Campylobacter fetus septic arthritis and bacteremia in a thalassemic patient
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1 Case Report Vol. 29 No. 1 Campylobacter fetus septic arthritis and bacteremia in a thalassemic patient:- Changpradub D, et al. 27 Campylobacter fetus septic arthritis and bacteremia in a thalassemic patient Dhitiwat Changpradub, M.D., Danabhan Phiboonbanakit, M.D., Ph.D., Kitti Trakulhun, M.D. ABSTRACT Campylobacter fetus subspecies fetus rarely causes arthritis with bacteremia in debilitated hosts. We have identified this infection in a patient with thalassemia/hemoglobin E and post-spenectomy who presented with additive polyarthritis. C. fetus subspecies fetus was recovered from blood and synovial fluid cultures and confirmed by PCR. It would be interesting whether thalassemia is also one of risk factors of C. fetus infection. (J Infect Dis Antimicrob Agents 2012;29:27-31.) Note: This case was presented in the Interhospital Case Conference on Infectious Diseases (ICCID), 13 October 2011, Chonburi, Thailand. INTRODUCTION Campylobacter are slender, curved microaerophilic gram-negative bacteria. A number of different species of Campylobacter (for example C. jejuni, C. fetus subspecies fetus, C. fetus subspecies venerealis, C. coli and C. lari) have now been described as a cause of infectious disease in human. 1 Campylobacter jejuni, and Campylobacter fetus subspecies fetus are commonly encountered as human pathogen. In contrast to C. jejuni, C. fetus subspecies fetus less frequently causes intestinal infections. 1-4 The clinical presentations of C. fetus subspecies fetus infections are characterized by systemic illness with bacteremia, meningitis, vascular infections, and abscesses in debilitated hosts; however, arthritis associated with bacteremia is rare Here, we report a case of C. fetus subspecies fetus septic arthritis associated with bacteremia in a thalassemic patient. CASE REPORT A 49 year-old military officer was admited in Phramongkutklao Hospital because of acute swelling and pain of joints for 6 hr prior to admission. Four days earlier, he felt not well but without specific symptom. However, 2 days later, he developed watery diarrhea twice a day and had abrupt pain at both ankles. He denied previous trauma on the ankles. The pain was severe enough to prevent him from walking normally. Division of Infectious Disease, Department of Medicine, Phramongkutklao Hospital, Bangkok 10400, Thailand. Reprint request: Dhitiwat Changpradub M.D., Division of Infectious Disease, Department of Medicine, Phramongkutklao Hospital, Bangkok 10400, Thailand. Keywords: Campylobacter fetus, Septic arthritis, Thalassemia, Additive polyarthritis 27
2 28 J INFECT DIS ANTIMICROB AGENTS Jan.-April 2012 He had taken 400 mg of Ibruprofen to relieve the pain. One day before admission, his knees became swollen while ankles still had pain. He also had high grade fever without shaking chills. No other specific organ or system was noticed. He took neither antibiotic nor other medication. Six hours before admission, inflammation of right wrist developed and prompting him to seek medical attention. He was a resident of Bangkok and had underlying β-thalassemia/hbe disease. Ten years ago, he had splenectomy due to an abdominal trauma. Notably, he did not frequently received blood transfusions. Apart from the time of operation, the last time he received blood transfusion for thalassemia was more than 20 years. He still drank about a half a bottle of alcohol every day for 10 years. The physical examination revealed vital signs as follows: body temperature of 38.3 C, respiratory rate of 22/min., pulse rate of 92/min., and blood pressure of 130/70 mmhg. Signs of arthritis were observed on both ankles, knees, and right wrist joints. The initial laboratory studies showed anemia with 16% of hematocrit. The white blood cell count was 25,000 /mm 3 with 85% of neutrophils and 2% of band form. The renal function plasma glucose, liver function test and serum electrolytes were in normal limits. Left knee arthrocentesis was performed to obtain yellowish and turbid synovial fluid. The fluid showed white blood cell count of 105,000 cell/mm 3 with 99% polymorphonuclear leukocytes. Gram stain of the synovial fluid was able to demonstrate numerous white blood cells and gram-negative curve bacilli (Figure 1). Only one day after admission, 2 specimens of gram-negative curve bacilli grew on the blood culture (Figure 2). Initially, intravenous ceftriaxone was given as empirical antibiotic. Once gram-negative curve bacilli were isolated, Vibrio spp., Helicobacter spp., and Campylobacter spp. had to be considered. Therefore, azithromycin was added to the regimen because of concern about Campylobacter. C. fetus was finally reported from blood and synovial fluid culture. The PCR also confirmed the presence of C. fetus subspecies fetus in blood and synovial fluid (Figure 3). The identification of Campylobacter spp. was based on the finding of 876 bp 16SrDNA. The species was identified using cdtb gene multiplex PCR and the 553 bp fragment. Fever disappeared after 3 days and after a week, he had no pain in all joints. Ceftriaxone and azithromycin were continued for 2 weeks. DISCUSSION The patient in this report presented with additive polyarthritis and synovial fluid analysis was compatible with septic arthritis. Epidemiologically, in a β- thalassemia/hb E disease, status post splenectomy patient, bacteria like Staphylococcus aureus, Streptococci i.e. S. pneumoniae, enteric gramnegative bacilli, and H. Influenzae are among common causative pathogens. In the present report, C. fetus septic joint was confirmed. The bacteria were susceptible to β-lactam antibiotics like amoxicillin/ clavulanate, ampicillin, cephalothin, to macrolides such as zithromycin and erythromycin, tetracycline, cotrimoxazole and gentamicin. However, the bacteria showed resistance to nalidixic acid and ciprofloxacin. C. fetus subspecies fetus has been isolated from sheep, cattle, poultry, reptile, and swine. Clinical manifestations of C. fetus infection are systemic illness with bacteremia, meningitis, vascular infections, abscesses, and gastroenteritis. Up to now, 16 cases of septic arthritis from C. fetus have been reported. 11 Most of the cases presented with monoarthritis (13/16 cases). Three cases were oligoarthritis; (knee and elbow arthritis, hip and knee arthritis, hip knee and shoulder arthritis). Four cases were found in prosthetic joint infection. In this
3 Vol. 29 No. 1 Campylobacter fetus septic arthritis and bacteremia in a thalassemic patient:- Changpradub D, et al. 29 Figure 1. Gram stain of synovial fluid shows gram-negative curved bacilli organisms. Figure 2. Gram stain of hemoculture shows gram-negative curved bacilli organisms. series of septic arthritis: knee trauma, alcoholism, osteoarthritis, diabetes and cirrhosis are risk factors. Gazaigne et al reported 12 C. fetus blood stream infections from 21 patients in 7 years. Most of them (62%) were associated with fever and non-digestive system symptoms (6 cardiovascular infections, 4 cellulitis, 1 meningitis, 1 arthritis and 1 primary peritonitis). Risk factors of infection in this study were diabetes, steroid therapy, cirrhosis and severe cardiovascular diseases. In the aspect of antimicrobial susceptibility, it was found that all C. fetus isolates were susceptible to amoxicillin, amoxicillin-clavulanate, 29 imipenem, gentamicin and chloramphenicol. Thirteen strains (62%) had intermediate susceptibility to cefotaxime. Resistance to ciprofloxacin, tetracycline and erythromycin was observed for four (19%), three (14%) and one (4.7%). All were resistant to nalidixic acid. This suggests that fluoroquinolones should not be used empirically once this bacterium is suspected as a cause of infection. This is the first case of C. fetus subspecies fetus septicemia presenting with additive polyarthritis in setting of post spenectomised β-thalassemia/hb E host. It would be interesting to determine whether
4 30 J INFECT DIS ANTIMICROB AGENTS Jan.-April 2012 A. Campylobacter 16s rrna gene B. Campylobacter cdtb gene -based multiplex PCR Lanes: Lanes: ,000 bps 876 bps 500 bps Campylobacter 15s rrna gene Lane 1: 100 bp DNA ladder 2: negative control 3: Campylobacter coli ATCC : Campylobacter fetis ATCC CF 876 bps 5: Campylobacter jejuni ATCC : Sample from Blood agar 1 7: Sample from Blood agar 2 8: Sample from CCDA 1 9: Sample from CCDA 2 Campylobacter cdtb gene-based multiplex PCR Lane 1: negative control 2: Campylobacter coli ATCC bp 3: Campylobacter fetis ATCC CF 553 bp 4: Campylobacter jejuni ATCC bp 5: Sample from Blood agar 1 6: Sample from Blood agar 2 7: Sample from CCDA 1 8: Sample from CCDA 2 9: 100 bp DNA ladder Figure 3. Results of Campylobacter 16s rrna gene and Campylobacter cdtb gene -based multiplex PCR. thalassemia is also one of the risk factors of C. fetus infection. References 1. Penner JL. The genus Campylobacter: a decade of progress. Clin Microbiol Rev 1988;1: Bokkenheuser V. Vibrio fetus infection in man. I. Ten new cases and some epidemiologic observations. Am J Epidemiol 1970;91: Blaser MJ, Reller LB. Campylobacter enteritis. N Engl J Med 1981;305: Riley LW, Finch MJ. Results of the first year of national surveillance of Campylobacter infections in the United States. J Infect Dis 1985;151: Kilo C, Hagemann PO, Marzi J. Septic arthritis and bacteremia due to vibrio fetus: report of an unusual case and review of the literature. Am J Med 1965; 38:
5 Vol. 29 No. 1 Campylobacter fetus septic arthritis and bacteremia in a thalassemic patient:- Changpradub D, et al Guerrant RL, Lahita RG, Winn WC Jr, Roberts RB. Campylobacteriosis in man: pathogenic mechanisms and review of 91 bloodstream infections. Am J Med 1978;65: Schmidt U, Chmel H, Kaminski Z, Sen P. The clinical spectrum of Campylobacter fetus infections: report of five cases and review of the literature. Q J Med 1980;49: Righter J, Wells WA, Hart GD, McNeely DJ. Relapsing septicemia caused by Campylobacter fetus subsp. fetus. Can Med Assoc J 1983;128: Carbone KM, Heinrich MC, Quinn TC. Thrombophlebitis and cellulitis due to Campylobacter fetus ssp. fetus. Report of four cases and a review of the literature. Medicine (Baltimore) 1985;64: Francioli P, Herzstein J, Grob JP, Vallotton JJ, Mombelli G, Glauser MP. Campylobacter fetus subspecies fetus bacteremia. Arch Intern Med 1985;145: Cone LA, Dreisbach PB, Hirschberg J, Shekar C, Dreisbach LP, Salatich W. Cellulitis and septic arthritis caused by Campylobacter fetus and Campylobacter jejuni: report of 2 cases and review of the literature. J Clin Rheumatol 2003;9: Gazaigne L, Legrand P, Renaud B, et al. Campylobacter fetus bloodstream infection: risk factors and clinical features. Eur J Clin Microbiol Infect Dis 2008;27:
6 32 J INFECT DIS ANTIMICROB AGENTS Jan.-April 2012
7 Case Report Vol. 29 No. 1 Vibrio cholerae non O1, non O139 septicemia:- Luxsameesathaporn P, et al. 33 Vibrio cholerae non O1, non O139 septicemia in a 19-year-old woman with β-thalassemia/hemoglobin E disease Pornpong Luxsameesathaporn, M.D., Tavatchai Jariyasethpong, M.D., Poj Intalapaporn, M.D., Anongnart Chinapha, M.D. ABSTRACT Vibrio cholera bacteremia is rare and mainly reported in liver cirrhotic patients. All cases previously reported in the English language literature occurred in the setting of immune deficiency. We herein reported a case of 19-year-old woman with β-thalassemia/hemoglobin E disease who had developed V. cholera non O1, non O139 septicemia and resulted in mortality. (J Infect Dis Antimicrob Agents 2011;29:33-5.) Note: This case had been presented and discussed in the Interhospital Case Conference on Infectious Disease (ICCID), 18 August 2011, Bangkok, Thailand. INTRODUCTION Bacteremia due to non-o1 Vibrio cholerae is rare and mainly reported in immunocompromised patients, particularly those with hematologic malignancy or cirrhosis. 1 The presenting symptoms of serogroup non O1, non O139 V. cholerae bacteremia were fever with abdominal pain. Some cases had peritonitis, cellulitis or cerebritis but diarrhea was not necessarily found in the presenting symptoms. 2,3 The degrees of infection were ranging from severe bacteremia to fatal disease. The mortality rate was varying in each report, but still high, up to 50 percent 3 and most of the patients were immunocompromised or cirrhotic. We reported a case of a 19-year-old woman with β-thalassemia/ hemoglobin E disease who developed acute renal failure and severe metabolic acidosis from non O1, non O139 V. cholerae septicemia and rapidly deteriorated until death. CASE REPORT A 19-year-old Thai woman with β-thalassemia/ hemoglobin E disease was hospitalized at Rajavithi Hospital, Bangkok, Thailand on June 28, 2011 because of high fever and watery diarrhea for 3 days. She had undergone splenectomy at 4-year-old of age and received iron chelator for 1 year. On examination, Rajavithi Hospital, Bangkok 10400, Thailand. Reprint request: Pornpong Luxsameesathaporn, M.D., Rajavithi Hospital, Bangkok 10400, Thailand. Keywords: Vibrio cholera, bacteremia, septicemia, thalassemia 33
8 34 J INFECT DIS ANTIMICROB AGENTS Jan.-April 2012 the temperature was 38.7 C, respiratory rate 40 per minute, pulse rate 140 beat per minute, blood pressure 119/82 mmhg and moderate dehydration. Abdomen was soft with generalized tenderness, bowel sounds were hypoactive. She was drowsy, the neck was supple and the remaining examinations were normal. Oxygen saturation was 84 percent before intubation. Laboratory investigations showed as the following; hematocrit 20.1 percent, WBC 21,500/mm 3 (N 60%, L 36%, M 4%), and platelet count 379,000/ mm 3, blood urea nitrogen 102 mg/dl and creatinine 5 mg/dl, respectively. Stool exam revealed a WBC of 30/HPF and no parasites. Liver function tests revealed albumin 4.2 g/dl, globulin 3.9 g/dl, alkaline phosphatase 88 U/L, aspartate aminotransferase 62 U/L, alanine transaminase 70 U/L, total bilirubin 19.2 mg/dl, and direct bilirubin 12.2 mg/dl. Electrolytes revealed sodium 128, potassium 7.7, chloride 86 and bicarbonate 7 mmol/ L. An electrocardiogram showed accelerated junction tachycardia with tall peak T. Chest X-ray was normal. The patient was hospitalized at an intensive care unit (ICU), stool and 2 sets of aerobic blood cultures were sent to the Microbiology Unit. The chosen antimicrobials on the first day were ceftriaxone and ciprofloxacin, with adjusted dosages to creatinine clearance. The patient was intubated with ventilation support due to acute respiratory failure. Hemodialysis was performed immediately due to hyperkalemia and severe metabolic acidosis from acute renal failure. Meropenem was prescribed instead of ceftriaxone by the attending physician, and ciprofloxacin was continued. On the second day of hospitalization, she still had a high fever and developed hypotension. Dopamine and norepinephrine were started to maintain her blood pressure. The second hemodialysis was performed due to unimproved metabolic acidosis, but it was not completely done because of unstable hemodynamic. She still had diarrhea and unconsciousness. Even though the maximal dose of inotropic drugs were prescribed, her vital signs were not stable and developed ventricular arrhythmia and died on the second day of hospitalization. Ten hours later, two specimens of her blood cultures revealed the growth of V. cholerae non O1, non O139 which were susceptible to ciprofloxacin. DISCUSSION The patient had septic shock from non O1, non O139 V. cholerae bacteremia. In addition, she also had acute renal failure and severe metabolic acidosis. Although the combined - broad spectrum antimicrobials were promptly administered and hemodialysis was performed, the patient expired rapidly because of the severity of disease. Most previously reported cases of non O1, non O139 V. cholerae bacteremia were found in immunodeficiency or cirrhotic patients. 1 Most cirrhotic patients came to the hospital with presenting sepsis and abdominal pains. 2,3 The first reported case of β-thalassemia/hemoglobin E disease with non O1, non O139 V. cholerae bacteremia in Thailand, reported by Thisyakorn U et al, was a 15-year-old girl who had undergone a splenectomy 3 years before the admission. She presented with peritonitis and bacteremia. She underwent exploratory laparotomy to rule out secondary peritonitis on the first day. Post operative course was uneventful and she became afebrile on the fifth day of hospitalization. 4 In this report, her condition was similar to our patient, but the clinical presentation was not as severe as our patient. However, our patient had no peritonitis, and we did not evaluate for a surgical condition. Even though our patient received proper antimicrobials as fast as possible, she still had uncontrolled septic shock and died. This may
9 Vol. 29 No. 1 Vibrio cholerae non O1, non O139 septicemia:- Luxsameesathaporn P, et al. 35 be from an underlying disease of the patient and/ or the complications of acute renal failure which were so severe collectively. She may have had a surgical condition such as bowel perforation as discussed above. Our case was an example of severe non O1, non O139 V. cholerae bacteremia in β-thalassemia/hemoglobin E disease not in a cirrhotic patient, which should be considered in differential diagnosis in such patients that come to the hospital with diarrhea and sepsis. References 1. Safrin S, Morris JG Jr, Adams M, Pons V, Jacobs R, Conte JE Jr. Non-O:1 Vibrio cholerae bacteremia: case report and review. Clin Infect Dis 1988;10: Suankratay C, Phantumchinda K, Tachawiboonsak W, Wilde H. Non-serogroup O:1. 3. Suankratay C, Phantumchinda K, Tachawiboonsak W, Wilde H. Vibrio cholerae bacteremia and cerebritis. Clin Infect Dis 2001;32:E Thamlikitkul V. Vibrio bacteremia in Siriraj Hospital. J Med Assoc Thai 1990;73: Thisyakorn U, Reinprayoon S. Non-01 Vibrio cholerae septicemia: a case report. Southeast Asian J Trop Med Public Health 1990;21:
Campylobacter fetus septic arthritis and bacteremia in a thalassemic patient
Case Report Vol. 29 No. 1 Campylobacter fetus septic arthritis and bacteremia in a thalassemic patient:- Changpradub D, et al. 27 Campylobacter fetus septic arthritis and bacteremia in a thalassemic patient
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