Mind and Body in ADHD: somatic comorbidity

Size: px
Start display at page:

Download "Mind and Body in ADHD: somatic comorbidity"

Transcription

1 Mind and Body in ADHD: somatic comorbidity Jan Haavik K.G. Jebsen Centre for Research on Neuropsychiatric Disorders Department of Biomedicine Haukeland University Hospital University of Bergen, Norway & UMC St. Radboud, Nijmegen, NL UKAAN conference Mermaid Conference and Events Centre 1 IMPACT Sept

2 Agenda Background and terminology; Comorbid" can be medical conditions existing simultaneously but independently; or can indicate related conditions ADHD symptoms are not specific: are observed in several somatic & psychiatric conditions: ADHD considered an exclusion diagnosis misdiagnosis or missed diagnoses? Evidence from Clinical studies Epidemiology Animal models (e.g. SHR rats) Biomarkers, including DNA variants Shared mechanisms? Implications for diagnosis or treatment

3 Literature data (Pubmed: August 2014) ADHD and (somatic) comorbidity 3357 references (40 adult, 11 reviews.) (Adult) ADHD and endocrine disorders ADHD and obesity: 287 ADHD and thyroid: 128 ADHD and corticoid: 113 (Adult) ADHD and neurological disorders (Sleep disorders: )852 Epilepsy: 678 Migraine: 82 (Adult) ADHD and other disorders Birth defects: 1339 Asthma: 239 Hypertension: 157 Autoimmunity: 61 Rheumatoid arthritis: 15

4 Literature data (Adult) ADHD and endocrine disorders ADHD and obesity ADHD and thyroid ADHD and corticoid (Adult) ADHD and neurological disorders Sleep disorders: Strong evidence, causality? Epilepsy: Migraine: Strong associations also reported for bipolar disorders (Adult) ADHD and other disorders Birth defects: Strong evidence, causality? Asthma: Some evidence, confounders? Hypertension: Autoimmunity: Some evidence, confounders? Rheumatoid arthritis: Some evidence, confounders?

5

6 Checklists / systematic interviews, examinations and laboratory tests to determine: Are symptoms better explained by other psychiatric or somatic conditions? Does the patient suffer from concurrent medical conditions (psychiatric or somatic comorbidity)? Causally related to ADHD or unrelated? What are the implications of these conditions for future management/ treatment? Cardiovascular diseases Endocrine diseases Neurological diseases

7 Norwegian clinical sample (572 adult ADHD patients): O.R.:

8 Selected Norwegian health registries Central health registries 8 Since Responsible 1. The Norwegian Cause of DEATH Registry 1951 NIPH 2. The Medical BIRTH Registry of Norway 1967 NIPH 3. The Norw. CARDIOVASCULAR Registry 2010 NIPH 4. The Norw. Surveill. Syst.for COMMUNICABLE DISEASES 1977 NIPH 5. The TUBERCULOSIS Registry 1962 NIPH 6. The Childhood VACCINATION Registry 1998 NIPH 9. The Norwegian PRESCRIPTION Database 2004 NIPH 11. The Norwegian CANCER Registry 1952 Helse Sør-Øst 12. The Norwegian PATIENT Registry 2007 Health dir 15. The Health Registry of the Nor. Off.of DEFENCE 2005 Defence ministry

9 Norwegian registry data: ADHD cases O.R.:

10

11 Norwegian clinical sample: 594 ADHD patients O.R.:

12 Prevalence of asthma Control group (n = 719) Males Females 9.2 % 12.7 % ADHD group (n = 594) Males Females 18.2 % 30.9 % 12

13 ADHD and self-reported asthma Clinical study logistic regression (OR) Unadjusted : Adjusted for : + + age gender education 2.55 anxiety/depression bipolar disorder Possible confounders: Smoking, other co-occurring conditions. Ongoing follow-up studies: Adjusting for serum cotinine levels. 13

14 Norwegian registry data: (population of 4. 6 million) O.R.:

15 Drug treatment females males 15

16 Age groups 16

17 Sleep disturbances frequently reported by children and adults with ADHD Hyposomnia, hypersomina, parasomnias May be causally related to ADHD symptoms, endocrine disturbances, obesity, hypertension etc. Implications for treatment Bergen study: Detailed sleep data from ~500 adult ADHD patients and controls, 18 questions, based on Pittsburgh Sleep Quality Index Bergen Insomnia Scale (ms. in prep.) Self-reported hours of sleep

18 Ongoing studies: Maternal health, ADHD risk & comorbid disorders:

19 ADHD cases Norwegians born : N = 48,396 dispensed central stimulants (CS) or atomoxetine , age 4 years excluded if narcolepsy 4 17 years (children); N = 27, years (adults); N = 21,038 Controls All remaining individuals in the MBRN born and surviving 4 first years N = 2,326,420 Young control group: Born > 1985 Adult control group: Born < 1995

20 Gestational age and birth weight (Instanes, Halmøy, Haavik & Klungsøyr, in prep.) Gestational age distribution (%) ADHD cases and control population 30 Birth weight distribution (%) ADHD cases and control population ADHD Ktr

21 Biomarkers can reveal shared risk factors and mechanisms: Genomics Polygenic risk scores Metabolomics Proteomics Cross-Disorder Group of the PGC. Nature genetics Genome wide studies: Shared polygenic contributions for many psychiatric and somatic disorders/diseases Some serum biomarkers, including immunological markers have indicated autoimmune mechanisms in ADHD

22 Haavik et al.,

23 Conclusions & Implications for diagnosis and treatment: Detailed psychiatric & somatic assessments needed for differential diagnosis to reveal comorbid conditions Biomarkers can reveal shared etiopathogenic pathways Overlapping polygenic contributions to many psychiatric and somatic disorders/diseases Some serum biomarkers, including immunological markers have indicted autoimmune mechanisms in ADHD Repositioning of previously drugs therapies are being investigated in ADHD More translational / cross disciplinary research is needed

24 K.G. Jebsen Centre for Research on Neuropsychiatric Disorders Patient recruitment and clinical studies Biostatistics & epidemiology Norwegian medical birth registry von Plessen) Families Fasmer/Ødegaard/ Haavik Knappskog/Johansson (2.3 million records): Klungsøyr Children (Lundervold/ Molecular genetics BioBanks: Norwegian ADHD Patient Registry & Biobank+others: 5000 clinical records 2000 DNA samples 1000 serum samples Functional and Molecular studies of Candidate genes Bramham/Martinez/Haavik Brain imaging Plessen/Hugdahl/Eichele Neuropsychology Lundervold Adults Fasmer/Ødegaard/ Haavik National and international collaboration: HUNT study & biobank, IMpACT, International ADHD molecular genetics network Toxicology/ pharmacological chaperones Martinez/Haavik

The Norwegian PSC Research Center Biobank

The Norwegian PSC Research Center Biobank The Norwegian PSC Research Center Biobank Trine Folseraas Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University

More information

International Registries: The Government-Driven Model

International Registries: The Government-Driven Model International Registries: The Government-Driven Model Pål Surén Norwegian Institute of Public Health Presentation outline Overview of Norwegian health registries The Norwegian Mother and Child Cohort Study

More information

Prevalence and clinical correlates of insomnia in adults with attention-deficit hyperactivity disorder

Prevalence and clinical correlates of insomnia in adults with attention-deficit hyperactivity disorder Acta Psychiatr Scand 2017: 136: 220 227 All rights reserved DOI: 10.1111/acps.12756 2017 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. ACTA PSYCHIATRICA SCANDINAVICA Prevalence

More information

Challenges in design and analysis of large register-based epidemiological studies

Challenges in design and analysis of large register-based epidemiological studies FMS/DSBS autumn meeting 2014 Challenges in design and analysis of large register-based epidemiological studies Caroline Weibull & Anna Johansson Department of Medical Epidemiology and Biostatistics (MEB)

More information

Department of Drug Abuse Research and Method Development

Department of Drug Abuse Research and Method Development Department of Drug Abuse Research and Method Development Division of forensic sciences National Institute of Public Health Stig Tore Bogstrand, PhD, project leader Saranda Kabashi, MSc Vigdis Vindenes,

More information

Evaluating Exam Review Book and Guide

Evaluating Exam Review Book and Guide Pharmacy Prep Evaluating Exam Review Book and Guide Misbah Biabani, Ph.D Director Toronto Institute of Pharmaceutical Sciences (TIPS) Inc. Toronto, ON M2N 6K7 Pharmacy Prep Professional Exams Preparation

More information

NeuroTox. Prenatal exposure to toxicants and childhood neurodevelopmental disorders and cognitive functions. Heidi Aase, PhD

NeuroTox. Prenatal exposure to toxicants and childhood neurodevelopmental disorders and cognitive functions. Heidi Aase, PhD NeuroTox Prenatal exposure to toxicants and childhood neurodevelopmental disorders and cognitive functions Heidi Aase, PhD heidi.aase@fhi.no NeuroTox opening seminar October 18, 2017 Background Neurodevelopmental

More information

Execu&ve func&oning in adult ADHD From basic mechanisms to func&onal outcome

Execu&ve func&oning in adult ADHD From basic mechanisms to func&onal outcome Execu&ve func&oning in adult ADHD From basic mechanisms to func&onal outcome NB! DeFe er en redigert versjon pga. copyright Helene Barone Ph.D. Spesialist i klinisk nevropsykologi Spesialpoliklinikken,

More information

What can genetic studies tell us about ADHD? Dr Joanna Martin, Cardiff University

What can genetic studies tell us about ADHD? Dr Joanna Martin, Cardiff University What can genetic studies tell us about ADHD? Dr Joanna Martin, Cardiff University Outline of talk What do we know about causes of ADHD? Traditional family studies Modern molecular genetic studies How can

More information

The Norwegian Mother and Child Cohort Study

The Norwegian Mother and Child Cohort Study The Norwegian Mother and Child Cohort Study Per Magnus October 18, 2017 Oslo Why did we start MoBa? Topics What is MoBa? What types of scientific questions can be studied? What are the limitations and

More information

Introduction to the Partners Biobank Portal. December 2016

Introduction to the Partners Biobank Portal. December 2016 Introduction to the Partners Biobank Portal December 2016 Agenda About the Partners Biobank About the Biobank Portal Data Types in the Biobank Sample types DNA. Plasma and Serum Consent Genomic Data Health

More information

PBCB Prospective Breast Cancer Biobanking

PBCB Prospective Breast Cancer Biobanking PBCB Prospective Breast Cancer Biobanking Personal monitoring of breast cancer Medicine Biomarkers Patient journey Fatigue Work-life participation Established by Ernst Lien (Bergen) Gunnar Mellgren (Bergen),

More information

MY.JHSPH.EDU HOME About the Center Projects Faculty and Staff Publications Contact Us PFRH Home Contact Us ADDRESS Johns Hopkins Bloomberg School of Public Health Department of Population, Family and Reproductive

More information

[Supplementary online-only material for Fiest KM, Fisk JD, Patten SB, et al: Fatigue and

[Supplementary online-only material for Fiest KM, Fisk JD, Patten SB, et al: Fatigue and [Supplementary online-only material for Fiest KM, Fisk JD, Patten SB, et al: Fatigue and comorbidities in multiple sclerosis. Int J MS Care. 2016;18(2):96 104.] Supplementary Table 1. Participants reporting

More information

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, PHYSICAL HEALTH, AND LIFESTYLE IN OLDER ADULTS

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, PHYSICAL HEALTH, AND LIFESTYLE IN OLDER ADULTS CHAPTER 5 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, PHYSICAL HEALTH, AND LIFESTYLE IN OLDER ADULTS J. AM. GERIATR. SOC. 2013;61(6):882 887 DOI: 10.1111/JGS.12261 61 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER,

More information

Section 3: Health and Independence Report 2013

Section 3: Health and Independence Report 2013 Section 3: Health and Independence Report 2013 Purpose of this report The Health and Independence Report (the Report) gives an overview of the current state of public health in New Zealand. It has three

More information

Checklist for Completion of Training Requirements in Sleep Medicine Pathway 2

Checklist for Completion of Training Requirements in Sleep Medicine Pathway 2 Checklist for Completion of Training Requirements in Sleep Medicine Pathway 2 This checklist follows the mandatory components of training in sleep medicine for physicians who have followed Pathway 2. Please

More information

Update on the genetics of ADHD

Update on the genetics of ADHD UKAAN Body and Mind conference, September 11, 2014 Update on the genetics of ADHD Barbara Franke, PhD Departments of Human Genetics & Psychiatry Donders Institute for Brain, Cognition and Behavior Radboud

More information

Does prenatal alcohol exposure affect neurodevelopment? Attempts to give causal answers

Does prenatal alcohol exposure affect neurodevelopment? Attempts to give causal answers Does prenatal alcohol exposure affect neurodevelopment? Attempts to give causal answers Luisa Zuccolo l.zuccolo@bristol.ac.uk MRC IEU, School of Social and Community Medicine Background Prenatal alcohol

More information

National Sleep Disorders Research Plan

National Sleep Disorders Research Plan Research Plan Home Foreword Preface Introduction Executive Summary Contents Contact Us National Sleep Disorders Research Plan Return to Table of Contents SECTION 5 - SLEEP DISORDERS SLEEP-DISORDERED BREATHING

More information

What nurses need to know about Trauma-Informed Care

What nurses need to know about Trauma-Informed Care What nurses need to know about Trauma-Informed Care Define trauma-informed care Identify how to assess for trauma Tap in to resources for these patients and their families Kaiser Permanente,1995-1997

More information

ESP 755A SUMMER Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Autosomal recessive disorders

ESP 755A SUMMER Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Autosomal recessive disorders ESP 755A SUMMER 2017 Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Autosomal recessive disorders a. affect only males c. are caused when the abnormal

More information

Supplementary Online Content

Supplementary Online Content Supplementary Online Content Huybrechts KF, Hernández-Díaz S, Patorno E, et al. Antipsychotic use in pregnancy and the risk for congenital malformations. JAMA Psychiatry. Published online August 17, 2016.

More information

Physical comorbidity with bipolar disorder: lessons from UK data

Physical comorbidity with bipolar disorder: lessons from UK data Physical comorbidity with bipolar disorder: lessons from UK data Daniel Smith Symposium 33: Big data and bipolar disorder in the UK A failure of social policy and health promotion, illness prevention and

More information

Pediatric Primary Care Mental Health Specialist Certification Exam. Detailed Content Outline

Pediatric Primary Care Mental Health Specialist Certification Exam. Detailed Content Outline Pediatric Primary Care Mental Health Specialist Certification Exam Detailed Content Outline Description of the Specialty The Pediatric Primary Care Mental Health Specialist (PMHS) builds upon the Advanced

More information

If you are looking for a ebook Comorbidities affect preschoolers' response to ADHD therapy.(child/adolescent Psychiatry)(Attention Deficit and

If you are looking for a ebook Comorbidities affect preschoolers' response to ADHD therapy.(child/adolescent Psychiatry)(Attention Deficit and Comorbidities Affect Preschoolers' Response To ADHD Therapy.(Child/Adolescent Psychiatry)(Attention Deficit And Hyperactivity Disorders)(Clinical Report): An Article From: Clinical Psychiatry News [HT

More information

Birth characteristics and asthma symptoms in young adults: results from a population-based cohort study in Norway

Birth characteristics and asthma symptoms in young adults: results from a population-based cohort study in Norway Eur Respir J 998; 2: 6 7 DOI:./996.98.266 Printed in UK - all rights reserved Copyright ERS Journals Ltd 998 European Respiratory Journal ISSN 9-96 Birth characteristics and asthma symptoms in young adults:

More information

Supplementary Online Content

Supplementary Online Content Supplementary Online Content Viktorin A, Uher R, Kolevzon A, Reichenberg A, Levine SZ, Sandin S. Association of antidepressant medication use during pregnancy with intellectual disability in offspring.

More information

Investigating Chronic and Physical Conditions as a Risk Factor for Selfharm in Correctional Settings

Investigating Chronic and Physical Conditions as a Risk Factor for Selfharm in Correctional Settings Investigating Chronic and Physical Conditions as a Risk Factor for Selfharm in Correctional Settings Asher Turney, MD, MBA, MSPH, CCHP 1, Kenneth Williams, MD, PhD 2, Michelle Staples-Horne, MD, MPH, MS

More information

Gut bugs and health. Patrick Bateson

Gut bugs and health. Patrick Bateson Gut bugs and health Patrick Bateson Characteristic odour of kin group is produced by inherited bacterial flora degrading fats secreted by anal glands An increasing number of people in developed countries

More information

Phenotyping of Human Immune Responses in Vaccination

Phenotyping of Human Immune Responses in Vaccination Phenotyping of Human Immune Responses in Vaccination Charles J. Hackett, Ph.D. National Institutes of Health National Institute of Allergy and Infectious Diseases February 9, 2012 Topics to be Covered

More information

YRD. DOÇ. DR. AYNUR GÖRMEZ MD, MRCPSYCH İSTANBUL MEDENIYET ÜNIVERSITESI, PSIKIYATRI ANABILIM DALı UPK, BURSA

YRD. DOÇ. DR. AYNUR GÖRMEZ MD, MRCPSYCH İSTANBUL MEDENIYET ÜNIVERSITESI, PSIKIYATRI ANABILIM DALı UPK, BURSA ADHD in Turkish college students: prevalence and co-existing mental and physical health problems and life style habits Aynur Görmez, Ayşe Kurtulmuş,Emel Koçer, Rabia Boyraz, Mehmet Akif Cansız YRD. DOÇ.

More information

Anxiety disorders in the general population: prevalences, impairments, and associations with physical illness

Anxiety disorders in the general population: prevalences, impairments, and associations with physical illness Eurocertificate XIV Canterbury, UK, 29 June - 04 July 2002 Anxiety disorders in the general population: prevalences, impairments, and associations with physical illness Frank Jacobi, PhD Clinical Psychology

More information

Developmental-Behavioral Pediatrics Questionnaire for New Patients

Developmental-Behavioral Pediatrics Questionnaire for New Patients Developmental-Behavioral Pediatrics Questionnaire for New Patients Date: Name of person completing questionnaire: Relationship to child: Email: IDENTIFYING INFORMATION: Information Child Name Child Birthdate

More information

Index SLEEP MEDICINE CLINICS. Note: Page numbers of article titles are in boldface type.

Index SLEEP MEDICINE CLINICS. Note: Page numbers of article titles are in boldface type. 299 SLEEP MEDICINE CLINICS Sleep Med Clin 1 (2006) 299 303 Note: Page numbers of article titles are in boldface type. A Acid reflux, sleep disturbances in older adults related to, 238 Aging, alterations

More information

Lessons from the Development of a Canadian National System of Surveillance

Lessons from the Development of a Canadian National System of Surveillance Lessons from the Development of a Canadian National System of Surveillance NATHALIE JETTÉ MD, MSc, FRCPC Assistant Professor Neurology Hotchkiss Brain Institute Calgary Institute of Population and Public

More information

HEALTH MATTERS, INC. SUMMARY OF PROJECTS AND KEY ACCOMPLISHMENTS TO 2016

HEALTH MATTERS, INC. SUMMARY OF PROJECTS AND KEY ACCOMPLISHMENTS TO 2016 Selected 2016 Highlights Epidemiologic research on chronic kidney disease and fistula patency, solid and hematologic malignancies Health economics and outcomes research on beta3-agonist treatment for overactive

More information

Genes, Diseases and Lisa How an advanced ICT research infrastructure contributes to our health

Genes, Diseases and Lisa How an advanced ICT research infrastructure contributes to our health Genes, Diseases and Lisa How an advanced ICT research infrastructure contributes to our health Danielle Posthuma Center for Neurogenomics and Cognitive Research VU Amsterdam Most human diseases are heritable

More information

UDS version 3 Summary of major changes to UDS form packets

UDS version 3 Summary of major changes to UDS form packets UDS version 3 Summary of major changes to UDS form packets from version 2 to VERSION 3 february 18 final Form A1: Subject demographics Updated question on principal referral source to add additional options

More information

LECOM Health Ophthalmology

LECOM Health Ophthalmology Patient Name: Date of Birth: New Patient Questionnaire Your answers will be used by your healthcare provider get an accurate history of your medical conditions and ocular concerns. If you are uncomfortable

More information

Janus Serum Bank. Hilde Langseth MSc, PhD Senior Researcher and head of Janus Serum Bank Cancer Registry of Norway Department of Research

Janus Serum Bank. Hilde Langseth MSc, PhD Senior Researcher and head of Janus Serum Bank Cancer Registry of Norway Department of Research Janus Serum Bank Hilde Langseth MSc, PhD Senior Researcher and head of Janus Serum Bank Cancer Registry of Norway Department of Research Biobank Conference March 13th 2018 Felix konferansesenter, Oslo

More information

Towards 2020: Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S. Director National Institute of Environmental Health Sciences National Toxicology Program

Towards 2020: Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S. Director National Institute of Environmental Health Sciences National Toxicology Program Towards 2020: What are the Critical Environmental Health Challenges? Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S. Director National Institute of Environmental Health Sciences National Toxicology Program

More information

SAFEMINDS EVALUATION OF IACC BUDGET Green denotes SafeMinds Recommendations, Red denotes IACC future action. IACC Budget Recommendation 5,300,000

SAFEMINDS EVALUATION OF IACC BUDGET Green denotes SafeMinds Recommendations, Red denotes IACC future action. IACC Budget Recommendation 5,300,000 Green denotes SafeMinds s, Red denotes IACC future action 1. When Should I Be Concerned? ST 1.1 Develop, with existing tools, at least one efficient diagnostic instrument (e.g., briefer, less time intensive)

More information

Index. sleep.theclinics.com. Note: Page numbers of article titles are in boldface type.

Index. sleep.theclinics.com. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Accidents, risk of, with insufficient sleep, 318 Acquired immunodeficiency syndrome (AIDS), comorbid with narcolepsy, 298 299 Actigraphy, in

More information

The Effects of Exercise on Sleep Quality in Adults Aged 50+ A systematic review

The Effects of Exercise on Sleep Quality in Adults Aged 50+ A systematic review Sleep Quality in Adults Aged 50+ A systematic review Dylan Feld, Ashley Dang-Vu, Lauryn Bryan, Melanie McIntyre; MScPT Candidates, Queen s University, Kingston, ON Helen Driver, PhD, RPSCT, DABSM, Somnologist,

More information

Summary & general discussion

Summary & general discussion Summary & general discussion 160 chapter 8 The aim of this thesis was to identify genetic and environmental risk factors for behavioral problems, in particular Attention Problems (AP) and Attention Deficit

More information

Barbara G. Wells, PharmD, FASHP, FCCP, BCPP Dean and Professor School of Pharmacy, The University of Mississippi Oxford, Mississippi

Barbara G. Wells, PharmD, FASHP, FCCP, BCPP Dean and Professor School of Pharmacy, The University of Mississippi Oxford, Mississippi Barbara G. Wells, PharmD, FASHP, FCCP, BCPP Dean and Professor School of Pharmacy, The University of Mississippi Oxford, Mississippi Joseph T. DiPiro, PharmD, FCCP Panoz Professor of Pharmacy, College

More information

DOB: / / Please list the names and telephone numbers of the other physicians involved in your care: Name Specialty Phone Address Receive Report (Y/N)

DOB: / / Please list the names and telephone numbers of the other physicians involved in your care: Name Specialty Phone Address Receive Report (Y/N) Medical History: Patient: DOB: / / Please list the names and telephone numbers of the other physicians involved in your care: Name Specialty Phone Address Receive Report (Y/N) List the names of prescription

More information

Summary of two retracted Mawson papers comparing health outcomes in vaccinated vs unvaccinated children from a survey of homeschooled children

Summary of two retracted Mawson papers comparing health outcomes in vaccinated vs unvaccinated children from a survey of homeschooled children Summary of two retracted Mawson papers comparing health outcomes in vaccinated vs unvaccinated children from a survey of homeschooled children By Melissa Smith and Rob Verkerk PhD, Science Unit, Alliance

More information

Genome Editing Research for Translational Toxicology Solutions

Genome Editing Research for Translational Toxicology Solutions Genome Editing Research for Translational Toxicology Solutions REBECCA FRY, PH.D. Carol Remmer Angle Distinguished Professor and Associate Chair Director, UNC Superfund Research Program Director, Graduate

More information

What is Statistics? Ronghui (Lily) Xu (UCSD) An Introduction to Statistics 1 / 23

What is Statistics? Ronghui (Lily) Xu (UCSD) An Introduction to Statistics 1 / 23 What is Statistics? Some definitions of Statistics: The science of Statistics is essentially a branch of Applied Mathematics, and maybe regarded as mathematics applied to observational data. Fisher The

More information

Jinliang Zhu, Carsten Obel, Jørn Olsen Department of Public Health, University of Aarhus

Jinliang Zhu, Carsten Obel, Jørn Olsen Department of Public Health, University of Aarhus Parental smoking during pregnancy and short- and long-term adverse outcomes in offspring: Using data from ad hoc birth cohorts and registers in Denmark Jinliang Zhu, Carsten Obel, Jørn Olsen Department

More information

What s happening in the Research World of Down syndrome? Overview of research in Down Syndrome: Guided by the NIH Down Syndrome Research Plan

What s happening in the Research World of Down syndrome? Overview of research in Down Syndrome: Guided by the NIH Down Syndrome Research Plan What s happening in the Research World of Down syndrome? Overview of research in Down Syndrome: Guided by the NIH Down Syndrome Research Plan What is our common goal? Increase quality of life of those

More information

Socioeconomic status and the 25x25 risk factors as determinants of premature mortality: a multicohort study of 1.7 million men and women

Socioeconomic status and the 25x25 risk factors as determinants of premature mortality: a multicohort study of 1.7 million men and women Socioeconomic status and the 25x25 risk factors as determinants of premature mortality: a multicohort study of 1.7 million men and women (Lancet. 2017 Mar 25;389(10075):1229-1237) 1 Silvia STRINGHINI Senior

More information

Early Intervention in Pregnancy

Early Intervention in Pregnancy Early Intervention in Pregnancy Dr Lucy Mackillop Obstetric Physician Honorary Senior Clinical Lecturer Women s Centre Oxford University Hospitals NHS Foundation Trust TVSCN conference 17 th January 2017

More information

Examples of Nordic collaborations: benefits and challenges

Examples of Nordic collaborations: benefits and challenges Examples of Nordic collaborations: benefits and challenges There are numerous well working ongoing Nordic research collaborations, and some Nordic organizations that have a long track record of systematic

More information

An Overview of the Non-Auditory Effects of Noise

An Overview of the Non-Auditory Effects of Noise An Overview of the Non-Auditory Effects of Noise Stephen Stansfeld Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts & the London School of Medicine and Dentistry, London UK Environmental

More information

CNNH NeuroGenomics Program Peer-to-Peer Service Consent/Information Form

CNNH NeuroGenomics Program Peer-to-Peer Service Consent/Information Form CNNH NeuroGenomics Program Peer-to-Peer Service Consent/Information Form WHO WEARE The Center for Neurological and Neurodevelopmental Health (CNNH) is an innovative patient- and family-centered "Specialty

More information

Parental antibiotics and childhood asthma : a population-based study. Örtqvist, A.K.; Lundholma, C.; Fang, F.; Fall, T.; Almqvist, C.

Parental antibiotics and childhood asthma : a population-based study. Örtqvist, A.K.; Lundholma, C.; Fang, F.; Fall, T.; Almqvist, C. This is an author produced version of a paper accepted by Journal of Allergy and Clinical Immunology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal

More information

Male New Patient Questionnaire

Male New Patient Questionnaire Patient Demographics First Name: Middle: Last Name: Home Phone: Cell Phone: Email: Address: SSN: City: State: Zip: Age: Date of Birth: Referred by: Occupation: Primary Care Physician: Employer: Emergency

More information

Vaccine Safety Datalink (VSD)

Vaccine Safety Datalink (VSD) Vaccine Safety Datalink (VSD) Overview Immunization Safety Branch National Immunization Program Institute of Medicine (IOM) Reports on Vaccine Safety "Many gaps and limitations" in current knowledge +

More information

Sleep and Neuropharmacology

Sleep and Neuropharmacology Sleep and Neuropharmacology Sleep and neuropharmacology: an unexpected combination CHDR has many years of experience studying the effects of CNS drugs on sleep, including medications for patients with

More information

Neuroimaging in Clinical Practice

Neuroimaging in Clinical Practice Neuroimaging in Clinical Practice John Gabrieli Department of Brain and Cognitive Sciences & Martinos Imaging Center at the McGovern Institute for Brain Research, MIT Disclosures Neither I nor my spouse/partner

More information

Obesity in Children. JC Opperman

Obesity in Children. JC Opperman Obesity in Children JC Opperman Definition The child too heavy for height or length Obvious on inspection 10 to 20% over desirable weight = overweight More than 20% = obese Use percentile charts for the

More information

Hospital Biobanks - Use of Specimens and Clinical Information in Disease Phenotyping

Hospital Biobanks - Use of Specimens and Clinical Information in Disease Phenotyping Hospital Biobanks - Use of Specimens and Clinical Information in Disease Phenotyping Olli Carpén Auria Biobank, University of Turku and Turku University Hospital ocarpen@utu.fi Understanding of disease

More information

Concurrent Disorders

Concurrent Disorders Concurrent Disorders Dr. Christy Sutherland MD CCFP dipabam Medical Director, PHS Community Services Methadone/Buprenorphine 101 Workshop April 1, 2017 Overview Introduction Epidemiology Treatment Principles

More information

Antidepressants. Professor Ian Jones May /WalesMentalHealth

Antidepressants. Professor Ian Jones May /WalesMentalHealth Antidepressants Professor Ian Jones May 2017 www.ncmh.info @ncmh_wales /WalesMentalHealth 029 2074 4392 info@ncmh.info We identified 19 740 pregnancies exposed to an antidepressant at some point during

More information

THE DANISH NATIONAL BIOBANK. Helle Konradsen Executive Vice President Director of DNB MD, Dr. Sci.

THE DANISH NATIONAL BIOBANK. Helle Konradsen Executive Vice President Director of DNB MD, Dr. Sci. THE DANISH NATIONAL BIOBANK Helle Konradsen Executive Vice President Director of DNB MD, Dr. Sci. BIOBANK OPENED IN 2012 The Danish National Biobank is placed at Statens Serum Institut, a national laboratory

More information

Pfizer Independent Grants for Learning & Change Track 2- Annual Meetings: Submission Deadlines, Areas of Interest & Educational Goals

Pfizer Independent Grants for Learning & Change Track 2- Annual Meetings: Submission Deadlines, Areas of Interest & Educational Goals In order to submit a request for general meeting support through Track 2- Annual Meetings the answer to the following questions must be Yes : Does the activity align with Pfizer s areas of interest? (listed

More information

Infections and autoimmunity as risk factors for mental disorders

Infections and autoimmunity as risk factors for mental disorders Common threads New York March 2018 Infections and autoimmunity as risk factors for mental disorders - Danish nationwide register and biobank studies M.D., Ph.D. The Danish Registers Prescription Database

More information

ADHD and Adverse Health Outcomes in Adults

ADHD and Adverse Health Outcomes in Adults Thomas J. Spencer, MD This work was supported in part by a research grant from Shire (Dr. Spencer) and by the Pediatric Psychopharmacology Council Fund. Disclosures Dr. Spencer receives research support

More information

Past Medical History. Chief Complaint: Patient Name: Appointment Date: Page 1

Past Medical History. Chief Complaint: Patient Name: Appointment Date: Page 1 Appointment Date: Page 1 Chief Complaint: (Please write reason, symptoms, condition or diagnosis that prompts your appointment) Past Medical History PERSONAL SKIN HISTORY YES NO Yes - Details Melanoma

More information

Case-Control Studies

Case-Control Studies Case-Control Studies Marc Schenker M.D., M.P.H Dept. of Public Health Sciences UC Davis Marc Schenker M.D., M.P.H, UC Davis 1 Case-Control Studies OBJECTIVES After this session, you will be familiar with:

More information

New Patient Questionnaire Pediatric Orthopaedic Surgery

New Patient Questionnaire Pediatric Orthopaedic Surgery Page 1 of 5 New Patient Questionnaire Pediatric Orthopaedic Surgery First Name: Last Name: Middle: DOB: Height: Weight: Primary Care Physician/Pediatrician Name: Address: Phone Number: Chief Compliant

More information

Elements of Successful PBS Applications. Barbara Radulski RN. Copyright

Elements of Successful PBS Applications. Barbara Radulski RN. Copyright Elements of Successful PBS Applications Barbara Radulski RN PBS Requirements April 1 2006 THE RULES PBS Requirements 18 years and over Psoriasis x 6 months Failed to achieve an adequate response to 3 systemic

More information

Medical Questionnaire

Medical Questionnaire Medical Questionnaire Date: Day Month Year Please answer these questions as completely as you can. We realize that this form is long, but the information in this form will be extremely valuable to us in

More information

Association of Body Mass Index and Prescription Drug Use in Children from the Medical Expenditures Panel Survey,

Association of Body Mass Index and Prescription Drug Use in Children from the Medical Expenditures Panel Survey, Association of Body Mass Index and Prescription Drug Use in Children from the Medical Expenditures Panel Survey, 2003-2006 Yvonne Lin MCH Research Festival June 10, 2009 BMI Changes with Age in Children

More information

Evolve180 / Ideal Northwest Health Profile

Evolve180 / Ideal Northwest Health Profile Evolve180 / Ideal Northwest Health Profile ABOUT YOU First Name: Last Name: Address: City: State: Zip: Phone: Email: Date of Birth: Age: Height: Occupation: How did you find out about our program? Marital

More information

Sleep in Children with Chronic Illness, and the Relation to Emotional and Behavioral Problems A Population-Based Study

Sleep in Children with Chronic Illness, and the Relation to Emotional and Behavioral Problems A Population-Based Study Sleep in Children with Chronic Illness, and the Relation to Emotional and Behavioral Problems A Population-Based Study Mari Hysing, 1 PSYD, Børge Sivertsen, 2 PHD, Kjell Morten Stormark, 3 PHD, Irene Elgen,

More information

Comorbidities of Migraine

Comorbidities of Migraine Comorbidities of Migraine Richard B. Lipton, MD Edwin S Lowe Professor and Vice Chair of Neurology Director, Montefiore Headache Center Albert Einstein College of Medicine Overview What is comorbidity?

More information

Language delay as an early marker in neurodevelopmental disorders. Nutritional influences

Language delay as an early marker in neurodevelopmental disorders. Nutritional influences Language delay as an early marker in neurodevelopmental disorders Nutritional influences Background Folate is important for neurodevelopment Neural tube defects More subtle cognitive effects? Fatty acids

More information

Environmental programming of respiratory allergy in childhood: the applicability of saliva

Environmental programming of respiratory allergy in childhood: the applicability of saliva Environmental programming of respiratory allergy in childhood: the applicability of saliva 10/12/2013 to study the effect of environmental exposures on DNA methylation Dr. Sabine A.S. Langie Flemish Institute

More information

SUMMARY TABLE OF MEASURES, PRODUCT LINES AND CHANGES

SUMMARY TABLE OF MEASURES, PRODUCT LINES AND CHANGES Summary Table of Measures, Product Lines and Changes 1 SUMMARY TABLE OF MEASURES, PRODUCT LINES AND CHANGES General Guidelines for Data Collection and Reporting Guidelines for Calculations and Sampling

More information

RESEARCH. What is already known about this subject

RESEARCH. What is already known about this subject RESEARCH Comparative Treatment Patterns, Resource Utilization, and Costs in Stimulant-Treated Children with ADHD Who Require Subsequent Pharmacotherapy with Atypical Antipsychotics Versus Non-Antipsychotics

More information

Pre-Admission Testing Questionnaire

Pre-Admission Testing Questionnaire Pre-Admission Testing Questionnaire Approximately 2 weeks prior to your surgery date you will receive a telephone call from our Pre-Admission Testing department. During this conversation, a Registered

More information

o Ongoing management of my

o Ongoing management of my Today s date: Patient s Name Date of Birth / / Age Gender Sex assigned at birth Parent s name Parent s name Please indicate the type of care that you are seeking for your child: o Primary management of

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Abuse sleep physiology effects of, 880 882 substance, in adolescents, sleep problems and, 929 946. See also Substance use and abuse, in adolescents,

More information

Cognitive Research Corporation

Cognitive Research Corporation Cognitive Research Corporation Contract Research Organization offering specialized expertise to fit the unique needs of each client Bobbie Theodore clinicaltrials@alliancesites.com An Alliance of Quality

More information

The Health of the Portuguese People in JULY 2015

The Health of the Portuguese People in JULY 2015 The Health of the Portuguese People in 2015 13 JULY 2015 The Better Life Index OECD 1 st LIFE SATISFACTION 2 nd HEALTH 3 rd PERSONAL SAFETY 2 Number of children per childbearing woman OUR POPULATION: 10.3

More information

Infections and autoimmunity as risk factors for mental disorders

Infections and autoimmunity as risk factors for mental disorders C O M M O N T h r e a d s N e w Yo r k M a r c h 2 0 1 8 Infections and autoimmunity as risk factors for mental disorders - Danish nationwide register and biobank studies M.D., Ph.D. Copenhagen University

More information

Annex. Scientific conclusions and grounds for refusal presented by the European Medicines Agency

Annex. Scientific conclusions and grounds for refusal presented by the European Medicines Agency Annex Scientific conclusions and grounds for refusal presented by the European Medicines Agency Scientific conclusions and grounds for refusal presented by the European Medicines Agency Overall summary

More information

Feil & Oppenheimer Psychological Services

Feil & Oppenheimer Psychological Services Feil & Oppenheimer Psychological Services 260 Waseca Ave. Barrington, RI 02806 401-245-4040 Fax: 401-245-1240 feiloppenheimer@gmail.com Adult Patient Questionnaire Name: Today's Date: Address: Home Phone:

More information

Prevalence of Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation United States,

Prevalence of Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation United States, Prevalence of Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation United States, 2010 2012 Kamil E. Barbour, PhD, Charles G. Helmick, MD, Kristina A. Theis, MPH, Louise B. Murphy,

More information

David V. McQueen. BRFSS Surveillance General Atlanta - Rome 2006

David V. McQueen. BRFSS Surveillance General Atlanta - Rome 2006 David V. McQueen Associate Director for Global Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Atlanta BRFSS Surveillance General Atlanta - Rome 2006 Behavioral Risk

More information

11/13/18. MICROBIOME AND THE BRAIN: How your gut impacts wellbeing. Approach. Lessons from Venice. Session One. Sue Langley

11/13/18. MICROBIOME AND THE BRAIN: How your gut impacts wellbeing. Approach. Lessons from Venice. Session One. Sue Langley MICROBIOME AND THE BRAIN: How your gut impacts wellbeing Session One Sue Langley 2018 2017 Langley Group IP Trust Approach Lessons from Venice 1 Lessons from Venice Agenda 2. Implications and research

More information

Pharmacology 260 Online Course Schedule Summer 2015

Pharmacology 260 Online Course Schedule Summer 2015 Pharmacology 260 Online Course Summer 201 The topics listed below do not necessarily correspond to a 1 - hour lecture period. You should cover the topics for each week at some time during that week. Readings

More information

Attention Deficit Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder AMS-MOH CLINICAL PRACTICE GUIDELINES 1/2014 Attention Deficit Hyperactivity Disorder Academy of Medicine, Singapore College of Paediatrics and Child Health, Singapore College of Family Physicians Singapore

More information

Researchers probe genetic overlap between ADHD, autism

Researchers probe genetic overlap between ADHD, autism NEWS Researchers probe genetic overlap between ADHD, autism BY ANDREA ANDERSON 22 APRIL 2010 1 / 7 Puzzling link: More than half of children with attention deficit hyperactivity disorder meet the diagnostic

More information

DOHaD ANZ. Rae-Chi HUANG MBBS, PhD, FRACP, DCH. A/Professor Telethon Kids Institute

DOHaD ANZ. Rae-Chi HUANG MBBS, PhD, FRACP, DCH. A/Professor Telethon Kids Institute DOHaD ANZ Rae-Chi HUANG MBBS, PhD, FRACP, DCH Rae-chi.huang@uwa.edu.au A/Professor Telethon Kids Institute The effects of the early environment can last a lifetime Early environment (diet, microbes, toxins,

More information

Welcome to MedWell. MedWell Health and Wellness Centers. Don t live with PAIN Live WELL MedWell. o Newspaper o Referred by.

Welcome to MedWell. MedWell Health and Wellness Centers. Don t live with PAIN Live WELL MedWell. o Newspaper o Referred by. 1 Welcome to MedWell Patient Information Date: Name: Date of Birth: / / Address: City: State: Zip Code: Home Phone: ( ) - Cell Phone: ( ) - Email: Gender: o Male o Female State Drivers License: Social

More information