Health research designs: a short play. Jamie Fox Juan M. Lozano

Size: px
Start display at page:

Download "Health research designs: a short play. Jamie Fox Juan M. Lozano"

Transcription

1 Health research designs: a short play Jamie Fox Juan M. Lozano

2 Compare and contrast common study designs RCT Prospective cohort Retrospective cohort Case control Demonstrate interactive teaching strategies and tools

3

4 But once upon at time.

5

6

7

8 Our PICO question P In healthy men with lots of hair, I (E) does shampooing daily, C O T T as compared with shampooing once or twice weekly, increase the risk of baldness (alopecia)? Type of question: harm Type of study: open..

9 Please take a few minutes (3) to think how you would conduct the following studies to answer the question: RCT Prospective cohort Retrospective cohort Case control

10 Case-control study Exposed to factor Unexposed to factor Exposed to factor Unexposed to factor Sample of individuals without disease Sample of individuals with disease Prospective (concurrent) cohort study Exposed to factor Unexposed to factor No disease Disease No disease Disease Retrospective (historical) cohort study Sample of individuals without disease Past time Exposed to factor Unexposed to factor Trace No disease Disease No disease Disease Present time Available in your workshop folder: tab 5 last page Follow Future time

11

12

13 Randomized controlled trial (RCT) Sample of individuals with hair Shampoo daily Shampoo weekly Hairy Bald Hairy Bald Past time Present time Future time Follow

14

15 Prospective (concurrent) cohort study Sample of individuals with hair Shampoo daily Shampoo weekly Hairy Bald Hairy Bald Past time Present time Future time Follow

16

17 Retrospective (historical) cohort study Sample of individuals with hair Shampoo daily Shampoo weekly Hairy Bald Hairy Bald Track Past time Present time Future time

18

19 Case-control study Shampoo daily Shampoo weekly Sample of bald individuals Shampoo daily Shampoo weekly Sample of hairy individuals Trace Past time Present time Future time

20

21

22 In a study of risk factors for the development of asthma, investigators enrolled consecutive children during their first newborn well child check. The child s caretakers were asked whether or not a dog lived in the house. The children were followed for 5 years and the frequency of asthma in children with and without dogs in their house was assessed. What type of study was this? a. Randomized controlled trial (RCT) b. Prospective cohort c. Retrospective cohort d. Case control

23 In a study of risk factors for the development of asthma, investigators accessed records from a primary care clinic s electronic database. They identified all children with a diagnosis of asthma. They also identified children of similar age and sex who did not have asthma. The investigators then looked to see how many children in each group had dogs in their home before they were diagnosed with asthma. What type of study was this? a. Randomized controlled trial (RCT) b. Prospective cohort c. Retrospective cohort d. Case control

24 In a study of risk factors for the development of asthma, last month investigators accessed records from a primary care clinic s electronic database from The investigators determined which children had a dog in their house at the time of their birth. They then looked to see which children developed asthma by their 5 th birthday. What type of study was this? a. Randomized controlled trial (RCT) b. Prospective cohort c. Retrospective cohort d. Case control

25 In a study of risk factors for the development of asthma, investigators enrolled families for a study during their newborn visit. After enrollment, the investigators used a computer to determine which families would raise a dog or a goldfish in their home. They followed families for 5 years to see which children developed asthma by their 5 th birthday. What type of study was this? a. Randomized controlled trial (RCT) b. Prospective cohort c. Retrospective cohort d. Case control

26

27 Feature Who assigns exposure Direction When Controlled trial Researcher (randomly, ideally) Exposure to outcome Now and future Prospective cohort Retrospective cohort Case - control Other Other Other Exposure to outcome Now and future Exposure to outcome Past Outcome to exposure Past

28 Health research designs: a short play Jamie Fox Juan M. Lozano

Trick or Treat. In April!

Trick or Treat. In April! Trick or Treat. In April! Take one small envelope but Don t open it! Teaching and Leading EBM 2018 Randomization: simple, stratified and block Juan M. Lozano, MD, MSc Describe three methods of randomization:

More information

UNDERSTANDING EPIDEMIOLOGICAL STUDIES. Csaba P Kovesdy, MD FASN Salem VA Medical Center, Salem VA University of Virginia, Charlottesville VA

UNDERSTANDING EPIDEMIOLOGICAL STUDIES. Csaba P Kovesdy, MD FASN Salem VA Medical Center, Salem VA University of Virginia, Charlottesville VA UNDERSTANDING EPIDEMIOLOGICAL STUDIES Csaba P Kovesdy, MD FASN Salem VA Medical Center, Salem VA University of Virginia, Charlottesville VA Study design in epidemiological research: Summary Observational

More information

Is Hair Transplant a Safe Option?

Is Hair Transplant a Safe Option? Is Hair Transplant a Safe Option? Hair transplant in Delhi, is a permanent solution for your hair when an established form of baldness is established. In most cases the ideal choice works out to be Follicular

More information

Common Statistical Issues in Biomedical Research

Common Statistical Issues in Biomedical Research Common Statistical Issues in Biomedical Research Howard Cabral, Ph.D., M.P.H. Boston University CTSI Boston University School of Public Health Department of Biostatistics May 15, 2013 1 Overview of Basic

More information

GATE CAT Intervention RCT/Cohort Studies

GATE CAT Intervention RCT/Cohort Studies GATE: a Graphic Approach To Evidence based practice updates from previous version in red Critically Appraised Topic (CAT): Applying the 5 steps of Evidence Based Practice Using evidence about interventions

More information

Online Supplementary Material

Online Supplementary Material Section 1. Adapted Newcastle-Ottawa Scale The adaptation consisted of allowing case-control studies to earn a star when the case definition is based on record linkage, to liken the evaluation of case-control

More information

Observational the researcher collects information on attributes or measurements of interest but DOES NOT influence the results.

Observational the researcher collects information on attributes or measurements of interest but DOES NOT influence the results. Distinction between Observational and Experimental Studies Observational the researcher collects information on attributes or measurements of interest but DOES NOT influence the results. Experimental the

More information

CAN EFFECTIVENESS BE MEASURED OUTSIDE A CLINICAL TRIAL?

CAN EFFECTIVENESS BE MEASURED OUTSIDE A CLINICAL TRIAL? CAN EFFECTIVENESS BE MEASURED OUTSIDE A CLINICAL TRIAL? Mette Nørgaard, Professor, MD, PhD Department of Clinical Epidemiology Aarhus Universitety Hospital Aarhus, Denmark Danish Medical Birth Registry

More information

EVIDENCE-BASED HEALTH CARE

EVIDENCE-BASED HEALTH CARE EVIDENCE-BASED HEALTH CARE AND OTHER MYTHS OF A MODERN AGE Peggy Mancuso, PhD, CNM, RN. 1 An Overview of EBM 2 Evidence-Based Health Care Definition Conscientious, explicit, judicious use Current best

More information

Evidence Based Medicine

Evidence Based Medicine Hamadan University of medical sciences School of Public Health Department of Epidemiology Evidence Based Medicine Amin Doosti-Irani, PhD in Epidemiology 10 March 2017 a_doostiirani@yahoo.com 1 Outlines

More information

Department of OUTCOMES RESEARCH

Department of OUTCOMES RESEARCH Department of OUTCOMES RESEARCH Clinical Research Design Sources of Error Types of Clinical Research Randomized Trials! Daniel I. Sessler, M.D. Professor and Chair Department of OUTCOMES RESEARCH The Cleveland

More information

CYCLE Vanguard: Flow Sheet for Protocol Schedule of Forms + Procedures. Binder Title and Cover Pages. Required Materials Study Schema RC flowsheet

CYCLE Vanguard: Flow Sheet for Protocol Schedule of Forms + Procedures. Binder Title and Cover Pages. Required Materials Study Schema RC flowsheet Binder Title and Cover Pages Required Materials Study Schema flowsheet 1 1. Screening a. Screen patient for eligibility. ASAP after ICU admission (within 4 days of mechanical ventilation and 7 days of

More information

Protocol Development: The Guiding Light of Any Clinical Study

Protocol Development: The Guiding Light of Any Clinical Study Protocol Development: The Guiding Light of Any Clinical Study Susan G. Fisher, Ph.D. Chair, Department of Clinical Sciences 1 Introduction Importance/ relevance/ gaps in knowledge Specific purpose of the

More information

Challenges in design and analysis of large register-based epidemiological studies

Challenges in design and analysis of large register-based epidemiological studies FMS/DSBS autumn meeting 2014 Challenges in design and analysis of large register-based epidemiological studies Caroline Weibull & Anna Johansson Department of Medical Epidemiology and Biostatistics (MEB)

More information

CONSORT 2010 checklist of information to include when reporting a randomised trial*

CONSORT 2010 checklist of information to include when reporting a randomised trial* CONSORT 2010 checklist of information to include when reporting a randomised trial* Section/Topic Title and abstract Introduction Background and objectives Item No Checklist item 1a Identification as a

More information

Asthma Management in Pregnancy HEATHER HOWE, MD UNIVERSITY OF UTAH PULMONARY DIVISION

Asthma Management in Pregnancy HEATHER HOWE, MD UNIVERSITY OF UTAH PULMONARY DIVISION Asthma Management in Pregnancy HEATHER HOWE, MD UNIVERSITY OF UTAH PULMONARY DIVISION Asthma Management in Pregnancy Effects of asthma on pregnancy outcomes Effects of pregnancy on asthma control Management

More information

Health Studies 315. Clinical Epidemiology: Evidence of Risk and Harm

Health Studies 315. Clinical Epidemiology: Evidence of Risk and Harm Health Studies 315 Clinical Epidemiology: Evidence of Risk and Harm 1 Patients encounter (possibly) risky exposures Alcohol during pregnancy (fetal risk) Electromagnetic fields (cancer risk) Vasectomy

More information

MCQ Course in Pediatrics Al Yamamah Hospital June Dr M A Maleque Molla, FRCP, FRCPCH

MCQ Course in Pediatrics Al Yamamah Hospital June Dr M A Maleque Molla, FRCP, FRCPCH MCQ Course in Pediatrics Al Yamamah Hospital 10-11 June Dr M A Maleque Molla, FRCP, FRCPCH Q1. Following statements are true in the steps of evidence based medicine except ; a) Convert the need for information

More information

VACCINE ACTIVE SURVEILLANCE I

VACCINE ACTIVE SURVEILLANCE I VACCINE ACTIVE SURVEILLANCE I Caitlin N Dodd, MS Biostatistician, Global Child Health Cincinnati Children s Hospital Medical Center CONTENTS M1 Compare epidemiological study methods Discuss the benefits

More information

CRITICAL APPRAISAL WORKSHEET

CRITICAL APPRAISAL WORKSHEET 1. THE RESEARCH QUESTION CRITICAL APPRAISAL WORKSHEET 1a. What question did the researchers want to answer? About the magnitude of health problem? About the impact of a therapy of some sort? Any differences

More information

Incorporating Clinical Information into the Label

Incorporating Clinical Information into the Label ECC Population Health Group LLC expertise-driven consulting in global maternal-child health & pharmacoepidemiology Incorporating Clinical Information into the Label Labels without Categories: A Workshop

More information

Syncytial Virus. Surveillance: A. Respiratory (RSV) New Initiative for NM

Syncytial Virus. Surveillance: A. Respiratory (RSV) New Initiative for NM Respiratory Syncytial Virus (RSV) Surveillance: A New Initiative for NM Sarah Shrum, MPH EIP Surveillance Officer, NMDOH EIP Day Conference September 23 rd, 2016 Objectives 1. Describe basic virology,

More information

Methodologies for vaccine safety surveillance. Nick Andrews, Statistics Unit Public Health England October 2015

Methodologies for vaccine safety surveillance. Nick Andrews, Statistics Unit Public Health England October 2015 Methodologies for vaccine safety surveillance Nick Andrews, Statistics Unit Public Health England October 2015 Some dramas of the past 20 years which do you think turned out to be real adverse reactions?

More information

115 remained abstinent. 140 remained abstinent. Relapsed Remained abstinent Total

115 remained abstinent. 140 remained abstinent. Relapsed Remained abstinent Total Chapter 10 Exercises 1. Intent-to-treat analysis: Example 1 In a randomized controlled trial to determine whether the nicotine patch reduces the risk of relapse among smokers who have committed to quit,

More information

1 Case Control Studies

1 Case Control Studies Statistics April 11, 2013 Debdeep Pati 1 Case Control Studies 1. Case-control (retrospective) study: Select cases, Select controls, Compare cases and controls 2. Cutaneous melanoma (Autier, 1996). 420

More information

Appendix. TABLE E-1 Search Terms

Appendix. TABLE E-1 Search Terms Page 1 Appendix TABLE E-1 Search Terms Category Search Terms* Disease (Chronic) osteomyelitis, osteitis, bone infection Antibiotics Gentamicin, vancomycin, anti-infective agent, (local) antibiotics Properties

More information

Important Facts About a Hair Transplant Process

Important Facts About a Hair Transplant Process Important Facts About a Hair Transplant Process For a considerable amount of time hair loss has been a problem plaguing millions. As your looks are connected to your social life, a receding hairline is

More information

Vaccine/toxoid Reimbursement Changes

Vaccine/toxoid Reimbursement Changes Vaccine/toxoid Reimbursement Changes Information posted July 3, 2008 This is an update to a banner message that first appeared on the February 29, 2008, Remittance and Status (R&S) Report about the delayed

More information

Sampling. (James Madison University) January 9, / 13

Sampling. (James Madison University) January 9, / 13 Sampling The population is the entire group of individuals about which we want information. A sample is a part of the population from which we actually collect information. A sampling design describes

More information

Choosing the right study design

Choosing the right study design Choosing the right study design Main types of study design Randomised controlled trial (RCT) Cohort study Case-control study Cross-sectional study Case series/case note review Expert opinion BEST QUALITY

More information

About Reading Scientific Studies

About Reading Scientific Studies About Reading Scientific Studies TABLE OF CONTENTS About Reading Scientific Studies... 1 Why are these skills important?... 1 Create a Checklist... 1 Introduction... 1 Abstract... 1 Background... 2 Methods...

More information

The Tennessee EHDI Information System

The Tennessee EHDI Information System Tracking Babies Along the 1-3-6 Journey The Tennessee EHDI Information System Yinmei Li, MD, PhD State Chronic Disease Epidemiologist Director, Surveillance, Epidemiology and Evaluation Tennessee Department

More information

Canadian Journal of Anesthesia/Journal canadien d anesthésie. Evidence-Based Clinical Updates (EBCU s) in Anesthesia

Canadian Journal of Anesthesia/Journal canadien d anesthésie. Evidence-Based Clinical Updates (EBCU s) in Anesthesia Canadian Journal of Anesthesia/Journal canadien d anesthésie Evidence-Based Clinical Updates (EBCU s) in Anesthesia INSTRUCTIONS FOR AUTHORS The Canadian Journal of Anesthesia considers for publication

More information

ADENIYI MOFOLUWAKE MPH APPLIED EPIDEMIOLOGY WEEK 5 CASE STUDY ASSIGNMENT APRIL

ADENIYI MOFOLUWAKE MPH APPLIED EPIDEMIOLOGY WEEK 5 CASE STUDY ASSIGNMENT APRIL ADENIYI MOFOLUWAKE MPH 510 - APPLIED EPIDEMIOLOGY WEEK 5 CASE STUDY ASSIGNMENT APRIL 4 2013 Question 1: What makes the first study a case-control study? The first case study is a case-control study because

More information

Overview of Study Designs in Clinical Research

Overview of Study Designs in Clinical Research Overview of Study Designs in Clinical Research Systematic Reviews (SR), Meta-Analysis Best Evidence / Evidence Guidelines + Evidence Summaries Randomized, controlled trials (RCT) Clinical trials, Cohort

More information

DECLARATION OF CONFLICT OF INTEREST

DECLARATION OF CONFLICT OF INTEREST DECLARATION OF CONFLICT OF INTEREST Warfarin and the risk of major bleeding events in patients with atrial fibrillation: a population-based study Laurent Azoulay PhD 1,2, Sophie Dell Aniello MSc 1, Teresa

More information

Study Designs. chapter. W hy. L earning O bjectives

Study Designs. chapter. W hy. L earning O bjectives holbox/shutterstock holbox/shutterstock chapter 2 Study Designs W hen and W hy Key Questions How do you know when the results of a study are credible? What makes a good study? How do you decide which kind

More information

Overview of Study Designs

Overview of Study Designs Overview of Study Designs Kyoungmi Kim, Ph.D. July 13 & 20, 2016 This seminar is jointly supported by the following NIH-funded centers: We are video recording this seminar so please hold questions until

More information

Guidelines for Writing and Reviewing an Informed Consent Manuscript From the Editors of Clinical Research in Practice: The Journal of Team Hippocrates

Guidelines for Writing and Reviewing an Informed Consent Manuscript From the Editors of Clinical Research in Practice: The Journal of Team Hippocrates Guidelines for Writing and Reviewing an Informed Consent Manuscript From the Editors of Clinical Research in Practice: The Journal of Team Hippocrates 1. Title a. Emphasize the clinical utility of the

More information

RESEARCH PROJECT. Comparison of searching tools and outcomes of different providers of the Medline database (OVID and PubMed).

RESEARCH PROJECT. Comparison of searching tools and outcomes of different providers of the Medline database (OVID and PubMed). RESEARCH PROJECT Comparison of searching tools and outcomes of different providers of the Medline database (OVID and PubMed). Karolina Kucerova Charles University in Prague Evidence-Based Medicine Course

More information

Research Methodology Workshop. Study Type

Research Methodology Workshop. Study Type Research Methodology Workshop Study Type What type of question? Frequency: how common is it? Aetiology: What caused this? Intervention: Does this intervention work? Diagnosis or test evaluation: How accurate

More information

When a Threshold Crossing approach may and may not be appropriate: A Case Study in SMA

When a Threshold Crossing approach may and may not be appropriate: A Case Study in SMA When a Threshold Crossing approach may and may not be appropriate: A Case Study in SMA EFSPI Regulatory Statistics Workshop, 24-25 th September 2018 Carol Reid and Uli Burger picture placeholder Outline

More information

Dr. Engle has received an unrestricted educational grant for the MD Anderson Pain Medicine Fellowship.

Dr. Engle has received an unrestricted educational grant for the MD Anderson Pain Medicine Fellowship. Mitchell Engle, MD, PhD Dr. Mitchell Engle earned his medical degree and a Ph.D. in Pharmacology from the University Of Iowa Carver College Of Medicine. His Ph.D. research examined the role of the spinal

More information

Newborn Screening Issues and Answers Workshop: Laboratory Health Information Exchange November 1-2, Utah Department of Health

Newborn Screening Issues and Answers Workshop: Laboratory Health Information Exchange November 1-2, Utah Department of Health Newborn Issues and Answers Workshop: Laboratory Health Information Exchange November 1-2, 2010 User Group Access Method Query / Display Software IHC HELP2 Webkids in HELP2, querying directly and displaying

More information

EVIDENCE DETECTIVES December 28, 2005 Edward Amores, M.D. Reviewed and edited by P. Wyer, M.D. Part I Question Formulation

EVIDENCE DETECTIVES December 28, 2005 Edward Amores, M.D. Reviewed and edited by P. Wyer, M.D. Part I Question Formulation EVIDENCE DETECTIVES December 28, 2005 Edward Amores, M.D. Reviewed and edited by P. Wyer, M.D. Part I Question Formulation Clinical Scenario Quite often in the Pediatric ED and at times in the adult ED

More information

Scientific Evidences in Homeopathy: a dynamic database

Scientific Evidences in Homeopathy: a dynamic database Scientific Evidences in Homeopathy: a dynamic database Introduction. Rationale. Instructions for use A. Scientific Research in the Era of EBM B. Scientific Research in Homeopathic Medicine: peculiarities

More information

The Cumulative Incidence of HIV Infection in HIVexposed Infants with a Birth Weight of 1500g Receiving Breast Milk and Daily Nevirapine

The Cumulative Incidence of HIV Infection in HIVexposed Infants with a Birth Weight of 1500g Receiving Breast Milk and Daily Nevirapine The Cumulative Incidence of HIV Infection in HIVexposed Infants with a Birth Weight of 1500g Receiving Breast Milk and Daily Nevirapine A retrospective, descriptive study conducted at Kalafong hospital,

More information

Trial Designs. Professor Peter Cameron

Trial Designs. Professor Peter Cameron Trial Designs Professor Peter Cameron OVERVIEW Review of Observational methods Principles of experimental design applied to observational studies Population Selection Looking for bias Inference Analysis

More information

Systematic reviews: From evidence to recommendation. Marcel Dijkers, PhD, FACRM Icahn School of Medicine at Mount Sinai

Systematic reviews: From evidence to recommendation. Marcel Dijkers, PhD, FACRM Icahn School of Medicine at Mount Sinai Systematic reviews: From evidence to recommendation Session 2 - June 18, 2014 Going beyond design, going beyond intervention: The American Academy of Neurology (AAN) Clinical Practice Guideline process

More information

Things to Consider Before You Plan For a Hair Transplant

Things to Consider Before You Plan For a Hair Transplant Things to Consider Before You Plan For a Hair Transplant Planning to visit a hair transplant surgeon in Delhi? A surgery is the last thing on your mind when you have gone bald. The main thing is that it

More information

Zoonotic Disease Report June 03 June 09, 2018 (Week 23)

Zoonotic Disease Report June 03 June 09, 2018 (Week 23) Zoonotic Disease Report June 03 June 09, 2018 (Week 23) Executive Summary Statewide 180 specimens have tested positive for rabies in 2018. This surpasses total positive specimens for all of 2017. 2018

More information

Tool to Assess Risk of Bias in Cohort Studies

Tool to Assess Risk of Bias in Cohort Studies Tool to Assess Risk of Bias in Cohort Studies Contributed by the CLARITY Group at McMaster University 1. Was selection of exposed and non-exposed cohorts drawn from the same population? Exposed and unexposed

More information

Vaccination Recommendations Practice and Shelter-Housed Dogs

Vaccination Recommendations Practice and Shelter-Housed Dogs Vaccination Recommendations Practice and Shelter-Housed Dogs 1. MIXING VACCINES. Can different types of vaccines be mixed in the same syringe? No. Unless specifically stated on the product label (package

More information

PICO Presentation: A review of the research RACHEL FOX COHP 450

PICO Presentation: A review of the research RACHEL FOX COHP 450 PICO Presentation: A review of the research RACHEL FOX COHP 450 In hospitalized patients, does the placement of an IV catheter in the antecubital fossa compared to other peripheral sites effect IV dwell

More information

RESPONSE TO THE LANGUAGE EQUALITY AND ACQUISITION FOR DEAF KIDS (LEAD K) TASK FORCE REPORT

RESPONSE TO THE LANGUAGE EQUALITY AND ACQUISITION FOR DEAF KIDS (LEAD K) TASK FORCE REPORT REPORT TO THE HOUSE AND SENATE COMMITTEES ON EDUCATION AND HEALTH AND SENATE COMMITTEES ON HEALTH AND WELFARE OF THE LOUISIANA LEGISLATURE RESPONSE TO THE LANGUAGE EQUALITY AND ACQUISITION FOR DEAF KIDS

More information

Quantitative Research Methods and Tools

Quantitative Research Methods and Tools Quantitative Research Methods and Tools Fraser Health Authority, 2011 The Fraser Health Authority ( FH ) authorizes the use, reproduction and/or modification of this publication for purposes other than

More information

Chapter 11: Experiments and Observational Studies p 318

Chapter 11: Experiments and Observational Studies p 318 Chapter 11: Experiments and Observational Studies p 318 Observation vs Experiment An observational study observes individuals and measures variables of interest but does not attempt to influence the response.

More information

observational studies Descriptive studies

observational studies Descriptive studies form one stage within this broader sequence, which begins with laboratory studies using animal models, thence to human testing: Phase I: The new drug or treatment is tested in a small group of people for

More information

Setting The setting was primary care. The economic study was carried out in the UK and the USA.

Setting The setting was primary care. The economic study was carried out in the UK and the USA. Validation of venous leg ulcer guidelines in the United States and United Kingdom McGuckin M, Waterman R, Brooks J, Cherry G, Porten L, Hurley S, Kerstein M D Record Status This is a critical abstract

More information

Concurrent use of alcohol interactive medications and alcohol in older adults: a systematic review of prevalence and associated adverse outcomes

Concurrent use of alcohol interactive medications and alcohol in older adults: a systematic review of prevalence and associated adverse outcomes Concurrent use of alcohol interactive medications and alcohol in older adults: a systematic review of prevalence and associated adverse outcomes Alice Holton Royal College of Surgeons in Ireland 21 September

More information

STI Treatment Guidelines. Teodora Wi. Training Course in Sexual and Reproductive Health Research

STI Treatment Guidelines. Teodora Wi. Training Course in Sexual and Reproductive Health Research Teodora Wi Geneva, 28 August 2017 STI Treatment Guidelines Teodora Wi Training Course in Sexual and Reproductive Health Research 2017 Twitter @HRPresearch 1 STI treatment guidelines Neisseria gonorrhoeae

More information

RESEARCH. Katrina Wilcox Hagberg, 1 Hozefa A Divan, 2 Rebecca Persson, 1 J Curtis Nickel, 3 Susan S Jick 1. open access

RESEARCH. Katrina Wilcox Hagberg, 1 Hozefa A Divan, 2 Rebecca Persson, 1 J Curtis Nickel, 3 Susan S Jick 1. open access open access Risk of erectile dysfunction associated with use of 5-α reductase inhibitors for benign prostatic hyperplasia or alopecia: population based studies using the Clinical Practice Research Datalink

More information

Seborrheic dermatitis. What is SEBORRHEIC DERMATITIS? This is a common condition which affects 1-3 % of individuals.

Seborrheic dermatitis. What is SEBORRHEIC DERMATITIS? This is a common condition which affects 1-3 % of individuals. 750 West Broadway Suite 905 - Vancouver BC V5Z 1H8 Phone: 604.283.9299 Fax: 604.648.9003 Email: vancouveroffice@donovanmedical.com Web: www.donovanmedical.com Seborrheic dermatitis What is SEBORRHEIC DERMATITIS?

More information

Supported by Australian Aid, AusAID

Supported by Australian Aid, AusAID Supported by Australian Aid, AusAID Contents Unit scenario 1 Papua New Guinea: a country profile 2-4 HIV and AIDS 5-6 Responding to HIV and AIDS in PNG 7-8 Nutrition, child and maternal health 9-10 Responding

More information

Clinical Research Scientific Writing. K. A. Koram NMIMR

Clinical Research Scientific Writing. K. A. Koram NMIMR Clinical Research Scientific Writing K. A. Koram NMIMR Clinical Research Branch of medical science that determines the safety and effectiveness of medications, devices, diagnostic products and treatment

More information

EVIDENCE BASED PRACTICE????

EVIDENCE BASED PRACTICE???? In the Name of God Sakineh Hajebrahimi Professor of Urology Department Iranian Center of EBM for Excellence, Tabriz, Iran EVIDENCE BASED PRACTICE???? INTRODUCTORY LECTURE: OBJECTIVES 1. What 2. How What

More information

Management of patients with should not use past or present history of solid cancer

Management of patients with should not use past or present history of solid cancer Practical management of patients receiving abatacept 1 Management of patients with should not use past or present history of solid Evidence-based Medicine Official Recommendations Expert opinion Steps

More information

First author. Title: Journal

First author. Title: Journal First author Title: Journal Year: Volume: Issue: First page: Last Page: 1. Type of study Controlled trial without randomization Section B Observational cohort study Section B 2. Type of report Full paper

More information

Opioid use in COPD: balancing benefits and harms. St. Michael s Hospital, University of Toronto

Opioid use in COPD: balancing benefits and harms. St. Michael s Hospital, University of Toronto Opioid use in COPD: balancing benefits and harms Nicholas Vozoris MHSc, MD, FRCPC Assistant Professor St. Michael s Hospital, University of Toronto Conflicts of interest None None of my own drug safety

More information

Azathioprine treatment for respiratory conditions. Information for patients Respiratory Medicine - Asthma

Azathioprine treatment for respiratory conditions. Information for patients Respiratory Medicine - Asthma Azathioprine treatment for respiratory conditions Information for patients Respiratory Medicine - Asthma What is azathioprine? Azathioprine (also known as Imuran) is a treatment for the immune system.

More information

Epidemiology: Overview of Key Concepts and Study Design. Polly Marchbanks

Epidemiology: Overview of Key Concepts and Study Design. Polly Marchbanks Epidemiology: Overview of Key Concepts and Study Design Polly Marchbanks Lecture Outline (1) Key epidemiologic concepts - Definition - What epi is not - What epi is - Process of epi research Lecture Outline

More information

Cost-Motivated Treatment Changes in Commercial Claims:

Cost-Motivated Treatment Changes in Commercial Claims: Cost-Motivated Treatment Changes in Commercial Claims: Implications for Non- Medical Switching August 2017 THE MORAN COMPANY 1 Cost-Motivated Treatment Changes in Commercial Claims: Implications for Non-Medical

More information

Clinical Evidence. A BMJ database of the very best evidence for effective health care

Clinical Evidence. A BMJ database of the very best evidence for effective health care Clinical Evidence A BMJ database of the very best evidence for effective health care Myleen Oosthuizen Academic Information Service School for Health Sciences What is Clinical Evidence? An international

More information

Frequently Asked Questions About Hair Transplantation?

Frequently Asked Questions About Hair Transplantation? Frequently Asked Questions About Hair Transplantation? The philosophy of hair transplant is hair follicles (resistant) are plucked from the side or back areas of the head and embedded on to the bald areas.

More information

ISPOR Good Research Practices for Retrospective Database Analysis Task Force

ISPOR Good Research Practices for Retrospective Database Analysis Task Force ISPOR Good Research Practices for Retrospective Database Analysis Task Force II. GOOD RESEARCH PRACTICES FOR COMPARATIVE EFFECTIVENESS RESEARCH: APPROACHES TO MITIGATE BIAS AND CONFOUNDING IN THE DESIGN

More information

MY FITNESS PAL USER GUIDE

MY FITNESS PAL USER GUIDE MY FITNESS PAL USER GUIDE DIET PROFILE To help personalize your fitness goals, enter the following: Current weight Goal weight Height Gender Date of birth You also enter your normal daily activity options

More information

USDA Nutrition Evidence Library: Systematic Review Methodology

USDA Nutrition Evidence Library: Systematic Review Methodology USDA Nutrition Evidence Library: Systematic Review Methodology Julie E. Obbagy, PhD, RD USDA Center for Nutrition Policy & Promotion Meeting #2 October 17, 2016 The National Academies of Sciences, Engineering,

More information

Observational Medical Studies. HRP 261 1/13/ am

Observational Medical Studies. HRP 261 1/13/ am Observational Medical Studies HRP 261 1/13/03 10-11 11 am To Drink or Not to Drink? Volume 348:163-164 January 9, 2003 Ira J. Goldberg, M.D. A number of epidemiologic studies have found an association

More information

THIS TALK STATINS REDUCE: Immortal time bias Immeasurable time bias Time-window bias TIME-RELATED BIASES IN PHARMACOEPIDEMIOLOGY

THIS TALK STATINS REDUCE: Immortal time bias Immeasurable time bias Time-window bias TIME-RELATED BIASES IN PHARMACOEPIDEMIOLOGY TIME-RELATED BIASES IN PHARMACOEPIDEMIOLOGY Samy Suissa McGill University and Jewish General Hospital Montreal, Canada ISPE mid-year meeting, Miami April 22, 2012 STATINS REDUCE: JAMA 2000: Fracture rate

More information

Farmers Market Voucher Program. A Community & Patient Engagement success story December 2, 2014

Farmers Market Voucher Program. A Community & Patient Engagement success story December 2, 2014 Farmers Market Voucher Program A Community & Patient Engagement success story December 2, 2014 Brockton Farmers Market 2014 Prescription for Healthy Eating Modern research has shown that a healthy diet

More information

Gene Expression and Mutation

Gene Expression and Mutation Gene Expression and Mutation GENE EXPRESSION: There are hormonal and environmental factors that may cause the expression of some genetic information. Some examples are: 1. The two- colour pattern of some

More information

EBM in action: "Does ovulation induction increase the risk of ovarian cancer?"

EBM in action: Does ovulation induction increase the risk of ovarian cancer? Middle East Fertility Society Journal Vol. 11, No. 2, 2006 Copyright Middle East Fertility Society EVIDENCE-BASED MEDICINE CORNER EBM in action: "Does ovulation induction increase the risk of ovarian cancer?"

More information

Anatomy of Medical Studies: Part I. Emily D Agostino Epidemiology and Biostatistics CUNY School of Public Health at Hunter College

Anatomy of Medical Studies: Part I. Emily D Agostino Epidemiology and Biostatistics CUNY School of Public Health at Hunter College Anatomy of Medical Studies: Part I!! Emily D Agostino Epidemiology and Biostatistics CUNY School of Public Health at Hunter College I. Standard format of a Medical Study Abstract (quick overview: what

More information

Risk Study. Section for Clinical Epidemiology and Biostatistics. Definition

Risk Study. Section for Clinical Epidemiology and Biostatistics. Definition Risk Study Section for Clinical Epidemiology and Biostatistics What is Risk? Definition The probability of some untoward event The likelihood that people who are exposed to certain factors (risk factors)

More information

CRITICAL APPRAISAL AP DR JEMAIMA CHE HAMZAH MD (UKM) MS (OFTAL) UKM PHD (UK) DEPARTMENT OF OPHTHALMOLOGY UKM MEDICAL CENTRE

CRITICAL APPRAISAL AP DR JEMAIMA CHE HAMZAH MD (UKM) MS (OFTAL) UKM PHD (UK) DEPARTMENT OF OPHTHALMOLOGY UKM MEDICAL CENTRE CRITICAL APPRAISAL AP DR JEMAIMA CHE HAMZAH MD (UKM) MS (OFTAL) UKM PHD (UK) DEPARTMENT OF OPHTHALMOLOGY UKM MEDICAL CENTRE MINGGU PENYELIDIKAN PERUBATAN & KESIHATAN PPUKM Lecture content Introduction

More information

Risk Ratio and Odds Ratio

Risk Ratio and Odds Ratio Risk Ratio and Odds Ratio Risk and Odds Risk is a probability as calculated from one outcome probability = ALL possible outcomes Odds is opposed to probability, and is calculated from one outcome Odds

More information

Transfusion triggers in acute coronary syndromes: The MINT trial

Transfusion triggers in acute coronary syndromes: The MINT trial Transfusion triggers in acute coronary syndromes: The MINT trial Paul Hébert, MD MHSc(Epid) Physician-in-Chief, CHUM Professor, University of Montreal Objectives Review evidence on transfusion triggers

More information

Sensitivity and Positive Predictive Value of the Measles Surveillance System In Uganda,

Sensitivity and Positive Predictive Value of the Measles Surveillance System In Uganda, Public Health Fellowship Program Field Epidemiology Track Sensitivity and Positive Predictive Value of the Measles Surveillance System In Uganda, 2012-2015 Dr.Fred Nsubuga, MBChB, MPH Fellow, Cohort 2015

More information

GLOSSARY of research terms

GLOSSARY of research terms GLOSSARY of research terms SETTING PRIORITIES FOR VITILIGO RESEARCH - WORKSHOP Thursday 25 th March 2010 Types of studies Case Series: A study reporting on a consecutive collection of patients, treated

More information

HBV-2 Group: neonates born to HBsAg+ and HBeAg+ mothers who received a 4-dose vaccination regimen (Part of

HBV-2 Group: neonates born to HBsAg+ and HBeAg+ mothers who received a 4-dose vaccination regimen (Part of The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.

More information

Systematic review ALHIV: Disclosure, adherence and retention in care

Systematic review ALHIV: Disclosure, adherence and retention in care WHO/HIV/2013.129 World Health Organization 2013 HIV and adolescents: guidance for HIV testing and counselling and care for adolescents living with HIV ANNEX 4: Systematic review ALHIV: Disclosure, adherence

More information

Comprehensive Outreach Education Certificate Program. & Health Modules. Spring 2014

Comprehensive Outreach Education Certificate Program. & Health Modules. Spring 2014 Comprehensive Outreach Education Certificate Program & Health Modules Community Health Education Center Lowell Community Health Center 161 Jackson Street Lowell, MA 01852 Tel: 978-452-0003 Fax: 978-221-6215

More information

Conceptual Framework for Follow-up Study of Thimerosalcontaining. Neurologic Developmental Disorders (NDDs) Paul A. Stehr-Green

Conceptual Framework for Follow-up Study of Thimerosalcontaining. Neurologic Developmental Disorders (NDDs) Paul A. Stehr-Green Conceptual Framework for Follow-up Study of Thimerosalcontaining Vaccines and Neurologic Developmental Disorders (NDDs) Paul A. Stehr-Green Thanks to all CDC/ATSDR contributors ESPECIALLY: Bill Thompson

More information

Evidence-Based Review Process to Link Dietary Factors with Chronic Disease Case Study: Cardiovascular Disease and n- 3 Fatty Acids

Evidence-Based Review Process to Link Dietary Factors with Chronic Disease Case Study: Cardiovascular Disease and n- 3 Fatty Acids Evidence-Based Review Process to Link Dietary Factors with Chronic Disease Case Study: Cardiovascular Disease and n- 3 Fatty Acids Alice H. Lichtenstein, D.Sc. Gershoff Professor of Nutrition Science and

More information

Clinic and Community-Based Intervention Programs: Impact on Gestational Weight Gain

Clinic and Community-Based Intervention Programs: Impact on Gestational Weight Gain Clinic and Community-Based Intervention Programs: Impact on Gestational Weight Gain Christine M. Olson, PhD Professor June 5, 2008 Introduction o 33 to 44% of US women gain within the IOM recommendations;

More information

Patterns and Cost of Health Care Transitions to Adult Care among Youth with Chronic Conditions in Ontario: A Population Based Cohort Study

Patterns and Cost of Health Care Transitions to Adult Care among Youth with Chronic Conditions in Ontario: A Population Based Cohort Study Patterns and Cost of Health Care Transitions to Adult Care among Youth with Chronic Conditions in Ontario: A Population Based Cohort Study Eyal Cohen, MD, MSc; Sima Gandhi, MSc; Charlotte Moore, MD; Alene

More information

The Intersection of Post-Traumatic Stress and Substance Use Disorders. Implications for an emerging integrated treatment approach

The Intersection of Post-Traumatic Stress and Substance Use Disorders. Implications for an emerging integrated treatment approach The Intersection of Post-Traumatic Stress and Substance Use Disorders Implications for an emerging integrated treatment approach Christal L. Badour, PhD Assistant Professor Department of Psychology Overview

More information

5-Part Series on Alport Syndrome by Dr. Clifford Kashtan

5-Part Series on Alport Syndrome by Dr. Clifford Kashtan 5-Part Series on Alport Syndrome by Dr. Clifford Kashtan Dr. Clifford Kashtan is the director of the Alport Syndrome Treatments and Outcomes Registry (ASTOR) and a member of the ASF Medical Advisory Committee.

More information

Clinical Evidence: Asking the Question and Understanding the Answer. Keeping Up to Date. Keeping Up to Date

Clinical Evidence: Asking the Question and Understanding the Answer. Keeping Up to Date. Keeping Up to Date Clinical Evidence: Asking the Question and Understanding the Answer Keeping Up to Date 5,000? per day 1,500 per day 95 per day Keeping Up to Date 5,000? per day 1,500 per day 95 per day 1 Bias Bias refers

More information

COASTING NEWS. SPRING 2007

COASTING NEWS. SPRING 2007 COASTING NEWS. SPRING 2007 Gymfinity The fourth Annual GYMFINITY Activity needs to be cancelled for this Sunday, March 11, 2007. Unfortunately, Gymfinity had a scheduling conflict, and the COAST staff

More information