Suicide: Phenomenology and Neurobiology
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1 Suicide: Phenomenology and Neurobiology
2 Keri E. Cannon Thomas J. Hudzik Editors Suicide: Phenomenology and Neurobiology 123
3 Editors Keri E. Cannon Global Safety Pharmacology Pfizer, Inc. Groton, CT USA Thomas J. Hudzik Preclinical Safety AbbVie North Chicago, IL USA ISBN ISBN (ebook) DOI / Library of Congress Control Number: Springer Cham Heidelberg New York Dordrecht London Springer International Publishing Switzerland 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (
4 Foreword We can remember as youngsters watching the television show, Mork and Mindy. We laughed along, while sometimes feeling unable to keep up with the soaring and roaring wit that was Robin Williams. But sometimes we were able to catch on to a suspender and fly along with him for a time, and that was a ride that inspired awe. His dramatic roles were no less inspiring; for example, Awakenings played a role in some of our career choices, Good Morning Vietnam in political perspectives. We wonder, now, how he could have kept up that quick cognitive pace, and what was required to do so. Did we imagine, later in his life, that when he puffed up the smile on his lips, the light sank from his eyes? Mr. Williams may have exemplified some of the risk factors known to be associated with suicidal behavior. But maybe these were hidden in plain sight, or just plain hidden. The present volume represents current thought and research on suicidal ideation and behavior, bringing together some of the top thought leaders in the field. All authors have contributed with the hope that application of the methods and theory that is discussed within along with increased momentum in research will assist in understanding this human vulnerability, with the aim of reducing the numbers of tragic outcomes. Thomas J. Hudzik, Ph.D. Keri E. Cannon, Ph.D. v
5 Contents 1 Introduction... 1 Thomas J. Hudzik and Keri E. Cannon Part I Epidemiology and Predictive Tools 2 Epidemiology Denise M. Oleske 3 Treatment Emergent Suicidal Ideation and Behavior Sian L. Ratcliffe, Phillip B. Chappell, Janel Boyce-Rustay, Svetlana Gloukhova and Denise M. Oleske 4 From Uniform Definitions to Prediction of Risk: The Columbia Suicide Severity Rating Scale Approach to Suicide Risk Assessment Kelly Posner, Randy Subramany, Leora Amira and J. John Mann Part II Risk Factors 5 Stress and Vulnerability: A Developing Model for Suicidal Risk Jorge Lopez-Castroman, Emilie Olié and Philippe Courtet 6 Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD) as Risk Factors for Suicidal Thoughts and Behaviors Sarra Nazem, Eryn Lonnquist, Lindsey L. Monteith and Lisa A. Brenner vii
6 viii Contents 7 Genetic Risk Factors for Suicidal Behavior Marco Sarchiapone and Marianna D Aulerio 8 Is Suicide Clinically Preventable? What Is the Evidence? Jan Fawcett 9 Neurological Disease and Suicidal Behavior Thomas J. Hudzik and Gerard J. Marek 10 Suicide in the Second Half of Life: Cognition and Decision Processes Katalin Szanto 11 Early Life Trauma and Suicide Aaron T.O. Short and Charles B. Nemeroff Part III Treatment Approaches 12 Experimental Pharmacologic Approaches for the Reduction of Suicidal Ideation and Behavior Elizabeth D. Ballard, Erica M. Richards, Dawn F. Ionescu, Mark J. Niciu, Jennifer Vande Voort and Carlos A. Zarate Jr 13 Psychotherapeutic Treatment Approaches for Suicidal Individuals Megan S. Chesin, Sadia Chaudhury and Barbara Stanley 14 Cognitive Therapy with Suicidal Patients Michael E. Thase Part IV Clinical and Preclinical Neurobiology 15 Human Imaging Studies of Suicidal Behavior and its Risk Factors Kees van Heeringen, Stefanie Desmyter and Stijn Bijttebier 16 Using Awake Animal Imaging to Fingerprint Drugs for CNS Liability: Risk of Suicide? Craig F. Ferris
7 Contents ix 17 microrna Function and Dysregulation in Depression and Suicide Yogesh Dwivedi 18 Animal Models of Risk Factors for Suicidal Ideation and Behaviour Sarah A. Stuart, Paul Butler and Emma S.J. Robinson
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