Course Outline: MIMM Department of Microbiology and Immunology McGill University

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1 Course Outline: MIMM214 1 Department of Microbiology and Immunology McGill University MIMM214 - INTRODUCTORY IMMUNOLOGY: ELEMENTS OF IMMUNITY COURSE OUTLINE 1. GENERAL INFORMATION Number of the course: Title of course: Description: MIMM214 Introductory Immunology: Elements of Immunity The curriculum in Immunology is structured as a ribbon of courses extending from U1 to U3. In each of these years, there is a corresponding Immunology course that provides an introduction to the discipline (MIMM214), a mechanistic approach to Immunology (MIMM314) and an advanced exposure to current topics in Immunology (MIMM414). MIMM214 is an introductory course providing an entry-level exposure to Immunology to a broad range of students: from those in a general science program to those going into Microbiology and Immunology as field of specialization. As an introductory course, it emphasizes the description of molecular and cellular elements of the immune system, and their basic function. Emphasis is also placed in the biological context in which these elements operate to provide immunity and how the impairments of their function may result in diseases. The course will provide the required basis to tackle subsequent more advanced courses in Immunology. Number of credits: 3 credits Name & title of the Instructor: J. (Quim) Madrenas Professor and Chair, Department of Microbiology & Immunology Office: Duff Medical Building, Room 511 Phone: (514) Joaquin.madrenas@mcgill.ca Office hours: Tuesdays from 03:00PM to 05:00PM. Contact Ms. Beatrice Doroga at (514) to make an appointment Day, place and time of classes: M-W-F 12:35 to 13:25 (from Jan 5/2015 to April 10/2015) Adams Auditorium. Prerequisite: BIOL200

2 Course Outline: MIMM214 2 Co-requisite: Notes: BIOL201 or ANAT212/BIOC212 Required course for U1 Microbiology & Immunology students Required course for Major Neuroscience (Stream A) students 2. COURSE CONTENT AND CALENDAR Overview of the course. A brief history of Immunology 1 hour Jan 5/15 Learning the jargon: Immunity, Antigens, Epitope, Primary vs. secondary immune response, immunization: active vs. passive, phases of an Immune response, immune memory Making an immune system: Hemopoiesis. Organs and cells of the immune system. Response to injury and infection: Innate Immunity: Physical, chemical and cellular players Innate Mechanisms of Immunity: complement activation, phagocytosis 1 hour Jan 7/15 1 hour Jan 9/15 1 hour Jan 12/15 1 hour Jan 14/15 Innate Mechanisms of Immunity: inflammation: initiation 1 hour Jan 16/15 Innate Mechanisms of Immunity: inflammation: consequences Cell language: Growth factors, Cytokines, Chemokines and their receptors 1 hour Jan 19/15 1 hour Jan 21/15 Real Life Translation: CASE STUDY #1 1 hour Jan 23/15 Adaptive immunity: Cellular and molecular players: antigen-presenting cells, MHC molecules Adaptive immunity: Cellular and molecular players: antigen processing and presentation Adaptive immunity: Cellular and molecular players: T lymphocytes, T-cell antigen receptor Adaptive immunity: Cellular and molecular players: coreceptors 1 hour Jan 26/15 1 hour Jan 28/15 1 hour Jan 30/15 1 hour Feb 2/15 Adaptive immunity: Cellular and molecular players: B 1 hour Feb 4/15

3 Course Outline: MIMM214 3 lymphocytes, B-cell antigen receptor, antibodies (I) Adaptive immunity: Cellular and molecular players: antibodies (II), co-receptors 1 hours Feb 6/15 Generation of antigen receptor diversity in B cells 1 hour Feb 9/15 Generation of antigen receptor diversity in T cells 1 hour Feb 11/15 Lymphocyte development and homeostasis 1 hour Feb 13/15 Real Life Translation CASE STUDY #2 1 hour Feb 16/15 MIDTERM EXAM: IN CLASS 1 hour Feb 18/15 General concepts on lymphocyte activation: MHC restriction and allorecognition, costimulation and two signal model General concepts on lymphocyte activation: Signalling pathways Leukocyte trafficking: adhesion molecules, homing receptors Profiles of cytokine expression and types of immune response 1 hour Feb 20/15 1 hour Feb 23/15 1 hour Feb 25/15 1 hour Feb 27/15 STUDY WEEK March 2-6/15 Real life translation CASE STUDY #3 1 hour Mar 9/15 Immunity against viruses and intracellular bacteria: How does a cellular (Th1) immune response take place? Clonal selection theory (I) Immunity against viruses and intracellular bacteria: How does a cellular (Th1) immune response take place? (II) Immunity against extracellular pathogens: How does a humoral (Th2) immune response take place? (I) Immunity against extracellular pathogens: How does a humoral (Th2) immune response take place? (II) 1 hour Mar 11/15 1 hour Mar 113/15 1 hour Mar 16/15 1 hour Mar 18/15

4 Course Outline: MIMM214 4 Inflammatory (Th17) adaptive immune responses and other profiles (Tfh, Th9, etc) Negative regulation of an immune response: FcR, CTLA-4, PD-1, activation-induced cell death Negative regulation of an immune response: Regulatory T cells and other mechanisms 1 hour Mar 20/15 1 hour Mar 23/15 1 hour Mar 25/15 Immune Tolerance 1 hour Mar 27/15 Immunological memory 1 hour Mar 30/15 Real life translation CASE STUDY #4 1 hour Apr 1/15 Review Session 1: Questions & Answers 1 hour Apr 8/15 Review Session 2: GRAND FINALE SESSION 1 hour Apr 10/15 FINAL EXAM 3 hour exam TBA 3. INSTRUCTIONAL METHOD Interactive lectures with pro-active student participation and discussion. It is highly recommended that students come to class having read the material for the particular lecture. 4. LEARNING OUTCOMES After taking this course students should be able to: To use standard terminology in the field of Immunology To list the cells and some of the molecules involved in immunity To describe the organs of the immune system To describe the main steps in the generation of cells of the immune system To describe the basic mechanisms that provide innate immunity To define inflammation and list the cellular and molecular players of inflammatory responses To define cytokines and chemokines To describe antigen processing and presentation To describe antibodies and antigen receptors on lymphocytes To explain cellular and molecular features of lymphocyte activation To describe the main steps in the development of adaptive immunity To explain cell-mediated adaptive immune responses against viruses and intracellular pathogens

5 Course Outline: MIMM214 5 To explain antibody-mediated adaptive immune responses against extracellular pathogens and parasites To list basic mechanisms that regulate immune responses To define immunological memory from an operational point of view To define, list mechanisms, and provide examples of immune tolerance To explore the biological and clinical implications of immune mechanisms 5. COURSE MATERIAL Janeway s Immunobiology, 8 th edition, Murphy, K. Garland Science, Also available as ipad textbook (inkling). Textbook is required 6. COURSE EVALUATION Midterm exam worth 35% of final mark and covering from first lecture to the lecture before Midterm exam. Final exam worth 65% of final mark. The final exam will cover all the material of the course. Both exams will be based on Multiple Choice Questions with 5 options, only 1 of which is correct. The questions in the final exam will be based on case studies. 7. MCGILL POLICY STATEMENTS 1) McGill University values academic integrity. Therefore, all students must understand the meaning and consequences of cheating, plagiarism and other academic offences under the Code of Student Conduct and Disciplinary Procedures (see for more information). L'université McGill attache une haute importance à l honnêteté académique. Il incombe par conséquent à tous les étudiants de comprendre ce que l'on entend par tricherie, plagiat et autres infractions académiques, ainsi que les conséquences que peuvent avoir de telles actions, selon le Code de conduite de l'étudiant et des procédures disciplinaires (pour de plus amples renseignements, veuillez consulter le site 2) In accord with McGill University s Charter of Students Rights, students in this course have the right to submit in English or in French any written work that is to be graded. Conformément à la Charte des droits de l étudiant de l Université McGill, chaque étudiant a le droit de soumettre en français ou en anglais tout travail écrit devant être noté (sauf dans le cas des cours dont l un des objets est la maîtrise d une langue). 3) In the event of extraordinary circumstances beyond the University s control, the content and/or evaluation scheme in this course is subject to change.

6 Course Outline: MIMM ) If you have a disability please contact the instructor to arrange a time to discuss your situation. It would be helpful if you contact the Office for Students with Disabilities at before you do this. 5) McGill has policies on sustainability, paper use and other initiatives to promote a culture of sustainability at McGill. 6) Additional policies governing academic issues which affect students can be found in the McGill Charter of Students' Rights (available at Student-Rights-and-Responsibilities-2010.pdf)