IMPORTANT DATES FOR THE 2008 FALL TERM. Fall term classes begin. Drop period ends. Thanksgiving Recess begins at 5PM. Thanksgiving recess ends at 8AM

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1 IMPORTANT DATES FOR THE 2008 FALL TERM Sept 3 Oct 10 Nov 26 Dec. 1 Dec 5 Dec 6-9 Dec Dec 17 Fall term classes begin Drop period ends Thanksgiving Recess begins at 5PM Thanksgiving recess ends at 8AM Last day of Fall term classes Reading days Final Exams Fall term ends OFFICE LOCATION/NUMBERS/ David Allman: 230 John Morgan Building (office) (lab) (cell) dallman@mail.med.upenn.edu - 1 -

2 IMMUNOLOGY IMMUNE MECHANISMS FALL 2008 MONDAY, WEDNESDAY, FRIDAY 1:00 3:00PM ROOM 252 BRB II/III COURSE GOALS: There are several objectives: First, we will introduce you to basic principles, as well as current and emerging concepts in immunology. Second, we want you to think with considerable depth about how these principles and concepts were shaped through experiment, as well as their implications, limits and caveats. Third, the lectures, readings and exams should hone your ability to think clearly and critically about the interpretation of data and the design of experiments. Finally, we expect you to leave with a foundation that will enable you to keep abreast of the field through reading and critical appraisal of the literature. COURSE DESCRIPTION: The course will be taught from an experimental standpoint and assume basic knowledge of the immune system. To the greatest extent possible, it will use the primary literature, with reference to texts for background information. We will begin with a brief overview of innate and adaptive immune processes, followed by in depth considerations of the underlying cellular, molecular, and genetic events. Following this, mechanisms governing immune activity and homeostasis at the organism level will be considered. EXAMS AND GRADING: There will be two exams, one mid-term and one final. Both will be closed book and in-class exams. The exact format of these will be announced prior to each exam, but both will consist of essay or brief answer questions based upon experimental descriptions and/or data. Each exam will be marked based on a maximum possible score of 100. Final letter grades will be determined solely by exam performance. The class-wide distribution of final scores will be used to determine the range that corresponds to a particular letter grade. READINGS: Each lecturer will assign up to three readings per lecture from the primary literature. Further, some lecturers have provided a more extensive (but not requisite) list for your benefit, should you wish to expand your depth or background in certain areas. Background readings using the following recommended texts may also be suggested by individual lecturers, although I would emphasize that in the end it is each students responsibility to ascertain how much background reading he/she needs and what specific readings would be beneficial. The recommended texts to be used for background reading are: Immunobiology (7 th edition), by Murphy et al; Garland Press. Fundamentals of Immunology (5 th edition) by Paul (ed). Raven Press Both are available in the University bookstore, Dolby, or via Amazon.com. You will need to download pdf s for assigned and suggested readings from the primary literature, as well as reading lists and outlines provided by individual lecturers, from a Blackboard web site assigned to Immun 506. To access this site you will need to know your PENNKEY and password. The URL for Blackboard sites at Penn is:

3 Sept. 5 Orientation David Allman Sept. 8 Introduction Mike Cancro WEEK 1 Sept. 10 Hematopoiesis Martin Carroll Sept. 12 Discussion and perspective: Hematopoiesis Martin Carroll Sept 15 Molecular genetics of B and T cell antigen receptors Session I Andy Caton WEEK 2 Sept. 17 Molecular genetics of B and T cell antigen receptors Session II Andy Caton Sept. 19 Discussion and perspective: Recombination Andy Caton Sept. 22 Why generate so many unique V L V H pairs in the first place? B lymphocyte differentiation and selection I Mike Cancro David Allman WEEK 3 Sept. 24 B lymphocyte differentiation and selection II David Allman Sept. 26 Enzymology of V(D)J recombination Craig Bassing - 3 -

4 September 29 The Molecular Basis of T Cell Recognition: Immune response genes Paula Oliver WEEK 4 October 1 The Molecular Basis of T Cell Recognition: Introduction to the MHC Paula Oliver October 3 The Molecular Basis of T Cell Recognition: Generation of T Cell Receptor Ligands I Mickey Marks WEEK 5 October 6 October 8 Origins of the Inbred Mouse The Molecular Basis of T Cell Recognition: Generation of T Cell Receptor Ligands II T cell development and selection I David Gasser Mickey Marks Avinash Bhandoola October 10 T cell development and selection II Terri Laufer WEEK 6 October 13 October 15 The epigenetics of allelic exclusion Lymphocyte receptor signaling pathways I Lymphocyte receptor signaling pathways II Craig Bassing Jon Maltzman Jon Maltzman October 17 Lymphocyte receptor signaling pathways III Yair Argon - 4 -

5 October 20 T cell development and selection III Integrating development and signaling Terri Laufer WEEK 7 October 22 Review October 24 Mid-Term Exam WEEK 8 October 27 October 29 Innate Immunity I Toll receptors Innate Immunity II Complement, neutrophils, and adhesion molecules Chris Hunter Kate Sullivan October 31 Innate Immunity III Macrophages and granulomas Kate Sullivan 3 Innate Immunity IV NK cells Jordan Orange WEEK 9 5 Dendritic cells Ed Pearce Nov. 7 Controlling the T cell immune response I Phil Scott - 5 -

6 Origin of the 2 signal hypothesis for T cell activation 10 Controlling the T cell immune response II James Riley Phil Scott/ Steve Reiner WEEK Controlling the T cell immune response III T cell memory John Wherry 14 IGG RETREAT NO CLASS WEEK Controlling the T cell immune response DISCUSSION Regulation of mucosal immunity Antibody-mediated immunity and peripheral B cell subsets Steve Reiner/ John Wherry David Artis David Allman 24 Leukocyte trafficking Gudrun Debes WEEK NO CLASS NO CLASS - 6 -

7 Enzymology of the germinal center response Craig Bassing December 1 T cell tolerance - beyond central deletion Andy Caton WEEK 13 December 3 Lymphocyte homeostasis Mike Cancro December 5 Apoptosis in the immune system Craig Thompson WEEK 14 December 8 December 10 Discussion and perspective Review Mike Cancro December 12 Final exam - 7 -

8 FACULTY PARTICIPATING IN IMMU 506 (FALL 2008) Name Location Phone Allman, David 230 John Morgan Argon, Yair 816B Abramson (267) Artis, David 314 Hill Pavilion Bassing, Craig 816E Abramson Bhandoola, Avinash 264 John Morgan Cancro, Mike 284 John Morgan Carroll, Martin 708 BRBII/III Caton, Andy 266 Wistar Debes, Gudrun 317 Hill Pavilion Erikson, Jan 4268 Wistar Gasser, David 575 CRB Hunter, Chris 310F Hill Pavilion Laufer, Terry 753 BRB II/III Marks, Mickey 513 Stellar Chance Maltzman, Jonathan 105 CRB Oliver, Paula Orange, Jordan 816F Abramson 1216F Abramson (267) (267) Pearce, Edward 318 Hill Pavilion Reiner, Steven 414 BRB II/III Riley, James 556 BRB II/III Scott, Phil 310B Hill Pavilion Sullivan, Kate 1208 Abramson Wherry, John 251 Wistar Thompson, Craig 451 BRB II/III