Pharmacology past year s questions.

Transcription

1 Hope: Pharmacology past year s questions. Q1) Treatment of prolactinomas, all are true except A. treatment with dopamine agonists, is almost always effective in normalizing prolactine level and restoration of gonadal function B. after menopause, treatment of microprolactnimoas is only indicated if there was a troublesome galactorrhea, otherwise can be left untreated C. trans-sphnenoidal surgery has a success rate approaching 80% D. macroprolactnimas may enlarge rapidly during pregnancy and hence bromocyptin should be continued despite pregnancy with close follow up during the whole pregnancy E. external irradiation is a useful first line treatment in the majority of patients Answer could be E or B. Q2) Hyperthyroid crisis, all are true, except: A. the commonest precipitation factor is infection in a previously undiagnosed or improperly treated hyperthyroidism patient B. although being a life threatening increase in the activity of the thyoird gland, fortunately in clinical practice it is rare C. rehydration and broad spectrum antibiotics are important in the management D. if the patient cannot swallow carbimazole then it should be given intravenously E. after days of treatments with various antithyroid measures, sodium iopodate and propraanolol can be stopped and the patient will continue ni carbimazole. Q3) During treatment of a patient with hypothyroidism all are true except: A. oral T4 is the cornerstone of treatment B. the correct dose of thyroxin is that which restores the serum TSH to normal C. the patient usually feels better after 2-3 weeks D. restoration of skin and hair texture is usually seen after 3 weeks E. elderly patients should be started on a low dose thyroxin with gradual escalation

2 Q4) During follow up of a patient treated by oral thyroxin for hypothyroidism, all are true except : A. it is important to ensure compliance and the drug should be taken infinitely. B. once the dose of thyroxin is stabilized based on serum TSH, the TSH and T4 should be measure every 1-2 years C. during a visit the combination of raised serum T4 and high TSH indicates a strict compliance D. some patients may take thyroxin erratically when they know that the half-life is long E. excessive sweating, tachycardia and anxiety may indicate over treatment Q5) Medications and thyroid hormones A. amiodarone may cause hypo or hyperthyroidism B. lithium may cause hypothyroidism C. potassium iodide may cause hypothyroidism D. phenytoin may decrease the needed dose of thyroxin E. oral contraceptive pills may increase the total but not the free thyroxin Q6) Treatment of malignancy associated hypercalcemia, all are true except A. iv fluids are very important B. un very high calicium levels, iv pamidronate is given initially with excellent results C. forced diuresis may be used D. like primary hyperparathyroidism, glucocorticoides are in effective E. there is a place for hemodialysis Q7) In the diagnosis of Cushing syndrome, all are true except: A. 24 hours urinary free cortisol or overnight low dose dexamethasone suppression test are the preferred initial screening tests B. unfortunately dexamethason cross reacts with cortisol immunoassay

3 C. chronic alcoholism sometimes exactly resembles Cushing's syndrome clinically and biochemically D. supprssed ACTH levels indicate an adrenal tumor Q8) Treatment of Cushing syndrome, all are true A. in pituitary dependent disease, trans-sphenoidal surgery is the preferred option B. if treated by bilateral adrenalectomy, the pituitary should be irradiated to prevent the development of Nelson's syndrome C. medical treatment is usually given in the way to prepare the patient for surgery D. adrenal carcinoma should be removed surgically and the tumor bed is irradiated and then the patient is given the drug o'p'ddd E. without treatment, the 5 year survival rate is 75% Q9) Drug induced gymecomastia may be due to all of the followings except A. digoxin B. cimetidin C. stilboestrol D. spironolactone E. ameloride EHSAN: Q10) Which of the following isn t given as an IV infusion Answer: Lente insulin Q11) Which of the following drugs have been proven to decrease CVS mortality in patients with diabetes type II Answer: Metformin Q12) Which of the following about propylthiouracil is correct? a. It can be given be pregnancy b. It can cross the placenta c. It has the same effect as carbimazole

4 d. It can inhibit the peripheral conversion of T4 e. All of the above Answer: e. All of the above Q13) A 40 year diabetic old man who has been controlled on metformin 850mg for 2 years now presents to the clinic with an acute onset of purulent sputum, a temperature of 39.5 Celsius and a blood glucose of about 320 mg/dl. Which of the following measure would be best applied to this patient? a. Add another hypoglycemic agent to the patient s treatment b. Stop the metformin, start the patient on insulin and antibiotic therapy c... Answer: b. Stop the metformin, start the patient on insulin and antibiotic therapy Q14) Which of the following hormones isn t derived from an aminoacid? a. rt3 b. Norepinephrine c. Epinephrine d. Growth hormone Answer: Growth hormone Q15) Which of the following statements is correct about methimazole/carbimazole? Answer: They can cause reversible granulocytopenia Q16) Which of the following uses of hormones isn t part of a hormone replacement type of therapy? Answer: Corticosteroids in bronchial asthma

5 Q17) Which of the following corticosteroids is the drug of choice in asthma treatment? Answer: Beclomethasone Other questions (least prior). Q18) All of the following are true about the action of metformin except a. Inhibit LDL and increase HDL levels b. Slow/inhibit absorption of glucose from the GIT c. Stimulate glucose usage in tissues d. Stimulate glucose uptake by muscles Answer: d. Stimulate glucose uptake by muscles Q19) Which of the following statements is true about bisphosphonates? Answer: They can be used in the treatment and prevention of osteoporosis is post-menopausal women Q20) Insulin can be given by a. Subcutaneous implanted pumps b. Orally c. All of the choices are correct d. Aerosols e. IV infusion Q21) Which is not true about insulin preparations? Answer: All of them can be given through IV infusion Q22) All of the following are side effects of Rosiglitazone except a. Increase LDL and HDL levels b. Liver toxicity c. Bone fractures in women d... Answer: I can t remember the correct answer