Diagnosis of a granular cell tumour at the abdominal wall using fine needle aspiration cytology and histology: Case report
|
|
- Gladys Simon
- 6 years ago
- Views:
Transcription
1 Case Report Diagnosis of a granular cell tumour at the abdominal wall using fine needle aspiration cytology and histology: Case report Journal of International Medical Research 2015, Vol. 43(4) ! The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalspermissions.nav DOI: / imr.sagepub.com Lixia Wang 1, Fang Zhu 1, Hongqi Shi 1, Shanxian Lou 1 and Wei Shen 2 Abstract This case report describes the use of fine needle aspiration cytology to diagnose a granular cell tumour (GCT) that presented as a painless, palpable mass at the abdominal wall in a 50-year-old woman who had had the mass for 1 year prior to presentation. Routine haematoxylin and eosin staining of the cytological smears demonstrated that the specimen was predominantly cellular; it contained both cell clusters and single cells with abundant granular cytoplasm and indistinct cell borders. Cells were fragile and had fairly uniform naked nuclei that were scattered with vacuolated and prominent nucleoli. Background material on the smears included eosinophilic, granular cytoplasmic material and some adipose tissue. Neither mitoses nor necrosis were observed. A cytological diagnosis of a GCTwas confirmed by histological examination of a surgical specimen stained with haematoxylin and eosin. This case report found that the GCT had a characteristic cytological appearance and that cells with prominent nucleoli can be present in benign GCTs. Keywords Granular cell tumour, fine needle, cytology, nucleoli Date received: 27 January 2015; accepted: 24 March 2015 Introduction Granular cell tumour (GCT) is a rare tumour that typically originates from the head and neck region, especially the tongue. 1 3 The majority of GCTs are benign, but they are often misdiagnosed, based on clinical and cytological tests and examination of frozen sections. 4 6 There have been few reports on the cytopathological examination 1 Department of Pathology, Jinhua Central Hospital, Jinhua, Zhejiang Province, China 2 Department of Surgery, Jinhua Central Hospital, Jinhua, Zhejiang Province, China Corresponding author: Dr Wei Shen, Department of Surgery, Jinhua Central Hospital, 351 Mingyue Street, Jinhua, Zhejiang , China. zhuqshenw@hotmail.com Creative Commons CC-BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (
2 Wang et al. 593 of GCTs The present case report describes the cytological features of a GCT of the abdominal wall, which was diagnosed by fine needle aspiration cytology and confirmed by histology. Case report A 50-year-old woman presented to the Department of Surgery, Jinhua Central Hospital, Jinhua, Zhejiang Province, China, in October 2013 with a painless, palpable mass at the abdominal wall that had been present for 1 year. On physical examination, a firm, flat, well-defined subcutaneous mass measuring cm was detected at the umbilical left lower abdominal wall. The initial clinical diagnosis was suspected lymphnoditis or lipomyoma. Fine needle aspiration cytology of the lesion was performed by a cytologist (L.W.) immediately, using a 10-ml disposable syringe with a 21 G needle to aid in diagnosis. Cells from the mass were aspirated into the syringe and smeared onto a slide. The smear was immediately submerged in 95% alcohol for min, followed by routine haematoxylin and eosin (H&E) staining. Cytological examination revealed the presence of predominantly cellular material composed of both cell clusters and single cells, with abundant amounts of eosinophilic granular cytoplasm and indistinct borders (Figure 1A). There were also fairly uniform naked nuclei that were scattered with vacuolated and prominent nucleoli. The nuclei had regular smooth membranes, finely granular and evenly distributed chromatin (Figure 1B). The background consisted of eosinophilic granular cytoplasmic material along with some adipose tissue. Neither mitoses nor necrosis were observed. There were also some pink cells that had abundant eosinophilic granular cytoplasm that resembled a comet tail (Figure 1C) and abnormal nuclei. The clusters of cells had indistinct cell borders with nuclei located on top of their cytoplasm, thus resembling a fried egg. Surgery to remove the mass was performed the next day; routine histological examination was carried out 1 week later. During routine histological examination of the surgical specimen, polygonal cells with small round nuclei and abundant granular eosinophilic cytoplasm, as well as areas of vesicular nuclei with prominent nucleoli and local tumour infiltration, were observed. However, neither mitosis nor necrosis were observed (Figure 1D). Immunohistochemistry determined that the tumour cells expressed neuron-specific enolase (NSE), S100, cluster of differentiation 68 (CD68), and vimentin, but not epithelial membrane antigen (EMA) or smooth muscle actin (SMA). Overall, the diagnosis of a GCT at the abdominal wall that was made by cytology was further confirmed by histological examination of the surgical specimen. A panel of immunohistochemical markers were employed to eliminate other possible tumour types, such as: squamous cell carcinoma and basal cell carcinoma (which both expressed EMA but not vimentin); melanoma (which expressed S-100 but not CD68); epithelioid leiomyomas (which expressed SMA but not S100 or NSE); and a nerve-sheath tumour (which expressed S100 and vimentin but not NSE and CD68). The surgical specimen was also stained with periodic acid Schiff (in addition to H&E) and the cytoplasm was strongly positive. Written informed consent was obtained from the patient to allow publication of this case report. Ethical approval for the study was given by Jinhua Central Hospital. Discussion Granular cell tumour is a rare, usually benign neoplasm that can occur in almost any part of the body. 1,2 The features of a malignant GCT (MGCT) include spindle-cell morphology, necrosis, prominent nucleoli, an increased
3 594 Journal of International Medical Research 43(4) (a) (b) (c) (d) Figure 1. (a) Representative photomicrograph of a smear taken using fine needle aspiration of a firm, flat, well-defined subcutaneous mass, detected at the umbilical left lower abdominal wall of a 50-year-old woman. The smear shows cellular material consisting of both cell clusters and single cells with a fairly uniform scattering of naked nuclei (haematoxylin and eosin [H&E] staining). Scale bar 50 mm. (b) The nucleoli are vacuolated and prominent, the membranes are regular and smooth, and the chromatin appears as fine granules and is evenly distributed (H&E staining). Scale bar 50 mm. (c) Pink cells with abnormal nuclei and abundant eosinophilic granular cytoplasm, shaped as a comet tail (arrow) (H&E staining). Scale bar 50 mm. (d) Routine histological examination of the surgical specimen shows polygonal cells with small round nuclei and abundant granular eosinophilic cytoplasm. Tumour cells infiltrating adipose tissue are observed (arrows) (H&E staining). Scale bar 50 mm. The colour version of this figure is available at: nuclear-to-cytoplasmic ratio, nuclear pleomorphism and an increased rate of mitosis. 3 To be diagnosed as MGCT, at least three of the features listed above must be met. 3,5,12,13 If only one or two of the features are present, then the diagnosis is atypical GCT. 3,5,12 14 Other features of MGCT include a diameter >5cmandrapidgrowth. 5,13 Most reports published on the histological features of GCTs have been on lesions from the breast, respiratory tract or digestive tract. 1 3,5,6 Few reports have been on the diagnosis of GCTs by fine needle aspiration cytology. 4,5,7,9 11 One report described a case of GCT in the inguinal region that was misdiagnosed by cytology, 4 while another reported that GCT of the breast could be misdiagnosed as breast cancer when using fine needle aspiration cytology. 5 El Aouni et al. 6 described the cytological features of GCT of the breast and, along with similar studies, 7 11 noted
4 Wang et al. 595 that such features include highly cellular material with abundant eosinophilic granular cytoplasm and indistinct cell borders. In this present case study, the additional cytological features of fairly uniform naked nuclei, scattered with vacuolated and prominent nucleoli, were observed. This present case of GCT could have been misdiagnosed as a malignant tumour if this disease was unknown to the clinicians and/or the smear had not been carefully examined. In this present case, the GCT cells were fragile and easily broken, which resulted in naked or abnormal nuclei with a comet taillike trailing of the cytoplasm. The residual cytoplasm was abundant and had eosinophilic granules and indistinct borders. Also, there were clusters of cells with nuclei located on top of their cytoplasm that looked like fried eggs. The nuclei on the smear were larger than those on the tissue section due to degeneration, and were uniformly naked with scattered vacuolated and prominent nucleoli. This corresponded with areas of vesicular nuclei with prominent nucleoli seen on the tissue section. Features associated with malignancy were not apparent, including a lack of mitosis and necrosis. A report has described the cytological features of atypical GCT of the thyroid as including focal cells with a spindle cell morphology, an increased nuclear-to-cytoplasmic ratio and prominent nucleoli. 14 In this present case report, the only characteristic associated with malignancy was the presence of focal cells with prominent nucleoli, but they did not reach the atypical standard. Therefore, clinicians should be careful not to misdiagnose these types of cases. GCT has a characteristic cytological appearance of cells with prominent nucleoli, which may be present even in benign GCTs. Declaration of conflicting interest The authors declare that there are no conflicts of interest. Funding This work was financially supported by the National Science Foundation of China (no ), Project of Science Technology Department of Zhejiang Province (2014C33141) and Project of Science Technology Department of Jinhua City ( ). References 1. Ordo n ez NG. Granular cell tumor: a review and update. Adv Anat Pathol 1999; 6: Vered M, Carpenter WM and Buchner A. Granular cell tumor of the oral cavity: updated immunohistochemical profile. J Oral Pathol Med 2009; 38: Fanburg-Smith JC, Meis-Kindblom JM, Fante R, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998; 22: Rao S, Rajendiran S, Surendran P, et al. Granular cell tumor in inguinal region: a case of mistaken identity on cytology. J Cytol 2012; 29: Wang J, Zhu XZ and Zhang RY. Malignant granular cell tumor: a clinicopathologic analysis of 10 cases with review of literature. Zhonghua Bing Li Xue Za Zhi 2004; 33: ([in Chinese, English Abstract]. 6. El Aouni N, Laurent I, Terrier P, et al. Granular cell tumor of the breast. Diagn Cytopathol 2007; 35: Chang SM, Wei CK and Tseng CE. The cytology of a thyroid granular cell tumor. Endocr Pathol 2009; 20: Loncar B, Marjanovic K, Pauzar B, et al. Granular cell tumor clinically presented as lymphadenopathy. Coll Antropol 2010; 34: Devi K, Mohanty P, Mohanty L, et al. Cytodiagnosis of granular cell tumor: a case report. Indian J Pathol Microbiol 2007; 50: Chae SW, Sohn JH and Shin HS. Granular cell tumor of the parotid gland. A case report. Acta Cytol 2002; 46: Singh A, Sawhney M and Das S. Granular cell tumor of skin diagnosed on fine needle
5 596 Journal of International Medical Research 43(4) aspiration cytology. Indian J Dermatol 2012; 57: Uzoaru I, Firfer B, Ray V, et al. Malignant granular cell tumor. Arch Pathol Lab Med 1992; 116: Behzatog lu K and Bahadir B. Malignant granular cell tumor with unusual histological features. Pathol Int 2007; 57: Cimino-Mathews A, Illei PB and Ali SZ. Atypical granular cell tumor of the thyroid: cytomorphologic features on fine needle aspiration. Diagn Cytopathol 2011; 39:
International Journal of Pharma and Bio Sciences CHROMOPHOBE VARIANT OF RENAL CELL CARCINOMA MASQUARDING AS RENAL ONCOCYTOMA ON CYTOLOGY.
Case Report Pathology International Journal of Pharma and Bio Sciences ISSN 0975-6299 CHROMOPHOBE VARIANT OF RENAL CELL CARCINOMA MASQUARDING AS RENAL ONCOCYTOMA ON CYTOLOGY. DR.MAMATHA K*, DR. ARAKERI
More informationSalivary gland tumor cytologic and histologic correlation: Algorithmic and risk stratification based approaches
Salivary gland tumor cytologic and histologic correlation: Algorithmic and risk stratification based approaches Christopher C. Griffith, MD, PhD Raja R. Seethala, MD 1. Salivary gland tumor cytology: A
More informationCase Scenario 1: Thyroid
Case Scenario 1: Thyroid History and Physical Patient is an otherwise healthy 80 year old female with the complaint of a neck mass first noticed two weeks ago. The mass has increased in size and is palpable.
More informationNODULAR CYSTIC HIDRADENOMA OVER THE GLUTEAL REGION: A RARE CYTOMORPHOLOGICAL DIAGNOSIS
NODULAR CYSTIC HIDRADENOMA OVER THE GLUTEAL REGION: A RARE CYTOMORPHOLOGICAL DIAGNOSIS Abstract: The primary as well as metastatic tumours of the skin can be diagnosed by fine needle aspiration cytology
More informationOutline 11/2/2017. Pancreatic EUS-FNA general aspects. Cytomorphologic features of solid neoplasms/lesions of the pancreas
ENDOSCOPIC ULTRASOUND GUIDED-FINE NEEDLE ASPIRATION CYTOLOGY OF PANCREAS Khalid Amin M.D. Assistant Professor Department of Laboratory Medicine and Pathology University of Minnesota Outline Pancreatic
More informationFine-Needle Aspiration Cytology of Low-Grade Cribriform Cystadenocarcinoma with Many Psammoma Bodies of the Salivary Gland
The Korean Journal of Pathology 2013; 47: 481-485 CASE STUDY Fine-Needle Aspiration Cytology of Low-Grade Cribriform Cystadenocarcinoma with Many Psammoma Bodies of the Salivary Gland Ji Yun Jeong Dongbin
More informationDOI: /jemds/2014/1921 ORIGINAL ARTICLE
CYTODIAGNOSIS OF GASTROINTESTINAL STROMAL TUMOURS (GISTs) ON ROMANOWSKY STAINED SMEARS Priyanka Agrawal 1, Subhash Agrawal 2, Atul Gupta 3, Anurag Gupta 4 HOW TO CITE THIS ARTICLE: Priyanka Agrawal, Subhash
More informationFine Needle Aspiration Cytology of Gastric Glomus Tumor
The Korean Journal of Pathology 2010; 44: 448-52 DOI: 10.4132/KoreanJPathol.2010.44.4.448 Fine Needle Aspiration Cytology of Gastric Glomus Tumor - A Case Report - Dong Geun Lee Kyu Yun Jang Myoung Ja
More informationMammary analogue secretory carcinoma of salivary gland A case report of new entity
Case Report Mammary analogue secretory carcinoma of salivary gland A case report of new entity Vaibhav Bhika Bari 1*, Sandhya Unmesh Bholay 2 1 Assistant Professor, 2 Associate Professor Rajiv Gandhi Medical
More informationCase # year old man with a 2 cm right kidney mass
Case # 4. 52 year old man with a 2 cm right kidney mass Figure 1 Figure 2 Figure 3 Figure 4 Diagnosis: Negative/Non-diagnostic Normal kidney tissue Fine needle aspiration (FNA) of the kidney is performed
More informationThyroid Nodules: Understanding FNA Cytology (The Bethesda System for Reporting of Thyroid Cytopathology) Shamlal Mangray, MB, BS
Thyroid Nodules: Understanding FNA Cytology (The Bethesda System for Reporting of Thyroid Cytopathology) Shamlal Mangray, MB, BS Attending Pathologist Rhode Island Hospital, Providence, RI DISCLOSURE:
More informationSarcomatoid (spindle cell) carcinoma of the cricopharynx presenting as dysphagia
Case Report Sarcomatoid (spindle cell) carcinoma of the cricopharynx presenting as dysphagia Jagtap Sunil V. 1, Shukla Dhirajkumar B. 2, Jagtap Swati S. 3, Havle Abhay D. 4 1 Associate Professor, Department
More information59 yo male with past medical history of prostate carcinoma, presented with upper abdominal pain
December 2016 59 yo male with past medical history of prostate carcinoma, presented with upper abdominal pain Contributed by: Divya Sharma, MD. Fellow, Gastrointestinal Pathology, Department of Pathology
More informationCINtec p16 INK4a Staining Atlas
CINtec p16 INK4a Staining Atlas Rating Rating Positive The rating positive will be assigned if the p16 INK4a -stained slide shows a continuous staining of cells of the basal and parabasal cell layers of
More informationDiplomate of the American Board of Pathology in Anatomic and Clinical Pathology
A 33-year-old male with a left lower leg mass. Contributed by Shaoxiong Chen, MD, PhD Assistant Professor Indiana University School of Medicine/ IU Health Partners Department of Pathology and Laboratory
More informationAlmost any suspected tumor can be aspirated easily and safely. Some masses are more risky to aspirate including:
DOES THIS PATIENT HAVE CANCER? USING IN-HOUSE CYTOLOGY TO HELP YOU MAKE THIS DIAGNOSIS. Joyce Obradovich, DVM, Diplomate, ACVIM (Oncology) Animal Cancer & Imaging Center, Canton, Michigan Almost every
More informationPrognostic Utility of Grading in Cytological Smears of Breast Carcinoma
Prognostic Utility of Grading in Cytological Smears of Breast Carcinoma Vishal Parekar*, Dinesh US0 and Poornima VK SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India Research Article
More informationNormal Morphology. Anatomic Considerations. Normal Urothelial Histology and Cytology
1 Normal Morphology Anatomic Considerations The urinary tract can be divided into three regions: the kidney; the calyces, pelves and ureters (upper collecting system or upper tract); and the bladder and
More informationSalivary Glands 3/7/2017
Salivary Glands 3/7/2017 Goals and objectives Focus on the entities unique to H&N Common board type facts Information for your future practice Salivary Glands Salivary Glands Major gland. Paratid. Submandibular.
More informationBasal cell carcinoma diagnosed on Fine-Needle Aspiration Cytology A. Pathological Case Report
Basal cell carcinoma diagnosed on Fine-Needle Aspiration Cytology A Abstract Dr. Madhuri S.Kate 1, Dr. Preeti Jain 2, Dr. Shailesh S. Patne 3 Introduction: Basal cell carcinoma (BCC) is a locally invasive
More informationAscitic Fluid and Use of Immunocytochemistry. Mercè Jordà, University of Miami
Ascitic Fluid and Use of Immunocytochemistry Mercè Jordà, University of Miami Is It Malignant? Yes? No Ascitic Fluid Cytomorphologic Useful Findings Tight clusters with smooth borders Cellular and nuclear
More informationHistopathology: Cervical HPV and neoplasia
Histopathology: Cervical HPV and neoplasia These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you need to learn about
More informationDisclosures. Parathyroid Pathology. Objectives. The normal parathyroid 11/10/2012
Disclosures Parathyroid Pathology I have nothing to disclose Annemieke van Zante MD/PhD Assistant Professor of Clinical Pathology Associate Chief of Cytopathology Objectives 1. Review the pathologic features
More informationCase 1. Slide 1 History: 65 year old male presents with bilateral pleural effusions, a 40 pack year smoking history and peripheral and hilar lung
Case 1. Slide 1 History: 65 year old male presents with bilateral pleural effusions, a 40 pack year smoking history and peripheral and hilar lung masses. Specimen shown is from a tap of the pleural effusion.
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More information1 NORMAL HISTOLOGY AND METAPLASIAS
1 NORMAL HISTOLOGY AND METAPLASIAS, MD Anatomy and Histology 1 Metaplasias 2 ANATOMY AND HISTOLOGY The female breast is composed of a branching duct system, which begins at the nipple with the major lactiferous
More informationROBINSON CYTOLOGICAL GRADING OF BREAST CARCINOMA ON FINE NEEDLE ASPIRATION CYTOLOGY- AN OVERVIEW
Page564 Research Article Biological Sciences ROBINSON CYTOLOGICAL GRADING OF BREAST CARCINOMA ON FINE NEEDLE ASPIRATION CYTOLOGY- AN OVERVIEW Charusheela Rajesh Gore, Chandanwale Shirish S, Ruchika Aggarwal,
More informationCase: The patient is a 24 year- old female who was found to have multiple mural nodules within the antrum. Solid and cystic components were noted on
Case: The patient is a 24 year- old female who was found to have multiple mural nodules within the antrum. Solid and cystic components were noted on imaging. There is no significant past medical history.
More informationRespiratory Tract Cytology
Respiratory Tract Cytology 40 th European Congress of Cytology Liverpool, UK Momin T. Siddiqui M.D. Professor of Pathology and Laboratory Medicine Director of Cytopathology Emory University Hospital, Atlanta,
More informationDIAGNOSTIC DILEMMA. Case Reports Clinical history. Materials and Methods
DIAGNOSTIC DILEMMA A Metastatic Renal Carcinoid Tumor Presenting as Breast Mass: A Diagnostic Dilemma Farnaz Hasteh, M.D., 1 Robert Pu, M.D., Ph.D., 2 and Claire W. Michael, M.D. 2 * We present clinicopathological
More informationDepartments of Pathology and *Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur
Malaysian J Pathol 2002; 24(2) : 107-112 CASE REPORT Papillary cystic type of acinic cell carcinoma of parotid: fine needle aspiration cytological features of a high grade variant with oncocytic metaplasia
More informationnumber Done by Corrected by Doctor Maha Shomaf
number 16 Done by Waseem Abo-Obeida Corrected by Zeina Assaf Doctor Maha Shomaf MALIGNANT NEOPLASMS The four fundamental features by which benign and malignant tumors can be distinguished are: 1- differentiation
More informationPancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA
Pancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA Jack Yang, MD Department of Pathology, Medical University of South Carolina Objectives Understand the indication of EUS
More informationPredictors of Malignancy in Thyroid Fine-Needle Aspirates Cyst Fluid Only Cases
Predictors of Malignancy in Thyroid Fine-Needle Aspirates Cyst Fluid Only Cases Can Potential Clues of Malignancy Be Identified? Mohammad Jaragh, MD 1 ; V. Bessie Carydis, MMedSci (Cytol) 1 ; Christina
More informationMedullary Thyroid Carcinoma. This case was provided by Treant Hospital, Bethesda, Hoogeveen, The Netherlands
Medullary Thyroid Carcinoma This case was provided by Treant Hospital, Bethesda, Hoogeveen, The Netherlands ADS-01504 Rev. 001 2016 Hologic, Inc. All rights reserved. Overview Medullary Thyroid Carcinoma
More informationA case of pedunculated intraperitoneal leiomyoma
Jichi Medical University Journal Chio Shuto Kuniyasu Soda Takayoshi Yoshida Fumio Konishi Abstract We report a very rare case of a pedunculated intraperitoneal leiomyoma in the parietal peritoneum of the
More informationProceeding of the SEVC Southern European Veterinary Conference
www.ivis.org Proceeding of the SEVC Southern European Veterinary Conference Oct. 17-19, 2008 Barcelona, Spain http://www.sevc.info Reprinted in the IVIS website with the permission of the SEVC www.ivis.org
More informationDesmoplastic Melanoma R/O BCC. Clinical Information. 74 y.o. man with lesion on left side of neck r/o BCC
R/O BCC Sabine Kohler, M.D. Professor of Pathology and Dermatology Dermatopathology Service Stanford University School of Medicine Clinical Information 74 y.o. man with lesion on left side of neck r/o
More informationFine Needle Aspiration Cytology Of The Thyroid Following Carbimazole Therapy In Graves' Disease: A Case Report
ISPUB.COM The Internet Journal of Endocrinology Volume 4 Number 2 Fine Needle Aspiration Cytology Of The Thyroid Following Carbimazole Therapy In Graves' Disease: A N Siddaraju, C Wilfred, N Singh, P Murugan,
More informationأملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5
Leiomyosarcoma 1 / 5 EPIDEMIOLOGY Exact incidence is unknown, but older studies suggest that leiomyosarcomas comprise approximately 3 percent of soft-tissue sarcomas. Superficial leiomyosarcoma occurs
More informationScoring system of fine needle aspiration cytology samples for the detection of non high grade ductal breast carcinoma
Oncocytology ;:. ORIGINAL ARTICLE OPEN ACCESS Scoring system of fine needle aspiration cytology samples for the detection of non high grade ductal breast carcinoma Ayumi Ryu, Akemi Takenaka, Shigenori
More informationClassification (1) Classification (3) Classification (2) Spindle cell lesions. Spindle cell lesions of bladder (Mills et al.
Non-epithelial tumours and nonepithelial tumour-like lesions of the bladder Dr Jonathan H Shanks The Christie NHS Foundation Trust, Manchester, UK Classification (1) Myofibroblastic proliferations and
More informationDivision of Pathology
Case 38 Adult woman with a 35mm right breast lump at the 10 o clock position. Excision performed. (Case contributed by Dr Mihir Gudi, KKH) Division of Pathology Merlion, One Fullerton Singapore Diagnosis
More informationPrepared By Jocelyn Palao and Layla Faqih
Prepared By Jocelyn Palao and Layla Faqih The structure of the suspected atypical cell should always be compared to the structure of other similar, benign, cells which are present in the smears. The diagnosis
More informationA 25 year old female with a palpable mass in the right lower quadrant of her abdomen
May 2016 A 25 year old female with a palpable mass in the right lower quadrant of her abdomen Contributed by: Paul Ndekwe, MD, Resident Physician, Indiana University School of Department of Pathology and
More informationA 53 year-old woman with a lung mass, right hilar mass and mediastinal adenopathy.
November 2015 Case of the Month A 53 year-old woman with a lung mass, right hilar mass and mediastinal adenopathy. Contributed by: Rasha Salama, M.D., IU Department of Pathology and Laboratory Medicine
More informationGynecologic Cytopathology: Glandular lesions
Gynecologic Cytopathology: Glandular lesions Lin Wai Fung (MSc, MPH, CMIAC) 17/4/2014 Glandular lesions of the uterus Endocervix Endometrium Normal endocervical cells Sheets, strips well-preserved architecture:
More informationPleomorphic adenoma of breast - a case report and distinction with metaplastic carcinoma D Gupta, S Agrawal, N Trivedi, A Tewari
of breast - a case report and distinction with metaplastic carcinoma D Gupta, S Agrawal, N Trivedi, A Tewari Introduction, also known as mixed tumour, is a benign tumour which typically presents as a painless,
More informationCytology for the Endocrinologist. Nicole Massoll M.D
Cytology for the Endocrinologist Nicole Massoll M.D Objectives Discuss slide preperation Definitions of adequacy ROSE (Rapid On-Site Evaluation) Thyroid Cytology Adequacy Nicole Massoll M.D. University
More informationCase Report. Cytological Diagnosis of Undifferentiated Carcinoma of The Pancreas with Osteoclast-like Giant Cells: Report of Three Cases
Case Report Cytological Diagnosis of Undifferentiated Carcinoma of The Pancreas with Osteoclast-like Giant Cells: Report of Three Cases Swapan Samanta* 1, S. K. Sharma 2 1 Department of Pathology, EKO
More informationThyroid master class. Thyroid Fine needle aspiration cytology and liquid-based techniques: Hologic and Becton Dickinson
Thyroid master class Thyroid Fine needle aspiration cytology and liquid-based techniques: Hologic and Becton Dickinson Principle of LBC Collection of cells in liquid medium Immediate fixation Processor-prepared
More informationDr. Issraa Ali Hussein
CLINICAL 09888888;rCYTOLOGY Dr. Issraa Ali Hussein objectives Define diagnostic cytology (clinical cytology). Explain the differences between histopathology and cytopathology. Recognize the methods for
More informationSynchronous squamous cell carcinoma of the breast. and invasive lobular carcinoma
Sentani K et al. 1 Letter to the editor Synchronous squamous cell carcinoma of the breast and invasive lobular carcinoma Kazuhiro Sentani, 1 Takashi Tashiro, 2 Naohide Oue, 1 Wataru Yasui 1 1 Department
More informationFNA of Thyroid. Toward a Uniform Terminology With Management Guidelines. NCI NCI Thyroid FNA State of the Science Conference
FNA of Thyroid NCI NCI Thyroid FNA State of the Science Conference Toward a Uniform Terminology With Management Guidelines Thyroid Thyroid FNA Cytomorphology NCI Thyroid FNA State of the Science Conference
More informationISPUB.COM. A Kochhar, G Duggal, K Singh, S Kochhar INTRODUCTION MATERIAL AND METHOD
ISPUB.COM The Internet Journal of Pathology Volume 13 Number 2 Spectrum Of Cytological Findings In Patients With Lymphadenopathy In Rural Population Of Southern A Kochhar, G Duggal, K Singh, S Kochhar
More informationRole of fine needle aspiration cytology and cytohistopathological co-relation in thyroid lesions: experience at a tertiary care centre of North India
International Journal of Research in Medical Sciences Chandra S et al. Int J Res Med Sci. 2016 Oct;4(10):4552-4556 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20163328
More informationHEAD AND NECK PATHOLOGY
Bosnian-British School of Pathology November 2012 HEAD AND NECK PATHOLOGY Slide seminar: Oral Pathology Preferred Diagnoses Dr A Sandison, Slide seminar: Pathology of the Oral Cavity Page 1 of 5 1. Female
More informationThe Korean Journal of Cytopathology 15(1) : 60-64, 2004
15 1 The Korean Journal of Cytopathology 15(1) : 60-64, 2004 : INTRODUCTION Papillary carcinoma of the thyroid gland has for long been traditionally diagnosed on the basis of the characteristic papillary
More informationPancreatic malignant tumors are the fifth leading cause of cancerrelated
44 CANCER CYTOPATHOLOGY Cytologic Criteria for Well Differentiated Adenocarcinoma of the Pancreas in Fine-Needle Aspiration Biopsy Specimens Fan Lin, M.D., Ph.D. 1 Gregg Staerkel, M.D. 2 1 Department of
More informationUncommon pattern in soft tissues epithelioid sarcoma
Romanian Journal of Morphology and Embryology 2005, 46(3):229 233 Uncommon pattern in soft tissues epithelioid sarcoma CARMEN ARDELEANU 1, 2), MARIA COMĂNESCU 3), VIOLETA COMĂNESCU 4), F. ANDREI 1) 1)
More informationA pitfall in the cytodiagnosis of sputum of asthmatics
J. clin. Path. (1964), 17, 84 A pitfall in the cytodiagnosis of sputum of asthmatics BERNARD NAYLOR AND CONSTANTINE RAILEY' From the Department ofpathology, the University of Michigan, Ann Arbor, Michigan,
More informationThyroid follicular neoplasms in cytology. Ulrika Klopčič Institute of Oncology, Department of Cytopathology, Ljubljana, Slovenia
Thyroid follicular neoplasms in cytology Ulrika Klopčič Institute of Oncology, Department of Cytopathology, Ljubljana, Slovenia Lecture overview importance of FNAB in assessing thyroid lesions follicular
More informationGastrointestinal Stromal Tumours - Report of Three Cases and Review of Literature
jc6906 7joc207-3rd proof Case Report Gastrointestinal Stromal Tumours - Report of Three Cases and Review of Literature Deshpande A *, Munshi MM ** Abstract Three cases of GIST were diagnosed on guided
More informationCN 925/15 History. Microscopic Findings
CN 925/15 History 78 year old female. FNA indeterminate lesion right thyroid lobe. Previous THY1C (UK) Bethesda category 1 cyst fluid. Ultrasound showed part solid/cystic changes, indeterminate in nature
More information3/24/2017 DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS. Disclosure of Relevant Financial Relationships
DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS Jason L. Hornick, M.D., Ph.D. Director of Surgical Pathology and Immunohistochemistry Brigham and Women s Hospital Professor
More informationCytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics. Mercè Jordà, University of Miami
Cytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics Mercè Jordà, University of Miami Mortality Lung cancer is the most frequent cause of cancer incidence and mortality
More informationUltrasound Guided Fine Needle Aspiration Biopsy of Retroperitoneal Masses
Ultrasound Guided Fine Needle Aspiration Biopsy of Retroperitoneal Masses Ahmad SS *, Akhtar K +, Akhtar SS +, Nasir A #, Khalid M **, Mansoor T ++ Abstract The study was undertaken to evaluate the reliability
More information21/07/2017. Hobnail endothelial cells are not the same as epithelioid endothelial cells
UPDATE IN CUTANEOUS VASCULAR S DERMATOPATHOLOGY SESSION BELFAST PATHOLOGY JUNE 21/2017 Dr E Calonje St John s Institute of Dermatology, London, United Kingdom THE FAMILY OF VASCULAR S WITH EPITHELIOID
More informationCase Presentation. Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD. Department of Pathology Jordan University Hospital Amman, Jordan
Case Presentation Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD Department of Pathology Jordan University Hospital Amman, Jordan The 25th Annual Congress of the ADIAP The 8/11/2013 1 5th International
More informationOncocytic carcinoma: A rare malignancy of the parotid gland
ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Oncocytic carcinoma: A rare malignancy of the parotid gland K Mardi, J Sharma Citation K Mardi, J Sharma.. The Internet Journal of Pathology.
More informationMaligna Melanoma and Atypical Fibroxanthoma: An Unusual Collision Tumour G Türkcü 1, A Keleş 1, U Alabalık 1, D Uçmak 2, H Büyükbayram 1 ABSTRACT
Maligna Melanoma and Atypical Fibroxanthoma: An Unusual Collision Tumour G Türkcü 1, A Keleş 1, U Alabalık 1, D Uçmak 2, H Büyükbayram 1 ABSTRACT Two different neoplasia in the same biopsy material called
More informationCellular Neurothekeoma
Cellular Neurothekeoma Scott W Binder, MD Pritzker Professor of Pathology & Dermatology Sr. Vice Chair Director, Pathology Clinical Services Chief, Dermatopathology Geffen/UCLA School of Medicine Clinical
More informationPleomorphic Adenoma: Cytologic Variations and Potential Diagnostic Pitfalls
Pleomorphic Adenoma: Cytologic Variations and Potential Diagnostic Pitfalls Uma Handa, M.D., Neerja Dhingra, M.D., D.N.B.,* Rajan Chopra, M.D., and Harsh Mohan, M.D., M.N.A.M.S., F.I.C.P. The diverse morphological
More informationLGM International, Inc.
Liqui-PREP TM Cytology Atlas Preface The following pictures are examples with descriptions of cytology slides processed with the Liqui-PREP TM System.. The descriptions are reviewed by Pathologists. It
More informationCASE REPORT Benign epithelioid peripheral nerve sheath tumour resembling schwannoma
Malaysian J Pathol 2014; 36(3) : 217 221 CASE REPORT Benign epithelioid peripheral nerve sheath tumour resembling schwannoma Thejasvi KRISHNAMURTHY MD and SR NIVEDITHA MD, DNB Department of Pathology,
More informationDifferentiation of Renal Tubular Epithelium in Renal Transplantation Cytology
Differentiation of Renal Tubular Epithelium in Renal Transplantation Cytology G. BERRY SCHUMANN, M.D., LAWRENCE J. PALMIERI, B.S., C.T.(ASCP), AND DAVID B. JONES, M.D. Schumann, G. Berry, Palmieri, Lawrence
More informationValue of antimesothelioma HBME 1 in the diagnosis of inflammatory and malignant pleural effusions
Romanian Journal of Morphology and Embryology 2006, 47(4):351 355 ORIGINAL PAPER Value of antimesothelioma HBME 1 in the diagnosis of inflammatory and malignant pleural effusions LILIANA MOCANU 1), ANCA
More informationPotential Pitfalls for False Suspicion of Papillary Thyroid Carcinoma:
SUPPLEMENT 1 SPECIAL ISSUE: CYTOPATHOLOGY OF THE THYROID GLAND Guest Editor: Zubair Baloch Potential Pitfalls for False Suspicion of Papillary Thyroid Carcinoma: A Cytohistologic Review of 22 Cases Xin
More informationFine Needle Aspiration of an Unusual Malignant Mixed Tumor in the Parotid Gland
Fine Needle Aspiration of an Unusual Malignant Mixed Tumor in the Parotid Gland Xiu Yang, MD, PhD, 1 * Adam Cole, MD, 1 Maja Oktay, MD, PhD, 1 Richard Smith, MD, 2 Antonio Cajigas, MD, 1 Samer Khader,
More informationDiagnostic problems in uterine smooth muscle tumors
Diagnostic problems in uterine smooth muscle tumors Marina Kos Ljudevit Jurak Clinical Department of Pathology, Clinical Hospital Center Sestre milosrdnice, Zagreb Institute of Pathology, University of
More informationMetastatic balloon cell malignant melanoma: a case report and literature review
Int J Clin Exp Pathol 2011;4(1):315-321 www.ijcep.com /IJCEP1102002 Metastatic balloon cell malignant melanoma: a case report and literature review Lili Lee 1*, Fang Zhou 1*, Anthony Simms 1, Rosemary
More informationCase 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset
Case 2 Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset History 24 year old male presented with a 3 day history of right flank pain, sharp in nature Denies fever, chills, hematuria or
More informationDiagnostic accuracy of percutaneous renal tumor biopsy May 10 th 2018
Diagnostic accuracy of percutaneous renal tumor biopsy May 10 th 2018 Dr. Tzahi Neuman Dep.Of Pathology Hadassah Medical Center Jerusalem, Israel, (tneuman@hadassah.org.il) Disclosure: 1 no conflicts of
More informationMody. AIS vs. Invasive Adenocarcinoma of the Cervix
Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive
More informationCase 27 Male 42. Painless, static, well-circumscribed, subcutaneous nodule right lower leg,?lipoma. The best diagnosis is:
Case 27 Male 42. Painless, static, well-circumscribed, subcutaneous nodule right lower leg,?lipoma. The best diagnosis is: A. Angiosarcoma B. Haemangiopericytoma C.Myopericytoma D.Myofibroma E. Angioleiomyoma
More informationCase Report Glomus tumor of uncertain malignant potential of the lung: a case report and review of literature
Int J Clin Exp Pathol 2015;8(11):15402-15406 www.ijcep.com /ISSN:1936-2625/IJCEP0015761 Case Report Glomus tumor of uncertain malignant potential of the lung: a case report and review of literature Peng-Zhi
More informationDifferentiation of Hepatocellular Carcinoma from Metastatic Carcinoma of the Liver - Clinical and Cytological Features
Original Article Differentiation of Hepatocellular Carcinoma from Metastatic Carcinoma of the Liver - Clinical and Cytological Features Ahuja A *, Gupta N +, Srinivasan R #, Kalra N **, Chawla Y ++, Rajwanshi
More informationLUNG CANCER PATHOLOGY: UPDATE ON NEUROENDOCRINE LUNG TUMORS
LUNG CANCER PATHOLOGY: UPDATE ON NEUROENDOCRINE LUNG TUMORS William D. Travis, M.D. Attending Thoracic Pathologist Memorial Sloan Kettering Cancer Center New York, NY PULMONARY NE TUMORS CLASSIFICATION
More informationRole of FNAC in Evaluation of Neck Masses
Original Article Elmer Press Role of FNAC in Evaluation of Neck Masses Mohd Hazmi Mohamed a, c, Shahrul Hitam b, Sushil Brito-Mutunayagam b, Mohd Razif Mohamad Yunus a Abstract Background: Despite fine
More informationDIAGNOSIS AND REPORTING OF FOLLICULAR-PATTERNED THYROID LESIONS BY FINE NEEDLE ASPIRATION
Follicular-patterned thyroid lesions, WC Faquin 1 DIAGNOSIS AND REPORTING OF FOLLICULAR-PATTERNED THYROID LESIONS BY FINE NEEDLE ASPIRATION William C. Faquin, M.D., Ph.D Department of Pathology, Massachusetts
More informationCase Report A case of matrix-producing carcinoma of the breast with micoglandular adenosis and review of literature
Int J Clin Exp Pathol 2015;8(7):8568-8572 www.ijcep.com /ISSN:1936-2625/IJCEP0010093 Case Report A case of matrix-producing carcinoma of the breast with micoglandular adenosis and review of literature
More informationFine Needle Aspiration Biopsy of a Myxoid Leiomyosarcoma with Epithelioid Features and It Metastasized to the Abdominal Wall - A Case Report -
The Korean Journal of Pathology 2010; 44: 220-4 DOI: 10.4132/KoreanJPathol.2010.44.2.220 Fine Needle Aspiration Biopsy of a Myxoid Leiomyosarcoma with Epithelioid Features and It Metastasized to the Abdominal
More informationOriginal Article Primary malignant mixed tumor of bone: a case report
Int J Clin Exp Pathol 2015;8(7):8433-8437 www.ijcep.com /ISSN:1936-2625/IJCEP0007490 Original Article Primary malignant mixed tumor of bone: a case report Zhansan Su 1, Zhi Li 1, Baoan Liu 2 1 Department
More informationNeuroendocrine Lung Tumors Myers
Diagnosis and Classification of Neuroendocrine Lung Tumors Jeffrey L. Myers, M.D. A. James French Professor Director, Anatomic Pathology & MLabs University of Michigan, Ann Arbor, MI myerjeff@umich.edu
More informationCase Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor
Case Reports in Medicine Volume 2015, Article ID 742920, 4 pages http://dx.doi.org/10.1155/2015/742920 Case Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor Omer Alici,
More informationSpecial slide seminar
Special slide seminar Tomáš Rozkoš The Fingerland Department of Pathology Charles University Medical Faculty and Faculty Hospital in Hradec Králové Czech Republic Case history, 33 years old resistance
More informationOncocytic-Appearing Salivary Gland Tumors. Oncocytic, Cystic, Mucinous, and High Grade Salivary Gland Tumors SALIVARY GLAND FNA: PART II
William C. Faquin, MD, PhD Professor of Pathology Harvard Medical School Director of Head and Neck Pathology Massachusetts Eye and Ear Massachusetts General Hospital SALIVARY GLAND FNA: PART II Oncocytic,
More informationNormal endometrium: A, proliferative. B, secretory.
Normal endometrium: A, proliferative. B, secretory. Nội mạc tử cung Nội mạc tử cung Cyclic changes in endometrium.. Approximate relationship of useful microscopic changes. Arias-Stella reaction in endometrial
More informationHistopathology: skin pathology
Histopathology: skin pathology These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual information
More informationBen Witt, MD University of Utah/ARUP Laboratories Assistant Professor of Anatomic Pathology
Ben Witt, MD University of Utah/ARUP Laboratories Assistant Professor of Anatomic Pathology Review some of the more common cytodiagnoses of the Head and Neck Establish an approach to some of the diagnostic
More information