Plan of the course. Immunology. Academic year 2017/2018. prof. dr. sc. Dora Višnjić doc. dr. sc. Vesna Lukinović-Škudar

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1 UNIVERSITY OF ZAGRE SCHOOL OF MEDICINE Plan of the course Immunology Academic year 2017/2018

2 I. COURSE AIMS The course is intended to provide important and recent knowledge of cellular and molecular immunology. Students will be presented large amount of complex information within three weeks; therefore, the main aim is to teach basic concepts of experimental immunology, which are also applicable in a clinical setting. The extensive additional reading will be provided for students who would like to learn more about immune system function in health and disease. will be focused on important concepts of immune system function in physiological and pathological conditions. s will include interactive discussion, as well as the presentation of clinical cases, in order to present complex mechanisms of immune response in a clear and understandable way. Practical part of the course will be performed in small groups to allow students to acquire lab-work skills related to some commonly used immunological techniques. II. COURSE STRUCTURE Course hours: : 9 : 26 Practicum: 15 Total hours: 50 s Practicals 4 (total 6 hours) 10 (total 29 hours) 3 (total 15 hours) Total 50 hours III. PLAN OF THE COURSE AND COURSE SCHEDULE LOCKS OF THE COURSE Number of blocks: 1 lock number Start End LOCKS OF THE COURSE Number of blocks: 1 lock number Start End LOCKS OF THE COURSE SHEME lock 1

3 Date Time Group Course hours type Theme 13:00-13:45; A+ Introduction to immunology 14:00-15:30; A+ Organization of the immune system Wednesday Thursday Monday Wednesday Thursday Monday :00-16:15; 08:00-12:30; MEF Fiziologija I A 13:00-17:30; MEF Fiziologija I 14:00-16:15; A Innate immunity Innate immunity Practicum Practicum Preparation of cell suspension, immunofluor. staining, FAC S Preparation of cell suspension, immunofluor. staining, FAC S Antibody, antigen, MHC A Antibody, antigen, MHC A A Lymphocyte development, activation of T lymphocytes Lymphocyte development, activation of T lymphocytes Differentiation and function of C D4+ and C D8+ T lymphocytes Differentiation and function of C D4+ and C D8+ T lymphocytes KC, Poliklinika Practicum Application of immunological techniques in clinical medicine 12:00-12:45; A+ C ytokines 15:00-17:15; KC, Poliklinika A Practicum Application of immunological techniques in clinical medicine A Humoral immunity Humoral immunity Immunity to infections. Vaccination. A Immunity to infections. Vaccination. A Tolerance. Autoimmunity. Tolerance. Autoimmunity. Teaching staff dr. sc. Hrvoje Lalić, Darja Flegar, dr. med., dr. sc. Vilma Dembitz dr. sc. Vilma Dembitz, dr. sc. Alan Šućur, Darja Flegar, dr. med.

4 Date Time Group Course hours type Theme Teaching staff Wednesday Thursday :00-11:30; Transplantation A Transplantation A Tumor A Tumor 13:00-17:30; MEF Fiziologija I A Practicum lood groups. Differential. Hypersensitivity A Hypersensitivity 13:00-17:30; MEF Fiziologija I Practicum lood groups. Differential. 11:00-12:30; 09:00-10:30; 09:00-10:30; MEF Č ačković MEF Fiziologija Vježbaonica MEF Fiziologija Vježbaonica MEF Fiziologija Vježbaonica SVI Immunodeficiency dr. sc. Alan Šućur, dr. sc. Hrvoje Lalić, Darja Flegar, dr. med. dr. sc. Vilma Dembitz, dr. sc. Alan Šućur, dr. sc. Hrvoje Lalić WEEK 1 TYPE TOPIC (duration) Chapter Introduction to immunology (45 min) Organization of the immune system (2 45 min)

5 s Innate immunity (3x45 min) Antibodies, antigens and MHC (3x45) Ch 4 Ch 5 & 6 Practicals Preparation of cell suspension, Immunoflurescence staining, Flow-cytometric analysis (6x45 min) WEEK 2 TYPE TOPIC (duration) Chapter Cytokines (45 min) s Lymphocyte development, activation of T lymphocytes (3x45) Differentiation and function of CD4+, CD8+ T cells (3x45 min) Humoral immunity (3x45) Immunity to infections. Vaccination (3x45) Ch 8 & 9 Ch 10 & 11 Ch 12 & 13 Ch 16 (+14) Practicals lood groups. Differential. (6 45 min) WEEK 3 TYPE TOPIC (duration) Chapter Immunodeficiency (2 45 min) s Tolerance. Autoimmunity. (3x45) Transplantation (2 45 min) Tumor immunology (3 45 min) Hypersensitivity (3x45 min) Ch 15 (+14) Ch 17 Ch 18 Ch 19 & 20 Practical Application of immunological techniques in clinical medicine (3 45) IV. EXAMINATIONS IV. EXAMINATION Final examination (written+oral) will be organized at the end of the course (, , 9.00 h Cackovic Room) and several times thereafter, within the academic year. Written exam (test) will include 40 multiple-choice questions. Students need to answer at least 55% of the questions correctly to pass the written exam and to qualify for taking the oral examination. Students seminar work and presentation will be evaluated and included in the final score (maximum 10% of total points). The final oral examination determines the final mark of the course.

6 Regular terms Date Winter Summer Autumn V./I. LIST OF LECTURERS AND TEACHING STAFF dr. sc. Vilma Dembitz dr. sc. Hrvoje Lalić 8. dr. sc. Alan Šućur Darja Flegar, dr. med. V./II EXTERNAL ASSOCIATES: V./III UNTENURED LECTURERS: VI. LITERATURE A. Obligatory 1. Abbas AK, Lichtman H, Pillai S. Cellular and molecular immunology, 8th edition, Philadelphia Saunders, 2015.

7 . Additional 1. Parham Peter. The Immune System, 4th Edition, New York-London, Garland Science, Taylor & Francis Group, Delves PJ. Martin SJ, urton DR, Roitt IM, Roitt's Essential Immunology, 13th edition. Wiley-lackwell, Murphy K., Weaver C. Janeway's Immunobiology, 9th edition. New York: Garland Science; Geha R, Notarangelo L. Case studies in immunology: A clinical companion, 7th edition. New York: Garland Science; Hawley L, Clarke. Microbiology & Immunology: oard Review Series, 6th edition. Philadelphia: Lippincott Williams & Wilkins; 2013.