Hamid M. Niknam, Ph.D.

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1 Hamid M. Niknam, Ph.D. PERSONAL IDENTIFICATIONS: Name: Hamid Family name: Mahmoudzadeh Niknam Date of birth: 1959 Place of birth: Tehran Address: Department of Immunology, Pasteur Institute of Iran, No 69 Pasteur Ave., Tehran 13164, Iran and Website: EDUCATION: Doctor of Veterinary Medicine, Tehran University, Faculty of Veterinary Medicine, 1984 Ph.D. (Immunology), Tehran University of Medical Sciences, Faculty of Medicine, 1992 TRAINING: Three-month training for Flow Cytometry and Immunochemistry, Immunocytochemistry Laboratory, Pasteur Institute, Paris, France, 1998 One-month training for Immunogenetics, Department of Microbiology and Epidemiology, University of Iowa, USA 2000 One year sabbatical for molecular biology of Leishmania, Infectious Disease Research Center of the CHUL Research Center (CHUQ), Laval University, Quebec, Canada, PROFESSIONAL EXPERIENCE: Head of Immunology Department (2013-present): Pasteur Institute of Iran Member of Scientific Board (1992-present): Pasteur Institute of Iran, Dept. of Immunology Ph.D. thesis: Study of effect of Donor Specific Blood Transfusion on the outcome of kidney transplantation. DVM thesis: Study of effect of different route of Newcastle disease vaccine on immunogenicity of broiler chickens Teaching: Immunology and advanced Immunology (Tehran University, Faculty of Science) Advanced Immunology for Ph.D. students (Pasteur Institute of Iran, 1992-present) Societies: Member of Iranian Society for Immunology & Allergy Member of Medical Council of Islamic Republic of Iran Member of Veterinary Medical Council of Islamic Republic of Iran Member of IranianVeterinary Association FOREIGN LANGUAGES: English (fluent) and French (basic) RESEARCH INTERESTS: Immunology of infectious diseases especially Leishmaniasis Vaccine against infectious diseases especially Leishmaniasis 1

2 TECHNICAL EXPERTISE: Culture of human and animal cells (e.g. PBMC, Leishmania parasites, cell lines, and bacteria) Handling of animals and performance of experimental studies (especially mice) Flowcytometry (Immunophenotyping and intracellular cytokine assay) and immunoflourescence Cytokine assay by ELISA SDS-PAGE and blotting DNA and RNA extraction Primer designing and PCR optimization Real-time PCR optimization Cloning (TA cloning and restriction enzyme cloning) Protein expression in prokaryotes (E. coli) Protein purification by affinity chromatography PUBLICATIONS: 1. Kiaei MM, Kargar R, Niknam HM (1991) The influence of the route of administration of Newcastle disease vaccine on immunity of cage reared broiler chickens. The Scientific Journal of Agriculture (Shahid Chamran University) 14(1&2): Mahmoudzadeh-Niknam H, Mansoori P, Nikbin B, Daneshpajouh M, Amirkhani A, Alimohammadian MH, (1996) HLA class I in Iranian psoriatic patients. Medical Journal of Islamic Republic of Iran 10(1): Mahmoudzadeh-Niknam H, Alimohammadian MH, Nasaft S, Amirkhani A (1996) Effect of mammalian ambient temperature on Leishmania major promastigote: viability, morphology, and immunogenicity in BALB/c mice. Iranian Journal of Medical Sciences 21(3&4): Mahmoudzadeh-Niknam H, Khalili Gh, Nikbakht-Dehkordi A, Alimohammadian MH, Nikbin-Moghadam B (2001) Advantages of placenta as a source for mass production of HLA-antisera. Iranian Biomedical Journal 5(1): Shokrgozar MA, Mahmoudzadeh-Niknam H, Shokri F (2002) Distribution of circulating immune cells in responder and non-responder individuals to Hepatitis B vaccine. Iranian Biomedical Journal 6(1): Mahmoudzadeh-Niknam H, Khalili G, Fadavi P (2003) Allelic distribution of human leukocyte antigen in Iranian patients with pulmonary tuberculosis. Human Immunology 64(1): Mahmoudzadeh-Niknam H, McKerrow JH. Leishmania tropica: cysteine proteases are essential for growth and pathogenicity. Exp Parasitol Mar-Apr; 106(3-4): Mahmoudzadeh-Niknam H. (2004) Induction of partial protection against Leishmania major in BALB/c mice by Leishmania tropica. Scand J Lab Anim Sci. 31(4): Partovi F., Khalili G., Kariminia A., Mahmoudzadeh-Niknam H. (2007) Effect of Giradia lamblia infection on the cognitive function of school children. Iranian Journal of Public Health 36(1): Mahmoudzadeh-Niknam H, Kiaei SS, Iravani D. (2007) Leishmania tropica infection, in comparison to Leishmania major, induces lower delayed type hypersensitivity in BALB/c mice. Korean J Parasitol. 45(2):

3 11. Mahmoudzadeh-Niknam H, Kiaei SS, Iravani D. (2007) Viscerotropic growth pattern of Leishmania tropica in BALB/c mice is suggestive of a murine model for human viscerotropic leishmaniasis. Korean J Parasitol. 45(4): Alimohammadian MH, Darabi H, Malekzadeh S, Mahmoodzadeh-Niknam H, Ajdary S, Khamesipour A, Bahonar A, Mofarrah A. (2007) Exposure to Leishmania major modulates the proportion of CD4+ T cells without affecting cellular immune responses. Microbiol Immunol. 51(10): Arasteh J, Pourpak Z, Ebtekar M, Pourfathollah AA, Hassan ZM, Farahmandian T, Mahmoudzadeh-Niknam H. (2010) Evaluation of the Effect of IL-22 on Human Cord Blood CD4+ T Cells. Iran J Allergy Asthma Immunol. 9(2): Mahmoudzadeh-Niknam H, Abrishami F, Doroudia M, Moradi M, Alimohammadian MH, Parviz P. (2010) Complete conservation of an immunogenic gene (lcr1) in Leishmania infantum and Leishmania chagasi isolated from Iran, Spain and Brazil. J Vector Borne Dis. 47(4): Mahmoudzadeh-Niknam H, Kiaei SS, Iravani D. (2011) Protective immunity against Leishmania major induced by Leishmania tropica infection of BALB/c mice. Exp Parasitol, 127(2): Mahmoudzadeh-Niknam H, Abrishami F, Doroudian M, Moradi M, Alimohammadian MH, Parvizi P, Hatam GR, Mohebali M, Khalaj V. (2011) The Problem of Mixing up of Leishmania Isolates in the Laboratory: Suggestion of ITS1 Gene Sequencing for Verification of Species. Iran J Parasitol, 6(1): Mahmoudzadeh-Niknam H, Jafari A, Abrishami F, Doroudian M, Moradi M, Kashef Bazazi B. (2011) Cloning and production of an LPS-free immunogenic protein (LCR1) from an Iranian clinical isolate of Leishmania infantum and its recognition by sera from Iranian patients with visceral leishmaniasis. As Pac J Mo Biol Biotechnol, 19(2): Khalili G, Dobakhti F, Mahmoudzadeh Niknam H, Khaze V, Partovi F. (2011) Immunotherapy with Imiquimod Increases the Efficacy of Glucantime Therapy of Leishmania major Infection. Iran J Immunol, 8(1): Mahmoudzadeh-Niknam H, Ajdary S, Riazi-Rad F, Mirzadegan E, Rezaeian A, Khaze V, Djadid ND, Alimohammadian MH. (2012) Molecular epidemiology of cutaneous leishmaniasis and heterogeneity of Leishmania major strains in Iran. Trop Med Int Health, 17(11): Mahmoudzadeh-Niknam H, Khalili G, Abrishami F, Najafy A, Khaze V. (2013) The Route of Leishmania tropica Infection Determines Disease Outcome and Protection against Leishmania major in BALB/c Mice. Korean J Parasitol, 51(1): Fadavi P, Rostamian M, Arashkia A, Shafaghi B and Niknam HM. (2013) Epstein-barr virus may not be associated with breast cancer in Iranian patients. Oncol Discov, 1: M Niknam H, Abrishami F, Doroudian M, Rostamian M, Moradi M, Khaze V, Iravani D. (2014) Immune Responses of Iranian Patients with Visceral Leishmaniasis and Recovered Individuals to LCR1 of Leishmania infantum. Clin Vaccine Immunol Apr;21(4): doi: /CVI Epub 2014 Feb 5. BOOKS TRANSLATED INTO FARSI: Medical Laboratory Immunology, 2 nd Edition, Authors: Linda O Miller, Harry R. Ludke, Julia E Peacock, Russell, H Tomar 3

4 Introducing Immunology, 2nd Edition Authors: Norman Staines, Jonathan Brostoff, Keith James PRESENTATION: 1- Mahmoudzadeh-Niknam H, Mansori P, Daneshpajouh. HLA class I in psoriatic patients referred to a dermatologic center in Iran M 2nd African Immunology Conference, The Federation of African Immunological Societies (FAIS) Hotel Intercontinental, Nairobi, Kenya October, Mahmoudzadeh-Niknam H, Mansori P, Nikbin B, Amirkhani A, Alimohammadian MH, Daneshpajouh M. HLA class I in Iranian psoriatic patients, 8th International Congress of Geographic Medicine & 3rd Iranian Congress of Immunology& Allergy Shiraz- Iran May 6-9, Mahmoudzadeh-Niknam H, Nasafat S, Alimohammadian MH, Amirkhani A. Immunogenicity of L. major promastigote transformed at 37 C in BALB/c mice, XIV International Congress for Tropical Medicine and Malaria, Nagasaki City, Novamber, Mahmoudzadeh-Niknam H, Nasafat S, Alimohammadian MH. Effect of mammalian ambient temperature on L. major promastigote: viability, morphology, and infectivity, XIV International Congress of Tropical Medicine and Malaria, Nov 1996, Nagasaki, Japan. 5- Alimohammadian MH, Darabi H, Malekzadeh Sh, Mahmoudzadeh-Niknam H, Bahonar A, Afzali H. The role of T-cell subsets and their cytokine in human cutaneous leishmaniasis The 4th International Congress of Immunology & Allergy, Iran, Isfahan, May Mahmoudzadeh-Niknam H, Khalili G, Nikbakht A, Alimohammadian MH, Nikbin B. Factors influencing formation and quality of antibodies against human leukocyte antigens (HLA) in parous women, The 4 th International Congress of Immunology & Allergy, Iran, Isfahan, May Shokrgozar MA, Mahmoudzadeh-Niknam H, Shokri F. Frequency analysis of HBsAg specific B-lymphocytes in normal individuals responding to hepatitis B vaccine, First joint seminar of the Pasteur Institute of Iran and Paris, Tehran, Iran, 9-11 Apr Mahmoudzadeh-Niknam H, Khalili G, Nikbakht A, Alimohammadian MH, Nimbi B. Acquisition of antibodies to human leukocyte antigens from placenta as compared to peripheral blood in Iranian parous women, First joint seminar of the Pasteur Institute of Iran and Paris, Tehran, Iran, 9-11 Apr Mahmoudzadeh-Niknam H, Khalili G, Nikbakht A, Alimohammadian MH, Nikbin B. Acquisition of antibodies to human leukocyte antigens from placenta as compared to peripheral blood in Iranian parous women, 5th Iranian Congress of Immunology and Allergy, Tehran, Iran, May Mahmoudzadeh-Niknam H, Yalda A, Fadavi P. Does HLA-DR2 play a significant role in susceptibility of Iranians population to tuberculosis? 5th Iranian Congress of Immunology and Allergy, Tehran, Iran, May Alimohammadian MH, Darabi H, Malekzadeh SH, Mahmoudzadeh-Niknam H, Bahonar A, Mofarrah A. Comparison of the immune response of naturally infected or healed cases of leishmania major with vaccinated cases, 5th Iranian Congress of Immunology and Allergy, Tehran, Iran, May Khabiri A, Alimohammadian MH, Aslanian S, Darabi H, Mahmoudzadeh-Niknam H, Amini S, Iravani D. Immunophetnotypic analysis of patients with chronic hepatitis B 4

5 infection, 5th Iranian Congress of Immunology and Allergy, Tehran, Iran, May Mahmoudzadeh-Niknam H, Yalda A, Fadavi P. Allelic distribution of Human Leukocyte Antigens (HLA) in Iranian pulmonary tuberculosis patients, 11th International congress of Immunology, Stockholm, Sweden Jul Shokrgozar M A, Mahmoudzadeh-Niknam H, Shokri F. Distribution of Circulating immune cells In responder and non-responder individuals to recombinant hepatitis B vaccine, 6 th Iranian Congress Of Immunology and Allergy, Tehran, Iran, 7-9 May Mahmoudzadeh-Niknam H, James H. MacKerrow. Cysteine proteases play an essential role in growth and viability of Leishmania Tropica promastigote, British Society for Parasitology Trypanosomiasis and Leishmaniasis seminar, Edinburgh, United Kingdom, 8-11, September Mahmoudzadeh-Niknam H. Leishmania tropica induces partial protection against leishmania major in BALB/c mice, La Quatrieme conference annuelle quebecoise sur la parasitologie moleculaire, Laval, Canada Jun Mahmoudzadeh-Niknam H, Iravani D. Leishmania tropica and leishmania major: cross-protection in BALB/c mice, The 8th Iranian Congress of Immunology & Allergy, Tehran, May Mahmoudzadeh-Niknam H, Kiaei S, Iravani D. Leishmania tropica-induced protection against leishmania major in BALB/c mice is associated with low DTH response, Regulatory T cells, Vancouver, Canada, 1-6 Feb Mahmoudzadeh-Niknam H, Kiaei S, Iravani D. Tissue specific pattern of leishmania tropica in BALB/c mice, 13th International Congress of Immunology, Rio de Janiero, Brazil, Aug Mahmoudzadeh-Niknam H, Arab F, Jamali M, Kiaei S, Iravani D. IFN- production With protection Induced By Leishmania tropica Infection against Leishmania major In BALB/C Mice. 6 th Iranian National Congress Of Parasitology, Karaj, Iran, May Pourpirali S, Kiaei S, Parvizi P, Mahmoudzadeh-Niknam H, Pedram M. Cloning of the Lcr Homolog from Leishmania infantum and Production of the Recombinant Protein for the Purpose of, 6 th Iranian National Congress of Parasitology, Karaj, Iran, May Mahmoudzadeh-Niknam H, Jamali M, Kiaei S, Iravani D, Arab F. Low Percentage of CD25+ Lymphocyte is associated with Leishmania tropica-induced protection against leishmania major in BALB/c mice, 9 th Iranian Congress of Immunology & Allergy, Tehran, Iran, Mahmoudzadeh-Niknam H, Jamali M, Kiaei S, Iravani D. BALB/c mice infected with L. tropica: a potential experimental model for human viscerotropic leishmaniasis, Research on infectious diseases: a global challenge, Paris, France, June Mahmoudzadeh-Niknam H, Jamali M, Arab F, Goodarzi A, Kiaei S, Iravani D, Eric P. Higher levels of IFN-γ and lower percentages of CD4+ lymphocytes are associated with protection induced by L. tropica against L. major in BALB/c mice, WorldLeish4, Lucknow, India, 3-7 Feb Mahmoudzadeh-Niknam H, Abrishami F, Parvizi P, Hatam GR, Mohebali, Alimohammadia MH. Importance of molecular methods for species identification of leishmania isolates in clinical and experimental studies. The 3 rd Iranian Congress of Clinical Microbiology 6-8 October 2009, Shiraz, Iran. 5

6 26- Niknam HM, Abrishami F, Moradi M, Doroudian M, Iravani D. Route of Leishmania tropica infection modulates pathogenicity, immune response and the induced protection against Leishmania major in BALB/c mice. 14th International Congress of Immunology, Kansai, Japan, Aug Mahmoudzadeh-Niknam H, Abrishami F, Doroudian M, Moradi M, Alimohammadia MH, Parvizi P, Soezi. Complete identity of an immunogenic gene (LCR1) between an Iranian clinical isolate of Leishmania infantum and its homologues in Leishmania chagasi from Brazil and Leishmania infantum from Spain. 7th National and 2nd Regional Congress of Parasitology and Parasitic Diseases in Iran, Tehran, Iran, Oct, Mahmoudzadeh-Niknam H, Abrishami F, Moradi M, Doroudian M, Iravani D. Route of Leishmania tropica infection modulates pathogenicity, immune response and the induced protection against Leishmania major in BALB/c mice. The 10 th International Congress of Immunology & Allergy, May 18-20, 2010 Tehran, Iran. 29- Mahmoudzadeh-Niknam H, Jafari J, Abrishami F, Doroudian M, Moradi M, Kashef Bazazi B. The recombinant immunogenic protein (LCR1) from an Iranian clinical isolate of Leishmania infantum is recognized by sera from Iranian patients with visceral leishmaniasis. The 5 th Iranian Congress of Clinical Microbiology, 8-10 Nov., 2011, Shiraz, Iran. 30- Mahmoudzadeh-Niknam H. Leishmaniasis Research in Iran: What are the priorities? Oral presentation at The 11th International Congress of Immunology and Allergy of Iran, Tehran, Iran, April, Mahmoudzadeh-Niknam H, Rostamian M, Abrishami, F, Khalili Gh, Kashef Bazazi B, Moradi, M, Doroudian M. Serum of Individual Patients with Visceral Leishmaniasis Recognizes the Recombinant Protein of LCR1. The 11th International Congress of Immunology and Allergy of Iran, Tehran, Iran, April, Mahmoudzadeh-Niknam H, Fadavi P, Rostamian M, Arashkia A, Shafaghi B. Epstein- Barr Virus is not associated with breast cancer in Iranian patients. Cancer and Prevention Symposium, Tehran, Iran, Jan

The Problem of Mixing up of Leishmania Isolates in the Laboratory: Suggestion of ITS1 Gene Sequencing for Verification of Species

The Problem of Mixing up of Leishmania Isolates in the Laboratory: Suggestion of ITS1 Gene Sequencing for Verification of Species Iranian J Parasitol: Vol. 6, No., 20, pp.4-48 Iranian J Parasitol Tehran University of Medical Sciences Publication http:// tums.ac.ir Open access Journal at http:// ijpa.tums.ac.ir Iranian Society of