MLABS DEPARTMENT OF PATHOLOGY ATTN: IMPORTANT TEST INFORMATION CPT UPDATES 2015 REVISED

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1 UPDATES 2015 REVISED NOTICE DATE: December 18, 2014 Please note that due to additional information obtained regarding industry recommendations concerning interpretation of the new code descriptions MLabs Updates 2015 has been revised with regard to Morphometric Analysis (FISH) s. Please disregard UPDATES 2015 sent on December 17, EFFECTIVE DATE: January 1, 2015 FLT3 AND IDH MUTATIONS Effective January 1, 2015, MLabs will begin billing for each mutation included in the FLT3 Mutation (ITD and TKD variants) and IDH1 and IDH2 Mutations assays as follows. There will be no change to the total client fee billed for these assays. FLT3 MUTATION 81245, G , 81246, G IDH1 AND IDH2 MUTATIONS 81403, G x2, G MORPHOMETRIC ANALYSIS (FISH) CODES Effective January 1, 2015, the AMA has revised the following Morphometric Analysis codes as noted: Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), manual, per specimen; initial single probe stain procedure Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), manual, per specimen; each additional single probe stain procedure Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), manual, per specimen; each multiplex probe stain procedure Note that the probe stain procedure is interpreted to refer to each specific test, not to the probe itself. Also the definition of multiplex is interpreted to refer to an ISH procedure consisting of two or more probes that result to a single conclusion. This change will result in the following revisions for billing of MLabs FISH assays. There will be no change to the total client fee billed for these tests. ALK (2P23) REARRANGE FISH TC x2, x TC, BCL6 (3Q27) REARRANGE FISH TC x2, x TC, BILIARY TRACT MALIGNANCY FISH TC x3, x TC, ERG REARRANGEMENT FISH TC x2, x TC, EWSR1 (22Q12) REARRANGE FISH TC x2, x TC, HER2 FISH TC x2, x TC, IGH/BCL2 TRANSLOCATION FISH TC x2, x TC, IGH/CCND1 TRANSLOCATION FISH TC x2, x TC, MALT1 (18Q21) REARRANGE FISH TC x2, x TC,

2 UPDATES 2015 REVISED MDM2 FISH TC x2, x TC, MYC (8Q24) REARRANGE FISH TC x2, x TC, RET (10Q11) REARRANGE FISH TC x2, x TC, ROS1 (6Q22) REARRANGE FISH TC x2, x TC, TFE3 REARRANGEMENT FISH TC x2, x TC, TFEB REARRANGEMENT FISH TC x2, x TC, UROVYSION FISH TC, NO CHANGE IMMUNOHISTOCHEMISTRY AND IN SITU HYBRIDIZATION STAIN PROCEDURES Effective January 1, 2015, the AMA has made revisions to immunohistochemistry and in situ hybridization stain codes as follows. In addition, G s G0461 and G0462 will be discontinued deleted Immunohistochemistry or immunocytochemistry, per specimen; initial single antibody stain procedure Immunohistochemistry or immunocytochemistry, per specimen; each additional single antibody stain procedure Immunohistochemistry or immunocytochemistry, per specimen; each multiplex antibody stain procedure In situ hybridization (eg, FISH), per specimen; initial single probe stain procedure In situ hybridization (eg, FISH), per specimen; each additional single probe stain procedure In situ hybridization (eg, FISH), per specimen; each multiplex probe stain procedure These changes will result in the following revisions for billing of MLabs stain procedures. There will be no change to the client fee billed for these tests. IMMUNOHISTOCHEM 1 ST STAIN (G0461) IMMUNOHISTOCHEM EA ADD STAIN RA (G0462) IMMUNOHISTOCHEM MULTIPLEX AB RA IN SITU TISSUE HYBRIDIZATION NO CHANGE IN SITU HYBRIDIZATION EA ADDL RA IN SITU HYBRIDIZATION MULTIPLEX RA MSH-1 IMMUNOSTAIN (MML MLH1B) NO CHANGE MSH-2 IMMUNOSTAIN (MML MSH2B) MSH-6 IMMUNOSTAIN (MML MSH6B) PMS-2 IMMUNOSTAIN (MML PMS2B) ADDITIONAL REVISIONS Please note the following additional revisions effective January 1, 2015: 6-ACETYLMORPHI GCMS QNT SO ACETAMINOPHEN ACTMN

3 UPDATES 2015 REVISED ACETAZOLAMIDE (DIAMOX) MMLR AMITRIPTYLINE AND NORTRIPTYLINE AMTRP AMOXAPINE (ASENDIN) SERUM AMOX AMPHETAMINE GCMS QNT AMPHU AMPHETAMINE GCMS QUAL MSAMP AMPHETAMINE SCREEN UR UAMP ANABOLIC STEROIDS ZW ANALGESICS NON-OPOID 1 OR 2 JA012 NA BARBITURATE GCMS QNT BARBU BARBITURATE GCMS QUAL MSBAR BARBITURATE SCREEN UR UBARB BENZODIAZEPINE GCMS QNT BENZU BENZODIAZEPINE GCMS QUAL MSBEN BENZODIAZEPINE SCREEN BLOOD KA001 SBENZ BENZODIAZEPINE SCREEN UR UBENZ BISMUTH MMLR BUPRENORPHINE URINE SCR UBUP BUPROPION SERUM FBUP BUTABARBITAL SERUM MMLR CANNABINOID GCMS QNT THCU CANNABINOID GCMS QUAL MSCAN CANNABINOID SCREEN UR UCAN CHLORDIAZEPOXIDE SERUM CDP CHLORPROMAZINE (THORAZINE) SO CLOMIPRAMINE CLOM CLONAZEPAM SERUM CLONZ COCAINE BLOOD MMLR COCAINE GCMS QNT COCU COCAINE GCMS QUAL MSCOC COCAINE SCREEN UR UCOC COTININE URINE (NICOTINE) UCOT DESIPRAMINE DESI DIAZEPAM & NORDIAZEPAM DIA DIHYDROTESTOSTERONE (DHT) DHTS DIURETICS SCREEN URINE MMLR DNA/RNA HPV HPVD DOXEPIN DXPN DRUG 10 SCREEN URINE SO DRUG SCREEN MECONIUM MECO DRUG SCREEN SERUM BLDSC DRUG SCRN MISC SUBSTANC DRUGQ DRUG SCRN PLASMA MML MMLR DRUG SCRN PRELIM UR PNL UDSIA G ETHANOL QUANT SERUM ETHAN ETHANOL QUANT URINE JA012 UETOH

4 UPDATES 2015 REVISED ETHCHLORVYNOL SERUM MMLR ETHYL GLUCURONIDE URINE ETGLU FELBAMATE SERUM FELB FENTANYL SERUM FENTS FENTANYL URINE MMLR FLUOXETINE (PROZAC) FLUOX FLUPHENAZINE (PROLIXIN) MMLR FLURAZEPAM FFLUR GAMMA HYDROXY BUTYRATE MMLR GOLD URINE OR SERUM MMLR HALCION MMLR HYPOGLYCEMIC AGENT SCRN HYPOG IBUPROFEN (ADVIL) MMLR IMIPRAMINE AND DESIPRAMINE IMPN MECO CONF AMPHETAMINE AMPCM MECO CONF CARBOXY THC THCCM MECO CONF COCAINE COCCM MECO CONF OPIATE OPICM MEPROBAMATE SERUM MMLR METHADONE SERUM MTDNS METHADONE & EDDP GCMS QNT SO METHADONE EDDP SCRN UR UMETM METHADONE GCMS QUAL UMETH METHSUXIMIDE SERUM MSX MORPHINE FREE GCMS QNT SO MSH2 GENE SEQUENCING DA070 MSH2S NICOTINE SERUM NICOS NICOTINE URINE NICOU NORTRIPTYLINE NORT OPIA GCMS QNT REFLX FRE SO OPIATE GCMS QNT OPTU OPIATE GCMS QUAL MSOPI OPIATE SCREEN UR UOP OXYCODONE SCREEN UR UOXYC OXYCODONE SER/PL SOXYC PAROXETINE PAXIL PCA PCA PENTOBARBITAL PENTO PHENCYCLIDINE SCREEN UR UPCP PHENELZINE MMLR PROPOXYPHENE GCMS QUAL SO PROTRIPTYLINE P OR S PROTR PTEN GENE SEQUENCING FAMILIAL DA026 PTENF SALICYLATE DETERM SAL STRYCHNINE MMLR

5 UPDATES 2015 REVISED SYNTHETIC GLUCOCOR SCRN SGSS THIORIDAZINE SERUM SO THIOTHIXENE (NAVANE) THIOX TOXICOLOGY GCMS QUAL UR GCMS TRAZODONE (DESYREL) MMLR TRICYCLICS 3-5 KA004 NA TRIFLUOPERAZINE SERUM MMLR VALPROIC ACID FREE FVALP VENLAFAXINE SO VOLATILES QUANT ALCO