Cover Page. Author: El Bannoudi, Hanane Title: Immune regulation by CD49b+ CD4+ T cells & modulation of B cell responses Issue Date:

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1 Cover Page The handle holds various files of this Leiden University dissertation Author: El Bannoudi, Hanane Title: Immune regulation by CD49b+ CD4+ T cells & modulation of B cell responses Issue Date:

2 Addendum Addendum

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4 List of publications List of publication 1. el Bannoudi H, H Jansen DT, Kerkman PF, van der Voort EI, Huizinga TW, Toes RE, Scherer HU. CD28 is expressed by synovial fluid B cells of Rheumatoid arthritis patients. Arthritis Res Ther. 2016, in press. 2. el Bannoudi H, Jansen DT, Arens R, Habets KL, Hameetman M, Huizinga TW, Stoop JN, Toes RE. Abatacept decreases disease activity in a absence of CD4+ T-cells in collagen induced arthritis model Arthritis Res Ther Aug 20;17: Franke L, el Bannoudi H, H Jansen DT, Kok K, Trynka G, Diogo D, Swertz M, Fransen K, Knevel R, Gutierrez-Achury J, Ärlestig L, Greenberg JD, Kremer J, Pappas DA, Kanterakis A, Weersma RK, van der Helm-van Mil AH, Guryev V, Rantapää-Dahlqvist S, Gregersen PK, Plenge RM, Wijmenga C, Huizinga TW, Ioan-Facsinay A, Toes RE, Zhernakova A. Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immunemediated phenotypes Eur J Hum Genet Feb;24(2): el Bannoudi H, H Ioan-Facsinay A, Toes REM. Bridging Autoantibodies and Arthritis; The Role of Fc Receptors. Curr Top Microbiol Immunol. 2014;382: el Bannoudi H, H Han WG, Stoop JN, Louis-Plence P, Huizinga TW, Toes RE. DX5+ CD4+ T cells modulate CD4+ T-cell response via inhibition of IL-12 production by DCs. Eur J Immunol Feb;43(2): Klein-Wieringa IR, Kloppenburg M, Bastiaansen-Jenniskens YM, Yusuf E, Kwekkeboom JC, El- Bannoudi H, H Nelissen RG, Zuurmond A, Stojanovic-Susulic V, Van Osch GJ, Toes RE, Ioan- Facsinay A. The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis May;70 (5): Han WG, van der Voort EI, el Bannoudi H, H Louis-Plence P, Huizinga TW, Toes RE. DX5+CD4+ T cells modulate cytokine production by CD4+ T cells towards IL-10 via the production of IL-4. Eur J Immunol Oct;40(10): Ioan-Facsinay A, el-bannoudi H, H Scherer HU, van der Woude D, Ménard HA, Lora M, Trouw LA, Huizinga TW, Toes RE Anti-cyclic citrullinated peptide antibodies are a collection of anticitrullinated protein antibodies and contain overlapping and non-overlapping reactivities Ann Rheum Dis Jan;70(1): Scherer HU, van der Woude D, Ioan-Fascinay A, el Bannoudi H, H Trouw LA, Wang J, Häupl T, Burmester GR, Deelder AM, Huizinga TW, Wuhrer M, Toes RE. Glycan profiling of anti- 179

5 citrullinated protein antibodies isolated from human serum and synovial fluid. Arthritis Rheum Jun; 62 (6): Feitsma AL, van der Voort EI, Franken KL, el Bannoudi H, Elferink BG, Drijfhout JW, Huizinga TW, de Vries RR, Toes RE, Ioan-Facsinay A. Identification of citrullinated vimentin peptides as T cell epitopes in HLA-DR4-positive patients with rheumatoid arthritis. Arthritis Rheum Jan;62(1): Franken WP, Thijsen S, Wolterbeek R, Bouwman JJ, el Bannoudi H, Kik SV, van Dissel JT, Arend SM. Variation in T-SPOT.TB spot interpretation between independent observers from different laboratories. Clin Vaccine Immunol Oct;16(10): Roukens AH, Vossen AC, Bredenbeek PJ, van Dissel JT, Visser LG. Intradermally administered yellow fever vaccine at reduced dose induces a protective immune response: a randomized controlled non-inferiority trial.plos One Apr 23;3(4):e1993 (name in acknowledgment) 180

6 Curriculum Vitae Curriculum Vitae Hanane el Bannoudi was born in Morocco and came to the Netherlands at a young age. Hanane always believed in the importance of education, but due to private circumstances she could resume her studies only when she reached the age of 23/24 years. After a successful completion of her Medical Biology studies at Rotterdam University of Applied Sciences, she started working at Leiden University Medical Center (LUMC) as a research technician, first at the department of Infectious diseases and later at the department of Rheumatology under supervision of Dr. Andreaa Ioan-Fascinay. At the end of 2009, she started her PhD training under supervision of Prof. René Toes and Prof. Tom Huizinga at the department of Rheumatology, where the research presented in this thesis was performed. Hanane is currently working as a Post-doc fellow at the department of medicine at New York University Langone Medical Center under supervision of Prof. Gregg Silverman. She is doing B cell repertoire studies in Systemic Lupus Erythematosus (SLE). 181

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8 Acknowledgment I would like to heartily thank every single one from the department of Rheumatology and all the people i came to know during my almost 7 years work at LUMC. To everyone who supported me in anyway, even with a smile or a friendly pat on the back. Working at Rheumatology department has been a great experience to me, I felt home. The work place was not only a place for doing science but also a place where people were taking care of each other and where everybody is appreciated. Therefore, I would like to thank everybody for creating this peaceful and friendly environment. I was privileged for being part of the Rheumatology team. Beste René, thank you for teaching me to be critical, for the trust you placed in me and for the time you gave me whenever I came to you. I have learned from you what it means to keep the focus. Now, I strongly believe that focus is one of the factors that can lead to success. Beste Tom your positive attitude, enthusiasm and the remarkable effort you make to keep the department as a team by bringing the people from the clinic and the lab together and giving everybody the chance to express themselves. I would like to thank everyone at the D3 lab; Nivine, Gerrie, Annemarie, Joris, Aleida, Joanneke, Marjolijn, Linda, Stefan and Koen. At C5; Marieke, Jing, Jurgen, Diahann, Inge, Jolien, Priscilla, Kim, Jeroen, Leendert, Parawee, Wang, Anja, Hilde, Rosanne, Ayla, Daniël, Bisheng, Yoann, Emeline, Felice, Lise, Marije, Tobias, Rute and Anouk. Our coffee time and adventurous activities were great!. At C1, Nina, Diane, Melek, Annemiek, Jozé, Cedric and all the staff. Joyce, Hughine, and Nancy, thank you for being always ready for help and making things happen. I apologize if I have forgotten to mention somebody. Thank you for you as well. Ellen and Andreea you were the first people I had to deal with in the beginning when I joined the Rheumatology-lab. Ellen, thank you for being helpful and supportive. Your friendly approach for managing the lab is an example. Andreea, you have been a great teacher. Your teaching and trust made me confident to start the PhD training. You embraced my willingness to participate at the Journal Club when I was at the time still working as a research technician, Thank you. Wanda, thank you for your help and for opening the door of DX5-cell-research at the beginning of my PhD training. Uli, thank you for being very kind. Having such a friendly aura was very helpful, especially when we had to deal with a challenging project. Peter, George, Ramon and Pascale, thank you for the great collaboration. Peter and George thank you for sharing our quest to identify the antigens 183

9 Acknowledgment Jeroen, Diahann, Marjolijn, Kim and Ellen, thank you for the fruitful collaboration and for making the long hours with mice experiments bearable. All my family and friends in the Netherlands, Morocco, Belgium, France, Germany, Spain, England and countries all over the world, you mean a lot to me. Thank you all. Jolien, you have been so good to me, both in the Netherlands and New York City, thank you. Fina, thank you for your advice and support. Mother and father, you have been a great support to me.thank you for the unconditional love and for having faith in me. 184