PREFACE. We hope that you will appreciate this course.

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Quentin Fields
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1 PREFACE This 10th graduate Neuropsychopharmacology course, designed for PhD students and postdocs in the field of neurosciences, is organized by the Graduate School Neurosciences Amsterdam Rotterdam and the Centre for Human Drug Research (Leiden). The course addresses our current understanding of the pharmacology of CNS active drugs, the discovery of CNS drug targets as well as the development of innovative medicines and therapies, allowing students to become familiar with the fascinating field of neuropsychopharmacology. During the course, the major classes of pharmacotherapeuticals for the clinical management of various neurological and psychiatric diseases and the pathological mechanisms of these brain disorders will be discussed. The program includes lectures, demonstrations, site visits and special lectures. The different topics of the course will be presented at different locations in Amsterdam and Leiden. Travel instructions can be found at the final page of this document. Attendance of all lectures is mandatory and will be honoured with a certificate. Accreditation covers 40 hours in the graduate teaching programs on neuroscience. If you are not able to attend a specific activity, please notify the course coordinator dr. Micha Wilhelmus (m.wilhelmus@vumc.nl). We hope that you will appreciate this course. The organizing committee, Dr. Micha M.M. Wilhelmus Dr. Benjamin Drukarch Prof.dr. Taco J. de Vries Prof.dr. Jack van Horssen

2 PROGRAM Course on Neuropsychopharmacology, September 11-15, 2017 Topics and places September 11 Basic neuropsychopharmacology and cognitive enhancement VUmc, Amsterdam September 12 Impulsivity, compulsivity & addiction VUmc, Amsterdam September 13 CNS drug development and clinical neuropsychopharmacology CHDR, Leiden September 14 Psychopharmacology and Parkinson s disease VUmc, Amsterdam September 15 Neuroinflammatory and neurodegenerative disorders VUmc, Amsterdam

3 Basic neuropsychopharmacology and cognitive enhancement Coordinator: Dr. Micha M.M. Wilhelmus Monday September 11, VU Amsterdam, O2 building room 1W Coffee/Tea h Opening and introduction Dr. Micha M.M. Wilhelmus and Dr. Benjamin Drukarch h Opening exam pharmacology h Coffee/Tea h Discussion of exam and PK/PD revived Dr. Micha M.M. Wilhelmus and Dr. Benjamin Drukarch h Lunch (provided) h Keynote lecture: Quantitative approaches to unravel PKPD relationships of CNS active drugs Prof.dr. E.C.M. de Lange Leiden Academic Centre for Drug Research h Lecture cognitive enhancement (ethics) Dr. Benjamin Drukarch h Coffee/Tea h Discussion Dr. Micha M.M. Wilhelmus and Dr. Benjamin Drukarch

4 Impulsivity, compulsivity & addiction Coordinator: Prof.dr. T.J. de Vries Tuesday September 12, VU Amsterdam, O2 building room 1W h Coffee/Tea and Introduction Prof.dr. T.J. de Vries h Compulsivity Dr. I. Willuhn Academic Medical Center and NIN, Amsterdam h Psychopharmacology of ADHD. Dr. T. Pattij h Lunch (provided) h Use of DREADDS to identify and manipulate addiction circuitry. Dr. N. Marchant VU University medical center, Amsterdam h Addiction: a treatable brain disease. Prof.dr. A. Goudriaan Academic Medical Center, Amsterdam h Coffee/Tea h Keynote lecture: Rational design of ligands for nicotinic acetylcholine receptors. Prof.dr. A.B. Smit CNCR, Vrije Universiteit Amsterdam, Amsterdam

5 CNS drug development and clinical neuropsychopharmacology Coordinator: Dr. Micha M.M. Wilhelmus Wednesday September 13, CHDR Leiden h Coffee/Tea 09:00 09:15h Welcome h CNS drug development: from phases to questions Prof.dr. A.F. Cohen, CHDR, Leiden 10:00 11:00h FIH studies CNS Prof.dr J.M. van Gerven, CHDR, Leiden 11:00 11:30h Coffee/tea :15h PK and PD of BBB penetrating drugs; does the compound enter the CNS, Dr. G.J. Groeneveld, CHDR, Leiden h Lunch (provided) 13:00 13:45h Case studies Ellen /Robert 13: h Caffeine in sustained attention. Dr. Micha Wilhelmus, CHDR, Leiden :00h Coffee/tea 15:00 15:45h Translating first in human studies to first in patient studies Dr. Gabriel Jacobs, CHDR, Leiden 15: h Laboratory visits, NeuroCart and PainCart demonstrations 17: h Drinks

6 Psychopharmacology and Parkinson s disease Coordinator: Dr. Micha M.M. Wilhelmus Thursday September 14, VU Amsterdam, O2 building, room 1W Coffee/Tea h Antipsychotic drugs: Mechanisms of action and pharmacological profiles Dr. Taco Werkman Swammerdam Institute for Life Sciences, Universiteit van Amsterdam h Pharmacogenetics in psychiatry Dr. Pierre Bet Pharmacy, VUmc, Amsterdam h Coffee/tea h Impulse control in Parkinson s disease Dr. Chris Vriend h Lunch (provided) h Keynote lecture: Parkinson s disease: aetiology, pathology and current and future treatments Dr. Wilma van de Berg

7 Neuroinflammatory and neurodegenerative disorders Coordinators: Prof.dr. J. van Horssen and Dr. M.M.M. Wilhelmus Friday September 15, VU Amsterdam, O2 building, Auditorium Coffee/Tea h Multiple sclerosis: aetiology and pathology Prof. dr. J. van Horssen, VUmc, Amsterdam h Multiple sclerosis: Animal models Prof. dr. B t Hart, UMCG, Groningen h Coffee/Tea h Multiple sclerosis: Clinical aspects and current treatment options Dr. B. van Oosten, VUmc, Amsterdam h Resolution of neuroinflammation, a solution for MS? Dr. G. Kooij, VUmc, Amsterdam h Lunch (provided) h Inflammation as therapy in AD Dr. J. Hoozemans, VUmc, Amsterdam h Alzheimer s disease: aetiology and pathology Dr. M.M.M. Wilhelmus, VUmc, Amsterdam h Coffee/Tea h PET imaging in AD and MS Dr. W. Beiano, VUmc, Amsterdam

8 VENUES / ROUTE DESCRIPTIONS VU UNIVERSITY MEDICAL CENTER, O 2 building Address: De Boelelaan 1108, Amsterdam September 11, 12 and 14, 2017 : September 15, 2017: Lecture room: 1W08 Auditorium CENTRE FOR HUMAN DRUG RESEARCH Address: Zernikedreef 8, Leiden September 14, 2017: Please call in at reception desk of CHDR Route description from Station Amsterdam Zuid by public transport: amsterdam zuid/leiden_zernikedreef 8/aankomst/ T0807 P.S. It takes an 11 minutes walk from Station Leiden Centraal to the Zernickedreef.

7th GRADUATE COURSE ON NEUROPSYCHOPHARMACOLOGY

7th GRADUATE COURSE ON NEUROPSYCHOPHARMACOLOGY OCTOBER 7 15, 2010 1 2 CONTENTS CONTENTS 3 PREFACE 5 PROGRAM 7 VENUES / ROUTE DESCRIPTIONS 15 ABSTRACTS 17 PARTICIPANTS 51 3 4 PREFACE This 7 th graduate