Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK

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1 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Hammersmith Medicines Research Limited Cumberland Avenue Park Royal London NW10 7EW Contact: Juan Naveda Tel: +44 (0) Fax: +44 (0) Website: Testing performed at the above address only DETAIL OF ACCREDITATION BLOOD (SERUM) Biochemistry examination activities : Alanine transferase Alkaline phosphatase Aspartate transferase Gamma glutamyl transferase Albumin Amylase Bilirrubin (total) Bilirubin (direct) Calcium Chloride Cholesterol CO2 Creatine Kinase Creatinine Coulter DxC 600: SLM804: Kinetic rate SLM801: Kinetic rate SLM807: Enzymatic rate SLM809: Enzymatic rate SLM875: Timed end-point SLM815: Enzymatic rate SLM866: Timed endpoint diazo SLM869: Timed endpoint diazo SLM833: Indirect ISE SLM830: Indirect ISE SLM848: Timed endpoint (enzymatic) SLM839: Differential rate ph SLM822: Enzymatic rate SLM902: Rate jaffe Assessment Manager: JR2 Page 1 of 7

2 BLOOD (SERUM) (cont d) Biochemistry examination activities (cont d): (cont d) Glucose HDL cholesterol Haemoglobin A1c Iron Immunoglobulin A Immunoglobulin G Immunoglobulin M Lactate dehydrogenase LDL cholesterol Lipase Magnesium Phosphate Potassium Protein total Sodium Triglycerides Urea Uric acid C-reactive protein (high sensitivity) Coulter DxC 600 (cont d): SLM836: UV hexokinase SLM854: Timed endpoint SLM941: Turbidimetric immunoinhibition SLM944: Timed endpoint SLM957: Immunoturbidimetric SLM956: Immunoturbidimetric SLM958: Immunoturbidimetric SLM813: Enzymatic rate SLM857: Colourimetry SLM818: Calmagite SLM845: Timed endpoint using Calmagite SLM842: Timed endpoint SLM827: Indirect ISE SLM872: Timed endpoint Biuret SLM824: Indirect ISE SLM851: Enzymatic rate SLM860: Enzymatic rate SLM863: Enzymatic rate SLM893: Immunoturbidimetric Assessment Manager: JR2 Page 2 of 7

3 URINE BLOOD (SERUM) Biochemistry examination activities (cont d): Albumin Creatinine Protein Blood (RBC) Detection of: Urinalysis: Blood, Leukocyte esterase, ph, Specific gravity, Bilirubin, Nitrites, Proteins, Ketones, Glucose, Urobilinogen Immunoassay examination activities Oestradiol Ferritin Follicle stimulating hormone Cortisol Growth hormone Insulin Luteinizing hormone (LH) Prolactin Triiodothyronine free (FT3) Thyroxine free (FT4) Coulter DxC 600 (cont d): SLM876: Turbidimetric SLM902: Rate jaffe SLM878: Spectrophotometry SLM001: Light microscopy instructions: SLM005: Siemens Clinitek 500 (Multistix dipsticks) Coulter DxI800: Chemiluminescent : SLM213 SLM259 SLM208 SLM210 SLM250 SLM214 SLM209 SLM211 SLM220 SLM206 Assessment Manager: JR2 Page 3 of 7

4 BLOOD (SERUM) (cont d) Immunoassay examination activities (cont d) (cont d) Testosterone TSH βhcg Troponin I Serology examination activities for the purposes of clinical trials Detection of: Hepatitis B core antibody Hepatitis B surface antibody Hepatitis B surface antigen Hepatitis C antibody HIV 1&2 antigen/antibody Hepatitis A virus IgM antibody Coulter DxI800 (cont d): Chemiluminescent : SLM212 SLM205 SLM204 Enzyme : SLM215 Coulter DxC 600 SLM201: Chemiluminescent SLM258: Chemiluminescent SLM200: Chemiluminescent SLM202: Chemiluminescent SLM203: One step immunoenzymatic SLM269: One step immunoenzymatic Assessment Manager: JR2 Page 4 of 7

5 WHOLE BLOOD BLOOD (PLASMA) Haematology examination activities Full blood count White cell differentials Haematocrit Haemoglobin Mean cell Haemoglobin Mean cell volume Mean platelet volume Platelets Red blood cells Red blood cell distribution width Reticulocyte count Manual differential count Manual reticulocyte counts Coagulation examination activities Prothrombin time and INR Activated partial thromboplastin time Fibrinogen instructions using ADVIA 120 SLM305 Flow cytometry Spectrophotometry Impedancemetry Electrical impedence Fluorescence SLM304 SLM002: Microscopy SLM302: Microscopy instructions using ACL TOP 300 SLM415: Coagulometric SLM417: Chromogenic SLM418: Coagulometric Assessment Manager: JR2 Page 5 of 7

6 URINE Toxicology examination activities for the purposes of clinical trials Detection of: Ethyl Alcohol Amphetamine and its metabolites (including d-methamphetamine, d- amphetamine, Methylenedioxyamphetamine (MDA), Methylenedioxymethamphetamine (MDMDA)) Barbiturates and its metabolites (including Secobarbital, Alphenal, Amobarbital, Aprobarbital, Barbital, Butabarbital, Butalbital, Butethal, Diallylbarbital, Pentobarbital, Phenobarbital, Talbutal, Thiopental) Methadone (Methadol) Cannabinoids (including I-11-Nor- 9-THC-9-COOH, Cannabinol, 8-β-11-Dihydroxy- 9-THC, 8-β- Hydroxy- 9-THC, I-11-Nor- 8-THC- 9-COOH, 9-THC) Cocaine metabolite, Benzoylecgonine (Cocaine) Cotinine (3-Hydroxy-Cotinine) Opiates (including Morphine, 6- Acetylmorphine, Codeine, Dihydrocodeine, Heroin, Hydrocodone, Hydromorphone, Levorphanol, Meperidine, Morphine-3-glucuronide, Naloxone, Naltrexone, Norcodeine, Oxycodone and Oxymorphone) Phencyclidine Coulter DxC 600: SLM899: Kinetic SLM905: Enzyme Immunoassay SLM908: Enzyme Immunoassay SLM917: Enzyme Immunoassay SLM923: Enzyme Immunoassay SLM914: Enzyme Immunoassay SLM896: Enzyme Inhibition SLM920: Enzyme Immunoassay SLM926: Enzyme Immunoassay Assessment Manager: JR2 Page 6 of 7

7 URINE (cont d) Toxicology examination activities for the purposes of clinical trials (cont d) Detection of: (cont d) Tricyclic antidepressants (Nortriptyline, Amitriptyline, Amoxapine, Chlorpromazine, Clomipramine, Cyclobenzaprine, Desimipramine, Doxepin, Imipramine, 2-Hydroxy-Imipramine, Protriptyline, Trimipramine) Coulter DxC 600 (cont d): SLM929: Enzyme Immunoassay END Assessment Manager: JR2 Page 7 of 7

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