COURSE MANUAL INTRO TO STEM CELLS 7 th January 18 th January 2019
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1 COURSE MANUAL INTRO TO STEM CELLS 7 th January 18 th January 2019 For info, please contact Koen Braat. k.braat@umcutrecht.nl This course will address diverse topics in stem cell biology and aims to bring together basic principles of stem cell biology and developmental biology, current techniques and models, and stem cell applications in regenerative medicine. Topics in the course are embryology, embryonic stem cells, induced pluripotent stem cells, in vivo stem cell models, identification of stem cells, organoids and epithelial stem cells, hematopoietic stem, the stem cell niche, skin and eye stem cells, cancer stem cells, and application of stem cell in regenerative medicine. Course venue: Stratenum VONDELZAAL (3 rd floor) (unless indicated otherwise in the daily program) Attendance is mandatory. Missing lectures will result in failing the course. In case of absence always inform one of the coordinators beforehand. k.braat@umcutrecht.nl and pcoffer@umcutrecht.nl
2 Grading: The grading will be based on participation (40%) and the final exam (60%). Participation is based on actively participating in the course and making outline notes and two open answer exam questions and 1 closed answer question (including answers) of two pre-assigned lectures. Our goal is to provide PDFs of the lectures. These will be made available on the website of the course after the outline notes have been submitted. IMPORTANT: It is not allowed to make video recordings/audio recordings or to take pictures of the presentations. Enjoy the course Koen Braat & Paul Coffer
3 Monday 7 th January Embryo, signaling and stem cell models Introduction to the course Dr. Koen Braat (Center for Molecular Medicine and Regenerative Medicine) From embryo to embryonic stem cells Dr. Bernard Roelen (Faculty of Veterinary Medicine UU) Signaling dynamics in stem cell biology Katharina Sonnen (Hubrecht Institute) Lunch Animal models to study tissue regeneration Dr. Kerstin Bartscherer (Hubrecht Institute) Preparation masterclass ESC and reprogramming Tuesday 8 th January Patient specific stem cells in different states of pluripotency Bjorn Heindryckx (Ghent University Hospital, Belgium) De novo formation of gametes from embryonic stem cells (open to all) Bjorn Heindryckx (Ghent University Hospital, Belgium) Lunch masterclass: Cellular reprogramming-induced Pluripotent Stem Cells Abdenour Soufi (MRC Center for Regenerative Medicine, Edinburgh, UK) Seminar Cellular reprogramming-induced Pluripotent Stem Cells (open to all) Abdenour Soufi (MRC Center for Regenerative Medicine, Edinburgh, UK)
4 Wednesday 9 th January Organization and Tissue stem cells Self-organization in embryo development Dr. Nicolas Rivron (MERLN Institute and Hubrecht Institute) Stem cells in bone development Dr. Debby Gawlitta (UMC Utrecht) Lunch Muscle stem cells Dr. Gerben Schaaf (Erasmus MC, Rotterdam) Stem cells in cartilage and bioprinting tissue models Florencia Abinzano (UMC Utrecht) Thursday 10 th January Preparation of Q(uestions)&A(nswers) and lecture by Prof. Michele de Luca Identifying stem cells. STEM-ID Anna Alemany Arias (Hubrecht Institute) Preparation of Q&A and prep for lecture by Prof. Michele de Luca Q&A Prof. Michele de Luca (Center for Regenerative Medicine University of Modena and Reggio Emilia, Italy) Seminar: Combined cell and gene therapy of Epidermolysis Bullosa shed light on human epidermal stem cells (open to all) Prof. Michele de Luca (Center for Regenerative Medicine University of Modena and Reggio Emilia, Italy)
5 Friday 11 th January (Intestinal) stem cells and Organoids Prof. Hans Clevers (Prinses Maxima Center and Hubrecht Institute) Liver stem cells Dr. Bart Spee (UU) Stem cells in the pancreas. Biology and application Dr. Francoise Carlotti (LUMC) Lunch Mutations in stem cells Dr. Ruben van Boxtel (Prinses Maxima Center) Monday 14 th January Hematopoietic stem cells Dr. Catherine Robin (Hubrecht Institute) The stem cell niche. Bone marrow microenvironment and hematopoietic disorders Dr. Marc Raaijmakers (Erasmus MC, Rotterdam) Lunch Regenerative nephrology Prof. Marianne Verhaar (UMCU) (re)generation of the heart Prof. Eva van Rooij (Hubrecht Institute)
6 Tuesday 15 th January Seminar Stem cells in the eye. Location UMCU in Q auditorium Aging in stem cells Prof. Gerald de Haan (ERIBA, UMCG) Lunch Stem cells in the brain Prof. Jeroen Pasterkamp (UMC Utrecht) masterclass: Stem cells in the eye. Prof. Graziella Pellegrini (Center for Regenerative Medicine Stefano Ferrari, Italy) Seminar: Stem cells in the eye (open to all) (Q auditorium UMCU) Prof. Graziella Pellegrini (Center for Regenerative Medicine Stefano Ferrari, Italy) Wednesday 16 th January Cancer stem cells Prof. Louis Vermeulen (AMC) Leukemic cancer stem cells Dr. Mirjam Belderbos (Prinses Maxima Center, Utrecht) Lunch Marketing of unproven stem cell based interventions Dr. Esther van Zimmeren (University of Antwerp, Belgium) Perhaps depending on travel time Self study Thursday 17 th January Friday 18 th January Exam Location to be announced
7 List of speakers Florencia Abinzano UMC Utrecht Dr. Anna Alemany Arias Hubrecht Institute Dr. Kerstin Bartscherer Hubrecht Institute Dr. Mirjam Belderbos Prinses Maxima Center Dr. Ruben van Boxtel Prinses Maxima Center Dr. Francoise Carlotti Leiden UMC Prof. Hans Clevers Prinses Maxima Center and Hubrecht Institute Dr. Debby Gawlitta UMC Utrecht Prof. Gerald de Haan ERIBA, UMC Groningen Prof. Bjorn Heindryckx Ghent University Hospital, Belgium Prof. Michele de Luca Center for Regenerative Medicine University of Modena and Reggio Emilia, Italy Prof. Jeroen Pasterkamp UMC Utrecht Prof. Graziella Pellegrini Center for Regenerative Medicine Stefano Ferrari, Italy Prof. Marc Raaijmakers Erasmus MC, Rotterdam Dr. Nicolas Rivron MERLN Institute and Hubrecht Institute Dr. Catherine Robin Hubrecht Institute Dr. Bernard Roelen Fac of Veterinary Medicine, Utrecht University Prof. Eva van Rooij Hubrecht Institute Dr. Gerben Schaaf Erasmus MC, Rotterdam Dr. Karharina Sonnen Hubrecht Institute Dr. Abdenour Soufi MRC Center for Regenerative Medicine, Edinburgh, UK Dr. Bart Spee Fac of Veterinary Medicine, Utrecht University Prof. Marianne Verhaar UMC Utrecht Prof. Louis Vermeulen Amsterdam Medical Center Dr. Esther van Zimmeren University of Antwerp, Belgium
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