Rosa Mercedes Andrade

Transcription

1 Rosa Mercedes Andrade Graduate Medical Education: Research Fellowship Training: Postdoctoral Research Fellowship, University of Cincinnati, OH Postdoctoral Research Fellowship, University of Alabama at Birmingham, AL. Residency Training: University of Texas Medical Branch Galveston at Austin Department of Internal Medicine Austin, TX. Clinical Fellowship Training: University of California, San Diego Department of Internal Medicine Division of Infectious Diseases San Diego, CA. Undergraduate Medical Education: Universidad Peruana Cayetano Heredia School of Medicine Doctor of Medicine Lima-Peru. Faculty academic appointment: 5/2013-current Assistant Professor of Medicine, Division of Infectious Diseases Licensure and Certification: - ABIM Board Certified in Internal Medicine (Oct 2009) -ABIM Board Certified in Infectious Diseases (Oct 2011) - California State Medical License (#A106912): 2009-present - U.S.A. DEA License (UCSD): September 2010-present Professional Associations: - Infectious Diseases Society of America Fellow member: 2009-present - Infectious Disease Association of California Fellow Member: 2010-present - American College of Physicians Associate Member: 2010-present

2 Teaching Experience -Microbiology I (SOM 208) Microbiology Laboratory Sessions for Medical and Pharmacy Students. Five sessions, averaging hours each. I gave a short lecture on the topic (10-15 minutes) and then reviewed cases with the 30 students. Committee Service 5/2013-current Antibiotic Utilization Committee Clinical Activities: 9/2010-current 4/2013-current HIV clinic: once a week One four-week block per year attending in Infectious Diseases Non-peer reviewed scientific or medical publications/materials in print or other media Book chapters : Andrade, RM ; Reed, SL. Thioredoxin Reductase and its Role as a New Drug Target. In Bhattacharya and Nosaki editors. Amebiasis: Biology and Pathogenesis of Entamoeba.Springer Publishing House. Submitted Reed, SL; Andrade, RM. Harrison s Internal Medicine: Chapter 245: Protozoal infections: Amebiasis and Infection with Free-Living Amebas. Submitted. Review articles: Andrade, RM, Alarcon, GS. Antimalarials in systemic lupus erythematosus: benefits beyond disease activity. Future Rheumatology. April 2006, Vol. 1, No. 2, Pages , DOI / Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings 1/2012 Andrade, Rosa; Hirata, Ken; Anjan Debnath; James McKerrow; Reed Sharon. A Reprofiled Drug, Auranofin, Targets the Thioredoxin Reductase of Entamoeba histolytica and is Cysticidal: preliminary data Oral presentation at Keystone Symposia J1 Drug Discovery for Protozoan Parasites, Santa Fe, New Mexico. 3/2013 Andrade, Rosa; Hirata, Ken; Anjan Debnath; James McKerrow; Reed Sharon A Reprofiled Drug, Auranofin, Targets the Thioredoxin Reductase of Entamoeba histolytica and is Cysticidal : Report of additional findings. Oral presentation at XVII International Amebiasis Seminar. Merida, Mexico. 9/2013 Andrade, RM; Chaparro, JD; Reed, SL. Auranofin is Highly Efficacious against Toxoplasma gondii in vitro and in an in vivo Experimental Model of Acute Toxoplasmosis. Poster presentation at the 2013 Woodshole Molecular Parasitology Meeting. Publications: 1. Andrade RM, Wessendarp M, Subauste CS. CD154 activates macrophage anti-microbial activity in the absence of IFN-gamma; through a TNF-alpha-dependent mechanism. J.

3 Immunology.2003 Dec; 171(12): Cited in PubMed; PMID: Pub Status: Published. 2. Subauste CS, Wessendarp M, Portillo JC, Andrade RM, Hinds L, Gomez FJ, Smulian AG, Grubbs PA, Haglund LA. Pathogen-specific induction of CD154 is impaired on CD4+T cells from HIV-infected individuals. J.Infect.Dis.2004 Jan; 189(1): Cited in PubMed; PMID: Pub Status: Published. 3. Andrade RM, Wessendarp M, Portillo JC, Yang J, Gomez FJ, Durbin JE, Bishop GA, Subauste CS. TRAF6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J. Immunology.2005 Nov; 175(9): Cited in PubMed; PMID: Pub Status: Published. 4. Andrade RM, Portillo JC, Wessendarp M, Subauste CS.. CD40 signaling in Macrophages induces Activity against an Intracellular Pathogen Independently of Gamma Interferon and Reactive Nitrogen Intermediates. Infect and Immun.2005 May;73(5): Cited in PubMed; PMID: Pub Status: Published. 5. Andrade RM, McGwin G Jr, Alarcon GS, Sanchez ML, Bertoli AM, Fernandez M, Fessler BJ, Apte M, Arango AM, Bastian HM, Vila LM, Reveille JD, LUMINA Study Group. Predictors of post-partum damage accrual in systemic lupus erythematosous : data from LUMINA, a multiethnic US cohort (XXXVIII). Rheumatology (Oxford).2006 Nov; 45(11): Cited in PubMed; PMID: Pub Status: Published. 6. Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS. CD40 induces macrophage anti-toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J. Clin Invest.2006 Sep; 116(9): Pub Status: Published. 7. Andrade, RM, Alarcon GS, Fernandez M, Apte M, Vila LM, Reveille JD, LUMINA Study Group. Accelerated damage accrual among men with systemic lupus erythematosus: XLIV. Results from a multiethnic US cohort. Arthritis Rheum.2007 Feb; 56(2): Cited in PubMed; PMID: Pub Status: Published. 8. Fernandez M, Alarcon GS, Apte M, Andrade RM, Vila LM, Reveille JD, LUMINA Study Group.. Systemic lupus erythematosus in a multiethnic US cohort: XLIII. The significance of thrombocytopenia as a prognostic factor. Arthritis Rheum.2007 Feb; 56(2): Cited in PubMed; PMID: Pub Status: Published. 9. Subauste CS, Andrade RM, Wessendarp M. CD40-TRAF6 and autophagy-dependent antimicrobial activity in macrophages. Autophagy.2007 May; 3(3): Cited in PubMed; PMID: Pub Status: Published. 10. Andrade RM, Alarcón GS, González LA, Fernández M, Apte M, Vilá LM, McGwin G Jr, Reveille JD; LUMINA Study Group. Seizures in patients with systemic lupus erythematosus:

4 data from LUMINA, a multiethnic cohort (LUMINA LIV).Ann Rheum Dis Jun;67(6): Epub 2007 Sep 17. PMID: Pub Status: Published. 11. Van Grol J, Subauste C, Andrade RM, Fujinaga K, Nelson J, Subauste CS. HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3. PLoS One Jul 22; 5(7):e PMID: Pub Status: Published. 12. Debnath,A.;Parsonage,D;Andrade,RM.;He,C.;Cobo,E.;Hirata,K.;Orozco,E.;Poole,L.;McKer row,j.;reed,sl.a High throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med May 20.doi: /nm PIMD: Pub Status: Published 13. Andrade, RM; Chaparro, JD.; Reed, SL. Auranofin is Highly Efficacious against Toxoplasma gondii in vitro and in an in vivo Experimental Model of Acute Toxoplasmosis. Under review. Awards and Honors 1998 First Prize in basic sciences. XIIIth National Scientific Congress of Medical Studienst: SOCIPEM-Cajamarca, Peru 1999 Third Prize: Medical students research projects. Universidad Peruana Cayetano Heredia, Lima, Peru 2003 Honorable Mention in basic sciences at Fellows Grand Rounds. Univ. Cincinnati College of Medicine, Dept. of Medicine, Cincinnati, OH 2004 Honorable Mention in basic sciences at the Trainees Research Grand Rounds. Univ. of Cincinnati College of Medicine, Cincinnati, OH 2011 Bill and Melinda Gates Foundation Global Health Travel Award for the Keystone Symposia J1 Drug Discovery for Protozoan Parasites The Harold Amos Medical Faculty Development Program (AMFDP) for the project Thioredoxin reductase: A Novel Therapeutic Target for Latent Parasites, provided by the Robert Wood Johnson Foundation. Time period of award/grant: 01/ /2016 (4 year-period). Total Amount $420, Vice Chancellor Health Sciences office: Funding to attend the AAMC Minority Faculty Career Development Seminar (September 20th-23rd) UCSD Vice Chancellor Health Sciences office: Awarded funding to attend the K-grant writing Seminar (September 20th) UCSD Health Sciences Academic Senate Research Grant Application, Spring Quarter 2 Awarded $10,000 for research supplies for 1 year UCSD Health Sciences Academic Senate Travel Grant, to attend Woodshole Molecular Parasitology Meeting Research Experience 07/ /2005 Postdoctoral Research Fellowship, University of Cincinnati, OH. 07/ /2006 Postdoctoral Research Fellowship, University of Alabama at Birmingham, AL.

5 07/2010- present Research training portion of Infectious Diseases fellowship, University of California, San Diego, CA. Major Research Interests: - Drug discovery for the treatment of Neglected Tropical Diseases: Toxoplasma gondii and Entamoeba histolytica. - Management of HIV and STDs patients.