Key words: diagnosis, immunoglobulin G4, immunoglobulin G4-related diseases, immunohistochemistry, pseudolymphoma. CASE HISTORY
|
|
- Gervais Hunter
- 5 years ago
- Views:
Transcription
1 doi: / Journal of Dermatology 2013; 40: ORIGINAL ARTICLE Case of immunoglobulin G4-related skin disease: Possible immunoglobulin G4-related skin disease cases in cutaneous pseudolymphoma only by immunohistochemical analysis Yohei IWATA, 1 Yoshikazu MIZOGUCHI, 2 Masayuki TAKAHASHI, 1 Beni TANAKA, 1 Makoto KURODA, 2 Akiko YAGAMI, 1 Kayoko MATSUNAGA 1 1 Departments of Dermatology, and 2 Pathology, Fujita Health University School of Medicine, Toyoake, Japan ABSTRACT Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized disease characterized by elevated serum IgG4 levels, tissue infiltration rich in IgG4 + plasma cells. We report on a case which was first considered as pseudolymphoma from the histopathological analysis, but finally diagnosed as IgG4-related skin lesions. As the morphological features of cutaneous involvement of IgG4-RD are consistent with those of cutaneous pseudolymphoma, we tried immunostaining past potential cases of IgG4-RD. Thirty-two skin specimens (15 men and 17 women; mean age, 53 years) diagnosed as having pseudolymphoma were retrieved from the archives to conduct hematoxylin eosin, IgG and IgG4 staining. Out of the 32 cases of cutaneous pseudolymphoma, germinal center formation was seen in 22 cases, and moderate severe fibrosis was seen in seven cases. Eleven cases showed more than 10 IgG4 + plasma cell infiltration/high-power field, and among these 11 cases, seven cases (22%) showed A ratio of IgG4 + /IgG + cells of more than 40%. Thus, out of the 32 cases of cutaneous pseudolymphomas, two cases (6.3%) satisfied IgG4-RD histopathological diagnostic criteria. As clinical presentations and histopathological features of skin involvement of IgG4-RD are analogous to cutaneous B-cell pseudolymphoma, careful identification is required through systemic examination, serum IgG4 measurement and other means. Key words: diagnosis, immunoglobulin G4, immunoglobulin G4-related diseases, immunohistochemistry, pseudolymphoma. INTRODUCTION Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized clinical disease characterized by elevated serum IgG4 concentration, tumefaction or tissue infiltration rich in IgG4 + plasma cells. 1,2 IgG4-RD can affect multiple organs, including the pancreas, hepatobiliary tract, lacrimal glands, salivary glands, lungs, kidneys, retroperitoneum, prostate, aorta and lymph nodes. 1,3 5 IgG4-RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz s disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm and inflammatory pseudotumor. 2 IgG4-RD has histopathological features such as prominent lymphocyte or plasma cell infiltrate, fibrosis and frequent formation of lymphoid follicles. Although IgG4-RD patients often have an excellent response to steroid therapy 1,2,6 and proper diagnosis is imperative, the condition has often been misdiagnosed as a malignant tumor, lymphoma, Sj ogren s syndrome or other diseases. 2 Although skin involvement of IgG4-RD has been rarely reported, 3,7 11 IgG4-related skin disease is still not widely recognized. The present study covers a case which was first considered as pseudolymphoma from the histopathological analysis of skin biopsy specimens, but finally diagnosed as IgG4-RD manifested as skin lesions through systemic examination including blood tests, magnetic resonance imaging and computed tomography. As the morphological features of cutaneous involvement of IgG4-RD are consistent with cutaneous pseudolymphoma, skin lesions conventionally diagnosed as cutaneous pseudolymphoma might have included IgG4-RD. We conducted immunostaining to search potential cases of IgG4-RD from the previous cutaneous pseudolymphomasdiagnosed cases. CASE HISTORY A 60-year-old man presented with itching subcutaneous nodules over a wide area, from the left cheek to the mandible, and many erythematous nodules on the extremities (Fig. 1a,b). It was 10 years ago when the patient first noticed soybean-sized Correspondence: Yohei Iwata, M.D., Department of Dermatology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi , Japan. iwayou@fujita-hu.ac.jp Received 11 June 2013; accepted 29 August Japanese Dermatological Association
2 IgG4-related disease in pseudolymphoma (b) (a) Figure 1. There was itching subcutaneous nodules over a wide area from the left cheek to the mandible (a). There were erythematous nodules on the right arm (b). Face magnetic resonance imaging revealed tumefaction in the subcutaneous tissue over a wide area from the left cheek to the mandible (c). nodules in front of the left ear, and they gradually grew in size. He had noticed subcutaneous tumors of various sizes on the extremities 5 years before. Physical examinations showed that these nodules were elastic hard and not well defined. Face magnetic resonance imaging revealed tumefaction in the subcutaneous tissue over the wide area from the left cheek to the mandible (Fig. 1c). Biopsy specimens taken from his face, neck and the right arm revealed dense lymphocytic or plasma cell infiltration with fibrosis in the region from the dermis to subcutaneous adipose tissue, part of which presented a lymphoid follicle structure (Fig. 2a c). Initial pathological diagnosis was of pseudolymphoma. However, the following laboratory investigation showed elevated serum IgG (2242 mg/dl; normal range, mg/dl), IgG4 (1310 mg/dl; normal range, mg/dl) and IgE (547 mg/dl; normal range, 0 99 mg/dl). This made us perform IgG, IgG4 and CD138 immunostaining of biopsy specimens. The number of IgG4 + and IgG + plasma cells was 113 and 114 per high-power field (HPF), respectively (Figs 2d f). Computed tomography showed no additional organ involvement, and ophthalmologic or otolaryngological examination also found no involvement for IgG4-RD. Considering the above clinical presentations and test results, the present case was diagnosed as having IgG4-related skin disease. All skin lesions diminished and serum IgG4 levels also lowered after the administration of prednisolone at a dose of 20 mg/day for 2 months (IgG, 1121 mg/dl; IgG4, 327 mg/dl; and IgE, 254 mg/dl). METHODS To examine the rate at which pseudolymphoma cases meet IgG4-RD histopathological diagnostic criteria 12 retrospectively, (c) 32 skin specimens (15 men and 17 women; mean age, 53 years; age range, years) which had been diagnosed as pseudolymphoma at the Department of Diagnostic Pathology, Fujita Health University, between January 2000 and December 2012 were retrieved from the archives to conduct hematoxylin eosin (HE), CD138, IgG and IgG4 staining. Immunostaining was performed on paraffin sections using an HX system discovery automated immunostainer (Roche, Tokyo, Japan) using a polymer-based detection system. The primary antibodies used were as follows: mouse antihuman CD138 (1:50, clone MI15; DAKO, Glostrup, Denmark), rabbit antihuman IgG, specific for c-chains (1:2000; DAKO), and mouse antihuman IgG4 (1:200, clone HP6025; Invitrogen, San Diego, CA, USA). To check the monoclonality of lymphocytes, we stained kappa/lambda immunostaining in all 32 cases of cutaneous pseudolymphoma. In all pseudolymphoma cases, the ratios of kappa or lambda positive cells were almost similar and there was no monoclonality. In addition, follicular colonization, which is typical for cutaneous marginal zone lymphoma, was not observed in all pseudolymphoma cases. Immunoglobulin G + or IgG4 + plasma cells were enumerated in areas with the highest density of positive cells. Three different HPF (910 eyepiece and 940 objective lenses) in each section were counted, and an average number of positive cells per HPF was calculated. Fibrosis, germinal center formation, eosinophil infiltration and obliterative phlebitis were also evaluated. Unless specified otherwise, all data are represented as the mean values. RESULTS Histopathological features of cutaneous pseudolymphomas are summarized in Table 1. Out of the 32 cases of cutaneous pseudolymphoma, lymphocyte infiltration was seen in all patients. Plasma cell infiltration was seen in 31 patients. CD138 + cell infiltration was seen in 28 patients. Eosinophil infiltration was seen in 15 cases. Germinal center formation was seen in 22 cases. Obliterative phlebitis was seen in three cases. Moderate severe fibrosis was seen in seven cases. Regarding infiltration of IgG4 + plasma cells, 11 cases showed more than 10 IgG4 + plasma cells/hpf, and among these 11 cases, seven (22%) showed a ratio of IgG4 + /IgG + cells of more than 40% (Fig. 3). Thus, out of the 32 cases of cutaneous pseudolymphomas, two cases (6.3%) satisfied IgG4-RD histopathological diagnostic criteria. DISCUSSION Immunoglobulin G4-RD is a newly recognized disease of unknown etiology with multi-organ involvement. 2 In the case presented here, subcutaneous tumors were observed over the range from the left cheek to the mandible as well as on the extremities. Histological examination of skin biopsy specimens revealed dermal and subcutaneous involvement with nodular lymphoid infiltration often interspersed with lymphoid follicles and sclerotic stroma. The infiltrate was rich in plasma cells and 2013 Japanese Dermatological Association 999
3 Y. Iwata et al. (a) (e) (i) (b) (f) (j) (c) (g) (l) (d) (h) (m) Figure 2. Histopathological examination of skin biopsy taken from the left face (a d), neck (e h) and right arm (i m). Dense lymphocytic or plasma cell infiltration with fibrosis in the region between the dermis to subcutaneous adipose tissue, part of which presented lymphoid follicle structure (a,e,i). The infiltrate contained numerous lymphocytes, plasma cells and eosinophils (b,f,j). The plasma cells were positive for immunoglobulin (Ig)G (c,g,l) and IgG4 (d,h,m) as assessed by immunohistochemistry Japanese Dermatological Association
4 IgG4-related disease in pseudolymphoma Table 1. Clinicopathological features of cutaneous pseudolymphomas Case Lesion number Lesion size and morphological features Lymphocyte Plasma cell CD138 + cell IgG4/IgG ratio (%) IgG4 + cell (/HPF) Intensity of fibrosis GC Obliterative phlebitis Eo 1 S Brown nodule of the face ++ + Mild S 2 S Round-shaped nodule ++ + F+ Mild L 3 S 6-mm red nodule in the face Mild L + 4 M Multiple invasive erythema in the back Mild S 5 S mm round nodule in the ear ++ + F Mild S 6 S Erythema and swelling in the right eyelid ++ + F+ 7 S Brown papule in the nose ++ + F S Brown papule in the nose ++ + F+ 9 S 10-mm hard mass in the cheek Severe L + 10 S Flat elevated erythematous lesion Mild S + 11 M Multiple brown nodules in the face and back M Swelling in the eyelid Mild S + 13 S Red papule in the nose ++ + F Mild S + 14 M Multiple red papules in the face Severe S 15-mm subcutaneous hard mass ++ + F Severe S +/ M Multiple red papules and nodules in the face Moderate S +/ + 17 S 5-mm red papule in the nose ++ + F+ Mild S 18 M Red nodule in the face, brown papule in the hand, and multiple dark-red papules in the knee + 19 M Multiple red papules in the back Moderate M Multiple red nodules in the cheek, nose and lip L 21 S mm red nodule in the left axilla M Multiple erythema in cheeks and nose Moderate +/ + 23 S Red papule in the forehead Mild SL +/ 24 S 30-mm subcutaneous soft mass in the forehead Mild L +/ M Multiple 3 4-mm subcutaneous masses in the face ++ + F LL 26 S Nodule in the left ear Mild L 27 S Erythema in the left cheek L 28 M Erythema in the lip and forehead Mild L +/ 29 M Multiple red nodules in the forehead, nose and lip Mild S +/ 30 S Brown nodule in the right elbow Moderate +/ + 31 S mm dark red nodule in the left shoulder Mild S + 32 M Multiple brown papules in the face and neck ++ + F Mild S +/ + F, focal; Eo, eosinophils; GC, germinal center; HPF, high-power field; L, large; LL, large and large; S, small; SL, small and large Japanese Dermatological Association 1001
5 Y. Iwata et al. (a) (e) (i) (m) (b) (f) (j) (n) (c) (g) (k) (o) (d) (h) (l) (p) Figure 3. Light microscopy findings and immunostaining for immunoglobulin (I)gG4 of representative pseudolymphoma cases in which IgG4 + plasma cells were observed. Case 4: (a,e) hematoxylin eosin (HE); (i) IgG; (m) IgG4. Case 9: (b,f) HE; (j) IgG; (n) IgG4. Case 24: (c,g) HE; (k) IgG; (o) IgG4. Case 30: (d,h) HE; (l) IgG; (p) IgG4. small lymphocytes, where eosinophils and histiocytes are mixed. Based on these histopathological features, the initial diagnosis of the patient was pseudolymphoma. However, IgG4 immunostaining, conducted due to high serum IgG4 detected in the blood test, found a lot of IgG4 + plasma cell infiltration. As no complication was found in the lungs, kidneys and other internal organs, we diagnosed this case as having IgG4-related skin disease finally. It was not until recently that IgG4-related skin lesions were widely recognized, and clinicopathological findings are reported by some studies. 3,11 Yamada et al. studied 80 IgG4- RD cases and found that five cases (6.3%) had some sort of skin involvement. 11 Such skin lesions were typically erythematous nodules/papules and brown papules like prurigo nodularis, which developed on the face, head and neck in four patients. All five patients had sialadenitis and/or dacryoadenitis. On the other hand, Sato et al. studied 10 IgG4-RD cases with skin involvement. 3 All patients had erythematous and itchy plaques or subcutaneous nodules on the skin of the head and neck, particularly in the periauricular, cheek and mandible regions, except for one patient, whose forearm and waist skin were affected. Those with a mere skin involvement were only two cases, and the remaining eight patients had extracutaneous lesions: lymph node in six, lacrimal gland in three, parotid gland in three, and kidney in one patient. Thus, clinical features of IgG4-related skin disease are typically erythematous itchy plaques or nodules/papules, which developed particularly in the periauricular, cheek and mandible regions. In addition, IgG4-related skin disease usually accompanies extracutaneous symptoms, and presenting only skin lesions as observed in the present case is rare in IgG4-RD. Regarding histological immunohistochemical findings in IgG4-RD, Yamada et al. reported five cases. 11 According to the study, lymphocyte and plasma cell infiltrations were seen in the dermis and subcutaneous tissue. Eosinophil infiltration was detected in all patients. Germinal center formation was seen in three patients, and fibrosis was seen in all patients. According to Sato et al., 3 IgG4-related skin disease cases were Japanese Dermatological Association
6 IgG4-related disease in pseudolymphoma classified into two histological patterns: those exhibiting a nodular dermatitis pattern and those with a subcutaneous nodule pattern. The infiltrate was rich in plasma cells, small lymphocytes and eosinophils, and the majority of the plasma cells were IgG4 +. Taking into consideration what Yamada et al. and Sato et al. have reported, 3,11 some of the clinical and pathological findings of IgG4-related skin lesions are similar to those of cutaneous B-cell pseudolymphoma. The term cutaneous pseudolymphoma is used to describe non-malignant accumulation of T and B lymphocytes in the skin, and etiology is unknown in most of the cases. 13,14 Face, chest and upper extremities are commonly involved sites. Lesions are usually asymptomatic, solitary, skin-colored to violaceous plaques or nodules. 13,14 The histological feature of cutaneous B-cell pseudolymphoma is predominantly nodular or diffused infiltrate of lymphocytes admixed with a variable number of histiocytes, eosinophils and plasma cells. 13,14 The hallmark of cutaneous B-cell pseudolymphoma is the formation of lymphoid follicles containing a mixed population of lymphoid cells. 14 Thus, both clinical and histopathological features are similar between IgG4-related skin disease and cutaneous pseudolymphoma. Actually, the present case was also first diagnosed as pseudolymphoma, and it was after serum IgG4 determination and IgG4 immunostaining that the patient was finally diagnosed as having IgG4-RD. Therefore, in the case of cutaneous pseudolymphoma, differential diagnosis for IgG4-RD is considered imperative. Therefore, we examined the ratio that satisfies IgG4-RD histopathological diagnostic criteria by conducting CD138, IgG4 and IgG immunostaining for 32 cases, which had diagnosed as pseudolymphoma in the past (Table 1). Out of the 32 cases, moderate severe fibrosis was seen in seven cases. Regarding infiltration of IgG4 + plasma cells, 11 cases showed more than 10 IgG4 + plasma cell infiltration/hpf, and among these 11 cases, seven cases (22%) showed a ratio of IgG4 + / IgG + cells of more than 40%. Collectively, two cases (6.3%) satisfied the histopathological diagnostic criteria for IgG4-RD (Fig. 3). 12 Definite diagnosis of IgG4-RD is impossible because serum IgG4 levels was not known in these cases. In addition, Takeuchi et al. has reported a case of cutaneous multicentric Castleman s disease that fulfilled the IgG4-RD histopathological diagnostic criteria. 15 Therefore, the diagnosis of IgG4-RD should be comprehensively done according to the serum IgG4 levels, histopathological findings and the existence of various organ involvements. Nevertheless, the present results may suggest the possibility that IgG4-RD is one of the etiologies of cutaneous pseudolymphoma, and it may be hidden in cutaneous pseudolymphoma-diagnosed cases. Therefore, it is important to examine a patient who seems to have pseudolymphoma with suspicion of the possibility of IgG4- related skin disease. In conclusion, cutaneous IgG4-RD, which had only skin involvement as in the present case, is rare in IgG4-RD as a whole. As clinical presentations and histopathological findings of skin involvement of IgG4-RD are similar to those of cutaneous B-cell pseudolymphoma, careful identification of IgG4-RD using systemic examination by means of computed tomography or magnetic resonance imaging, IgG and IgG4 immunostaining of skin specimens, and blood test (checking serum IgG4 levels) are required. CONFLICT OF INTEREST: None. REFERENCES 1 Hamano H, Kawa S, Horiuchi A et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001; 344: Umehara H, Okazaki K, Masaki Y et al. A novel clinical entity, IgG4- related disease (IgG4RD): general concept and details. Mod Rheumatol 2012; 22: Sato Y, Takeuchi M, Takata K et al. Clinicopathologic analysis of IgG4-related skin disease. Mod Pathol 2013; 26: Sato Y, Notohara K, Kojima M, Takata K, Masaki Y, Yoshino T. IgG4-related disease: historical overview and pathology of hematological disorders. Pathol Int 2010; 60: Deshpande V, Zen Y, Chan JK et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012; 25: Masaki Y, Dong L, Kurose N et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis 2009; 68: Sato Y, Kojima M, Takata K et al. Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman s disease. Mod Pathol 2009; 22: Cheuk W, Lee KC, Chong LY, Yuen ST, Chan JK. IgG4-related Sclerosing disease: a potential new etiology of cutaneous pseudolymphoma. Am J Surg Pathol 2009; 33: Shiomi T, Yoshida Y, Horie Y, Yamamoto O. Acquired reactive perforating collagenosis with the histological features of IgG4-related sclerosing disease in a patient with Mikulicz s disease. Pathol Int 2009; 59: Hattori T, Miyanaga T, Tago O et al. Isolated cutaneous manifestation of IgG4-related disease. J Clin Pathol 2012; 65: Yamada K, Hamaguchi Y, Saeki T et al. Investigations of IgG4- related disease involving the skin. Mod Rheumatol 2012; 23: Umehara H, Okazaki K, Masaki Y et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), Mod Rheumatol 2012; 22: Ploysangam T, Breneman DL, Mutasim DF. Cutaneous pseudolymphomas. J Am Acad Dermatol 1998; 38: ; quiz Hasan M, Shahid M, Varshney M, Mubeen A, Gaur K. Idiopathic lymphocytoma cutis: a diagnostic dilemma. BMJ Case Rep 2011; 25: Takeuchi M, Sato Y, Takata K et al. Cutaneous multicentric Castleman s disease mimicking IgG4-related disease. Pathol Res Pract 2012; 208: Japanese Dermatological Association 1003
Mikulicz s Disease with Progressively Transformed Germinal Centers-type Immunoglobulin G4-related Lymphadenopathy Mimicking Sjögren s Syndrome
Journal of Rheumatic Diseases Vol. 22, No. 6, December, 2015 http://dx.doi.org/10.4078/jrd.2015.22.6.395 Case Report Mikulicz s Disease with Progressively Transformed Germinal Centers-type Immunoglobulin
More informationChronic Sclerosing Dacryoadenitis
The Korean Journal of Pathology 2008; 42: 118-22 Chronic Sclerosing Dacryoadenitis - Report of 2 Cases - Ji Eun Kwon Sang Kyum Kim Sang-Ryul Lee 1 Woo-Ick Yang Haeryoung Kim 2 Department of Pathology and
More informationImmunoglobulin G4-Related Disease with Several Inflammatory Foci
CASE REPORT Immunoglobulin G4-Related Disease with Several Inflammatory Foci Akira Sakamaki 1, Kenya Kamimura 1, Kazuhiko Shioji 1, Junko Sakurada 2, Takeshi Nakatsue 3, Yoko Wada 3, Michitaka Imai 1,
More informationRenal manifestations of IgG4-related systemic disease
Renal manifestations of IgG4-related systemic disease Lynn D. Cornell, M.D. Mayo Clinic Rochester, MN While autoimmune pancreatitis (AIP) has been recognized since the first description by Sarles et al
More informationClinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor
ORIGINAL ARTICLE Korean J Intern Med 2019;34:220-226 Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor Hong Ki Min
More informationIgG4-related Kidney Disease in Which the Urinalysis, Kidney Function and Imaging Findings Were Normal
CASE REPORT IgG4-related Kidney Disease in Which the Urinalysis, Kidney Function and Imaging Findings Were Normal Miho Otani 1, Masahiro Morinaga 1, Yoshihiko Nakajima 1, Hiromi Tomioka 2, Michiko Nishii
More informationAmong the benign intraepithelial melanocytic proliferations, Inflamed Conjunctival Nevi. Histopathological Criteria. Resident Short Reviews
Resident Short Reviews Inflamed conjunctival nevi (ICN) may suggest malignancy because of their rapid growth and atypical histology. The objective of this study was to characterize the diagnostic features
More informationCME/SAM. Increased Immunoglobulin (Ig) G4 Positive Plasma Cell Density and IgG4/IgG Ratio Are Not Specific for IgG4- Related Disease in the Skin
Increased Immunoglobulin (Ig) G4 Positive Plasma Cell Density and IgG4/IgG Ratio Are Not Specific for IgG4- Related Disease in the Skin Julia S. Lehman, MD, 1,2 Thomas C. Smyrk, MD, 1 and Mark R. Pittelkow,
More informationOverview of the Immunoglobulin G4-related Disease Spectrum
Review Article The Korean Journal of Pancreas and Biliary Tract 2015;20:124-129 http://dx.doi.org/10.15279/kpba.2015.20.3.124 pissn 1976-3573 eissn 2288-0941 면역글로불린 G4 연관질환의개요 1 한림대학교의과대학한림대학교성심병원내과, 2
More informationCase Report An IgG4-Related Salivary Gland Disorder: A Case Series Presenting with a Different Clinical Setting
Case Reports in Immunology Volume 2011, Article ID 236079, 4 pages doi:10.1155/2011/236079 Case Report An IgG4-Related Salivary Gland Disorder: A Case Series Presenting with a Different Clinical Setting
More informationReview Article Orbital IgG4-Related Disease: Clinical Features and Diagnosis
International Scholarly Research Network Volume 2012, Article ID 412896, 5 pages doi:10.5402/2012/412896 Review Article Orbital IgG4-Related Disease: Clinical Features and Diagnosis Toshinobu Kubota 1
More informationCase Report Usefulness of minor salivary gland biopsy in the diagnosis of IgG4-related disease: a case report
Int J Clin Exp Pathol 2014;7(5):2673-2677 www.ijcep.com /ISSN:1936-2625/IJCEP0000175 Case Report Usefulness of minor salivary gland biopsy in the diagnosis of IgG4-related disease: a case report Kentaro
More informationA subset of ocular adnexal marginal zone lymphomas may arise in association with
A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease 1)*, Yasuharu Sato 1) 2)*, Koh-ichi Ohshima 3), Katsuyoshi Takata 1), Tomoko Miyata-Takata 1), Mai
More informationIgG4-related hypophysitis presenting as a pituitary adenoma with systemic disease
Asian Journal of Surgery (2013) 36, 93e97 Available online at www.sciencedirect.com journal homepage: www.e-asianjournalsurgery.com CASE REPORT IgG4-related hypophysitis presenting as a pituitary adenoma
More informationValue of Serum IgG4 in the Diagnosis of Autoimmune Pancreatitis and in Distinguishing it from Acute and Chronic Pancreatitis of Other Etiology
94 Jul 2017 Vol 10 No.3 North American Journal of Medicine and Science Original Research Value of Serum IgG4 in the Diagnosis of Autoimmune Pancreatitis and in Distinguishing it from Acute and Chronic
More informationDermatopathology. Dr. Rafael Botella Estrada. Hospital La Fe de Valencia
Dermatopathology Dr. Rafael Botella Estrada. Hospital La Fe de Valencia DERMATOPATHOLOGY CASE CHALLENGE: RECOGNIZING MIMIS AND MASQUERADERS Rosalie Elenitsas. University of Pennsylvania Spectrum Lupus
More informationPerifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis
J Hematopathol (2011) 4:207 214 DOI 10.1007/s12308-011-0117-5 ORIGINAL ARTICLE Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis Imran
More informationIgG4-Related Disease: Puzzles and Pitfalls
IgG4-Related Disease: Puzzles and Pitfalls Roberto Novoa, MD Section of Dermatopathology Departments of Pathology and Dermatology Stanford University Medical Center Stanford, CA Disclosures I have no relevant
More informationIgG4-related sclerosing disease
IgG4-related sclerosing disease TERUMI KAMISAWA, KENSUKE TAKUMA, NAOTO EGAWA Department of Internal Medicine Tokyo Metropolitan Komagome Hospital 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan JAPAN
More informationNozomu Kurose. Key Words: IgG4-related disease, comprehensive diagnostic criteria, fibrosis grade, IL-6. J Kanazawa Med Univ , 2016
J Kanazawa Med Univ 41 76 85, 2016 Clinicopathological Analysis between IgG4-related and Non-IgG4-related Diseases Occurring in Various Organs and Tissues: Re-evaluation of Comprehensive Diagnostic Criteria
More informationIgG4 Disease. General Principles of IgG4-related disease. EL Cluvar, AC Bateman
IgG4 Disease General Principles of IgG4-related disease. EL Cluvar, AC Bateman Diagnostic Guidelines for IgG4-related disease with a focus on histopathological criteria. V Deshpande, A Khosroshahi Diagnostic
More informationA 44-Year-Old Man With Chronic Cough, Weakness, and a Mediastinum Mass
[ Pulmonary, Critical Care, and Sleep Pearls ] A 44-Year-Old Man With Chronic Cough, Weakness, and a Mediastinum Mass Dimitrios Theofilos, MD ; Christina Triantafillidou, MD, PhD ; Athanasios Zetos, MD
More informationA case of retroperitoneal fibrosis responding to steroid therapy
Challenging Clinical Cases Vol. 43 (6): 1185-1189, November - December, 2017 doi: 10.1590/S1677-5538.IBJU.2016.0520 A case of retroperitoneal fibrosis responding to steroid therapy Ryuta Watanabe 1, Akira
More informationCLINICAL SCIENCES. Ocular Adnexal IgG4-Related Lymphoplasmacytic Infiltrative Disorder
CLINICAL SCIENCES Ocular Adnexal IgG4-Related Lymphoplasmacytic Infiltrative Disorder Toshinobu Kubota, MD; Suzuko Moritani, MD; Masao Katayama, MD; Hiroko Terasaki, MD, PhD Objective: To determine the
More informationIsolated Mass-Forming IgG4-Related Cholangitis as an Initial Clinical Presentation of Systemic IgG4-Related Disease
Journal of Pathology and Translational Medicine 2016; 50: 300-305 CASE STUDY Isolated Mass-Forming IgG4-Related Cholangitis as an Initial Clinical Presentation of Systemic IgG4-Related Disease Seokhwi
More informationSonographic findings of immunoglobulin G4-related sc. Author(s) Akihiro; Nakamaru, Yuji; Hatanaka, Kanako C.; Shimiz
Title Sonographic findings of immunoglobulin G4-related sc Omotehara, Satomi; Nishida, Mutsumi; Satoh, Megumi; Author(s) Akihiro; Nakamaru, Yuji; Hatanaka, Kanako C.; Shimiz CitationJournal of medical
More informationLymphoma and Pseudolymphoma
Lymphoma and Pseudolymphoma Laura B. Pincus, MD Co-Director, Cutaneous Lymphoma Clinic Associate Professor Dermatology and Pathology University of California, San Francisco I HAVE NO RELEVANT RELATIONSHIPS
More informationRenal Pathology Case Conference. Case 2
Renal Pathology Case Conference Case 2 Lynn D. Cornell, M.D. Mayo Clinic, Rochester, MN cornell.lynn@mayo.edu March 2, 2008 Clinical presentation 68 year old woman, initially with normal renal function
More informationIgG4-related disease: features and treatment response in a multi-ethnic cohort in Singapore
IgG4-related disease: features and treatment response in a multi-ethnic cohort in Singapore W. Fong 1,2,3, I. Liew 1, D. Tan 2,3,4, K.H. Lim 5, A. Low 6, Y.Y. Leung 1,2 1 Department of Rheumatology and
More informationLymphocytoma Cutis. Cynthia M. Magro MD. Director of Dermatopathology Weill Medical College of Cornell University New York, New York
Lymphocytoma Cutis Cynthia M. Magro MD Professor of Pathology Director of Dermatopathology Weill Medical College of Cornell University New York, New York Lymphocytoma Cutis Falls under other designations
More informationDiagnostic And Therapeutic Challenges in IgG4-Related disease in the Sphenoid Sinus
Diagnostic And Therapeutic Challenges in IgG4-Related disease in the Sphenoid Sinus Omar Abu Suliman, MBBS, SB-ORL Senior Registrar, otolaryngology Head & neck surgery King Abdullah Medical City, Makkah,
More informationDiagnostic dilemma of IgG4-related primary localized cervical lymphadenopathy associated with aberrant IL-6 expression level
Nakamura et al. Diagnostic Pathology (2016) 11:43 DOI 10.1186/s13000-016-0493-3 CASE REPORT Open Access Diagnostic dilemma of IgG4-related primary localized cervical lymphadenopathy associated with aberrant
More informationUnusual Involvement of IgG4-Related Sclerosing Disease in Lacrimal and Submandibular Glands and Extraocular Muscles
pissn: 1011-8942 eissn: 2092-9382 Korean J Ophthalmol 2012;26(3):216-221 http://dx.doi.org/10.3341/kjo.2012.26.3.216 Case Report Unusual Involvement of IgG4-Related Sclerosing Disease in Lacrimal and Submandibular
More informationConsensus Statement on the Pathology of IgG4-Related Disease
Consensus Statement on the Pathology of IgG4-Related Disease The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Deshpande,
More informationESIM Winter School 2014 Case Presentation
ESIM Winter School 2014 Case Presentation Hacettepe University School of Medicine Ankara/Turkey Ozant Helvaci, M.D. Patient T.K., 59 years old, male, married with one child, unemployed, place of birth/
More informationIgG4-Negative Autoimmune Pancreatitis with Sclerosing Cholangitis and Colitis: Possible Association with Primary Sclerosing Cholangitis?
CASE REPORT IgG4-Negative Autoimmune Pancreatitis with Sclerosing Cholangitis and Colitis: Possible Association with Primary Sclerosing Cholangitis? Keita Saeki 1, Shigenari Hozawa 1, Naoteru Miyata 1,
More informationFOLLICULARITY in LYMPHOMA
FOLLICULARITY in LYMPHOMA Reactive Follicular Hyperplasia Follicular Hyperplasia irregular follicles Follicular Hyperplasia dark and light zones Light Zone Dark Zone Follicular hyperplasia MIB1 Follicular
More informationReview Article The Utility of Serum IgG4 Concentrations as a Biomarker
International Rheumatology Volume 2012, Article ID 198314, 4 pages doi:10.1155/2012/198314 Review Article The Utility of Serum IgG4 Concentrations as a Biomarker Shigeyuki Kawa, 1 Tetsuya Ito, 2 Takayuki
More informationIgG4 ᛶ ᝈ䛸 ᶫᮏ ᕫච ᛶ ⅖ ḷᒣ Ꮫ య Ꮫ ぬ㐨
IgG4 Autoimmune pancreatitis Histopathological features: Diffuse lymphoplasmacytic infiltration Stromal fibrosis Acinar atrophy Obliterative phlebitis 1. Hamano et al reported that serum IgG4 levels were
More informationOverlap of IgG4-related Disease and Multicentric Castleman s Disease in a Patient with Skin Lesions
CASE REPORT Overlap of IgG4-related Disease and Multicentric Castleman s Disease in a Patient with Skin Lesions Hiroki Mochizuki 1, Manako Kato 1, Takakazu Higuchi 2, Ryosuke Koyamada 2, Satoru Arai 3,
More informationCase Report Thoracic Paravertebral Mass as an Infrequent Manifestation of IgG4-Related Disease
Hindawi Case Reports in Rheumatology Volume 2017, Article ID 4716245, 4 pages https://doi.org/10.1155/2017/4716245 Case Report Thoracic Paravertebral Mass as an Infrequent Manifestation of IgG4-Related
More informationAutoimmune pancreatitis (AIP) was described more than a
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2007;5:1229 1234 The Use of Immunoglobulin G4 Immunostaining in Diagnosing Pancreatic and Extrapancreatic Involvement in Autoimmune Pancreatitis MAESHA G. DEHERAGODA,*
More informationIgG4-Related Disease
IgG4-related disease (IgG4-RD) is a systemic autoimmune fibroinflammatory disease that produces sclerotic, tumefactive masses containing dense lymphoplasmacytic infiltrates rich in immunoglobulin (Ig)
More informationRefractory bilateral scrotal ulcers with numerous IgG4-positive plasma cells: Another skin location for IgG4-related sclerosing disease
www.edoriumjournals.com CASE REPORT OPEN ACCESS Refractory bilateral scrotal ulcers with numerous IgG4-positive plasma cells: Another skin location for IgG4-related sclerosing disease Jaclyn L Jerz, Jae
More informationIgG4-Related Tubulointerstitial Nephritis and Lymphadenopathy after Therapy for Malignant Lymphoma
CASE REPORT IgG4-Related Tubulointerstitial Nephritis and Lymphadenopathy after Therapy for Malignant Lymphoma Yasuko Oshima 1, Ryosuke Usui 1, Shun Manabe 1, Naoki Hasegawa 2, Yukio Kakuta 2, Kosaku Nitta
More informationA Case of IgG4-Related Disease Presenting as Massive Pleural Effusion and Thrombophlebitis
CASE REPORT http://dx.doi.org/10.4046/trd.2014.76.4.179 ISSN: 1738-3536(Print)/2005-6184(Online) Tuberc Respir Dis 2014;76:179-183 A Case of IgG4-Related Disease Presenting as Massive Pleural Effusion
More informationHistopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells
480 & 2012 USCAP, Inc. All rights reserved 0893-3952/12 $32.00 Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells Kate E Grimm 1, Todd S Barry 1, Vladislav Chizhevsky
More information*Department of Pathology, **Surgery, and ***Radiology, Eulji University School of Medicine, Daejeon, Republic of Korea. Abstract
Malaysian J Pathol 2018; 40(1) : 73 78 CASE REPORT Unrecognised IgG4 association in progressively transformed germinal centers of lymph nodes with subsequent full-blown IgG4- related chronic fibrosing
More informationPrimary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression
1568 & 2013 USCAP, Inc All rights reserved 0893-3952/13 $32.00 Primary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression Isabel Brenner 1, Sabine Roth 1,
More informationOsteosclerotic Myeloma (POEMS Syndrome)
Osteosclerotic Myeloma (POEMS Syndrome) Osteosclerotic Myeloma (POEMS Syndrome) Synonyms Crow-Fukase syndrome Multicentric Castleman disease Takatsuki syndrome Acronym coined by Bardwick POEMS Scheinker,
More informationFOR PUBLIC CONSULTATION ONLY. Evidence Review: Rituximab for immunoglobulin G4-related disease (IgG4-RD)
Evidence Review: Rituximab for immunoglobulin G4-related disease (IgG4-RD) NHS England FOR PUBLIC CONSULTATION ONLY Evidence Review: Rituximab for immunoglobulin G4-related disease (IgG4- RD) First published:
More informationCase Report IgG4-Related Nasal Pseudotumor
Case Reports in Otolaryngology Volume 2015, Article ID 749890, 4 pages http://dx.doi.org/10.1155/2015/749890 Case Report IgG4-Related Nasal Pseudotumor L. K. Døsen, 1 P. Jebsen, 2 B. Dingsør, 3 and R.
More informationA case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis
Ohta et al. World Journal of Surgical Oncology (2015) 13:67 DOI 10.1186/s12957-015-0459-z WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access A case of marginal zone B cell lymphoma mimicking IgG4-related
More informationA Case of Multiple Giant Coronary Aneurysms and Abdominal Aortic Aneurysm Coexisting with IgG4-related Disease
CASE REPORT A Case of Multiple Giant Coronary Aneurysms and Abdominal Aortic Aneurysm Coexisting with IgG4-related Disease Hirofumi Takei 1, Hayato Nagasawa 1, Ryota Sakai 1, Koji Nishimura 1, Takahiko
More informationCLINICAL SCIENCES. Orbital Inflammation With IgG4-Positive Plasma Cells
CLINICAL SCIENCES Orbital Inflammation With IgG4-Positive Plasma Cells Manifestation of IgG4 Systemic Disease José Antonio Plaza, MD; James A. Garrity, MD; Ahmet Dogan, MD, PhD; Anuradha Ananthamurthy,
More informationOcular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells
JCP Online First, published on October 27, 2010 as 10.1136/jcp.2010.082156 1 Department of Ophthalmology, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan 2 Department of Pathology,
More informationClinical Study Evaluation and Clinical Validity of a New Questionnaire for Mikulicz s Disease
International Rheumatology Volume 2, Article ID 283459, pages doi:1.1155/2/283459 Clinical Study Evaluation and Clinical Validity of a New Questionnaire for Mikulicz s Disease Motohisa Yamamoto, 1 Hiroki
More informationCase report: IgG4-related mass-forming thyroiditis accompanied by regional lymphadenopathy
Sakai and Imamura Diagnostic Pathology (2018) 13:3 DOI 10.1186/s13000-017-0681-9 CASE REPORT Case report: IgG4-related mass-forming thyroiditis accompanied by regional lymphadenopathy Yasuhiro Sakai 1,2*
More informationComparison of multidetector-row computed tomography findings of IgG4-related sclerosing cholangitis and cholangiocarcinoma
Comparison of multidetector-row computed tomography findings of IgG4-related sclerosing cholangitis and cholangiocarcinoma Poster No.: C-0245 Congress: ECR 2014 Type: Scientific Exhibit Authors: M. Yata,
More informationIgG4-related Lung Disease Associated with Autoimmune Hemolytic Anemia: A Case Report and a Literature Review
CASE REPORT IgG4-related Lung Disease Associated with Autoimmune Hemolytic Anemia: A Case Report and a Literature Review Shingo Noguchi 1,2, Kazuhiro Yatera 2,3, Mitsutaka Jinbo 2, Sohsuke Yamada 4, Ikuko
More informationClinical Features of Patients with Basedow s Disease and High Serum IgG4 Levels
ORIGINAL ARTICLE Clinical Features of Patients with Basedow s Disease and High Serum IgG4 Levels Keiichi Torimoto, Yosuke Okada, Akira Kurozumi, Manabu Narisawa, Tadashi Arao and Yoshiya Tanaka Abstract
More informationRosai-Dorfman disease with features of IgG4-related disease in the breast: Cases report and literature review
Asian Pacific Journal of Allergy and Immunology CASE REPORT Rosai-Dorfman disease with features of IgG4-related disease in the breast: Cases report and literature review Mei Liu, 1 * Xiru Li, 2 * Ying
More informationKazuichi Okazaki 1 and Hisanori Umehara Introduction. 2. The Concept of IgG4-Related Disease
Hindawi Publishing Corporation International Journal of Rheumatology Volume 2012, Article ID 357071, 9 pages doi:10.1155/2012/357071 Review Article Are Classification Criteria for IgG4-RD Now Possible?
More informationImmunoglobulin G4-Related Sclerosing Disease Involving the Urethra: Case Report
Case Report http://dx.doi.org/10.3348/kjr.2012.13.6.803 pissn 1229-6929 eissn 2005-8330 Korean J Radiol 2012;13(6):803-807 Immunoglobulin G4-Related Sclerosing Disease Involving the Urethra: Case Report
More informationInt J Clin Exp Pathol 2016;9(3): /ISSN: /IJCEP Sun Young Choi 1, Sanghui Park 2
Int J Clin Exp Pathol 2016;9(3):4033-4037 www.ijcep.com /ISSN:1936-2625/IJCEP0020891 Case Report Is the presence of IgG4+ cells within urothelial carcinomas of the renal pelvis that contain rhabdoid and
More informationClinical Study IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor
International Rheumatology Volume 2012, Article ID 139409, 6 pages doi:10.1155/2012/139409 Clinical Study IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor Arezou Khosroshahi,
More informationImmunoglobulin G4 Non-Related Sclerosing Disease with Intracardiac Mass Mimicking Mitral Stenosis: Case Report
SE REPORT ardiovascular isorders J Korean Med Sci 2013; 28: 1830-1834 Immunoglobulin G4 Non-Related Sclerosing isease with Intracardiac Mass Mimicking Mitral Stenosis: ase Report Ji-won Hwang, 1 * Sung-Ji
More informationCitation The Journal of dermatology, 37(1), available at
NAOSITE: Nagasaki University's Ac Title Author(s) Case of localized scleroderma assoc Muroi, Eiji; Ogawa, Fumihide; Yamao Sato, Shinichi Citation The Journal of dermatology, 37(1), Issue Date 2010-01 URL
More informationIgG4-Related Disease: Dataset of 235 Consecutive Patients
IgG-Related Disease: Dataset of 235 Consecutive Patients Dai Inoue, MD, PhD, Kotaro Yoshida, MD, PhD, Norihide Yoneda, MD, PhD, Kumi Ozaki, MD, PhD, Takashi Matsubara, MD, PhD, Keiichi Nagai, MD, PhD,
More informationLongstanding IgG4-related Ophthalmic Disease Dramatically Improved after Steroid Therapy
doi: 10.2169/internalmedicine.0300-17 Intern Med 57: 2879-2883, 2018 http://internmed.jp CASE REPORT Longstanding IgG4-related Ophthalmic Disease Dramatically Improved after Steroid Therapy Yoko Hirata
More informationAutoimmune Pancreatitis: A Great Imitator
Massachusetts General Hospital Harvard Medical School Autoimmune Pancreatitis: A Great Imitator Dushyant V Sahani MD dsahani@partners.org Autoimmune Pancreatitis: Learning Objectives Clinical manifestations
More informationEarly Detection and Intervention of Coronary Artery Involvement in Immunoglobulin G4-related Disease
doi: 10.2169/internalmedicine.7816-16 http://internmed.jp CASE REPORT Early Detection and Intervention of Coronary Artery Involvement in Immunoglobulin G4-related Disease Yoji Komiya 1, Makoto Soejima
More informationCASE REPORT. Abstract. Introduction. Case Report
CASE REPORT Branch Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas Involving Type 1 Localized Autoimmune Pancreatitis with Normal Serum IgG4 Levels Successfully Diagnosed by Endoscopic Ultrasound-guided
More informationSpuriously Low Serum IgG4 Concentrations Caused by the Prozone Phenomenon in Patients With IgG4-Related Disease
ARTHRITIS & RHEUMATOLOGY Vol. 66, No. 1, January 2014, pp 213 217 DOI 10.1002/art.38193 2014, American College of Rheumatology BRIEF REPORT Spuriously Low Serum IgG4 Concentrations Caused by the Prozone
More informationGastric Carcinoma with Lymphoid Stroma: Association with Epstein Virus Genome demonstrated by PCR
Gastric Carcinoma with Lymphoid Stroma: Association with Epstein Virus Genome demonstrated by PCR Pages with reference to book, From 305 To 307 Irshad N. Soomro,Samina Noorali,Syed Abdul Aziz,Suhail Muzaffar,Shahid
More informationmanifestations are uncommon. Initial descriptions of the disease (Rosai and Dorfman, 1969) specifically
Postgraduate Medical Journal (July 1980) 56, 521-525 Diffuse cutaneous involvement and sinus histiocytosis with massive lymphadenopathy A. A. WOODCOCK B.Sc., M.B., Ch.B., M.R.C.P. Summary Severe skin involvement
More informationPrimer of Immunohistochemistry (Leukocytic)
Primer of Immunohistochemistry (Leukocytic) Paul K. Shitabata, M.D. Dermatopathology Institute Torrance, CA BENIGN LYMPHOID SKIN LESIONS CAPABLE OF SIMULATING LYMPHOMA -Jessner s lymphoid infiltrate -Dermal-subcutaneous
More informationCase Reports. Extranodal Rosai-Dorfman Disease Associated With Increased Numbers of Immunoglobulin G4 Plasma Cells Involving the Colon
Case Reports Extranodal Rosai-Dorfman Disease Associated With Increased Numbers of Immunoglobulin G4 Plasma Cells Involving the Colon Case Report With Literature Review Daniel B. Wimmer, DO; Jae Y. Ro,
More informationCASE 01 LA Path Slide Seminar 13 March, 08. Deepti Dhall, MD Department of Pathology and Laboratory Medicine Cedars-Sinai Medical Center
CASE 01 LA Path Slide Seminar 13 March, 08 Deepti Dhall, MD Department of Pathology and Laboratory Medicine Cedars-Sinai Medical Center Clinical History 60 year old male presented with obstructive jaundice
More informationTitle: An ulcerated gastric ulcer and pseudotumour with pancreatic affectation associated with immunoglobulin G4-
Title: An ulcerated gastric ulcer and pseudotumour with pancreatic affectation associated with immunoglobulin G4- related disease: a case report and literature review Authors: María Isabel Ortuño Moreno,
More informationGlistening, Skin-Colored Nodule
To Print: Click your browser's PRINT button. NOTE: To view the article with Web enhancements, go to: http://www.medscape.com/viewarticle/436334 Medscape Dermatology Clinic Glistening, Skin-Colored Nodule
More informationLymphomatoid Papulosis 3 Case Reports
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 14, Issue 7 Ver. III (July. 2015), PP 31-35 www.iosrjournals.org Lymphomatoid Papulosis 3 Case Reports
More informationCitation The Journal of Dermatology, 37(8), available at
NAOSITE: Nagasaki University's Ac Title Two cases of blaschkitis with promi Author(s) Utani, Atsushi Citation The Journal of Dermatology, 37(8), Issue Date 2010-08 URL Right http://hdl.handle.net/10069/25634
More informationDiagnosticUtility of Interleukin-6 Expression by Immunohistochemistry in Differentiating Castleman Disease Subtypes and Reactive Lymphadenopathies
474 Available online at www.annclinlabsci.org Annals of Clinical & Laboratory Science, vol. 46, no. 5, 2016 DiagnosticUtility of Interleukin-6 Expression by Immunohistochemistry in Differentiating Castleman
More informationMantle Cell Lymphoma
HEMATOPATHOLOGY Original Article Mantle Cell Lymphoma Morphologic Findings in Bone Marrow Involvement JAY WASMAN, MD, 1 NANCY S. ROSENTHAL, MD,' AND DIANE C. FARHI, MD 2 Although mantle cell lymphoma (MCL),
More informationPrimary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report
Primary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report Pages with reference to book, From 148 To 149 Suhail Muzaffar,Irshad Nabi Soomro,Naila Kayani,Shahid Siddiqui ( Departments of Pathology, The Aga
More informationCase Scenario 1: Thyroid
Case Scenario 1: Thyroid History and Physical Patient is an otherwise healthy 80 year old female with the complaint of a neck mass first noticed two weeks ago. The mass has increased in size and is palpable.
More informationDepartment of Dermatology, Christian Medical College and Hospital, Ludhiana, Punjab, India.
Bullous pemphigoid mimicking granulomatous inflammation Abhilasha Williams, Emy Abi Thomas. Department of Dermatology, Christian Medical College and Hospital, Ludhiana, Punjab, India. Egyptian Dermatology
More informationdoi: /s x
doi: 10.1038/s41598-018-28405-x www.nature.com/scientificreports Received: 5 December 2017 Accepted: 21 June 2018 Published: xx xx xxxx OPEN Factors in glucocorticoid regimens associated with treatment
More informationDepartment of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea 2
Case Report pissn 1738-2637 / eissn 2288-2928 J Korean Soc Radiol 2018;79(5):276-281 https://doi.org/10.3348/jksr.2018.79.5.276 Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease:
More informationImmunoglobulin G4 related Disease in Genitourinary Organs: An Emerging Fibroinflammatory Entity Often Misdiagnosed Preoperatively as Cancer
EUROPEAN UROLOGY 64 (2013) 865 872 available at www.sciencedirect.com journal homepage: www.europeanurology.com Platinum Opinion Editorial Immunoglobulin G4 related Disease in Genitourinary Organs: An
More informationCase Report The Challenging Diagnosis of Pancreatic Masses: Not All Tumors Are Cancers
Case Reports in Medicine Volume 2015, Article ID 832463, 4 pages http://dx.doi.org/10.1155/2015/832463 Case Report The Challenging Diagnosis of Pancreatic Masses: Not All Tumors Are Cancers Alessandro
More informationCharacteristic feautures of cholangitis with serum IgG4 elevation compared with primary sclerosing cholangitis
Characteristic feautures of cholangitis with serum IgG4 elevation compared with primary sclerosing cholangitis Poster No.: C-2005 Congress: ECR 2011 Type: Scientific Paper Authors: T. Takeda, T. Ueda,
More informationClinical Study Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients
International Rheumatology Volume 2012, Article ID 303506, 6 pages doi:10.1155/2012/303506 Clinical Study Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients M. Hermet, 1 M. André,
More informationCase Report Kimura s Disease in a Caucasian Female: A Very Rare Cause of Lymphadenopathy
Case Reports in Otolaryngology, Article ID 415865, 4 pages http://dx.doi.org/10.1155/2014/415865 Case Report Kimura s Disease in a Caucasian Female: A Very Rare Cause of Lymphadenopathy Ewa Osuch-Wójcikiewicz,
More informationCase Report IgG4-Related Disease Presenting as Isolated Scleritis
Hindawi Case Reports in Ophthalmological Medicine Volume 2017, Article ID 4876587, 4 pages https://doi.org/10.1155/2017/4876587 Case Report IgG4-Related Disease Presenting as Isolated Scleritis Eran Berkowitz,
More informationOverview of Cutaneous Lymphomas: Diagnosis and Staging. Lauren C. Pinter-Brown MD, FACP Health Sciences Professor of Medicine and Dermatology
Overview of Cutaneous Lymphomas: Diagnosis and Staging Lauren C. Pinter-Brown MD, FACP Health Sciences Professor of Medicine and Dermatology Definition of Lymphoma A cancer or malignancy that comes from
More informationImmunoglobulin G4-related diseases in the head and neck: a systematic review
Mulholland et al. Journal of Otolaryngology - Head and Neck Surgery (2015) 44:24 DOI 10.1186/s40463-015-0071-9 ORIGINAL RESEARCH ARTICLE Open Access Immunoglobulin G4-related diseases in the head and neck:
More informationImmunoglobulin G4-related disease (IgG4-
review article Oman Medical Journal [2018], Vol. 33, No. 2: 97-103 ARTICLE INFO Article history: Received: 12 April 2017 Accepted: 14 August 2017 Online: DOI 10.5001/omj.2018.20 Keywords: Immunoglobulin
More informationInt J Clin Exp Pathol 2013;6(11): /ISSN: /IJCEP
Int J Clin Exp Pathol 2013;6(11):2560-2568 www.ijcep.com /ISSN:1936-2625/IJCEP1309012 Case Report Occurrence of anaplastic large cell lymphoma following IgG4-related autoimmune pancreatitis and cholecystitis
More information