Cellular Neurobiology BIPN140
|
|
|
- Curtis Holt
- 5 years ago
- Views:
Transcription
1 Cellular Neurobiology BIPN140 8 th (last) problem set will be on the class website this weekend; answers will be posted on Monday Review Session with Antonia & Susie: Monday Dec. 5 th 10:00-1:00 pm 3502 Pacific Hall Review Session with all IAs: Wednesday Dec. 7 th 5:00-7:00 pm 3500 Pacitic Hall Final exam: Thursday Dec. 8 th 3:00-6:00 pm Format: 1 hr = 3 rd midterm 2 hr = review of the material of the entire course 2 bonus questions, drawn from the last six lectures
2
3 Discovery of the chemical synapse Otto Loewi Henry Dale Nobel Prize, 1936
4 Activity-dependent transmitter respecification in the developing nervous system 1. Involves addition, loss or switching of neurotransmitters 2. Driven by ion channel misexpression or sensory or motor stimulation 3. Generated by expression or phosphorylation of transcription factors 4. Coupled to corresponding changes in postsynaptic receptor identity 5. Leads to changes in behavior Spitzer, Nature Rev Neurosci 2012
5 Does activity-dependent transmitter switching occur in the adult mammalian brain? If so, does it lead to changes in behavior?
6 Hypothalamic circuitry mediating a photoperiod stress response PaVN 3rd 3 rd ventricle icle PaVN PeVN CRF PeVN LPO LPO SCN SCN optic chiasm Retinal ganglion cell axons SCN, suprachiasmatic neurons PaVN, paraventricular neurons PeVN, periventricular neurons LPO, lateral preoptic neurons CRF, corticotrophin releasing factor neurons Dulcis et al.
7 Photoperiod regulates the number of dopaminergic neurons in the hypothalamus of adult rats Tyrosine hydroxylase-ir - paraventricular nucleus 19L / 5D 150 µm 12L / 12D 5L / 19D TH-IR cells / nucleus (x1000) lateral preoptic area paraventricular nucleus periventricular nucleus ** ** ** ** ** 19L/5D 12L/12D 5L/19D * Dulcis et al.
8 Tyrosine hydroxylase and dopamine are colocalized in the paraventricular nucleus (PaVN) 12L / 12D 5L / 19D TH DA TH DA TH DA 200 µm TH DA Dulcis et al.
9 Photoperiod also regulates the number of somatostatin neurons in the hypothalamus of adult rats Somatostatin-IR - paraventricular nucleus 19L / 5D 12L / 12D 5L / 19D TH 100 µm SST-IR cells / nucleus (x1000) PaVN PeVN 19L/5D 12L/12D 5L/19D Dulcis et al.
10 Induction of TH-IR or SST-IR neurons by short or long day photoperiods does not involve adult neurogenesis 12L / 12D PavN 5L / 19D PavN 200 µm TH BrdU TH BrdU BrdU Dentate gyrus BrdU BrdU Dulcis et al.
11 Disappearance of TH-IR or SST-IR neurons following long or short day photoperiods does not involve apoptosis PaVN & PeVN 19L / 5D 19L / 5D (+ DNase1) 1500 TUNEL DRAQ5 DRAQ5 TUNEL DRAQ5 TUNEL 100 µm TUNEL, DRAQ5 cells / ROI L: 5D 12L: 12D 5L: 19D ** 5L:19D (DNase1) Dulcis et al.
12 Somatostatin and dopamine expression in cell bodies and nerve terminals are switched by photoperiod 19L / 5D 12L / 12D 5L / 19D PaVN cell bodies 30 µm Terminals in the PeVN 3 µm Dulcis et al.
13 Numbers of SST and TH neurons in the PaVN change reciprocally following exposure to long and short day photoperiods SST-IR / TH-IR neurons (x1000) Somatostatin Dopamine 19L / 5D 12L / 12D 5L / 19D Dulcis et al.
14 SST 2,4 R and D 2 R expression on corticotrophin releasing factor cells following exposure to different photoperiods SSTR 2,4 CRF D 2 R Labeled cells / section (30 μm) *** CRF+ SSTR2,4+ SSTR2,4+ D2R+ *** 19L / 5D 12L / 12D 5L / 19D 0 *** ** 19:5 / 5D L:D 12L 12:12 / 12D L:D 5L 5:19 / 19D L:D Dulcis et al.
15 Corticotrophin releasing factor levels are correlated with photoperiod exposure ** CRF level in the CSF (pg/ml) L 19:5 / L:D 5D 12L 12:12 / 12D L:D 5L 5:19 / 19D L:D * Dulcis et al.
16 Transmitter and receptor switching SCN input 19L / 5D 12L / 12D 5L / 19D PaVN interneurons SST upregulation SST downregulation Terminals in the PeVN CRF target cells 3rd ventricle DA downregulation DA upregulation SST2/4R D2R SST storage vesicles DA GABA
17 Measures anxiety Behavioral effect of photoperiod manipulation: elevated plus maze 12L / 12D 5L / 19D L:D (hr) Open arm (sec) Closed arm (sec) 5L/19D 127±3 473±3 12L/12D 74±9 526±9 19L/5D 11±6 589±6 Dulcis et al., Science 2013
18 Behavioral effect of photoperiod manipulation: forced swim test 5L / 19D 120 Measures depression 19L / 5D Immobility time (sec) / 7 min L:5D 12L:12D 5L:19D Dulcis et al., Science 2013
19 Determining the role of newly dopaminergic neurons in behavioral responses to stress 6-OHDA infusion Ablation of dopaminergic neurons Behavioral tests Behavioral tests, -/+ local dopamine Short-day receptor blockers treatment and respecification of dopaminergic neurons Dopamine Somatostatin Dulcis et al.
20 Reductions in the numbers of dopaminergic neurons by 6-OHDA can be rescued by photoperiod exposure 6-OHDA TH+ cells / nucleus (x1000) OHDA sham LPO PaVN PeVN LPO PaVN PeVN TH+ cells / nucleus (x1000) OHDA (12L/12D) sham (12L/12D) 6-OHDA, 5L/19D 6-OHDA,19L/5D LPO PaVN PeVN Dulcis et al.
21 The increase in the numbers of dopaminergic neurons leads to improved behavioral performance in response to stress Elevated plus maze Open arm time (sec) sham (12L/12D) 6-OHDA (12L/12D) 6-OHDA, 5L/19D 6-OHDA, 5L/19D + local DA receptor blockers 6-OHDA, 5L/19D + ACSF Dulcis et al.
22 Conclusions Photoperiod exposure regulates the identity of the transmitters expressed in the adult rat hypothalamus The DA SST switch in neurotransmitter specification, with corresponding changes in expression of transmitter receptors, leads to changes in animal behavior, regulating responses to stress Activity-dependent neurotransmitter respecification is a novel form of plasticity in both young and mature brains
23 Activity-dependent neurotransmitter respecification: a down side?
24 Forms of neuronal plasticity Classical Plasticity Novel Plasticity Synaptic Strength Synapse Number Neuronal Excitability Neurotransmitter Switching Axon activity activity activity activit y Synapse Dendrite NMDAR AMPAR Na V NT1 NT2 Action potentials
25 Acknowledgements Spitzer Lab Davide Dulcis Matt Eckler Kyle Jackson Pouya Jamshidi James Lee Hui-quan Li Da Meng Nandu Prakash Christiana Stark Dena Weinberger Stefania Zambetti Collaboration Stefan Leutgeb Funding Ellison Medical Foundation W.M. Keck Foundation NINDS, NIMH
26
Cellular Neurobiology BIPN140
Cellular Neurobiology BIPN140 1st Midterm Exam Ready for Pickup By the elevator on the 3 rd Floor of Pacific Hall (waiver) Exam Depot Window at the north entrance to Pacific Hall (no waiver) Mon-Fri, 10:00
Neurons, Synapses, and Signaling
Chapter 48 Neurons, Synapses, and Signaling PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions
35-2 The Nervous System Slide 1 of 38
1 of 38 35-2 The Nervous System The nervous system controls and coordinates functions throughout the body and responds to internal and external stimuli. 2 of 38 Neurons Neurons The messages carried by
The Nobel Prize in Physiology or Medicine 2000
The Nobel Prize in Physiology or Medicine 2000 Press Release NOBELFÖRSAMLINGEN KAROLINSKA INSTITUTET THE NOBEL ASSEMBLY AT THE KAROLINSKA INSTITUTE 9 October 2000 The Nobel Assembly at Karolinska Institutet
NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES 34.3
NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES 34.3 NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES Neurons communicate with other neurons or target cells at synapses. Chemical synapse: a very narrow
Lecture 22: A little Neurobiology
BIO 5099: Molecular Biology for Computer Scientists (et al) Lecture 22: A little Neurobiology http://compbio.uchsc.edu/hunter/bio5099 Larry.Hunter@uchsc.edu Nervous system development Part of the ectoderm
Neurons, Synapses, and Signaling
Neurons, Synapses, and Signaling The Neuron is the functional unit of the nervous system. Neurons are composed of a cell body, which contains the nucleus and organelles; Dendrites which are extensions
How Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 http://neuroscience.uth.tmc.edu/s1/chapter06.html http://neuroscience.uth.tmc.edu/s1/chapter07.html Chris Cohan, Ph.D. Dept. of
Outline. Animals: Nervous system. Neuron and connection of neurons. Key Concepts:
Animals: Nervous system Neuron and connection of neurons Outline 1. Key concepts 2. An Overview and Evolution 3. Human Nervous System 4. The Neurons 5. The Electrical Signals 6. Communication between Neurons
COGS 101A: Sensation and Perception
COGS 101A: Sensation and Perception 1 Virginia R. de Sa Department of Cognitive Science UCSD Lecture 4: Coding Concepts Chapter 2 Course Information 2 Class web page: http://cogsci.ucsd.edu/ desa/101a/index.html
Anatomy of a Neuron. Copyright 2000 by BSCS and Videodiscovery, Inc. Permission granted for classroom use. Master 2.1
Anatomy of a Neuron Master 2.1 Neurons Interact With Other Neurons Through Synapses Master 2.2 How Do Neurons Communicate? 1 2 3 4 5 6 Master 2.3 Neurons Communicate by Neurotransmission Neurons communicate
PSYCH 260 Exam 2. March 2, Answer the questions using the Scantron form. Name:
PSYCH 260 Exam 2 March 2, 2017 Answer the questions using the Scantron form. Name: 1 1 Main Please put in their proper order the steps that lead to synaptic communication between neurons. Begin with the
Modeling Excitatory and Inhibitory Chemical Synapses
In review, a synapse is the place where signals are transmitted from a neuron, the presynaptic neuron, to another cell. This second cell may be another neuron, muscle cell or glandular cell. If the second
Chapter 2. The Cellular and Molecular Basis of Cognition Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed.,
Chapter 2. The Cellular and Molecular Basis of Cognition Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., M. S. Gazzaniga, R. B. Ivry, and G. R. Mangun, Norton, 2002. Summarized by B.-W. Ku,
First lecture: Cells of the nervous system and how their use of electrical signlling. MAIN POINTS of first lecture:
First lecture: Cells of the nervous system and how their use of electrical signlling Break Second lecture: Chemical communication between neurons (neurotransmission) MAIN POINTS of first lecture: 1. Structure
Chapter 2. The Cellular and Molecular Basis of Cognition
Chapter 2. The Cellular and Molecular Basis of Cognition Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., M. S. Gazzaniga,, R. B. Ivry,, and G. R. Mangun,, Norton, 2002. Summarized by B.-W. Ku,
BIPN100 F15 Human Physiology 1 Lecture 3. Synaptic Transmission p. 1
BIPN100 F15 Human Physiology 1 Lecture 3. Synaptic Transmission p. 1 Terms you should know: synapse, neuromuscular junction (NMJ), pre-synaptic, post-synaptic, synaptic cleft, acetylcholine (ACh), acetylcholine
Action potential. Definition: an all-or-none change in voltage that propagates itself down the axon
Action potential Definition: an all-or-none change in voltage that propagates itself down the axon Action potential Definition: an all-or-none change in voltage that propagates itself down the axon Naturally
Function of the Nervous System
Nervous System Function of the Nervous System Receive sensory information, interpret it, and send out appropriate commands to form a response Composed of neurons (functional unit of the nervous system)
Cellular Neurobiology BIPN140
Cellular Neurobiology BIPN140 1st Midterm Exam Ready for Pickup By the elevator on the 3 rd Floor of Pacific Hall (waiver) Exam Depot Window at the north entrance to Pacific Hall (no waiver) Mon-Fri, 10:00
9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. 9.01 Recitation (R02)
Cell Neurobiology Course
Cell Neurobiology Course 2017-18 Textbooks - this course is not based on a specific textbook. However for basic or additional information you can refer to the following books (DBIOS library): Neuroscience
Neurons, Synapses and Signaling. Chapter 48
Neurons, Synapses and Signaling Chapter 48 Warm Up Exercise What types of cells can receive a nerve signal? Nervous Organization Neurons- nerve cells. Brain- organized into clusters of neurons, called
Nsci 2100: Human Neuroanatomy Examination 1
Name KEY Lab Section Nsci 2100: Human Neuroanatomy Examination 1 On this page, write your name and lab section. On your scantron answer sheet, enter your name (last name, space, first name), internet ID
Announcements. Returning to Lecture. Measurement in Psychology 2/5/2014. C. Correlation. 1. Correlated = related 2. Coefficient of correlation (r)
Announcements Check Attendance/Grade Query Tool on class website (psy150a1.org) for: Attendance tracking Syllabus Quiz Chapter 2 Aplia Homework due next Monday (Feb 10) Aplia deadline for purchase extended
Synapse Formation. Steven McLoon Department of Neuroscience University of Minnesota
Synapse Formation Steven McLoon Department of Neuroscience University of Minnesota 1 Course News Midterm Exam Monday, Nov 13 9:30-11:30am Bring a #2 pencil!! 2 Course News Lecture schedule: Mon (Oct 31)
THE NEUROBIOLOGY OF THE NEURON AND THE NEUROGLIA
THE NEUROBIOLOGY OF THE NEURON AND THE NEUROGLIA DEFINITION OF A NEURON Neuron is the name given to the nerve cell and all its processes. Neurons are excitable cells that are specialized for the reception
MOLECULAR BIOLOGY OF DRUG ADDICTION. Sylvane Desrivières, SGDP Centre
1 MOLECULAR BIOLOGY OF DRUG ADDICTION Sylvane Desrivières, SGDP Centre Reward 2 Humans, as well as other organisms engage in behaviours that are rewarding The pleasurable feelings provide positive reinforcement
How Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 https://nba.uth.tmc.edu/neuroscience/s1/chapter06.html https://nba.uth.tmc.edu/neuroscience/s1/chapter07.html Chris Cohan, Ph.D.
All questions below pertain to mandatory material: all slides, and mandatory homework (if any).
ECOL 182 Spring 2008 Dr. Ferriere s lectures Lecture 6: Nervous system and brain Quiz Book reference: LIFE-The Science of Biology, 8 th Edition. http://bcs.whfreeman.com/thelifewire8e/ All questions below
PSYC& 100: Biological Psychology (Lilienfeld Chap 3) 1
PSYC& 100: Biological Psychology (Lilienfeld Chap 3) 1 1 What is a neuron? 2 Name and describe the functions of the three main parts of the neuron. 3 What do glial cells do? 4 Describe the three basic
Anatomy Review. Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (
Anatomy Review Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction Neurons communicate with other cells at junctions
Ch. 45 Continues (Have You Read Ch. 45 yet?) u Central Nervous System Synapses - Synaptic functions of neurons - Information transmission via nerve
Ch. 45 Continues (Have You Read Ch. 45 yet?) u Central Nervous System Synapses - Synaptic functions of neurons - Information transmission via nerve impulses - Impulse may be blocked in its transmission
Physiology of synapses and receptors
Physiology of synapses and receptors Dr Syed Shahid Habib Professor & Consultant Clinical Neurophysiology Dept. of Physiology College of Medicine & KKUH King Saud University REMEMBER These handouts will
3) Most of the organelles in a neuron are located in the A) dendritic region. B) axon hillock. C) axon. D) cell body. E) axon terminals.
Chapter 48 Neurons, Synapses, and Signaling Multiple-Choice Questions 1) A simple nervous system A) must include chemical senses, mechanoreception, and vision. B) includes a minimum of 12 ganglia. C) has
Full file at TEST BANK. R.H. Ettinger. Eastern Oregon University. Psychopharmacology. 1/e. R.H. Ettinger
TEST BANK R.H. Ettinger Eastern Oregon University Psychopharmacology 1/e R.H. Ettinger Eastern Oregon University Prentice Hall Boston Columbus Indianapolis New York San Francisco Upper Saddle River Amsterdam
Synaptic plasticityhippocampus. Neur 8790 Topics in Neuroscience: Neuroplasticity. Outline. Synaptic plasticity hypothesis
Synaptic plasticityhippocampus Neur 8790 Topics in Neuroscience: Neuroplasticity Outline Synaptic plasticity hypothesis Long term potentiation in the hippocampus How it s measured What it looks like Mechanisms
Notes: Synapse. Overview. PSYC Summer Professor Claffey PDF. Conversion from an signal to a signal - electrical signal is the
PSYC 170 - Summer 2013 - Professor Claffey Notes: Synapse PDF Overview Conversion from an signal to a signal - electrical signal is the - chemical signal is the Presynaptic - refers to that sends/receives
Neurons: Structure and communication
Neurons: Structure and communication http://faculty.washington.edu/chudler/gall1.html Common Components of a Neuron Dendrites Input, receives neurotransmitters Soma Processing, decision Axon Transmits
Sleep-Wake Cycle I Brain Rhythms. Reading: BCP Chapter 19
Sleep-Wake Cycle I Brain Rhythms Reading: BCP Chapter 19 Brain Rhythms and Sleep Earth has a rhythmic environment. For example, day and night cycle back and forth, tides ebb and flow and temperature varies
Part 11: Mechanisms of Learning
Neurophysiology and Information: Theory of Brain Function Christopher Fiorillo BiS 527, Spring 2012 042 350 4326, fiorillo@kaist.ac.kr Part 11: Mechanisms of Learning Reading: Bear, Connors, and Paradiso,
Psych 181: Dr. Anagnostaras
Psych 181: Dr. Anagnostaras Lecture 5 Synaptic Transmission Introduction to synaptic transmission Synapses (Gk., to clasp or join) Site of action of most psychoactive drugs 6.5 1 Synapses Know basic terminology:
Concept 48.1 Neuron organization and structure reflect function in information transfer
Name Chapter 48: Neurons, Synapses, and Signaling Period Chapter 48: Neurons, Synapses, and Signaling Concept 48.1 Neuron organization and structure reflect function in information transfer 1. What is
FIRST MIDTERM EXAM October 18, 2011 BILD2
FIRST MIDTERM EXAM October 18, 2011 BILD2 WRITE YOUR NAME ON ALL 6 PAGES. ANSWER ALL 10 QUESTIONS (100 POINTS). CONFINE YOUR ANSWERS TO THE SPACE ALLOWED. If you would like to write on the back of the
Synaptic plasticity. Activity-dependent changes in synaptic strength. Changes in innervation patterns. New synapses or deterioration of synapses.
Synaptic plasticity Activity-dependent changes in synaptic strength. Changes in innervation patterns. New synapses or deterioration of synapses. Repair/changes in the nervous system after damage. MRC Centre
ACTIVITY2.15 Text:Campbell,v.8,chapter48 DATE HOUR NERVOUS SYSTEMS NEURON
AP BIOLOGY ACTIVITY2.15 Text:Campbell,v.8,chapter48 NAME DATE HOUR NERVOUS SYSTEMS NEURON SIMPLE REFLEX RESTING POTENTIAL ACTION POTENTIAL ACTION POTENTIAL GRAPH TRANSMISSION ACROSS A SYNAPSE QUESTIONS:
COGS 269. Lecture 1 Spring 2018
COGS 269 Lecture 1 Spring 2018 Psychological Experience Methods of Cognitive Neuroscience Dissociation experiments (patients with brain damage) Neuroimaging experiments Computational modeling Brain damage
The Nervous System Mark Stanford, Ph.D.
The Nervous System Functional Neuroanatomy and How Neurons Communicate Mark Stanford, Ph.D. Santa Clara Valley Health & Hospital System Addiction Medicine and Therapy Services The Nervous System In response
Chapter 12: Fundamentals of the Nervous System and Nervous Tissue
Chapter 12: Fundamentals of the Nervous System and Nervous Tissue Overview of the NS PNS (Peripheral Nervous System) CNS (Central Nervous System) Neurons Neuroglia Synapse Some nomenclature Developed by
Organization of the nervous system. [See Fig. 48.1]
![Organization of the nervous system. [See Fig. 48.1]](/thumbs/90/103926552.jpg "Organization of the nervous system. [See Fig. 48.1]")
Nervous System [Note: This is the text version of this lecture file. To make the lecture notes downloadable over a slow connection (e.g. modem) the figures have been replaced with figure numbers as found
Summarized by B.-W. Ku, E. S. Lee, and B.-T. Zhang Biointelligence Laboratory, Seoul National University.
Chapter 2. The Cellular l and Molecular Basis of Cognition Cognitive Neuroscience: The Biology of the Mind, 3 rd Ed., M. S. Gazzaniga, R. B. Ivry, and G. R. Mangun, Norton, 2008. Summarized by B.-W. Ku,
BIPN100 F12 (Kristan) MIDTERM #1 Name PID p. 1
BIPN100 F12 (Kristan) MIDTERM #1 Name PID p. 1 General Instructions: READ THIS PAGE BEFORE YOU BEGIN THE EXAM. 1. Write your name on every page. (5 points off for EACH unnamed page.) 2. For your own benefit,
Introduction to Neurobiology
Biology 240 General Zoology Introduction to Neurobiology Nervous System functions: communication of information via nerve signals integration and processing of information control of physiological and
QUIZ YOURSELF COLOSSAL NEURON ACTIVITY
QUIZ YOURSELF What are the factors that produce the resting potential? How is an action potential initiated and what is the subsequent flow of ions during the action potential? 1 COLOSSAL NEURON ACTIVITY
Lecture Series Outline
Impact of vitamins & nutrients on neurological function Lecture Series Outline Week 1: Introduction to the brain Week 2: B-vitamins and development (Guest Lecture: Usha Shan) Week 3: B-vitamins and aging
6.5 Nerves, Hormones and Homeostasis
6.5 Nerves, Hormones and Homeostasis IB Biology SL Part 1 - Nerves Outcomes Part 1 6.5.1State that the nervous system consists of the central nervous system (CNS) and peripheral nerves, and is composed
BIPN 140 Problem Set 6
BIPN 140 Problem Set 6 1) The hippocampus is a cortical structure in the medial portion of the temporal lobe (medial temporal lobe in primates. a) What is the main function of the hippocampus? The hippocampus
7.012 Problem Set 7. c) What % of females in this population should be red-green colorblind?
MIT Biology Department 7.012: Introductory Biology - Fall 2004 Instructors: Professor Eric Lander, Professor Robert A. Weinberg, Dr. Claudette Gardel Name: Question 1 7.012 Problem Set 7 Please print out
Synaptic Communication. Steven McLoon Department of Neuroscience University of Minnesota
Synaptic Communication Steven McLoon Department of Neuroscience University of Minnesota 1 Course News The first exam is next week on Friday! Be sure to checkout the sample exam on the course website. 2
Name: Period: Chapter 2 Reading Guide The Biology of Mind
Name: Period: Chapter 2 Reading Guide The Biology of Mind The Nervous System (pp. 55-58) 1. What are nerves? 2. Complete the diagram below with definitions of each part of the nervous system. Nervous System
Neurobiology of Addiction
Neurobiology of Addiction Domenic A. Ciraulo, MD Director of Alcohol Pharmacotherapy Research Center for Addiction Medicine Department of Psychiatry Massachusetts General Hospital Disclosure Neither I
Nervous System 2. Quick Video
Nervous System 2 McMurray/Tarshish Intro Psych Quick Video https://www.youtube.com/watch? v=4gdjcd68sge 1 10/16/15 Divisions of Nervous System Nervous system divisions CNS PNS Sensory (in) Motor (out)
BIPN 140 Problem Set 6
BIPN 140 Problem Set 6 1) Hippocampus is a cortical structure in the medial portion of the temporal lobe (medial temporal lobe in primates. a) What is the main function of the hippocampus? The hippocampus
The nervous system regulates most body systems using direct connections called nerves. It enables you to sense and respond to stimuli
The nervous system regulates most body systems using direct connections called nerves. It enables you to sense and respond to stimuli The basic function of nervous system are: Receive sensory input internal
Section: Chapter 5: Multiple Choice. 1. The structure of synapses is best viewed with a(n):
Section: Chapter 5: Multiple Choice 1. The structure of synapses is best viewed with a(n): p.155 electron microscope. light microscope. confocal microscope. nissle-stained microscopic procedure. 2. Electron
Neurophysiology. Corresponding textbook pages: ,
Neurophysiology Corresponding textbook pages: 436-440, 442-455 Organization Helps maintain homeostasis in the body Nervous system and endocrine system Nervous system is faster due to nerve impulses 1 Fig.
Nervous System Communication. Nervous System Communication. The First Nerve Cells 1/2/11
Nervous System Communication Nervous System Communication Process information Transfer information to other neurons Generate behavior and experience The First Nerve Cells Developed in primitive animals
Limbic system. Lecture 29, November 10, 2017
Limbic system Lecture 29, November 10, 2017 Circadian rhythms (Latin, approximately a day ) Regulation of our daily rhythm Eating Sleeping Defecating Periods of activity Suprachiasmatic n. http://slideplayer.com/slide/6351731/
Study Guide Answer Key Nervous System
Biology 12 Human Biology Textbook: BC Biology 12 Study Guide Answer Key Nervous System 1. Draw a neuron, label 3 parts and give the function of those parts. Dendrite: carry signals to the cell body Cell
Chapter Nervous Systems
The Nervous System Chapter Nervous Systems Which animals have nervous systems? (Which do not) What are the basic components of a NS? What kind of fish performs brain operations? What differentiates one
Cephalization. Nervous Systems Chapter 49 11/10/2013. Nervous systems consist of circuits of neurons and supporting cells
Nervous Systems Chapter 49 Cephalization Nervous systems consist of circuits of neurons and supporting cells Nervous system organization usually correlates with lifestyle Organization of the vertebrate
Biology 3201 Quiz on Nervous System. Total 33 points
Biology 3201 Quiz on Nervous System Total 33 points Name: Circle the best response to the following: (33 points) 1. What do we call the long fibre that carries impulses away from the nerve cell body? A.
Biology 218 Human Anatomy
Chapter 17 Adapted form Tortora 10 th ed. LECTURE OUTLINE A. Overview of the Nervous System (p. 537) 1. The nervous system and the endocrine system are the body s major control and integrating centers.
Blood & Nervous Tissue. Blood. Nervous Tissue 10/13/2008. BY: Jeremiah Peters, Brett Maggard, Miranda Asher, and Benjamin Oakes
Blood & Nervous Tissue BY: Jeremiah Peters, Brett Maggard, Miranda Asher, and Benjamin Oakes Blood Fluid within blood vessels Doesn t connect or give mechanical support Transports Nutrients, wastes, respiratory
Applied Neuroscience. Conclusion of Science Honors Program Spring 2017
Applied Neuroscience Conclusion of Science Honors Program Spring 2017 Review Circle whichever is greater, A or B. If A = B, circle both: I. A. permeability of a neuronal membrane to Na + during the rise
Chapter 17. Nervous System Nervous systems receive sensory input, interpret it, and send out appropriate commands. !
Chapter 17 Sensory receptor Sensory input Integration Nervous System Motor output Brain and spinal cord Effector cells Peripheral nervous system (PNS) Central nervous system (CNS) 28.1 Nervous systems
9.01 Midterm Examination NAME October 27, 2003
9.01 - Neuroscience & Behavior, Fall 2003 Massachusetts Institute of Technology Instructor: Professor Gerald Schneider 9.01 Midterm Examination NAME 1) Karl Wernicke, in the 1870s, formulated a model of
Chapter 2 The Brain or Bio Psychology
Chapter 2 The Brain or Bio Psychology 1 2 3 1 Glial Cells Surround neurons and hold them in place Make Myelin (covering for neurons) Manufacture nutrient chemicals neurons need Absorb toxins and waste
Endocrine System Nervous System
Cells Endocrine System Nervous System Tissues Controls Organs Nervous System vs Endocrine System Electrical signals (graded potentials and action potentials) and chemical signals (neurotransmitters) Fast
Ion Channels Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com)
Ion Channels Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction At synapses, ions move across cell membranes through
MCB MIDTERM EXAM #1 MONDAY MARCH 3, 2008 ANSWER KEY
MCB 160 - MIDTERM EXAM #1 MONDAY MARCH 3, 2008 ANSWER KEY Name ID# Instructions: -Only tests written in pen will be regarded -Please submit a written request indicating where and why you deserve more points
AP Biology Unit 6. The Nervous System
AP Biology Unit 6 The Nervous System Branches of the Nervous System There are 2 main branches of the nervous system Central Nervous System Brain Spinal Cord Peripheral Nervous System All nerves leading
Cellular Neurobiology BIPN140. 1st Midterm Exam October 18 th, Tuesday Material covered: Lectures 1-6 & Reading
Cellular Neurobiology BIPN140 1st Midterm Exam October 18 th, Tuesday Material covered: Lectures 1-6 & Reading Review session October 17 th 3500 Pacitic Hall, 6-8 pm (access code is 127895) Come with questions!
Neurons Chapter 7 2/19/2016. Learning Objectives. Cells of the Nervous System. Cells of the Nervous System. Cells of the Nervous System
Learning Objectives Neurons Chapter 7 Identify and describe the functions of the two main divisions of the nervous system. Differentiate between a neuron and neuroglial cells in terms of structure and
Memory Systems II How Stored: Engram and LTP. Reading: BCP Chapter 25
Memory Systems II How Stored: Engram and LTP Reading: BCP Chapter 25 Memory Systems Learning is the acquisition of new knowledge or skills. Memory is the retention of learned information. Many different
Cellular Bioelectricity
ELEC ENG 3BB3: Cellular Bioelectricity Notes for Lecture 24 Thursday, March 6, 2014 8. NEURAL ELECTROPHYSIOLOGY We will look at: Structure of the nervous system Sensory transducers and neurons Neural coding
Neuropharmacology NOTES
Neuropharmacology NOTES Contents Topic Page # Lecture 1- Intro to Neurochemical Transmission & Neuromodulation 2 Lecture 2- Serotonin & Noradrenaline 7 Lecture 3- Acetylcholine & Dopamine 14 Lecture 4-
Fundamentals of the Nervous System and Nervous Tissue: Part C
PowerPoint Lecture Slides prepared by Janice Meeking, Mount Royal College C H A P T E R 11 Fundamentals of the Nervous System and Nervous Tissue: Part C Warm Up What is a neurotransmitter? What is the
LECTURE 2. C. Reason correlation and synaptic delay not enough to prove direct connection. D. Underlying mechanism behind oscillations possibilities
LECTURE 2 A. Identifying Swimmy neurons B. Finding E and I inputs to cells 1 and 2 C. Reason correlation and synaptic delay not enough to prove direct connection D. Underlying mechanism behind oscillations
Nerve Cell Flashcards
1. What does the word innervates mean? Refers to a nerve supplying a muscle or organ. For example, The phrenic nerve innervates the diaphragm muscle. 2. 3 parts of the Nervous System 1. Central Nervous
The study of drugs. Pharmacology
The study of drugs Pharmacology Psychopharmacology The study of psychoactive drugs Psychoactive drugs Drugs that influence psychological processes mood emotion perception cognition behavior Psychoactive
Autonomic Nervous System and Hypothalamus
Lu Chen LSA room 201 Phone: (510) 643-8163 Email: luchen@berkeley.edu Office hours: M,W,F, 10-11 am 1 Autonomic Nervous System and Hypothalamus Lu Chen, Ph.D. MCB, UC Berkeley 2 Hypothalamus Brain stem
UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE PHYSIOLOGY DEPARTMENT COURSE DESCRIPTION
UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE PHYSIOLOGY DEPARTMENT COURSE DESCRIPTION COURSE TITLE: INTRODUCTION TO NEUROSCIENCE COURSE CODE: FISA 8525 CREDIT HOURS: COURSE DURATION: 3 CREDITS (54 HOURS)
NEUROBIOLOGY ALCOHOLISM
NEUROBIOLOGY ALCOHOLISM THERE HAS BEEN A MAJOR THEORETICAL SHIFT IN MEDICATION DEVELOPMENT IN ALCOHOLISM Driven by animal models of intermittent ethanol administration followed by termination, then access
2Lesson. Outline 3.2. Lesson Plan. The OVERVIEW. Lesson 3.2: How do our neurons communicate with each other? LESSON. Unit1.2
Outline OVERVIEW Rationale: This lesson is intended to introduce students to the process of synaptic transmission, which is how one neuron communicates with another neuron. Using the pain pathway as a
Endocrine System Nervous System
Cells Endocrine System Nervous System Tissues Controls Organs Nervous System vs Endocrine System Electrical signals (graded potentials and action potentials) and chemical signals (neurotransmitters) Fast
Neural Communication. Central Nervous System Peripheral Nervous System. Communication in the Nervous System. 4 Common Components of a Neuron
Neural Communication Overview of CNS / PNS Electrical Signaling Chemical Signaling Central Nervous System Peripheral Nervous System Somatic = sensory & motor Autonomic = arousal state Parasympathetic =
Hole s Human Anatomy and Physiology Tenth Edition. Chapter 10
PowerPoint Lecture Outlines to accompany Hole s Human Anatomy and Physiology Tenth Edition Shier Butler Lewis Chapter 10 Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or