면역유전자치료법개발 : 면역결핍환자들에서발병하는바이러스질환과종양의치료를위해 CTLs를이용한세포성면역치료법과수지상세포를이용한종양백신의개발하고, 면역치료의연구자임상을수행하고있음.

Transcription

1 약력 1. 인적사항 작성 : 2010 년 4 월 성명김태규 ( 金泰圭, Tai-Gyu Kim ) 주민등록번호 소속기관가톨릭대학교의과대학미생물학교실직위교수 전화 이동통신 연락처 팩스 전자메일 kimtg@catholic.ac.kr 직장주소서울특별시서초구반포동 505 ( 우편번호 : ) 2. 학력 / 경력 연도학교 / 기관전공 / 직위학위 / 비고 가톨릭대학교의과대학의학의학사 가톨릭대학교대학원미생물학의학석사 가톨릭대학교대학원미생물학의학박사 가톨릭대학교의과대학미생물학교실조교 국립보건원공중보건의군복무 가톨릭대학교의과대학미생물학교실전임강사 가톨릭대학교의과대학미생물학교실조교수 St. Jude Children's Research Hospital, TN, USA 해외연수 가톨릭대학교의과대학미생물학교실부교수 가톨릭암센터연구부장 가톨릭조혈모세포은행소장 가톨릭대학교의과대학미생물학교실 교수 가톨릭세포치료사업단 운영위원 가톨릭대학교의과대학미생물학교실주임교수 3. 주요연구분야 면역유전학연구 : HLA 유전자검사법개발과가톨릭조혈모세포은행을통해조혈모세포이식과장기이식등의이식면역학분야에기여하고있으며, 자가면역질환, 감염성질환및종양에대해다양한면역유전자 ( 항원처리및항원제시에연관된유전자, 사이토카인등 ) 의연관성을조사하여질병의발병과진전등에대한면역유전학적배경을규명하고있음. 면역유전자치료법개발 : 면역결핍환자들에서발병하는바이러스질환과종양의치료를위해 CTLs를이용한세포성면역치료법과수지상세포를이용한종양백신의개발하고, 면역치료의연구자임상을수행하고있음.

2 4. Publications : (recently published in 5 yrs) 1. Fusion of the HCMV pp65 antigen with both ubiquitin and ornithine decarboxylase additionally enhances antigen presentation to CD8+ T cells in human dendritic cells. Min-Ji Park, Eun-Kyung Kim, Ji-Young Han, Hyun-Woo Cho, Hyun-Jung Sohn, Su-Yeon Kim, Tai-Gyu Kim. Human Gene Therapy Mar Efficient co-transduction of adenoviral vectors encoding carcinoembryonic antigen and survivin into dendritic cells by the CAR-TAT adaptor molecule enhance antitumor immunity in a murine colorectal cancer model. Kim HS, Kim CH, Park MY, Park JS, Park HM, Sohn HJ, Kim HJ, Kim SG, Oh ST, Kim TG. Immunology Letter Mar Establishment and characterization of gastric carcinoma cell clones expressing LMP2A of Epstein-Barr virus. Jung Seon Seo, Se Mo Jun, Sang Wook Kwon, Il-Hoan Oh, Tai-Gyu Kim, Suk Kyeong Lee. International Journal of Molecular Medicine Jan;25(1): Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model. Tai-Gyu Kim, Chang-Hyun Kim, Jung-Sun Park, Sung-Dong Park, Chung Kwon Kim, Dong-Sup Chung, and Yong-Kil Hong Jan;17(1): Topoisomerase II alpha as a universal tumor antigen: antitumor immunity in murine tumor models and H-2K(b)-restricted T cell epitope. Jung-Sun Park, Hye-Sung Kim, Mi-Young Park, Chang-Hyun Kim, Yeun-Jun Chung, Yong-Kil Hong and Tai-Gyu Kim. Cancer Immunology Immunotherapy May;59(5): Association between IL-4R and TGF-β1 Gene Polymorphisms and the Risk of Colorectal Cancer in a Korean Population Lee Yoon Suk, Choi Hee Beak, Lee In Kyu, Kim Tea Gyu,Oh Seung Teak. Colorectal Disease Oct Potential role of adoptively transferred allogeneic WT1-specific CD4+ and CD8+ T lymphocytes for the sustained remission of refractory AML. Yoo-Jin Kim, Seok-Goo Cho, Seok Lee, M-S Kim, Eun-Kyung Kim, Byung-Sik Cho, Hyun-Jung Sohn, Hee Baeg Choi, Ki-Sung Eom, Chang-Ki Min, Hee-Je Kim, Yang-Kyum Kim, Dong-Wook Kim, Jong-Wook Lee, Woo-Sung Min, Chun-Choo Kim and Tai-Gyu Kim. Bone Marrow Transplantation, 2009 Aug; 17: Transfer of Her-2/neu Specificity into Cytokine-Induced Killer (CIK) Cells with RNA Encoding Chimeric Immune Receptor (CIR). Sung Hee Yoon, Jin Myung Lee, Sun-Je Woo, Min-Ji Park, Jung-Sun Park, Hye-Sung Kim, Mi-Young Park, Hyun-Jung Sohn and Tai-Gyu Kim. Journal of Clinical Immunology, 2009 Nov;29(6): Selective addition of CXCR3+CCR4-CD4+ Th1 cells enhances generation of cytotoxic T cells by DC in vitro. Sung Hee Yoon, Sun Ok Yun, Jung Yong Park, Hee Yeun Won, Eun-Kyung Kim, Hyun-Jung Sohn, Hyun-Il Cho, and Tai-Gyu Kim. Experimental and Molecular Medicine Mar 31;41(3): Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model. Sung Hee Yoon, Jin Myung Lee, Hyun-Il Cho, Eun-Kyung Kim, Hye-Sung Kim, Mi-Young Park, Tai-Gyu Kim. Cancer Gene Therapy Jun;16(6): Modification of CEA with both CRT and TAT PTD induces potent anti-tumor immune responses in RNA-pulsed DC vaccination. Sung-Guh Kim, Mi-Young Park, Chang-Hyun Kim,

3 Hyun-Jung Sohn, Hye-Sung Kim, Jung-Sun Park, Hyung-Jin Kim, Seong-Taek Oh and Tai-Gyu Kim. Vaccine Nov 25;26(50): Efficient antitumor immunity in a murine colorectal cancer model induced by CEA RNA-electroporated B cells. Mi-Young Park, Hye-Sung Kim, Sun-Je Woo, Chang-Hyun Kim, Jung-Sun Park, Hyun-Jung Sohn, Hyung-Jin Kim, Seong-Taek Oh, Tai-Gyu Kim. European Journal of Immunology Aug;38(8): Efficient generation of survivin-specific cytotoxic T lymphocytes from healthy persons in vitro: Quantitative and qualitative effects of CD4+ T cells. Eun-Kyung Kim, Hyun-Il Cho, Sung Hee Yoon, Min-Ji Park, Hyun-Jung Sohn, Hyung-Jin Kim, Seong-Taek Oh and Tai-Gyu Kim, Vaccine Jul 29;26(32): Co-administration of carcinoembryonic antigen and HIV TAT fusion protein with CpG-oligodeoxynucleotide induces potent antitumor immunity. Woo Sun Je, Kim Chang Hyun, Park Mi Young, Kim Hye Sung, Sohn Hyun Jung, Park Jung Sun, Kim Hyung Jin, Oh Seong Tak, Kim Tai Gyu. Cancer Science May;99(5): Polymorphisms of human le ukocyte antigen genes in korean children with kawasaki disease. Jin Hee Oh, Ji Whan Han, Soon Ju Lee, Kyung Yil Lee, Byung Kyu Suh, Dae Kyun Koh, Joon Sung Lee, Chang Kyu Oh, Tai Gyu Kim, and Hee Baeg Choi. Pediatric Cardiology Mar29(2): Association of HLA alleles with non-hodgkin's lymphoma in Korean population. Hee-Baeg Choi, Sang-Young Roh, Eun-Jung Choi, Ho-Yeul Yoon, Su-Yeonm Kim, Young-Sun Hong, Dong-Wook Kim, and Tai-Gyu Kim. International Journal of Hematology Feb;87(2): A membrane-bound form of IL-4 enhances proliferation and antigen presentation of CD40-activated human B cells. Jung-Yong Park a, Sung Hee Yoon, Eun-Kyung Kim, Sun-Ok Yun, Mi-Young Park, Hyun-Jung Sohn and Tai-Gyu Kim. Immunology Letter Feb 15;116(1): Identification of Leukemia-Specific Fusion Gene Transcripts with a Novel Oligonucleotide Array. Sung-Min Chun, Yoo-Li Kim, Hee Baeg Choi, Yong-Taek Oh, Yoo-Jin Kim, Seok Lee, Tai-Gyu Kim, Eun Gyeong Yang, Yong-Keun Park, Dong-Wook Kim and Byoung-Don Han. Molecular Diagnosis & Therapy Nov 1; Enhanced induction of anti-tumor immunity in human and mouse by dendritic cells pulsed with recombinant TAT fused human survivin protein. Hyun-Il Cho, Eun-Kyung Kim, Soo-Young Park, Su Kyung Lee, Yong-Kil Hong, Tai-Gyu Kim. Cancer Letters Dec 18;258(2): Enhanced antitumour immunity by combined use of temozolomide and TAT-survivin pulsed dendritic cells in a murine glioma. Chang-Hyun Kim, Sun-Je Woo, Jung-Sun Park, Hye-Sung Kim, Mi-Young Park, Sung-Dong Park, Yong-Kil Hong, and Tai-Gyu Kim. Immunology Dec;122(4): The Activating Killer Cell Immunoglobulin-Like Receptors as Important Determinantsof Acute Graft-Versus Host Disease in Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia. Hee-Je Kim, Young Choi, Woo-Sung Min, Tai-Gyu Kim, Byung-Sik Cho, Sung-Yong Kim, Ki-Sung Eom, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee, Chun-Choo Kim. Transplantation Nov 15;84(9): Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean

4 population. Yang-Kyum Kim, Chul-Woo Pyo, Hee-Baeg Choi, Su-Yeon Kim, Tae-Yoon Kim, Tai-Gyu Kim. Journal of Dermatological Science Nov;48(2): The optimal interval for dendritic cell vaccination following adoptive T cell transfer is important for boosting potent anti-tumor immunity. Mi-Young Park, Chang-Hyun Kim, Hyun-Jung Sohn, Seong-Taek Oh, Sung-Guh Kim, Tai-Gyu Kim. Vaccine Oct 16;25(42) Distribution of the minor histocompatibility antigens in Korean population and disparities in unrelated hematopoietic SCT. M-J Park, H-B Choi, J-P Jang, H-J Kim, Y-J Kim, K-S Eom, S Lee, D-W Kim, J-W Lee, W-S Min, C-C Kim, and T-G Kim. Bone Marrow Transplantation Oct;40(8): Direct vaccination with pseudotype baculovirus expressing murine telomerase induces anti-tumor immunity comparable with RNA-electroporated dendritic cells in a murine glioma model. Chang-Hyun Kim, Jong-Sub Yoon, Hyun-Jung Sohn, Chung-Kwon Kim, Soon-Young Paik, Yong-Kil Hong and Tai-Gyu Kim. Cancer Letters Jun 8;250(2): Influence of killer cell immunoglobulin-like receptor genotypes on acute graft-vs-host disease after unrelated hematopoietic stem cell transplantation in Koreans. Kim SY, Choi HB, Yoon HY, Choi EJ, Cho B, Kim HK, Kim YJ, Kim HJ, Min CK, Kim DW, Lee JW, Min WS, Kim CC, Kim TG. Tissue Antigens Apr;69(1): Cross-priming by temozolomide enhances antitumor immunity of dendritic cell vaccination in murine brain tumor model. Sung-Dong Park, Chang-Hyun Kim, Chung-Kwon Kim, Jin-A Park, Hyun-Jung Sohn, Yong-Kil Hong and Tai-Gyu Kim. Vaccine Apr 30;25(17): Potentiation of antiglioma effect with combined temozolomide and interferon-beta.. Park Jin Ah, Young-Ae Joe, Tai-Gyu Kim, Yong-Kil Hong. Oncology Reports Dce;16(6): Early apoptosis in CD34+ cells as a potential heterogeneity in quality of cryopreserved umbilical cord blood. Shim Jae Seung, Bin Cho, Myung-Shin Kim, Gyeong-Sin Park, Jong-Chul Shin, Hong-Kyu Whang, Tai-Gyu Kim and Il-Hoan Oh. British Journal of Haematology Oct; 135(2), 210~ Alteration of the influences of HLA classes I and II alleles on the perinatal hepatitis B virus infection after immunoprophylaxis in Korean children. Jong-Hyun Kim, Chul-Woo Pyo, Dae-Kyun Koh, Jae-Kyun Hur, Jin-Han Kang, Tai-Gyu Kim. Hepatology Research Jun;35(2) 118~ Dendritic cells transduced with recombinant adenoviruses induce more efficient anti-tumor immunity than dendritic cells pulsed with peptide. Seong-Taek Oh, Chang-Hyun Kim, Mi-Young Park, Eun-Ha Won, Hyun-Jung Sohn, Hyun-Il Cho, Won-Kyung Kang, Yon-Kil Hong, Tai-Gyu Kim. Vaccine Apr 24(15) 2860~ Typing by nested PCR SSP approach raises a question about the feasibility of using this technique for detecting feto-maternal microchimerism. Byoung Sik Cho, Hee-Baeg Choi, Hee-Je Kim, Woo-Sung Min, Chun-Choo Kim, Tai-Gyu Kim. Leukemia May;20(5): Analysis of T cell receptor alpha-chain variable region (Va) usage and CDR3a of T cells infiltrated into lesions of psoriasis patients. Ha Young Hwang, Tai-Gyu Kim, Tae-Yoon Kim. Molecular Immunology Feb;43(0),

5 34. Enhancement of anti-tumor immunity specific to murine glioma by vaccination with tumor cell lysate-pulsed dendritic cells engineered to produce interleukin-12. Chang-Hyun Kim, Min-Jung, Sung-Dong Park, Choong-Kwon, Mi-Young Park, Hyun-Jung Son, Hyun-Il Cho, Tai-Gyu Kim and Yong-Kil Hong, Cancer Immunology Immunotherpy Nov;55(11): Associations of IFN-γ Polymorphism with HIV-1 Infection in the Korean Population. AIDS Research and Human Retroviruses. Moon-Won Kang, Chul-Woo Pyo, Seong-Heo Wie, Hee-Baeg Choi, Su-Yeon Kim, Yang-Kyum Kim, Joo-Sil Lee, Tai-Gyu Kim. AIDS Res Hum Retroviruses Mar;22(3): Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis. Hee-Jin Cheong, Joon-Young Song, Jeong-Won Park, Jong-Eun Yeon, Kwan-Soo Byun, Chang-Hong Lee, Hyun-Il Cho, Tai-Gyu Kim and Woo-Joo Kim. Vaccine Mar 20;24(13): Analysis of T cell receptor alpha-chain variable region (Vα) usage and CDR3α of T cells infiltrated into lesions of psoriasis patients. Ha-Young Hwang, Tai-Gyu Kim, Tae-Yoon Kim. Molecular Immunology Feb;43(5): Adoptive transferof Epstein-Barr virus-specific cytotoxic T-lymphocytes for the treatment of angiocentric lymphomas. Hyun-Il Cho, Young-Seon Hong, Myoung-Ah Lee, Kim Eun Kyung, SungHee Yoon, Chun-Choo Kim, Tai-Gyu Kim. International Journal of Hematology Jan;83(1): Activation of B cells Using Schneider 2 cell Expressing CD40 Ligand for the Egenhancement of Antigen Presentation in vitro. Sung Hee Yoon, Hyun Il Cho, Tai-Gyu Kim. Experimental and Molecular Medicine Dec 31;37(6): Association Between human leukocytes antigen alleles and chronic hepatitis C virus ifection in the Korean population. Seung Kew Yoon, Joon Yeol Han, Chul Woo Pyo, Jin Mo Yang, Jeong Won Jang, Chang Wook Kim, U Im Chang, Si Hyun Bae, Jong Young Choi, Kyu Won Chung, Hee Sik Sun, Hee Baeg Choi, and Tai-Gyu Kim. Liver International Dec;25(6): Korean red ginseng slows depletion of CD4 T cells in human immunodeficiency virus type 1-infected patients. Heungsup Sung, Sang-Moo Kang, Moo-Song Lee, Tai-Gyu Kim, Young-Keol Cho. Clinical and Diagnostic Laboratory Immunology Apr;12(4):497~ Pretransplant imatinib can improve the outcome of nonmyeloablative stem cell transplantation without increasing the morbidity in Philadelphia chromosome-positive chronic myeloid leukemia. Dong-Wook Kim, Yang Jo Chung, Seok Lee, Yoo-Jin Kim, Nak-Gyun Chung, Yeong-A Kim, Il Hoan Oh, Tai-Gyu Kim, Kim YL, Goh HG, Kim SH, Bin Cho, Hee-Je Kim, Chang-Ki Min, Jong-Wook Lee, Jong-Youl Jin, Chi-Wha Han, Jin-Woo Kim, Woo-Sung Min, Hack-Ki Kim, Chun-Choo Kim, Kim HJ. Leukemia Nov;18(11): Early Prediction of Molecular Remission by Monitoring BCR-ABL Transcript Levels in Patients Achieving a Complete Cytogenetic Response after Imatinib Therapy for Posttransplantation Chronic Myelogenou. Yoo-Jin Kim, Dong-Wook Kim, Seok Lee, Chang-Ki Min, Hyun-Gyung Goh, Su-Hyun Kim, Ji-Young Lee, Yoo-Li Kim, Hee-Je Kim, Hyeoung-Jun Kim, Jong-Wook Lee, Tai-Gyu Kim, Woo-Sung Min, Chun-Choo Kim. Biology of Blood Marrow Transplantation Oct;10(10): Efficient Transduction with recombinant Adenovirus in EBV-transformed B

6 Lymphoblastoid Cell Lines. Hye-Jin Kim, Hyun-Il Cho, Yoon-Hee Han, Soo-young Park, Dong-Wook Kim, Dong-Gun Lee, Kim Ji Hoon, Wan-Shik Shin, Soon-Young Paik, Chun-Choo Kim, Young-Seon Hong, Tai-Gyu Kim. Journal of Biochemistry and Molecular Biology May 31;37(3): CpG-ODN-stimulated dendritic cells act as a potent adjuvant for E7 protein delivery to induce antigen-specific antitumour immunity in a HPV 16 E7-associated animal tumour model. Tai-Gyu Kim, Chang-Hyun Kim, Eun-Ha Won, Su-Mi Bae, Woong-Shick Ahn, Jae-Bok Park, Jeong-Im Sin. Immunology May;112(1): Identification of HLA-B*56 variant (B*560502) in the Korean population. Chul-Woo Pyo, Seong-Suk Hur, Dong-Wook Kim, Chun-Choo Kim, Hoon Han, Tai-Gyu Kim. Tissue Antigens Apr;63(4): Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation. Dong-Wook Kim, Yang-Jo Chung, Tai-Gyu Kim, Yoo-Li Kim, Il-Hoan Oh. Blood Mar 1;103(5):1941-8