REGIONAL ALLERGY RESPIRATORY AREAS

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2 INDEX Profiles Page Regional Respiratory Allergen Profiles...2 General Allergy Profiles Allergy Profiles...7 Allergy Profiles Components... 7 Workplace Exposure Profiles...8 Individual Allergens...9 REGIONAL ALLERGY RESPIRATORY AREAS 18 AK WA OR ID NV CALIFORNIA 13 CA 12 UT AZ MT WY 11 CO NM ND SD 9 NE KS OK 10 TX MI MN 7 WI MI IA OH 8 IN IL MO 5 KY WV TN AR 6 3 AL MS GA LA 1 NY PA 2 VA NC SC ME VT NH MA CT RI NJ DE MD FL 20 HI 4 19 PR Map used with permission of Thermo Fisher Scientific. LabCorp s policy is to provide physicians, in each instance, with the flexibility to choose appropriate tests to assure that the convenience of ordering test combinations/profiles does not prevent physicians who wish to order a test combination/profile from making deliberate informed decisions regarding which tests are medically necessary. All the tests offered in test combinations/profiles may be ordered individually using the LabCorp test request form. 1

3 REGIONAL RESPIRATORY ALLERGEN PROFILES Allergen Profile With Total IgE, Respiratory Area 1 (CT, MA, ME, NH, NJ, NY, PA, RI, VT) Sycamore, Maple Leaf Bermuda Timothy Allergen Profile With Total IgE, Respiratory Area 2 (DC, DE, MD, NC, VA) Pecan, Hickory Bermuda Johnson Timothy Allergen Profile With Total IgE, Respiratory Area 3 (GA, North FL, SC) Pecan, Hickory Nettle Bahia Bermuda Timothy Allergen Profile With Total IgE, Respiratory Area 4 (FL, South of Orlando) Pine, White Nettle Bahia Bermuda Timothy Blomia tropicalis Allergen Profile With Total IgE, Respiratory Area 5 (IN, KY, OH, TN, WV) Pecan, Hickory Sycamore, Maple Leaf Bermuda Timothy 2

4 REGIONAL RESPIRATORY ALLERGEN PROFILES (CONTINUED) Allergen Profile With Total IgE, Respiratory Area 6 (AL, AR, LA, MS) Pecan, Hickory Rough Marshelder Bermuda Timothy Allergen Profile With Total IgE, Respiratory Area 7 (MI, MN, WI) Nettle Rough Marshelder Bermuda Timothy Allergen Profile With Total IgE, Respiratory Area 8 ( IA, IL, MO) Pecan, Hickory Sycamore, Maple Leaf Rough Marshelder Bermuda Timothy Allergen Profile With Total IgE, Respiratory Area 9 (KS, ND, NE, SD) Nettle Bermuda Timothy Allergen Profile With Total IgE, Respiratory Area 10 (OK, TX) Pecan, Hickory Nettle Rough Marshelder Bermuda Timothy 3

5 REGIONAL RESPIRATORY ALLERGEN PROFILES (CONTINUED) Allergen Profile With Total IgE, Respiratory Area 11 (AZ mtns, CO, ID mtns, MT, NM, UT mtns, WY) Alder, Grey Olive Bermuda Timothy Allergen Profile With Total IgE, Respiratory Area 12 (Southern AZ desert area, Southern CA desert area) Mimosa/Acacia Olive Bermuda Johnson Rye, Perennial Allergen Profile With Total IgE, Respiratory Area 13 (Southern CA coastal area) Alder, Grey Olive Bermuda Johnson Timothy Allergen Profile With Total IgE, Respiratory Area 14 (Central CA) Alder, Grey Olive Sycamore, Maple Leaf Bermuda Timothy Allergen Profile With Total IgE, Respiratory Area 15 (NV, Southern ID) Olive Bermuda Timothy 4

6 REGIONAL RESPIRATORY ALLERGEN PROFILES (CONTINUED) Allergen Profile With Total IgE, Respiratory Area 16 (Central & East WA, OR) Alder, Grey Timothy Allergen Profile With Total IgE, Respiratory Area 17 (Northwest CA, WA, Western OR) Alder, Grey Nettle Timothy Allergen Profile With Total IgE, Respiratory Area 18 (AK) Alder, Grey Timothy Allergen Profile With Total IgE, Respiratory Area 19 (PR) Eucalyptus Pine, White Wall pellitory Bermuda Johnson Red Top, Bentgrass Aureobasidium pullulans Blomia tropicalis Allergen Profile With Total IgE, Respiratory Area 20 (HI) Bayberry/Sweet Gale Eucalyptus Mesquite Palm, Queen Pine, White Cocklebur Plantain, English Wormwood Bahia Bermuda Rye, Perennial Mucor racemosus Mouse Epithelium 5

7 GENERAL ALLERGY PROFILES Allergen Profile, Mini-Panel Specimen Requirement: 2 ml serum (room temperature) Bermuda Bluegrass, Kentucky Plantain, English Allergen Profile, Specimen Requirement: 2 ml serum (room temperature) Aureobasidium pullulans Candida albicans Epicoccum purpurascens Fusarium proliferatum Mucor racemosus Phoma betae Setomelanomma rostrata Stemphylium herbarum Allergen Profile, Perennial Specimen Requirement: 2 ml serum (room temperature) Aureobasidium pullulans Candida albicans Chicken Feathers Cow Dander Duck Feathers Goose Feathers Mucor racemosus Phoma betae Setomelanomma rostrata Stemphylium herbarum Allergen Profile Plus, IgE (Pediatric) Specimen Requirement: 2 ml serum (room temperature) Shrimp Allergen Profile Plus, IgE (Pediatric) With Component Reflexes* Specimen Requirement: 3 ml serum (room temperature) Shrimp If milk IgE 0.35 ku/l, reflex tests α-lactalbumin, β-lactoglobulin, and casein will be added. If egg white IgE 0.35 ku/l, reflex tests ovalbumin and ovomucoid will be added. If peanut (whole) IgE is 0.10 ku/l, reflex tests Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, and Ara h 9 will be added Allergen Profile, IgE (Pediatric) With Component Reflexes* Specimen Requirement: 4 ml serum (room temperature) Almond Brazil Nut Cashew Nut Hazelnut (Filbert) Macadamia Nut Pecan Pistachio Scallop Sesame Seed Shrimp If milk IgE 0.35 ku/l, reflex tests α-lactalbumin, β-lactoglobulin, and casein will be added. If egg white IgE 0.35 ku/l, reflex tests ovalbumin and ovomucoid will be added. If IgE to Brazil nut, cashew nut, hazelnut (filbert), peanut (whole), and/or walnut is 0.10 ku/l, reflex testing will be completed as follows: Brazil nut: Ber e 1 / cashew nut: Ana o 3 / hazelnut (filbert): Cor a 1, Cor a 8, Cor a 9, and Cor a 14 / peanut (whole): Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, and Ara h 9 / walnut: Jug r 1 and Jug r Allergen Profile, Hymenoptera Profile 2 Bumblebee Honeybee Hornet, White Face Hornet, Yellow Paper Wasp Yellow Jacket *If reflex testing is performed, additional charges/cpt code(s) may apply. 6

8 FOOD ALLERGY PROFILES Quantitative Allergen-specific IgE tests performed using the Thermo Fisher ImmunoCAP method Allergen Profile, Specimen Requirement: 2 ml serum (room temperature) Clam Corn Scallop Sesame Allergen Profile, Basic Shrimp Allergen Profile, Berry Blueberry Raspberry Strawberry Allergen Profile, Citrus Grapefruit Lemon Lime Orange Allergen Profile, Fish Tangerine Halibut Mackerel Salmon Trout Allergen Profile, Fruit Apple Banana Grape Peach Allergen Profile, Grain Tuna Walleye Pike Pear Barley Corn Oat Rice Allergen Profile, Legume Rye Lentil Allergen Profile, Meat Beef Chicken Pork Allergen Profile, α-lactalbumin β-lactoglobulin Casein Cheese, Cheddar Type Allergen Profile, Nuts Almond Brazil Nut Cashew Nut Filbert Cheese, Cheese Pecan Nut FOOD ALLERGY PROFILES Quantitative Allergen-specific IgE tests performed using the Thermo Fisher ImmunoCAP method Allergen Profile, Shellfish Clam Crab Lobster Oyster Allergen Profile, Vegetable I Scallop Shrimp Broccoli Cabbage Cauliflower Celery Cucumber Allergen Profile, Vegetable II Lettuce Spinach Carrot Green Bean Green Pea Kidney Bean Onions Potato, White Pumpkin Tomato FOOD ALLERGY PROFILES COMPONENTS Quantitative Allergen-specific IgE tests performed using the Thermo Fisher ImmunoCAP method Allergen Profile, IgE II With Component Reflexes* Specimen Requirement: 4 ml serum (room temperature) Almond Brazil Nut Cashew Nut Clam Corn Hazelnut (Filbert) Macadamia Nut Pecan Pistachio Scallop Sesame Seed Shrimp If milk IgE 0.35 ku/l, reflex tests α-lactalbumin, β-lactoglobulin, and casein will be added. If egg white IgE 0.35 ku/l, reflex tests ovalbumin and ovomucoid will be added. If IgE to Brazil nut, cashew nut, hazelnut (filbert), peanut (whole), and/or walnut is 0.10 ku/l, reflex testing will be completed as follows: Brazil nut: Ber e 1 / cashew nut: Ana o 3 / hazelnut (filbert): Cor a 1, Cor a 8, Cor a 9, and Cor a 14 / peanut (whole): Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, and Ara h 9 / walnut: Jug r 1 and Jug r Allergen Profile, -basic IgE With Component Reflexes* Specimen Requirement: 2 ml serum (room temperature) If milk IgE 0.35 ku/l, reflex tests α-lactalbumin, β-lactoglobulin, and casein will be added. If egg white IgE 0.35 ku/l, reflex tests ovalbumin and ovomucoid will be added. If peanut (whole) IgE is 0.10 ku/l, reflex tests Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, and Ara h 9 will be added Allergen Profile, Egg Component IgE Ovalbumin Ovomucoid Allergen Profile, IgE With Component Reflexes* If egg white IgE is 0.35 ku/l, then reflex testing is completed for ovalbumin IgE and ovomucoid IgE. *If reflex testing is performed, additional charges/cpt code(s) may apply. 7

9 FOOD ALLERGY PROFILES COMPONENTS Quantitative Allergen-specific IgE tests performed using the Thermo Fisher ImmunoCAP method Allergen Profile, Component IgE α-lactalbumin β-lactoglobulin Casein Allergen Profile, IgE With Component Reflexes* If milk IgE is 0.35 ku/l, then reflex testing is completed for α-lactalbumin, β-lactoglobulin, and Casein IgE Allergen Profile, Nut, IgE With Component Reflexes* Specimen Requirement: 3 ml serum (room temperature) Almond Brazil Nut Cashew Nut Hazelnut (Filbert) Macadamia Nut Pecan Pistachio If IgE to Brazil nut, cashew nut, hazelnut (filbert), peanut (whole), and/or walnut is 0.10 ku/l, reflex testing will be completed as follows: Brazil nut: Ber e 1 / cashew nut: Ana o 3 / hazelnut (filbert): Cor a 1, Cor a 8, Cor a 9, and Cor a 14 / peanut (whole): Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, and Ara h 9 / walnut: Jug r 1 and Jug r Allergen Profile, Brazil Nut, IgE With Component Reflexes* Brazil Nut If Brazil nut IgE is 0.10 ku/l, then reflex testing is completed for Ber e Allergen Profile, Cashew Nut, IgE With Component Reflex* Cashew Nut If cashew nut IgE is 0.10 ku/l, then reflex testing is completed for Ana o Allergen Profile, Hazelnut, IgE With Component Reflexes* Hazelnut (Filbert) If hazelnut (filbert) IgE is 0.10 ku/l, then reflex testing is completed for Cor a 1, Cor a 8, Cor a 9, and Cor a Allergen Profile, Peanut, IgE With Components Ara h 1 Ara h 2 Ara h 3 Ara h 8 Ara h 9 WORKPLACE EXPOSURE PROFILES Quantitative allergen-specific IgE tests performed using the ImmunoCAP method Tests for precipitating IgG antibodies to individual allergens performed using the Double diffusion (Ouchterlony) method Acid Anhydride Profile Method: Thermo Fisher ImmunoCAP Phthalic Anhydride-specific IgE Trimellitic Anhydride-specific IgE Isocyanates Profile Method: Thermo Fisher ImmunoCAP Hexanethylene Diisocyanate (HDI)-specific IgE Methylene Diphenyl Diisocyanate (MDI)-specific IgE Toulene Diisocyanate (TDI)-specific IgE Hypersensitivity Pneumonitis Profile Method: Double diffusion (Ouchterlony) Precipitating Antibodies, IgG Aureobasidium pullulans Precipitating Antibodies, IgG Micopolyspora faeni Precipitating Antibodies, IgG Pigeon Serum Precipitating Antibodies, IgG Thermoactinomyces sacchari Precipitating Antibodies, IgG Thermoactinomyces vulgaris Precipitating Antibodies, IgG See the table on page 9 for additional workplace exposure testing options Allergen Profile, IgE With Component Reflexes* If peanut (whole) IgE is 0.10 ku/l, then reflex testing is completed for Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, and Ara h Allergen Profile,, IgE With Component Reflexes* Specimen Requirement: 0.6 ml serum (room temperature) If walnut IgE is 0.10 ku/l, then reflex testing is completed for Jug r 1 and Jug r 3. *If reflex testing is performed, additional charges/cpt code(s) may apply. 8

10 Tests for precipitating IgG antibodies to individual allergens associated with hypersensitivity pneumonitis are listed in the table below, along with sources of exposure and the names given to various conditions. Each test requires 1 ml of serum (room temperature). Test Antigen Source(s) of Exposure Disease(s) Aspergillus flavus Precipitating Antibodies, IgG Precipitating Antibodies, IgG Aspergillus glaucus Precipitating Antibodies, IgG Aspergillus nidulans Precipitating Antibodies, IgG from various sources, including compost, barley, tobacco, espartograss dust (stucco) Malt worker s lung, compost lung, tobacco worker s disease Aspergillus niger Precipitating Antibodies, IgG Aureobasidium pullulans Precipitating Antibodies, IgG Contaminated water in humidification and forced air conditioning systems, moldy sequoia dust Humidifier lung, air-conditioner lung, ventilation pneumonitis, saunataker sdisease, sequoiosis Micropolysposa faeni (Saccharopolyspora rectivirgula) Precipitating Antibodies, IgG y hay Farmer s lung Pigeon serum Precipitating Antibodies, IgG Avian droppings or feathers Bird fancier s, breeder s, or handler s lung Saccharomonospora viridis Precipitating Antibodies, IgG Dried es and leaves Thatched roof disease Thermoactinomyces candidus Precipitating Antibodies, IgG Contaminated heating system Forced air system disease Thermoactinomyces sacchari Precipitating Antibodies, IgG y sugar cane Malt worker s lung, bagassosis Thermoactinomyces vulgaris Precipitating Antibodies, IgG Method: Double diffusion (Ouchterlony) from various sources, including compost, hay, grain, silage Farmer s lung, mushroom-picker s lung, composter s lung INDIVIDUAL ALLERGEN LISTING BY ALLERGEN GROUP Specimen Requirement: 0.2 ml serum (room temperature) per each allergen Animals Budgerigar Droppings Budgerigar Feathers Canary Feathers Chicken Feathers Cow Dander Deer Epithelium Duck Feathers Feathers, Finch Gerbil Epithelium Goat Epithelia Goose Feathers Guinea Pig Epithelium Hamster Epithelium Horse Dander Mouse Epithelium Mouse Serum Pigeon Feathers Rabbit Epithelia Rat Epithelia Rat Epithelia/Protein Rat Serum Rat Urine Sheep Epithelia Swine Epithelia Turkey Feathers Bacteria Staph enterotoxin A Drugs ACTH Bovine Insulin Cefaclor Chymopapain Human Insulin Insulin Porcine Penicilloyl G Penicilloyl V Suxamethonium s Acacia Gum Allspice Almond α-lactalbumin Anchovy Aniseed Apple Apricot Asparagus Avocado Banana Barley Basil Bayleaf (Laurel) Beef β-lactoglobulin Bing Cherry Black Pepper Blackberry Blueberry Boiled Brazil Nut Broccoli Brussel Sprouts Buckwheat Cabbage Carmine Red Dye Carob Bean Carrot Casein Cashew Nut Catfish Cauliflower Celery Cheese, Cheddar Type Cheese, Type Chick Pea Chicken Chili Pepper Chocolate/Cacao Cinnamon Clam Cloves Coconut Coffee Coriander/Cilantro Corn Cottonseed Crab Cranberry Crayfish Freshwater Cucumber Cumin Curry Powder Date Dill Egg (Yolk) Egg, Whole Eggplant Fennel, Fresh Fig Flounder Garlic Gelatin Ginger Gluten Goat s Grape Grapefruit Green Bean

11 INDIVIDUAL ALLERGEN LISTING BY ALLERGEN GROUP Specimen Requirement: 0.2 ml serum (room temperature) per each allergen Green Bell Pepper Green Pea Haddock Hake Halibut Hazelnut (Filbert) Herring Honey Hop () Kidney Bean Kiwi Fruit Lamb Lemon Lentil Lettuce Lima Bean Lime Linseed Lobster Macadamia Nut Mackerel Malt Mango Melon Millet Mint Mushroom Mussel Mustard Nutmeg Oat Olive, Black Onion Orange Oregano Ovalbumin Ovomucoid Oyster Papaya Paprika Parsley Peach Pear Pecan Nut Pine Nut, Pignoles Pineapple Pistachio Nut Plum Poppy Seed Pork Potato, White Pumpkin Rabbit Meat Raspberry Red Beet Red Snapper Rice Rye Sage, Salvia Salmon Sardine Scallop Sesame Seed Shrimp Sole Spinach Squid Strawberry Sunflower Seed Sweet Chestnut Sweet Potato Swordfish Tangerine Tea Thyme Tilapia Tomato Trout Tuna Turkey Vanilla Walleye Pike Watermelon Whey White Bean Whitefish Yeast es Bahia Barley Bermuda Bluegrass, Kentucky Brome, Smooth Canary, Reed Corn, Cultivated Fescue, Meadow Foxtail, Meadow Johnson Oat, Cultivated Orchard Red Top, Bentgrass Reed, Common Rye Rye, Perennial Rye, Wild Salt Sweet Vernal Timothy Velvet , Cultivated Insects Body Cockroach, American Fire Ant (Invicta) Horsefly Midge Moth Whole Body: Mosquito Insects Venom Bumblebee Honeybee Hornet, White Face Hornet, Yellow Paper Wasp Yellow Jacket Mites Acarus Mite Blomia tropicalis D microceras Euroglyphus maynei Glycyophagus Lepidoglyph Tyrophagus Acremonium kiliense (Alternaria tenuis) Aspergillus niger Aureobasidium pullulans Bipolaris Botrytis cinerea Candida albicans Chaetomium globosum Curvularia lunata Epicoccum purpurasrens Fusarium proliferatum Mucor racemosus (Penicillium notatum) Phoma betae Pityrosporium orbiculare Rhizopus nigricans Setomelanomma rostrata Stachybotrys atra Stemphylium herbarum Trichoderma viridae Trichophyton mentagro Trichophyton rubrum Occupational Chemicals α-amylase Castor Bean Cotton Lint Ethylene Oxide Ficus Formalydehyde Isocyanate HDI Isocyanate MDI Isocyanate TDI Ispaghula Latex Ox-eye Daisy Papain Phthalic anhydride Seminal fluid Silk Sunflower Seed Tobacco Dust Trimellitic Anhydride Parasites Ascaris Severe Systemic Reactions Tryptase Smuts Tilletia Tritici s Alder, Grey Bayberry/Sweet Gale Beech (American) Cedar, Red Cypress, Bald Cypress, Italian Elm, Cedar Eucalyptus Fir, Douglas Hackberry Hazelnut Hickory, White Hop-Hornsbeam Japanese Cedar Lime /Linden Melaleuca Mesquite Mimosa/Acacia Oak, Live/Virginia Olive Olive, Russian Palm, Queen Pecan, Hickory Pepper Pine, White Privet, Common Spruce Sweet Gum Sycamore, Maple Leaf Willow s Alfalfa Careless Cocklebur Dandelion Dockweed, Yellow Fennel, Dog Goldenrod Kochia Lamb s Quarters Lenscale Nettle Oxeye Daisy Plantain, English Ragweed, False Ragweed, Giant Ragweed, Western Rough Marshelder Sunflower Pollen Wall Pellitory Wormwood

Milan Analytica AG Baslerstrasse Rheinfelden

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