FELASA profile in 7 days!

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1 Lab Animal Health Screening & Biological Sample Testing FELASA profile in 7 days!

2 Your Lab Animal Health Surveillance Partner We believe our work adds value to scientific research, and that every facility must provide guarantees of cleanliness, hygiene, animal welfare and quality to the various research groups it works for (its clients). reliable and quick results is what customers are after. This is why we process animals and samples immediately, i.e. we do not house in the animals. there is always road for improvement ; that is why we are never satisfied with false positives or doubtful results. We check these twice. a solution to almost everything can always be found. If there is something you are after, let us know: we will find it for you! Key features: Speed. We provide complete FELASA profiles in 7 days. Experience. Our team has over 20 years experience in the diagnosis of lab animal infections and clinical diagnosis. Reliability. Any doubtful result(s) is/are retested and corroborated if necessary. Real time results. You will be obtaining results from the moment we start working on your samples, and as soon as these become available. Personalised attention. We offer personalized attention to our customers.

3 Integrated Lab Animal Diagnostic Services SERVICES FOR LAB ANIMALS: LAB ANIMAL HEALTH SCREENING INDIVIDUAL SAMPLE TESTING CELL LINE & BIOLOGICAL PRODUCT SCREENING GENOTYPING NEW! MICROBIOME STUDIES PRODUCTS: LAB ANIMAL SHIPPING BOXES KITS ADDITIONAL SERVICES: LAB ANIMAL CONSULTANCY SERVICES

4 Lab Animal Health Screening IMMUNOCOMPETENT MOUSE FELASA profile in 7 days! FELASA PROFILES ANNUAL QUARTERLY PATHOLOGY VIRUSES BACTERIA PARASITES Necropsy PATHOLOGY PATHOLOGY Study of different organs HISTOPATHOLOGY HISTOPATHOLOGY Pneumocystis murina HISTOPATHOLOGY HISTOPATHOLOGY Ectromelia virus (ECTRO) Epizootic diarrhea of infant mice (EDIM) Hantaan virus K virus (Kvir) Lymphocytic choriomeningitis virus (LCMV) Murine adenovirus FI (MAD-1) Murine adenovirus K87 (MAD-2) Mouse cytomegalovirus (MCMV) Mouse hepatitis virus (MHV) Mouse parvovirus (MPV 1 y 2) Murine parvovirus (NS1) Murine norovirus (MNV) Minute virus of mice (MVM) Polyoma virus (Poly) Pneumonia virus of mice (PVM) Reovirus type 3 (REO-3) Sendai virus Theiller`s murine encephalomyelitis virus (TMEV) Murine thymic virus (MTLV) Cillia-Associated Respiratory Bacillus (CARB) Mycoplasma pulmonis (Mpul) Clostridium piliforme Tyzzer`s (Cpil) / HISTOPAT HISTOPATHOLOGY Helicobacter spp (SEQ) (SEQ) Bordetella bronchiseptica Citrobacter rodentium Corynebacterium kutscheri Pasteurella pneumotropica Salmonella spp Streptococcus β-haemolyticus (excl. group D) Streptococcus pneumoniae Streptobacillus moniliformis HISTOPATHOLOGY HISTOPATHOLOGY Other bacteria: Opportunistic and commensal bacteria Encephalitozoon cuniculi (ECUN) Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY All profiles can be performed from individual samples, thus avoiding the shipment of animals. Contact us for more information: laboratorio@dynamimed.com

5 Lab Animal Health Screening BASIC FELASA PROFILES ANNUAL QUARTERLY Necropsy and Sample collection INCLUDED INCLUDED VIRUSES Ectromelia virus (ECTRO) Epizootic diarrhea of infant mice (EDIM) Lymphocytic choriomeningitis virus (LCMV) Murine adenovirus FI (MAD-1) Murine adenovirus K87 (MAD-2) Mouse hepatitis virus (MHV) Mouse parvovirus Murine norovirus (MNV) Minute virus of mice (MVM) Pneumonia virus of mice (PVM) Reovirus type 3 (REO-3) Sendai virus Theiller`s murine encephalomyelitis virus (TMEV) BACTERIA PARASITES Mycoplasma pulmonis (Mpul) Clostridium piliforme Tyzzer`s (Cpil) Helicobacter spp (SEQ) (SEQ) Citrobacter rodentium Corynebacterium kutscheri Pasteurella pneumotropica Salmonella spp Streptococcus β-haemolyticus (excl. group D) Streptococcus pneumoniae Streptobacillus moniliformis Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY

6 Lab Animal Health Screening IMMUNOSUPPRESSED MOUSE PATHOLOGY VIRUSES BACTERIA PARASITES FELASA PROFILES ANNUAL QUARTERLY Necropsy PATHOLOGY PATHOLOGY Study of different organs HISTOPATHOLOGY HISTOPATHOLOGY Pneumocystis murina HISTOPATHOLOGY HISTOPATHOLOGY Ectromelia virus (ECTRO) Epizootic diarrhea of infant mice (EDIM) RT- RT- Hantaan virus RT- K virus (Kvir) Lymphocytic choriomeningitis virus (LCMV) RT- Lactic dehydrogenase virus (LDHV) RT- Murine adenovirus FI (MAD-1) Murine adenovirus K87 (MAD-2) Mouse cytomegalovirus (MCMV) Mouse hepatitis virus (MHV) RT- RT- Murine parvoviruses (MPV, H1, KRV, RPV, RMV ) Minute virus of mice (MVM) Murine norovirus (MNV) RT- RT- Polyoma virus (Poly) Pneumonia virus of mice (PVM) RT- RT- Reovirus type 3 (REO-3) RT- Sendai virus RT- RT- Theiller`s murine encephalomyelitis virus (TMEV) RT- RT- Murine thymic virus (MTLV) Cillia-Associated Respiratory Bacillus (CARB) Mycoplasma pulmonis (Mpul) Clostridium piliforme Tyzzer`s (Cpil) / HISTOPATH HISTOPATHOLOGY Helicobacter spp (SEQ) (SEQ) Bordetella bronchiseptica Citrobacter rodentium Corynebacterium kutscheri Pasteurella pneumotropica Salmonella spp Streptococcus β-haemolyticus (excl. group D) Streptococcus pneumoniae Streptobacillus moniliformis HISTOPATHOLOGY HISTOPATHOLOGY Other bacteria: Opportunistic and commensal bacteria Encephalitozoon cuniculi (ECUN) Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY

7 Lab Animal Health Screening BASIC FELASA PROFILES ANNUAL QUARTERLY Necropsy and Sample collection INCLUDED INCLUDED VIRUSES BACTERIA Ectromelia virus (ECTRO) Epizootic diarrhea of infant mice (EDIM) RT- RT- Lymphocytic choriomeningitis virus (LCMV) RT- Murine adenovirus FI (MAD-1) Murine adenovirus K87 (MAD-2) Mouse hepatitis virus (MHV) RT- RT- Mouse parvovirus Murine norovirus (MNV) RT- RT- Minute virus of mice (MVM) Pneumonia virus of mice (PVM) RT- Reovirus type 3 (REO-3) RT- Sendai virus RT- Theiller`s murine encephalomyelitis virus (TMEV) RT- RT- Mycoplasma pulmonis (Mpul) Clostridium piliforme Tyzzer`s (Cpil) Helicobacter spp (SEQ) (SEQ) Citrobacter rodentium Corynebacterium kutscheri Pasteurella pneumotropica Salmonella spp Streptococcus β-haemolyticus (excl. group D) Streptococcus pneumoniae Streptobacillus moniliformis PARASITES Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY

8 Lab Animal Health Screening IMMUNOCOMPETENT RAT PATHOLOGY VIRUSES BACTERIA PARASITES FELASA PROFILES ANNUAL QUARTERLY Necropsy PATHOLOGY PATHOLOGY Study of different organs HISTOPATHOLOGY HISTOPATHOLOGY Pneumocystis carinii HISTOPATHOLOGY HISTOPATHOLOGY Hantaan virus Kilham rat virus Lymphocytic choriomeningitis virus (LCMV) Murine adenovirus FL (MAD-1) Murine adenovirus K 87 (MAD-2) Pneumonia virus of mice (PVM) Rat parvovirus Rat minute virus Rat coronavirus/ Sialoacrydenitis virus (RCV/SDAV) Reovirus type 3 (REO-3) Sendai virus Theiller s murine virus (TMEV) Toolan s H-1 virus (H-1) Cillia-Associated Respiratory Bacillus (CARB) Mycoplasma pulmonis (Mpul) Clostridium piliforme Tyzzer`s (Cpil) / HISTOPAT / HISTOPAT Helicobacter spp (SEQ) (SEQ) Bordetella bronchiseptica Citrobacter rodentium Corynebacterium kutscheri Pasteurella pneumotropica Salmonella spp Streptococcus β-haemolyticus (excl. group D) Streptococcus pneumoniae Streptobacillus moniliformis HISTOPATHOLOGY HISTOPATHOLOGY Other bacteria: Opportunistic and commensal bacteria Encephalitozoon cuniculi (ECUN) Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY Do you require lab animal shipping boxes? Speak to us.

9 Lab Animal Health Screening BASIC FELASA PROFILES ANNUAL QUARTERLY Necropsy and Sample collection INCLUDED INCLUDED VIRUSES Hantaan virus Kilham rat virus Murine adenovirus FL (MAD-1) Murine adenovirus K 87 (MAD-2) Pneumonia virus of mice (PVM) Rat parvovirus Rat minute virus Rat coronavirus/ Sialoacrydenitis virus (RCV/SDAV) Reovirus type 3 (REO-3) Sendai virus Theiller s murine virus (TMEV) Toolan s H-1 virus (H-1) BACTERIA PARASITES Cillia-Associated Respiratory Bacillus (CARB) Mycoplasma pulmonis (Mpul) Clostridium piliforme Tyzzer`s (Cpil) Helicobacter spp (SEQ) (SEQ) Pasteurella pneumotropica Salmonella spp Streptococcus β-haemolyticus (excl. group D) Streptococcus pneumoniae Streptobacillus moniliformis Pneumocystis spp. Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY

10 Lab Animal Health Screening PATHOLOGY VIRUSES BACTERIA & DERMATOPHYTES PARASITES RABBIT PROFILES ANNUAL QUARTERLY Necropsy PATHOLOGY PATHOLOGY Study of different organs HISTOPATHOLOGY HISTOPATHOLOGY Rabbit haemorrhagic disease virus Rabbit rotavirus Rabbit Pox SV5 Rabbit Pneumonia Virus Sendai virus Cillia-Associated Respiratory Bacillus (CARB) Clostridium piliforme Tyzzer`s (Cpil) / HISTOPAT Bordetella bronchiseptica Pasteurella multicocida Salmonella spp Dermatophytes Other bacteria: Opportunistic and commensal bacteria Encephalitozoon cuniculi (ECUN) Rabbit toxoplasma Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY Design your own screening panel. Tell us what you are after.

11 Lab Animal Health Screening HAMSTER PROFILES ANNUAL QUARTERLY PATHOLOGY VIRUSES BACTERIA PARASITES Necropsy PATHOLOGY PATHOLOGY Study of different organs HISTOPATHOLOGY HISTOPATHOLOGY Reovirus type 3 Pneumonia virus Lymphocytic choriomeningitis virus Sendai virus SV5 Helicobacter spp. (SEQ) (SEQ) Clostridium piliforme Tyzzer`s (Cpil) / HISTOPAT Mycoplasma pulmonis Corynebacterium kutscheri Pasteurella pneumotropica Salmonella spp Other bacteria: Opportunistic and commensal bacteria Encephalitozoon cuniculi (ECUN) Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY Design your own screening panel. Tell us what you are after.

12 Lab Animal Health Screening PATHOLOGY VIRUSES BACTERIA PARASITES GUINEA PIG PROFILES ANNUAL QUARTERLY Necropsy PATHOLOGY PATHOLOGY Study of different organs HISTOPATHOLOGY HISTOPATHOLOGY Guinea Pig adenovirus FL Guinea Pig adenovirus K87 Guinea pig parainfluenza virus 3 Sendai virus Guinea pig cytomegalovirus Clostridium piliforme Tyzzer`s (Cpil) / HISTOPAT Bordetella bronchiseptica Corynebacterium kutscheri Streptococci b-haemolytic (not group D) Streptococcus pneumoniae Salmonella spp Streptobacillus moniliformis HISTOPATHOLOGY HISTOPATHOLOGY Other bacteria: Opportunistic and commensal bacteria Encephalitozoon cuniculi (ECUN) Ectoparasites PARASITOLOGY PARASITOLOGY Endoparasites PARASITOLOGY PARASITOLOGY

13 Lab Animal Health Screening ZEBRAFISH (Danio rerio) & MEDAKA (Oryzias latipes) STANDARD PLUS PATHOLOGY NECROPSY HISTOPATHOLOGY NECROPSY HISTOPATHOLOGY PARASITOLOGY BACTERIOLOGY & FUNGUS Encysted metacercariae MICROSCOPY MICROSCOPY Ichthyophthirius multifiliis MICROSCOPY MICROSCOPY Myxidium sp HISTOPATHOLOGY HISTOPATHOLOGY Zchokkella sp HISTOPATHOLOGY HISTOPATHOLOGY Piscinoodinium sp MICROSCOPY MICROSCOPY Tetrahymena sp MICROSCOPY MICROSCOPY Ichthyobodo MICROSCOPY MICROSCOPY Pseudoloma neurophilia (Microsporidia) HISTOPATHOLOGY HISTOPATH + Nematodes MICROSCOPY MICROSCOPY Cestodes MICROSCOPY MICROSCOPY Fungus Aeromonas sp Mycobacterium sp - Flexibacter maritimus + Cytophaga sp + Streptococcus iniae + SAMPLE REQUIRED > 3 specimen > 4 specimen Analysis water (optional) ph, Conductivity, Turbidity, ammonium nitrogen, nitrite, nitrate, oxygen, aerobic microorganisms (22-37 C) ADDITIONAL SERVICES INCLUDED Reports of bacteria growing in culture media can be obtained.

14 Individual Sample Testing SEROLOGIES DYNAMIMED offers a complete screening panel to study viral pathogens, bacteria and other parasites found in rodents following FELASA s recommendations. These tests are carried out by in order to detect specific pathogen antibodies in serum. In addition, we offer you the possibility to design your own serological profile adapted to your specific needs. Individual serology assays are available too. MOUSE ANNUAL QUARTERLY Ectromelia virus (ECTRO) Epizootic diarrhea of infant mice (EDIM) Hantaan virus K virus (Kvir) Lymphocytic choriomeningitis virus (LCMV) Murine adenovirus FI (MAD-1) Murine adenovirus K87 (MAD-2) Mouse cytomegalovirus (MCMV) VIRUSES Mouse hepatitis virus (MHV) Mouse parvovirus (MPV 1 y 2) Mouse parvovirus (NS1) Murine norovirus (MNV) Minute virus of mice (MVM) Polyoma virus (Poly) Pneumonia virus of mice (PVM) Reovirus type 3 (REO-3) Sendai virus Theiller`s murine encephalomyelitis virus (TMEV) Cillia-Associated Respiratory Bacillus (CARB) BACTERIA Mycoplasma pulmonis (Mpul) Clostridium piliforme Tyzzer`s (Cpil) PARASITES Encephalitozoon cuniculi (ECUN) Contact us for information on IFA/MFI tests.

15 Individual Sample Testing RAT ANNUAL QUARTERLY Hantaan virus Kilham rat virus Lymphocytic choriomeningitis virus (LCMV) Murine adenovirus FL (MAD-1) Murine adenovirus K 87 (MAD-2) Pneumonia virus of mice (PVM) VIRUSES Rat parvovirus Rat minute virus Rat coronavirus/ Sialoacrydenitis virus (RCV/SDAV) Reovirus type 3 (REO-3) Sendai virus Theiller s murine virus (TMEV) Toolan s H-1 virus (H-1) Cillia-Associated Respiratory Bacillus (CARB) BACTERIA Mycoplasma pulmonis (Mpul) Clostridium piliforme Tyzzer`s (Cpil) PARASITES Encephalitozoon cuniculi (ECUN) Do It Yourself: We have a full range of Kits on sale. Contact us for more information.

16 Individual Sample Testing RABBIT ANNUAL QUARTERLY Rabbit haemorrhagic disease virus (RHDV) VIRUSES BACTERIA PARASITES Rabbit rotavirus Rabbit pox Simian virus 5 (SV-5) Rabbit Pneumonia Virus Sendai virus Cillia associated respiratory bacillus (CARB) Clostridium piliforme (CPIL) Encephalitozoon cuniculi (ECUN) Rabbit Toxoplasma HAMSTER ANNUAL QUARTERLY Reovirus type 3 (REO-3) Pneumonia virus of mice (PVM) VIRUSES Lymphocytic choriomeningitis virus (LCMV) Sendai virus Simian virus 5 (SV-5) BACTERIA Mycoplasma pulmonis Clostridium piliforme (CPIL) PARASITES Encephalitozoon cuniculi (ECUN) VIRUSES GUINEA PIG ANNUAL QUARTERLY Guinea Pig adenovirus FL Guinea Pig adenovirus K87 Guinea pig parainfluenza virus 3 Sendai virus Guinea pig cytomegalovirus BACTERIA Clostridium piliforme (CPIL) PARASITES Encephalitozoon cuniculi (ECUN)

17 Individual Sample Testing MOLECULAR DETECTION OF PATHOGENS The molecular detection of microorganisms can discriminate the presence or absence of genetic material of pathogens, by RT- or as appropriate. At DYNAMIMED, molecular detections are carried out routinely in our standard screening panels. However, we also design customized molecular tests to detect genetic material from any pathogen you may be interested in. PREVALENT PATHOGENS PROFILE / RT- IN FAECES VIRUSES BACTERIA RT- Murine noroviruses (MNV) Reovirus type 3 (REO3) Theiller s murine virus TMEV (GDVII) Mouse hepatitis virus (MHV) Epizootic diarrhea of infant mice (EDIM) Minute virus of mice (MVM) Murine parvoviruses (MPV, H1, KRV, RPV, RMV ) MAD-1 Murine adenovirus FL MAD-2 Murine adenovirus K87 Helicobacter spp Samples required : minimum 3 fresh faecal pellets (maximum 10) (refrigerated shipping). Speed and simplicity of sampling, Minor exposure to the above pathogens by technicians, Confirmation of positive results and pathogen strain determination can be carried out by sequencing.

18 Individual Sample Testing MICROBIOLOGICAL Samples from live animals are routinely collected from respiratory and enteric tracts using aseptic techniques. At Dynamimed we go one step further and gather swabs from lesions and/or any other abnormalities detected during necropsy. This service includes a thorough search for any bacterial species that are considered primary and opportunistic pathogens, as recommended by FELASA. The agent identification is carried out using biochemical methods. We always provide additional reports informing about any commensal - normally not pathogenic - and opportunistic bacteria growing on the media. Do not hesitate to forward any sample you wish to test, indicating its source, and what are you after. PATHOLOGY SERVICES Our pathology department, efficiently managed by our veterinary medicine professionals, has over two decades experience in animal pathology. We offer: Sampling of cells and tissues (biopsies) for thorough examination purposes, Complete pathological studies from live animals (necropsies, gross pathology and histopathology using specific techniques when necessary). PARASITOLOGY Our experts in veterinary medicine will look for, and study, the parasites found in your animals, i.e. endo- and ecto-parasites.

19 Cell Line & Biological Product Screening We offer a complete study on both murine and human cell lines and other biological products as they represent a source of high risk contamination in lab animal unit establishments. These tests discard the presence of multiple pathogens, including Mycoplasma spp and are carried out following FELASA s recommendations. MURINE PLUS MURINE HUMAN VIRUSES Epizootic diarrhea of infant mice (EDIM) Mouse cytomegalovirus (MCMV) Polyoma virus Hantaan virus Lactate dehydrogenase elevating virus (LDHV) Lymphocytic choriomeningitis virus (LCMV) Reovirus type 3 Sendai virus Theiller s murine virus (TMEV) Mouse hepatitis virus (MHV) Murine noroviruses (MNV) Pneumonia virus of mice (PVM) Minute virus of mice (MVM) Murine parvoviruses (MPV, H1, KRV, RPV, RMV ) Ectromelia virus MAD-1 Murine adenovirus FL MAD-2 Murine adenovirus K87 BACTERIA Mycoplasma spp (M.arthitridis, M. pulmonis, M.rodent...) Minimum Sample Quantity Required: 1x10 6 cells / 30mg biological product Extra tests available (please contact us): HIV Hepatitis C Hepatitis B. Results in hours!

20 Genotyping GENOTYPING SERVICES Interested in screening your newborn lab animals for a desired gene mutation? Do you want to know which animals carry or lack the allele of choice? Send us your samples and let us take the burden off your lab. Users must provide information about: sequences of the primers employed, conditions sizes of the expected fragments. Additionally users should provide DNA samples or control animals expected for different genotypes.

21 Microbiome Study Microbiome Study NGS (Next Generation Sequencing) is emerging as a powerful tool for profiling complex microbial communities. This new technology reduces the cost and time of DNA sequencing. 16 S rdna Sequencing Metagenomic 16 S rdna sequencing enables efficient identification of bacterial and archaeal microorganism diversity in a specific environment. Bioinformatic analysis of the results obtained is also available. Contact us for more information.

22 Lab Animal Shipping Boxes SMALL BOX (155 mm x 155 mm x 125 mm) - mouse, hamster - LARGE BOX (275 mm x 275 mm x 125 mm) - rat, guinea pig - AUTO-MOUNTABLE FULLY AUTOCLAVABLE IATA COMPLIANT White polypropylene cell punched box 2 windows with filter paper + galvanized meshed vents 1 upper window with PVC + galvanized meshed vents

23 Kits MOUSE Adenovirus (FL) Adenovirus (K87) Bordetella hinzii Cilia-Associate Respiratory Bacillus (CARB) Clostridium Piliformis (Tyzzers) Ectromelia Virus Encephalitozoon cuniculi (ECUN) Epizootic diarrhea of infant mice (EDIM) Hantaan Virus Helicobacter hepaticus K Virus Lymphocytic choriomeningitis virus (LCMV) Minute Virus of Mice (MVM) Hepatitis Virus (MHV) Norovirus (MNV) Mycoplasma Arthritidis Mycoplasma pulmonis Parvovirus (MPV1 & MPV2), VP2 Parvovirus Native Antigen Pasteurella haemolytica Pasteurella multocida Pasteurella pneumotropica Pneumocystis Murina Pneumonia Virus (PVM) Polyoma Virus Reovirus type 3 Sendai Virus Theiller`s murine encephalomyelitis virus (TMEV) Anti-Anthrax PA83 Anti-Diptheria Toxoid Anti-Haemophilus influenzae B (HIB) Anti-HBsAg Anti-Pertussis Anti-Tetanus toxoid IgA IgE total IgG1 IgG2a IgG2b IgG3 IgM RAT Adenovirus (FL) Adenovirus (FL/K87) Adenovirus (K87) Clostridium Piliformis (Tyzzers) Coronavirus / Sialodacryoadenitis virus (RCV/SDA) Encephalitozoon cuniculi Hantaan Virus Helicobacter hepaticus KRV Lymphocytic Choriomeningitis Virus (LCR) Minute Virus (RMV) Mycoplasma Arthritidis Mycoplasma pulmonis Parvovirus (RPV), Native Antigen Pasteurella haemolytica Pasteurella multocida Pasteurella pneumotropica Pneumocystis carinii Pneumonia Virus (PVM) Reovirus Type 3 (REO-3) Reovirus Type-1 Sendai Virus Theiler's Murine Ecephalomyelitis Virus (TMEV) Toolan's H-1 Cilia-Associate Respiratory Bacillus(CARB) Kilham Rat Virus / H1 (KRV-H1) IgA IgG1 IgG2a IgG2b IgG2C IgM IgE total

24 Kits HAMSTER Encephalitozoon cuniculi Clostridium piliformis LCMV Mycoplasma pulmonis Pneumonia Virus (PVM) Reovirus type 3 Sendai Virus SV5 RABBIT CARB Clostridium piliformis Encephalitozoon cuniculi (ECUN) Pneumonia Virus (PVM) Pox RHDV Rotavirus Sendai Virus SV5 Toxoplasma Anti-Anthrax PA83 Anti-Diptheria Toxoid Anti-Haemophilus influenzae B (HIB) Anti-HBsAg Anti-Pertussis Anti-Tetanus Toxoid GUINEA PIG Adenovirus (FL/K87) CARB Chlamydia Psittaci Clostridium piliformis CMV Encephalitozoon cuniculi LCMV Mycoplasma Pulmonis Parainfluenza Virus 3 (PI3) Pneumonia Virus (PVM) Reovirus type 3 Sendai Virus SV5 SIMIAN B-Virus CMV Foamy Virus Herpes-1 Herpes-2 Malaria Measles Rabies Rubella SIV SIV-1 p27 SRV STLV Tuberculosis Varicella Zoster Simia Mumps CANINE CAV 1&2 (Hepatitis) Coronavirus (CCV) Distemper (CDV) Herpes Virus Parainfluenza Virus (CPI) FELINE Calicivirus (FCV) Chlamydia Psittaci Coronavirus (FIP) Rhinotracheitis Toxoplasma

25 Lab Animal Consultancy Service ANIMAL WELFARE CONSULTANCY SERVICES Our team offers you its experience. We want to help you in any subject related to animal welfare. is not just your solution provider, but also your partner in Designing personalised screening panels, Consultancy in lab animal care and handling, Interpreting results, Engineering new lab animal units.

26 Sample Collection & Shipment Recommendations Samples for bacteriology: should be sent using transport media, processing them within 24 hours from collection in order to enhance bacterial viability. We recommend that sera do not contain red blood cells or haemolysed blood. A clean serum provides more accurate and reliable results. Tissue extraction should be carried out immediately after culling the animal. Tissues can be sent to us either frozen or refrigerated: Fresh tissue: should be sent using ice as long as it arrives at our premises in a short period of time. Frozen tissue: should be sent using dried ice in instances in which the logistics or distance from our lab hinder an immediate delivery. Also note that cryopreservation is the only means by which RNA agents genomes are viable. When sending samples for biochemical analyses, always use the appropriate anticoagulant required for each clinical determination. Do not hesitate to contact us to learn more about the conditions and/or volumes required. When collecting samples, it is considered good laboratory practice to always label them immediately and freeze/refrigerate straightaway. This avoids keeping tissue/blood/sera at room temperature and other transcription errors. Always use our digital or paper forms when shipping animals or samples. Every shipment must be acknowledged by our lab. laboratorio@dynamimed.com

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28 DYNAMIMED S.L. C/ Faraday 7, Laboratorio 0.05 Parque Científico de Madrid, Campus de Cantoblanco, Madrid. Spain info@dynamimed.com / laboratorio@dynamimed.com