take place at the: Melià Buenos Aires hotel Reconquista 945, C1003ABS CABA Language The official language of the live intervention will be English. Simultaneous translation from and to Spanish will be provided. Continuing medical education An application has been made to the EACCME for CME accreditation of the EXCEMED workshop Immune and clinical profiling in multiple sclerosis: laying groundwork for advanced approaches to treatment to be held on in. INVITED FACULTY Ethel Ciampi Pontifical Catholic University of Chile Santiago, Chile Jorge Correale Raúl Carrea Institute for Neurological Research (FLENI) Edgardo Cristiano Italian Hospital of Buenos Aires Josè Flores Rivera Universidad Nacional Autónoma de México (UNAM) Mexico City, Mexico Xavier Montalban Multiple Sclerosis Centre of Catalonia (Cemcat) Neurology-Neuroimmunology Department Vall d Hebron University Hospital Barcelona, Spain Department of Medicine Division of Neurology St. Michael's Hospital Toronto, Canada Liliana Patrucco Italian Hospital of Buenos Aires Juan Ignacio Rojas Italian Hospital of Buenos Aires Heinz Wiendl Institute of Translational Neurology University Hospital Muenster Muenster, Germany 6 7

5 PROGRAMME Thursday, Opening and introduction E. Cristiano (Argentina) Session I Immunological dynamics in MS Session III Treatment dynamics in MS L1: Rewriting MS immunology J. Correale (Argentina) L2: Evolving treatment targets and mechanisms of action Speaker to be announced L3: Immune reconstitution therapies: implications for efficacy H. Wiendl (Germany) Q&A Coffee break L8: Revising induction and escalation strategies in the current treatment scenario X. Montalban (Canada and Spain) L9: Sequencing of disease-modifying therapies: efficacy versus risks and wash- out H. Wiendl (Germany) L10: Treatment monitoring and emerging risks of new treatments E. Ciampi (Chile) Q&A Coffee break Session II Clinical dynamics in MS Session IV Conversations on clinical cases L4: Multiple Sclerosis in Latin America: epidemiology and clinical severity E. Cristiano (Argentina) L5: New diagnostic criteria: changes in practice J. Flores Rivera (Mexico) L6: Consolidated and promising biomarkers of disease prognosis X. Montalban (Canada and Spain) L7: Progressive MS: from immunopathology to clinical features Speaker to be announced Q&A Lunch Legend: L : Lecture : Question & answer : Working group : Wrap up The session includes parallel working groups, each lasting one hour. Participants will be divided into groups and will attend both in rotation. Pregnancy and lactancy in MS: what to do? L. Patrucco (Argentina) The patient with MS and comorbidities: who comes first in treatment decision making? J.I. Rojas (Argentina) Black to plenary Take home messages from the working groups J. Correale (Argentina) Wrap up J. Correale (Argentina) End of the workshop 8 9

6 Continue your Learning Journey after the live intervention! Online tutorials following the live intervention will help you delve deeper into content and put the key messages of this Learning Journey into clinical context. EXPERT PERSPECTIVE The first in-depth tutorial is a video presentation by Prof. J. Correale (Argentina) entitled Immunosenescence and MS: clinical and therapeutical issues. Learning objectives: Clarify the immunological changes associated with healthy ageing Analyze the relationship between immunoesenescence and clinical features in aged MS patients Discuss the increased risks of treatment in aged MS patients VIDEO LECTURE Prof. B. Banwell (Canada) discusses biological and MRI studies in pediatric MS in the final video tutorial which is supported by a graphic scribing technique. Learning objectives: Analyze the peculiar immunological, clinical and radiological features of pediatric MS Illustrate key elements useful for differential diagnosis Demonstrate an approach to treatment Registration The registration fee for the whole blended programme is EUR 150,00 and includes: Access to the online tutorials Scientific sessions Coffee breaks and lunch Educational materials Certificate of attendance Dinner is not included For registration, accommodation and any logistic inquiry, please contact: Meridiano Congress International Event Manager: Concetta Di Palma T F concetta.dipalma@meridiano.it Visit Follow us on 10 11

12 All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted.

7 12 All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of EXCEMED. This independent programme is made possible thanks to educational grants received from: Merck KGaA Darmstadt Germany and San Raffaele Hospital Milan.

Improving the patient's life through medical

org EXCEMED - Excellence in Medical Education 14,

This live educational workshop is endorsed by MENACtrims (Middle East North Africa Committee for Treatment and Research in Multiple Sclerosis).

This live educational workshop is endorsed by MENACtrims (Middle East North Africa Committee for Treatment and Research in Multiple Sclerosis). EXCEMED Blended Education Back to the future: redefining the clinical course of multiple sclerosis Live intervention in Dubai, UAE - Pre-MENACTRIMS PRELIMINARY PROGRAMME Back to the future: redefining