Neuroendocrine Lung Tumors Myers
|
|
- Austen Oliver
- 5 years ago
- Views:
Transcription
1 Diagnosis and Classification of Neuroendocrine Lung Tumors Jeffrey L. Myers, M.D. A. James French Professor Director, Anatomic Pathology & MLabs University of Michigan, Ann Arbor, MI Lost In Processing Neuroendocrine Lung Neoplasms As a result of this presentation, attendees who were fully engaged will be able to, apply criteria for separating low grade from high grade neuroendocrine tumors, and articulate the clinical, biological, histologic, immunohistochemical, and molecular overlap between them. Neuroendocrine Lung Neoplasms Classification WHO* Typical carcinoid Atypical carcinoid Small cell carcinoma Large cell neuroendocrine carcinoma Other Well differentiated/ low grade Moderately differentiated/ intermediate grade Poorly differentiated/ high grade Neuroendocrine carcinoma *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon 2004.
2 Neuroendocrine Lung Neoplasms Classification WHO* Typical carcinoid Atypical carcinoid Small cell carcinoma Large cell neuroendocrine carcinoma Other Well differentiated/ low grade Moderately differentiated/ intermediate grade Poorly differentiated/ high grade Neuroendocrine carcinoma *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon TYPICAL CARCINOID TUMOR ~ 75% central ~ 25% peripheral TYPICAL CARCINOID TUMOR Definition* neuroendocrine growth pattern organoid, trabecular, insular, palisading, ribbon, rosette-like *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon 2004.
3 organoid, trabecular, insular, palisading, ribbon, rosette-like organoid, trabecular, insular, palisading, ribbon, rosette-like organoid, trabecular, insular, palisading, ribbon, rosette-like
4 uniform cytology ± atypia TYPICAL CARCINOID TUMOR Definition* neuroendocrine growth pattern uniform cytology ± atypia < 2 mits/2 mm 2 no necrosis *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon Neuroendocrine Lung Neoplasms Classification WHO* Typical carcinoid Atypical carcinoid Small cell carcinoma Large cell neuroendocrine carcinoma Other Well differentiated/ low grade Moderately differentiated/ intermediate grade Poorly differentiated/ high grade Neuroendocrine carcinoma *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon 2004.
5 ATYPICAL CARCINOID TUMOR Definition* neuroendocrine growth pattern uniform cytology ± atypia 2-10 mits/2 mm 2, and/or necrosis *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon TYPICAL VS. ATYPICAL CARCINOID TUMOR Ha et al. Lung Cancer 2013; 80: 146 Histology Typical (40) Atypical (23) p value rosettes 0 6 (26%).001 parenchymal invasion* 5 (13%) 9 (39%).01 vascular invasion 0 3 (13%).04 lymphatic invasion 2 (5%) 6 (26%).04 abundant basophilic cytoplasm 10 (25%) 0.01 * invasion to the adjacent lung parenchyma with an infiltrative border
6 TYPICAL VS. ATYPICAL CARCINOID TUMOR Ha et al. Lung Cancer 2013; 80: 146 invasion to the adjacent lung parenchyma with an infiltrative border moderate marked * ATYPICAL CARCINOID TUMOR Comparison with Typical Carcinoid from Garcia-Yuste et al. Eur J CV Surg 2007 (n = 661 surgical patients) Survival 5 years 10 years typical carcinoid 89-99% 82-93% atypical carcinoid 61-78% 35-67% ATYPICAL CARCINOID TUMOR Definition* 97 (91.5%) of 106 cases had neuroendocrine 2 mits/2 mm 2 growth pattern Beasley et al Hum Pathol 2000; 31: 1255 uniform cytology ± atypia 2-10 mits/2 mm 2 *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon 2004.
7 TYPICAL VS. ATYPICAL CARCINOID TUMOR Ha et al. Lung Cancer 2013; 80: 146 Mitoses ATYPICAL CARCINOID TUMOR Definition* 71 (67%) of 106 cases had neuroendocrine necrosis growth pattern Beasley et al Hum Pathol 2000; 31: 1255 uniform cytology ± atypia 2-10 mits/2 mm 2 ± necrosis *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon Neuroendocrine Lung Neoplasms Classification WHO* Typical carcinoid Atypical carcinoid Small cell carcinoma Large cell neuroendocrine carcinoma Other Well differentiated/ low grade Moderately differentiated/ intermediate grade Poorly differentiated/ high grade Neuroendocrine carcinoma *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon 2004.
8 SMALL CELL CARCINOMA General cigarette smoking ~ 15% of incident cases men women (~1-2:1) central >> peripheral SMALL CELL CARCINOMA General clinical stage (n=7,960 ) I 7% II 4% III 32% IV 57% clinical stage (n=4,532 ) limited 45% extensive 55% from Shepherd et al. J Thorac Oncol 2007 SMALL CELL CARCINOMA General clinical stage (n=4,532 ) limited 45% extensive 55% from Shepherd et al. J Thorac Oncol 2007 Survival (n = 7,960 ) cstage % of pts 1 year 5 years I 7% 41% 28% II 4% 73% 21% III 32% 54% 11% IV 57% 22% 1%
9 SMALL CELL CARCINOMA WHO Definition malignant epithelial tumor consisting of, small cells with scant cytoplasm, ill-defined cell borders usually less than the size of three small resting lymphocytes WHO size rule 3 x lymphocyte diameter SMALL CELL CARCINOMA WHO Definition small cells with scant cytoplasm, illdefined cell borders
10 SMALL CELL CARCINOMA WHO Definition small cells with scant cytoplasm, illdefined cell borders finely granular nuclear chromatin, and absent or inconspicuous nucleoli finely granular chromatin absent/inconspicuous nucleoli In 29 cases, a varying percentage of cells demonstrated nucleoli that were conspicuous but small. Nicholson et al. AJSP 2002
11 SMALL CELL CARCINOMA WHO Definition small cells with scant cytoplasm, illdefined cell borders finely granular nuclear chromatin, and absent or inconspicuous nucleoli cells are round, oval and spindleshaped; nuclear molding is prominent round, oval and spindle-shaped nuclear molding is prominent
12 nuclear spooning is prominent spooning high mitotic count (>10/2 mm 2 )
13 Regional Pathologists SMALL CELL CARCINOMA WHO Definition small cells with scant cytoplasm, illdefined cell borders finely granular nuclear chromatin, and absent or inconspicuous nucleoli cells are round, oval and spindleshaped; nuclear molding is prominent mitotic count is high (>10/2 mm 2 ) CLASSIFICATION OF LUNG TUMORS Rates of Diagnostic Agreement SqCC Adca LCC SCLC SCLC SqCC Adca LCC Mixed Other 0% 25% 50% 75% 100% Central Pathologist N = 668 (tissue ± cytology specimens) SCLC highest rates of agreement (92%, Κ = 0.82) Stang et al. Lung Cancer 2006; 52: WHO IASLC WHO (1981) (1988) ( ) oat cell small cell small cell intermediate cell SMALL CELL CARCINOMA Histologic Variants mixed small/large cell combined combined combined small cell small cell small cell
14 small cell & adenocarcinoma Neuroendocrine Lung Neoplasms Classification WHO* Typical carcinoid Atypical carcinoid Small cell carcinoma Large cell neuroendocrine carcinoma Other Well differentiated/ low grade Moderately differentiated/ intermediate grade Poorly differentiated/ high grade Neuroendocrine carcinoma *Travis et al (editors). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon LARGE CELL CARCINOMA WHO 2004 poorly differentiated NSCLC that lacks cytologic and architectural features of SCLC and glandular or squamous differentiation
15 LARGE CELL CARCINOMA WHO 2004 poorly differentiated NSCLC that lacks cytologic and architectural features of SCLC and glandular or squamous differentiation 5 variants: large cell neuroendocrine basaloid carcinoma lymphoepithelioma-like carcinoma clear cell carcinoma large cell ca with rhabdoid phenotype LARGE CELL NEUROENDOCRINE CARCINOMA Definition neuroendocrine morphology
16 LARGE CELL NEUROENDOCRINE CARCINOMA Definition neuroendocrine morphology necrosis (extensive) >10 mitosis/2 mm 2 (10 hpf) cytologic features of NSCLC: large size, low N:C, nucleoli, coarse chromatin
17 LARGE CELL NEUROENDOCRINE CARCINOMA Definition neuroendocrine morphology necrosis (extensive) >10 mitosis/2 mm 2 (10 hpf) cytologic features of NSCLC: large size, low N:C, nucleoli, coarse chromatin immunohistochemical confirmation chromogranin LARGE CELL NEUROENDOCRINE CARCINOMA Comparison with Atypical Carcinoid Asamura et al. J Clin Oncol 2006; 24: 70-6 atypical carcinoid LCNEC NE morphology necrosis ± atypia mitotic rate 2-10/2 mm 2 >10/2 mm 2
18 LARGE CELL NEUROENDOCRINE CARCINOMA Comparison with Atypical Carcinoid atypical carcinoid LCNEC 10 mits/2 mm 2 LARGE CELL NEUROENDOCRINE CARCINOMA Comparison with Small Cell Carcinoma small cell ca LCNEC 3 x lymphocytes, nucleoli, cytoplasm Hypothesis: LCNEC & SCLC are different They look (and stain) differently. They behave differently. They are genetically distinct.
19 Large Cell Neuroendocrine Carcinoma Definition neuroendocrine morphology necrosis (extensive) >10 mitosis/2 mm 2 (10 hpf) cytologic features of NSCLC: large size, low N:C, nucleoli, coarse chromatin LCNEC vs immunohistochemical confirmation SCLC Large Cell Neuroendocrine Carcinoma Definition Is cell size a reliable criterion for separating large cell neuroendocrine carcinoma from small cell carcinoma? Marchevsky et al. Am J Clin Pathol 2001; 116: 466. SCLC vs LCNEC Nuclear Size Overlap n = 12 LCNEC and 16 SCLC measured tumor cell (TC) and lymphocyte (L) nuclear areas histograms for each peak TC/L: A = 2 B = 3 C = 4 D = 5 E = 6 F no peak e.g. type A (peak TC/L = 2)
20 small SCLC vs LCNEC Nuclear Size Overlap 5 (31%) of 16 SCLC had predominant population SCLC of cells 4-6 times larger LCNEC than lymphocytes * * * large 0 TC/L = 2 (Type A) TC/L = 3 (Type B) TC/L = 4 (Type C) TC/L = 5 (Type D) TC/L = 6 (Type E) no peak (Type F) Marchevsky et al. Am J Clin Pathol 2001; 116: 466. SCLC vs LCNEC Role of Immunohistochemistry 100% 50% c-kit pos bcl-2 pos c-kit/bcl-2 pos c-kit/bcl-2 expression in SCLC & LCNEC 0% typical carcinoid (16) atypical carcinoid (6) small cell ca (7) LCNEC (14) LaPoint et al. Appl IHC Mol Morphol 2007; 15: SCLC vs LCNEC Role of Immunohistochemistry 90% 60% 30% Diffuse (> 10%) 2-3+ intensity PAX-5 expression in SCLC & LCNEC 0% typical carcinoid (44) atypical carcinoid (7) small cell ca (26) LCNEC (3) Sica et al. Am J Clin Pathol 2008; 129:
21 SCLC vs LCNEC Role of Immunohistochemistry 100% POSITIVE EQUIVOCAL 80% NEGATIVE 60% 40% 20% 0% typical carcinoid (31) atypical carcinoid (15) small cell ca (54) LCNEC (4) CRMP5 expression in SCLC & LCNEC Meyronet et al. Am J Surg Pathol 2008; 32: SCLC vs LCNEC Role of Immunohistochemistry 100% 80% SCLC LCNEC p.0018 p.0422 p % p.0022 p % 20% 0% CRG SYN CD56 mash1 NeuroD TTF p63 p16 PTEN Hiroshima et al. Mod Pathol 2006; 19: 1358 SCLC vs LCNEC Role of Immunohistochemistry 100% 80% 60% FoxM1 p27kip1(high) p21waft1/cip1(+) 40% 20% 0% TC (19) AC (6) LCNEC (17) SCLC (18) Ha et al. Histopathology 2012; 60: 731-9
22 Large Cell Neuroendocrine Carcinoma Conclusion Neither cell size nor immunohistochemistry reliably separate large cell neuroendocrine carcinoma from small cell carcinoma. Large Cell Neuroendocrine Carcinoma Definition neuroendocrine morphology necrosis (extensive) LCNEC vs >10 mitosis/2 mm 2 other NSCLC (10 hpf) cytologic features of NSCLC: large size, low N:C, nucleoli, coarse chromatin immunohistochemical confirmation squamous cell carcinoma organoid?
23 trabecular? CK5/6 p63 TTF1 POS POS NEG squamous cell carcinoma, basaloid variant ribbons?
24 small cell? LCNEC? CD56 SYN Neuroendocrine Lung Tumors Diagnostic Reproducibility 120 n = 170 large bxs, resections, mets 9 assessors ( special interest in lung cancer ) (12%) = unanimous 117 (69%) = consensus ( 5) 40 0 SCLC LCNEC Comb Carcinoid Other NSCLC Unsuitable den Bakker et al. Histopathol 2010; 56: 356
25 Neuroendocrine Lung Tumors Diagnostic Reproducibility SCLC & LCNEC accounted for the largest number of outliers compared to the consensus diagnosis den Bakker et al. Histopathol 2010; 56: 356 Hypothesis: LCNEC & SCLC are different They look (and stain) differently. They behave differently. LCNEC versus SCLC? Survival P =.9147 Asamura, 2006 J Clin Oncol 2006; 24: 70-6
26 Takei 2002 LCNEC versus SCLC? Survival in Stage I Disease P =.1851 Asamura 2006 Lung cancer-specific survival by histology for patients undergoing lobectomy or bilobectomy without radiation for pt1n0 tumors SEER database LCNEC versus SCLC? Survival in Stage I Disease multivariate Cox analysis demonstrated no significant differences between SCLC and LCNELC... or between OLC and LCNELC. Varlotto et al. J Thorac Oncol 2012; 6: 1050 Fig 5. Kaplan-Meier curves for overall survival stratified according to chemotherapeutic protocols in the adjuvant setting and tumor stage LCNEC is more likely to respond to chemotherapeutic strategies targeting SCLC Rossi, G. et al. J Clin Oncol 2005; 23: SCLC-based = platinum-etoposide
27 Hypothesis: LCNEC & SCLC are different They look (and stain) differently. They behave differently. They are genetically distinct. 2,803 differentially expressed genes Lancet 2004; 363 (9411): 775 unsupervised hierarchical clustering neuroendocrine tumors (38) typical (12) & atypical (1) carcinoids pure small cell ca (15) small cell & adca (2) pure LCNEC (6) LCNEC & adca (2) large cell carcinoma (13) well differentiated adenocarcinoma (12) normal (30) Lancet 2004; 363 (9411): 775 Most SCLC & LCNEC were comingled in 2 related but distinct groups HGNT1 HGNT2 HGNT3 4 pure SCLC 1 SCLC & adca 1 pure LCNEC 8 pure SCLC 4 pure LCNEC 2 pure SCLC 1 pure LCNEC 1 LCC
28 Lancet 2004; 363 (9411): 775 genetic profiles, but not histologic classification, separated patients with high grade NE tumors into prognostically distinct groups Hypothesis: LCNEC & SCLC are different They look (and stain) differently. They behave differently. They are genetically distinct. Large Cell Neuroendocrine Carcinoma Comparison with Small Cell Carcinoma small cell ca LCNEC 3 x lymphocytes, nucleoli, cytoplasm
29 Large Cell Neuroendocrine Carcinoma Practical Approach? LCNEC? any way to make this SCLC? finely dispersed chromatin? inconspicuous nucleoli? scant cytoplasm? is cell size the only issue? clinical context? central mass in smoker with mediastinal adenopathy? Large Cell Neuroendocrine Carcinoma Practical Approach? any way to make this SCLC? YES! SCLC Large Cell Neuroendocrine Carcinoma Practical Approach? any way to make this SCLC? NO compelling reason to acknowledge neuroendocrine differentiation? LCNEC already diagnosed IHC stains and it really, really looks neuroendocrine but atypical carcinoid been called SCLC but it isn t
30 Large Cell Neuroendocrine Carcinoma Practical Approach? LCNEC any way to make this SCLC? NO compelling reason to acknowledge neuroendocrine differentiation? YES! Large Cell Neuroendocrine Carcinoma Practical Approach? LCC, sq cell ca, adca any way to make this SCLC? NO NO compelling reason to acknowledge neuroendocrine differentiation? Neuroendocrine Lung Neoplasms As a result of this presentation, attendees who were fully engaged will be able to, apply criteria for separating low grade from high grade neuroendocrine tumors, and articulate the clinical, biological, histologic, immunohistochemical, and molecular overlap between them.
LUNG CANCER PATHOLOGY: UPDATE ON NEUROENDOCRINE LUNG TUMORS
LUNG CANCER PATHOLOGY: UPDATE ON NEUROENDOCRINE LUNG TUMORS William D. Travis, M.D. Attending Thoracic Pathologist Memorial Sloan Kettering Cancer Center New York, NY PULMONARY NE TUMORS CLASSIFICATION
More informationNeuroendocrine neoplasms of the lung
Neuroendocrine neoplasms of the lung M Papotti, L Righi, & M Volante University of Turin at San Luigi Hospital TORINO NETs OF THE LUNG Menu - Spectrum of NE lung tumors - CARCINOID TUMORS - SCLC /LCNEC
More informationRespiratory Tract Cytology
Respiratory Tract Cytology 40 th European Congress of Cytology Liverpool, UK Momin T. Siddiqui M.D. Professor of Pathology and Laboratory Medicine Director of Cytopathology Emory University Hospital, Atlanta,
More informationSmall cell lung cancer and large cell neuroendocrine tumours interobserver variability. Michael den Bakker Erasmus MC
Small cell lung cancer and large cell neuroendocrine tumours interobserver variability Michael den Bakker Erasmus MC PPC London 2007 WEB presentation Pulmonary pathology Club presentation, London, November
More informationProblem 1: Differential of Neuroendocrine Carcinoma 3/23/2017. Disclosure of Relevant Financial Relationships
Differential of Neuroendocrine Carcinoma Alain C. Borczuk,MD Weill Cornell Medicine Disclosure of Relevant Financial Relationships USCAP requires that all faculty in a position to influence or control
More informationThe Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC)
The Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC) Disclosure None Background Torino, Italy LCNC Rare tumor (2% to 3% all resected primary lung cancers) Preoperative
More informationNon-Small Cell Lung Carcinoma - Myers
Role of Routine Histology and Special Testing in Managing Patients with Non- Small Cell Lung Carcinoma Jeffrey L. Myers, M.D. A. James French Professor Director, Anatomic Pathology & MLabs University of
More informationInsulinoma-associated protein (INSM1) is a sensitive and specific marker for lung neuroendocrine tumors in cytologic and surgical specimens
Insulinoma-associated protein (INSM1) is a sensitive and specific marker for lung neuroendocrine tumors in cytologic and surgical specimens Kartik Viswanathan, M.D., Ph.D New York Presbyterian - Weill
More informationBasaloid Carcinoma of the Lung: A Really Dismal Histologic Variant?
Carcinoma of the Lung: A Really Dismal Histologic Variant? Dae Joon Kim, MD, Kil Dong Kim, MD, Dong Hwan Shin, MD, Jae Y Ro, MD, and Kyung Young Chung, MD Departments of Thoracic and Cardiovascular Surgery,
More informationMody. AIS vs. Invasive Adenocarcinoma of the Cervix
Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive
More informationNeuroendocrine (NE) lung tumors represent a broad
Large Cell Neuroendocrine Carcinoma of the Lung: A 10-Year Clinicopathologic Retrospective Study Massimiliano Paci, MD, Alberto Cavazza, MD, Valerio Annessi, MD, Innocenza Putrino, MD, Guglielmo Ferrari,
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More informationDifficult Diagnoses and Controversial Entities in Neoplastic Lung
Difficult Diagnoses and Controversial Entities in Neoplastic Lung Lynette M. Sholl, M.D. Associate Pathologist, Brigham and Women s Hospital Chief, Pulmonary Pathology Service Associate Professor, Harvard
More informationCase year old female presented with asymmetric enlargement of the left lobe of the thyroid
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationCase 4 Diagnosis 2/21/2011 TGB
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationLung neuroendocrine tumors: pathological characteristics
Review Article Lung neuroendocrine tumors: pathological characteristics Luisella Righi 1, Gaia Gatti 1, Marco Volante 1, Mauro Papotti 2 1 Department of Oncology, San Luigi Hospital, Orbassano, Italy;
More informationARTHUR PURDY STOUT SOCIETY COMPANION MEETING: DIFFICULT NEW DIFFERENTIAL DIAGNOSES IN PROSTATE PATHOLOGY. Jonathan I. Epstein.
1 ARTHUR PURDY STOUT SOCIETY COMPANION MEETING: DIFFICULT NEW DIFFERENTIAL DIAGNOSES IN PROSTATE PATHOLOGY Jonathan I. Epstein Professor Pathology, Urology, Oncology The Reinhard Professor of Urological
More informationTHYMIC CARCINOMAS AN UPDATE
THYMIC CARCINOMAS AN UPDATE Mark R. Wick, M.D. University of Virginia Medical Center Charlottesville, VA CARCINOMA OF THE THYMUS General Clinical Features No apparent gender predilection Age range of 35-75
More informationTumors of the Lungs and Pleura
5 Tumors of the Lungs and Pleura Saul Suster and Cesar Moran Introduction Carcinoma of the lung is a common malignant tumor. Histological typing of lung tumors has long been a source of controversy in
More informationNon Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק
Non Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק 26.06.09 Lecture outlines WHO histological classification Macro/Micro assessment Early diagnosis Minimal pathology Main subtypes SCC, AdCa, LCLC
More informationCytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics. Mercè Jordà, University of Miami
Cytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics Mercè Jordà, University of Miami Mortality Lung cancer is the most frequent cause of cancer incidence and mortality
More informationFNA of Thyroid. Toward a Uniform Terminology With Management Guidelines. NCI NCI Thyroid FNA State of the Science Conference
FNA of Thyroid NCI NCI Thyroid FNA State of the Science Conference Toward a Uniform Terminology With Management Guidelines Thyroid Thyroid FNA Cytomorphology NCI Thyroid FNA State of the Science Conference
More informationInternational Society of Gynecological Pathologists Symposium 2007
International Society of Gynecological Pathologists Symposium 2007 Anais Malpica, M.D. Department of Pathology The University of Texas M.D. Anderson Cancer Center Grading of Ovarian Cancer Histologic grade
More informationHyperchromatic Crowded Groups: What is Your Diagnosis? Session 3000
Hyperchromatic Crowded Groups: What is Your Diagnosis? Session 3000 Thomas A. Bonfiglio, M.D. Professor Emeritus, Pathology and Laboratory Medicine University of Rochester Disclosures In the past 12 months,
More informationFollicular Derived Thyroid Tumors
Follicular Derived Thyroid Tumors Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for Medical Sciences
More informationSalivary Glands 3/7/2017
Salivary Glands 3/7/2017 Goals and objectives Focus on the entities unique to H&N Common board type facts Information for your future practice Salivary Glands Salivary Glands Major gland. Paratid. Submandibular.
More informationImpact of immunostaining of pulmonary and mediastinal cytology
Impact of immunostaining of pulmonary and mediastinal cytology Harman Sekhon MD, PhD Director of Cytopathology Head of Ottawa-site Ontario Tumour Bank June 20, 2014 Disclaimer Pfizer: Honorarium-Advisory
More informationProposal of a prognostically relevant grading scheme for pulmonary squamous cell carcinoma
ORIGINAL ARTICLE LUNG CANCER Proposal of a prognostically relevant grading scheme for pulmonary squamous cell carcinoma Wilko Weichert 1,2,3, Claudia Kossakowski 1, Alexander Harms 1, Peter Schirmacher
More informationUpdate on 2015 WHO Classification of Lung Adenocarcinoma 1/3/ Mayo Foundation for Medical Education and Research. All rights reserved.
1 Our speaker for this program is Dr. Anja Roden, an associate professor of Laboratory Medicine and Pathology at Mayo Clinic as well as consultant in the Anatomic Pathology Laboratory and co-director of
More informationPrepared By Jocelyn Palao and Layla Faqih
Prepared By Jocelyn Palao and Layla Faqih The structure of the suspected atypical cell should always be compared to the structure of other similar, benign, cells which are present in the smears. The diagnosis
More information3/23/2017. Differentiation: Differentiation: Immunohistochemistry. Well Differentiated vs. Poorly Differentiated Neuroendocrine Neoplasms
Disclosure Statement When Immunostains Can Get You Into Trouble (and how they can help you out): Neuroendocrine Neoplasms Arthur Purdy Stout Society March 5, 2017 Dr. Klimstra receives royalty payments
More informationACCME/Disclosures. Cribriform Lesions of the Prostate. Case
Cribriform Lesions of the Prostate Ming Zhou, MD, PhD Departments of Pathology and Urology New York University Langone Medical Center New York, NY Ming.Zhou@NYUMC.ORG ACCME/Disclosures The USCAP requires
More informationMorphologic Criteria of Invasive Colonic Adenocarcinoma on Biopsy Specimens
ISPUB.COM The Internet Journal of Pathology Volume 12 Number 1 Morphologic Criteria of Invasive Colonic Adenocarcinoma on Biopsy Specimens C Rose, H Wu Citation C Rose, H Wu.. The Internet Journal of Pathology.
More informationSquamous Cell Carcinoma of Thyroid: possible thymic origin, so-called ITET/CASTLE 2012/03/22
Squamous Cell Carcinoma of Thyroid: possible thymic origin, so-called ITET/CASTLE 2012/03/22 History of ITET/CASTLE First Report Gross Appearance and Prognosis 1) Miyauchi A et al: Intrathyroidal epithelial
More informationEBUS-TBNA Diagnosis and Staging of Lung Cancer
EBUS-TBNA Diagnosis and Staging of Lung Cancer Nirag Jhala MD, MIAC Professor of Pathology and Lab Med. Director of Anatomic Pathology and Cytopathology Lewis Katz School of Medicine@ Temple University
More informationIn 1991, Travis et al. 1,2 described a rare but distinct histologic
ORIGINAL ARTICLE Should Large Cell Neuroendocrine Lung Carcinoma be Classified and Treated as a Small Cell Lung Cancer or with Other Large Cell Carcinomas? John M. Varlotto, MD,* Laura Nyshel Medford-Davis,
More informationObjectives. Atypical Glandular Cells. Atypical Endocervical Cells. Reactive Endocervical Cells
2013 California Society of Pathologists 66 th Annual Meeting San Francisco, CA Atypical Glandular Cells to Early Invasive Adenocarcinoma: Cervical Cytology and Histology Christina S. Kong, MD Associate
More informationLung Neoplasia II Resection specimens Pathobasic. Lukas Bubendorf Pathology
Lung Neoplasia II Resection specimens Pathobasic Lukas Bubendorf Pathology Agenda Preneoplastic lesions Histological subtypes of lung cancer Histological patterns of AC Cells of origin and characteristic
More informationACCME/Disclosures. Diagnosing Mesothelioma in Limited Tissue Samples. Papanicolaou Society of Cytopathology Companion Meeting March 12 th, 2016
Diagnosing Mesothelioma in Limited Tissue Samples Papanicolaou Society of Cytopathology Companion Meeting March 12 th, 2016 Sanja Dacic, MD, PhD University of Pittsburgh ACCME/Disclosures GENERAL RULES
More informationHistology: Its Influence on Therapeutic Decision Making
Histology: Its Influence on Therapeutic Decision Making Mark A. Socinski, MD Professor of Medicine and Thoracic Surgery Director, Lung Cancer Section, Division of Hematology/Oncology Co-Director, UPMC
More informationLung Cytology: Lessons Learned from Errors in Practice
Lung Cytology: Lessons Learned from Errors in Practice Stephen S. Raab, M.D. Department of Laboratory Medicine Eastern Health and Memorial University of Newfoundland, St. John s, NL and University of Washington,
More informationPancreatic Cancer: The ABCs of the AJCC and WHO
Pancreatic Cancer: The ABCs of the AJCC and WHO Aatur D. Singhi, MD PhD Assistant Professor University of Pittsburgh Medical Center Department of Pathology singhiad@upmc.edu Case presentation Objectives
More informationNeuroendocrine carcinomas (carcinoids) of the thymus
Neuroendocrine carcinomas (carcinoids) of the thymus Cesar A. Moran, MD Professor of Pathology Director of Thoracic Pathology M D Anderson Cancer Center Houston, TX Primary thymic neuroendocrine carcinomas
More informationImmunohistochemical Profile of Lung Tumors in Image Guided Biopsies
Original Article DOI: 10.21276/APALM.1342 Immunohistochemical Profile of Lung Tumors in Image Guided Biopsies T. Pavithra 1 *, A. Dhanalakshmi 1, C. Lalitha 1, K.B. Lavanya 1 and S. Shifa 2 Department
More informationCombined Large Cell Neuroendocrine Carcinoma and Spindle Cell Carcinoma of the Lung
Case Reports Jpn J Clin Oncol 2011;41(6)797 802 doi:10.1093/jjco/hyr034 Advance Access Publication 16 March 2011 Combined Large Cell Neuroendocrine Carcinoma and Spindle Cell Carcinoma of the Lung Taichiro
More informationDisclosures. Parathyroid Pathology. Objectives. The normal parathyroid 11/10/2012
Disclosures Parathyroid Pathology I have nothing to disclose Annemieke van Zante MD/PhD Assistant Professor of Clinical Pathology Associate Chief of Cytopathology Objectives 1. Review the pathologic features
More informationWhen Immunostains Can Get You Into Trouble (and how they can help you out): Neuroendocrine Neoplasms
When Immunostains Can Get You Into Trouble (and how they can help you out): Neuroendocrine Neoplasms Arthur Purdy Stout Society March 5, 2017 David S. Klimstra, MD Chairman, Department of Pathology James
More informationGynecologic Cytopathology: Glandular lesions
Gynecologic Cytopathology: Glandular lesions Lin Wai Fung (MSc, MPH, CMIAC) 17/4/2014 Glandular lesions of the uterus Endocervix Endometrium Normal endocervical cells Sheets, strips well-preserved architecture:
More informationMedullary Thyroid Carcinoma. This case was provided by Treant Hospital, Bethesda, Hoogeveen, The Netherlands
Medullary Thyroid Carcinoma This case was provided by Treant Hospital, Bethesda, Hoogeveen, The Netherlands ADS-01504 Rev. 001 2016 Hologic, Inc. All rights reserved. Overview Medullary Thyroid Carcinoma
More information3/24/2017. Disclosure of Relevant Financial Relationships. Mixed Epithelial Endometrial Carcinoma. ISGyP Endometrial Cancer Project
Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to influence or control the content of CME disclose any relevant financial relationship
More informationDisclosure. Relevant Financial Relationship(s) None. Off Label Usage None MFMER slide-1
Disclosure Relevant Financial Relationship(s) None Off Label Usage None 2013 MFMER slide-1 Case Presentation A 43 year old male, with partial nephrectomy for a right kidney mass 2013 MFMER slide-2 2013
More information5/1/2009. Squamous Dysplasia/CIS AAH DIPNECH. Adenocarcinoma
Pathological Assessment of Diagnostic Specimens Keith Kerr Department of Pathology Aberdeen University Medical School Aberdeen Royal Infirmary Foresterhill, Aberdeen, Scotland, UK Tumours of the Lung:
More informationLarge cell neuroendocrine carcinoma: retrospective analysis of 24 cases from four oncology centers in Turkey
Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Large cell neuroendocrine carcinoma: retrospective analysis of 24 cases from four oncology centers in Turkey Bala Başak Oven Ustaalioglu 1, Arife Ulas 2,
More informationThyroid follicular neoplasms in cytology. Ulrika Klopčič Institute of Oncology, Department of Cytopathology, Ljubljana, Slovenia
Thyroid follicular neoplasms in cytology Ulrika Klopčič Institute of Oncology, Department of Cytopathology, Ljubljana, Slovenia Lecture overview importance of FNAB in assessing thyroid lesions follicular
More informationThe 2015 World Health Organization Classification for Lung Adenocarcinomas: A Practical Approach
The 2015 World Health Organization Classification for Lung Adenocarcinomas: A Practical Approach Dr. Carol Farver Director, Pulmonary Pathology Pathology and Laboratory Medicine Institute Objectives Discuss
More informationA 53 year-old woman with a lung mass, right hilar mass and mediastinal adenopathy.
November 2015 Case of the Month A 53 year-old woman with a lung mass, right hilar mass and mediastinal adenopathy. Contributed by: Rasha Salama, M.D., IU Department of Pathology and Laboratory Medicine
More informationOncocytic carcinoma: A rare malignancy of the parotid gland
ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Oncocytic carcinoma: A rare malignancy of the parotid gland K Mardi, J Sharma Citation K Mardi, J Sharma.. The Internet Journal of Pathology.
More informationThe Spectrum of Pulmonary Neuroendocrine Carcinomas: Radiologic and Pathologic Findings 1
The Spectrum of Pulmonary Neuroendocrine Carcinomas: Radiologic and Pathologic Findings 1 Eun-Young Kang, M.D., h Ryung Shin, M.D., Jung-h Choi, M.D., ong Kyung Shin, M.D. 2, Yu-Whan Oh, M.D., Han Kyeom
More informationUpdate on large cell neuroendocrine carcinoma
Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer Update on large cell neuroendocrine carcinoma Kenzo Hiroshima 1, Mari Mino-Kenudson 2 1 Department of Pathology, Tokyo Women
More informationNEUROENDOCRINE DIFFERENTIATED BREAST CARCINOMA
+ NEUROENDOCRINE DIFFERENTIATED BREAST CARCINOMA + INTRODUCTION + NEUROENDOCRINE FEATURES IN BREAST CARCINOMA Incidence of 2-5% Seen in various histopathological types of breast carcinoma Seen in both
More informationSmall cell neuroendocrine carcinoma icd 10
Small cell neuroendocrine carcinoma icd 10 1-10-2017 Free, official coding info for 2018 ICD - 10 -CM C34.90 - includes detailed rules, notes, synonyms, ICD -9- crosswalks, DRG. In most series, LCLC's
More informationnumber Done by Corrected by Doctor Maha Shomaf
number 16 Done by Waseem Abo-Obeida Corrected by Zeina Assaf Doctor Maha Shomaf MALIGNANT NEOPLASMS The four fundamental features by which benign and malignant tumors can be distinguished are: 1- differentiation
More informationG3.02 The malignant potential of the neoplasm should be recorded. CG3.02a
G3.02 The malignant potential of the neoplasm should be recorded. CG3.02a Conventional adrenocortical neoplasm. Each of the below parameters is scored 0 when absent and 1 when present. 3 or more of these
More informationWhat s New in Pathology of Genitourinary Tumors. Jiaoti Huang, MD, PhD Department of Pathology Duke University School of Medicine
What s New in Pathology of Genitourinary Tumors Jiaoti Huang, MD, PhD Department of Pathology Duke University School of Medicine Kidney Tumors Multilocular cystic renal neoplasm of low malignant potential
More informationPapillary Lesions of the breast
Papillary Lesions of the breast Emad Rakha Professor of Breast Pathology The University of Nottingham Papillary lesions of the breast are a heterogeneous group of disease, which are characterised by neoplastic
More informationLGM International, Inc.
Liqui-PREP TM Cytology Atlas Preface The following pictures are examples with descriptions of cytology slides processed with the Liqui-PREP TM System.. The descriptions are reviewed by Pathologists. It
More information04/09/2018. Follicular Thyroid Tumors Updates in Classification & Practical Tips. Dissecting Indeterminants. In pursuit of the low grade malignancy
Follicular Thyroid Tumors Updates in Classification & Practical Tips Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University
More informationCurrent Concept in Ovarian Carcinoma: Pathology Perspectives
Current Concept in Ovarian Carcinoma: Pathology Perspectives Rouba Ali-Fehmi, MD Professor of Pathology The Karmanos Cancer Institute, Wayne State University School of Medicine Current Concept in Ovarian
More informationPathology of Tumors of Lung Pathology of Tumors of Lung o Classify lung tumors.
Pathology of Tumors of Lung Pathology of Tumors of Lung o Classify lung tumors. o Classify bronchogenic carcinoma. o Discuss etiopathogenesis of bronchogenic ca. o Discuss morphological features of squamous
More informationMinimally invasive adenocarcinoma. 5mm or less = microinvasion No necrosis No lymphatic or pleural invasion No spread through air-spaces (STAS)
Minimally invasive adenocarcinoma 5mm or less = microinvasion No necrosis No lymphatic or pleural invasion No spread through air-spaces (STAS) 2b lepidic acinar 2c papillary micropapillary solid 2d cribriform
More informationLarge-Cell Neuroendocrine Carcinoma of the Lung
Accurate classification of this malignancy will help to guide management decisions regarding resection and adjuvant therapy. Manus Island Tree Snail_2281. Photograph courtesy of Henry Domke, MD. www.henrydomke.com.
More information3/27/2017. Pulmonary Pathology Specialty Conference. Disclosure of Relevant Financial Relationships. Clinical History:
Pulmonary Pathology Specialty Conference Saul Suster, M.D. Medical College of Wisconsin Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position
More informationHistopathology of NSCLC, IHC markers and ptnm classification
ESMO Preceptorship on Non-Small Cell Lung Cancer November 15 th & 16 th 2017 Singapore Histopathology of NSCLC, IHC markers and ptnm classification Prof Keith M Kerr Department of Pathology, Aberdeen University
More informationThe classification of neuroendocrine lung tumors (NE tumor)
ORIGINAL ARTICLE Reclassification of Neuroendocrine Tumors Improves the Separation of Carcinoids and the Prediction of Survival Birgit Guldhammer Skov, MD, DrMSci,* Mark Krasnik, MD, Sylvie Lantuejoul,
More informationCINtec p16 INK4a Staining Atlas
CINtec p16 INK4a Staining Atlas Rating Rating Positive The rating positive will be assigned if the p16 INK4a -stained slide shows a continuous staining of cells of the basal and parabasal cell layers of
More informationLung/Thoracic Neoplasms. Manish Powari
Lung/Thoracic Neoplasms Manish Powari Biopsy Techniques in Lung cancer diagnosis Decreased cellularity and architecture; thereby influencing subtyping Thoracotomy, resection VATS biopsy/resection L.node
More informationVilloglandular adenocarcinoma of cervix a tumour with bland cytological features: report of a case missed on cytology
Malaysian J Pathol 2003; 25(2) : CERVICAL 139 143 VILLOGLANDULAR ADENOCARCINOMA CYTOLOGY CASE REPORT Villoglandular adenocarcinoma of cervix a tumour with bland cytological features: report of a case missed
More informationPancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA
Pancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA Jack Yang, MD Department of Pathology, Medical University of South Carolina Objectives Understand the indication of EUS
More informationOvarian Clear Cell Carcinoma
Ovarian Clear Cell Carcinoma Rouba Ali-Fehmi, MD Professor of Pathology The Karmanos Cancer Institute, Wayne State University School of Medicine 50 year old woman with chief complaint of shortness of breath
More informationGround Glass Opacities
Ground Glass Opacities A pathologist s perspective Marie-Christine Aubry, M.D. Professor of Pathology Mayo Clinic Objectives Discuss the proposed new pathologic classification of adenocarcinoma with historical
More informationCase Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor
Case Reports in Medicine Volume 2015, Article ID 742920, 4 pages http://dx.doi.org/10.1155/2015/742920 Case Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor Omer Alici,
More informationLUNG CANCER. pathology & molecular biology. Izidor Kern University Clinic Golnik, Slovenia
LUNG CANCER pathology & molecular biology Izidor Kern University Clinic Golnik, Slovenia 1 Pathology and epidemiology Small biopsy & cytology SCLC 14% NSCC NOS 4% 70% 60% 50% 63% 62% 61% 62% 59% 54% 51%
More informationProtocol for the Examination of Specimens From Patients With Thymic Tumors
Protocol for the Examination of Specimens From Patients With Thymic Tumors Version: Protocol Posting Date: June 2017 Includes ptnm requirements from the 8 th Edition, AJCC Staging Manual For accreditation
More informationPathology of the Thyroid
Pathology of the Thyroid Thyroid Carcinoma Arising from Follicular Cells 2015-01-19 Prof. Dr. med. Katharina Glatz Pathologie Carcinomas Arising from Follicular Cells Differentiated Carcinoma Papillary
More informationImmunohistochemistry and Bladder Tumours
Immunohistochemistry and Bladder Tumours Dr. Andrew J. Evans MD PhD FRCPC Consultant in Genitourinary Pathology University Health Network Toronto, ON Objec ves Review markers of urothelial differen a on
More informationSmall (and large) Blue Cell Tumors of the Skull Base
Small (and large) Blue Cell Tumors of the Skull Base Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for
More informationDiagnostic problems in uterine smooth muscle tumors
Diagnostic problems in uterine smooth muscle tumors Marina Kos Ljudevit Jurak Clinical Department of Pathology, Clinical Hospital Center Sestre milosrdnice, Zagreb Institute of Pathology, University of
More informationQUALITY ASSURANCE PROGRAM CYTOLOGY CYCLE 01/2018 (TRIAL)
[Pick the Date] FINAL REPORT QUALITY ASSURANCE PROGRAM CYTOLOGY CYCLE 01/2018 (TRIAL) NOTES FROM THE COORDINATOR 1. For this cycle 01/2018, a total of 32 pen drives had been circulated. Twenty-eight institutions
More informationDOI: /jemds/2014/1921 ORIGINAL ARTICLE
CYTODIAGNOSIS OF GASTROINTESTINAL STROMAL TUMOURS (GISTs) ON ROMANOWSKY STAINED SMEARS Priyanka Agrawal 1, Subhash Agrawal 2, Atul Gupta 3, Anurag Gupta 4 HOW TO CITE THIS ARTICLE: Priyanka Agrawal, Subhash
More informationPOORLY DIFFERENTIATED, HIGH GRADE AND ANAPLASTIC CARCINOMAS: WHAT IS EVERYONE TALKING ABOUT?
POORLY DIFFERENTIATED, HIGH GRADE AND ANAPLASTIC CARCINOMAS: WHAT IS EVERYONE TALKING ABOUT? AGGRESSIVE THYROID CANCERS PAPILLARY CARCINOMA CERTAIN SUBTYPES POORLY DIFFERENTIATED CARCINOMA HIGH GRADE DIFFERENTIATED
More informationIn the mid 1970s, visceral pleural invasion (VPI) was included
ORIGINAL ARTICLE Tumor Invasion of Extralobar Soft Tissue Beyond the Hilar Region Does Not Affect the Prognosis of Surgically Resected Lung Cancer Patients Hajime Otsuka, MD,* Genichiro Ishii, MD, PhD,*
More informationCASE REPORT Malignant transformation of breast ductal adenoma: a diagnostic pitfall
Malaysian J Pathol 2015; 37(3) : 281 285 CASE REPORT Malignant transformation of breast ductal adenoma: a diagnostic pitfall Hiroko HAYASHI, Hiroshi OHTANI,* Junzo YAMAGUCHI,** and Isao SHIMOKAWA Department
More informationSynonyms. Nephrogenic metaplasia Mesonephric adenoma
Nephrogenic Adenoma Synonyms Nephrogenic metaplasia Mesonephric adenoma Definition Benign epithelial lesion of urinary tract with tubular, glandular, papillary growth pattern Most frequently in the urinary
More informationPapillary Lesions of the Breast A Practical Approach to Diagnosis. (Arch Pathol Lab Med. 2016;140: ; doi: /arpa.
Papillary Lesions of the Breast A Practical Approach to Diagnosis (Arch Pathol Lab Med. 2016;140:1052 1059; doi: 10.5858/arpa.2016-0219-RA) Papillary lesions of the breast Span the spectrum of benign,
More informationSteering Committee. Waiting on photo. Paul A. Bunn, Jr., MD Kavita Garg, MD Kim Geisinger, MD Fred R. Hirsch, Gregory Riely, MD, PhD.
Steering Committee Paul A. Bunn, Jr., MD Kavita Garg, MD Kim Geisinger, MD Fred R. Hirsch, Gregory Riely, MD, PhD MD, PhD Waiting on photo Paul Van Schil, MD, PhD William D. Travis, MD Ming-Sound Tsao,
More informationPathological Classification of Hepatocellular Carcinoma
3 rd APASL Single Topic Conference: HCC in 3D Pathological Classification of Hepatocellular Carcinoma Glenda Lyn Y. Pua, M.D. HCC Primary liver cancer is the 2 nd most common cancer in Asia HCC is the
More informationIntraductal carcinoma of the prostate on needle biopsy: histologic features and clinical significance
& 2006 USCAP, Inc All rights reserved 0893-3952/06 $30.00 www.modernpathology.org Intraductal carcinoma of the prostate on needle biopsy: histologic features and clinical significance Charles C Guo 1 and
More informationLarge cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty-seven cases
Takei et al General Thoracic Surgery Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty-seven cases Hidefumi Takei, MD a,b Hisao Asamura, MD b Arafumi Maeshima, MD c Kenji
More informationExtent of visceral pleural invasion and the prognosis of surgically resected node-negative non-small cell lung cancer
Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Extent of visceral pleural invasion and the prognosis of surgically resected node-negative non-small cell lung cancer Yangki Seok 1, Ji Yun Jeong 2 & Eungbae
More informationSpectrum of Lesions in Cystoscopic Bladder Biopsies -A Histopathological Study
AJMS Al Ameen J Med Sci (2 012 )5 (2 ):1 3 2-1 3 6 (A US National Library of Medicine enlisted journal) I S S N 0 9 7 4-1 1 4 3 C O D E N : A A J M B G ORIGI NAL ARTICLE Spectrum of Lesions in Cystoscopic
More information