Malaria Threats Map. Malaria Policy Advisory Committee Meeting Geneva, Switzerland 18 October 2017

Transcription

1 Malaria Threats Map Malaria Policy Advisory Committee Meeting Geneva, Switzerland 18 October 2017

2 Overview 1. Scope 2. Progress 3. Status 4. Data overview 5. Demonstration 6. Plans

3 Scope Biological challenges to malaria control and elimination Vector insecticide resistance (bioassays, mechanisms) hrp2/3 gene deletions (single and mixed) Antimalarial drug efficacy and drug resistance (therapeutic efficacy studies (TES), molecular markers)

4 Progress Updates since MPAC March 2017 Extra data ie. 2016/2017 Significant refinement of: Data filters Dynamic legends Symbols ie. toggle for country/site data Popup content ie. text, tables and figures Geographies navigator Formulated explanatory text Translated all content ie. French, Spanish

5 Status As of 18 October % completed Pending: minor updates to functionality and aesthetics Launch: anticipated by end October 2017

6 Data overview Vector insecticide resistance bioassays (all), mechanisms 91 countries = 29,137 tests GMP Databases hrp2/3 gene deletions suspected, confirmed 26 countries = 131 survey areas Drug efficacy & drug resistance TES results, molecular markers 78 countries = 2,133 studies Vector insecticide resistance bioassays (standard), mechanisms 83 countries = 18,712 tests Malaria Threats Map hrp2/3 gene deletions confirmed 24 countries = 125 survey areas Drug efficacy & drug resistance TES results, molecular markers 71 countries = 1,006 studies Bioassays (standard only) discriminating concentration intensity concentration Mechanisms (biochemical, molecular, synergist-insecticide assays) metabolic - mono oxygenases, esterases, GSTs target-site mutations - kdr, Ace1R

7 Data overview Vector insecticide resistance bioassays (all), mechanisms 91 countries = 29,137 tests GMP Databases hrp2/3 gene deletions suspected, confirmed 26 countries = 131 survey areas Drug efficacy & drug resistance TES results, molecular markers 78 countries = 2,133 studies Vector insecticide resistance bioassays (standard), mechanisms 83 countries = 18,712 tests Malaria Threats Map hrp2/3 gene deletions confirmed 24 countries = 125 survey areas Drug efficacy & drug resistance TES results, molecular markers 71 countries = 1,006 studies Type of deletion pfhrp2 pfhrp2 and 3 Clinical status symptomatic asymptomatic mixed or unknown Survey type Cross sectional Convenience/screening Case report DHS Across surveys, the criteria for selecting samples to test for pfhrp2/3 deletions varies. Percentage of samples tested with deletions is presented

8 Data overview Vector insecticide resistance bioassays (all), mechanisms 91 countries = 29,137 tests GMP Databases hrp2/3 gene deletions suspected, confirmed 26 countries = 131 survey areas Drug efficacy & drug resistance TES results, molecular markers 78 countries = 2,133 studies Vector insecticide resistance bioassays (standard), mechanisms 83 countries = 18,712 tests Malaria Threats Map hrp2/3 gene deletions confirmed 24 countries = 125 survey areas Drug efficacy & drug resistance TES results, molecular markers 71 countries = 1,006 studies Therapeutic efficacy studies P. falciparum P. vivax Molecular marker studies K13 Pfcrt (next version)

9 Live demonstration

10 Live demonstration

11 Live demonstration

12 Live demonstration

13 Mobile compatibility: pending

14 Plans Interim Finalise pending updates Shift to WHO server and launch Beta test and address arising issues (eg. bugs) Conduct consultations to define priorities for optimising / expanding Phase II development Potential options: Regional symbols and pop-ups (to compare across countries) Data upload / download Automated summary report Print functionality Mobile compatibility

15 Thank you For further information: Tessa Knox: Jane Cunningham: Amy Barrette: The URL to the Malaria Threats Map beta application will be circulated widely upon launch