I. EXTRACELLULAR VESICLES I.

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1 WEDNESDAY, 17 th OCTOBER :00-14:00 Registration 11:00-13:30 Board meeting Hungarian Society for Immunology 14:00-16:25 Session I. EXTRACELLULAR VESICLES I. Session chairs: Edit Buzás, Gabriella Sármay 14:00-14:10 Welcome and Introduction to extracellular vesicles - Edit Buzás 14:10-14:40 Cristoph J. Binder ROLE AND FUCTION OF MISCROVESICLES CARRYING OXIDATION-SPECIFIC EPITOPES Medical University of Vienna & CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria 14:40-15:05 Éva Pállinger EXTRACELLULAR VESICLES IN PREGNANCY 15:05-15:30 Krisztián Kvell TRANSGENIC EXOMES FOR THYMUS REGENERATION Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs 15:30-15:55 Krisztina Buzás MELANOMA EXOSOMES INDUCE PD-1 OVEREXPRESSION AND TUMOR PROGRESSION VIA MESENCHYMAL STEM CELL ONCOGENIC REPROGRAMMING Biological Research Centre of Hungarian Academy of Sciences, Szeged 15:55-16:10 György Nagy EXTRACELLULAR VESICLES IN RHEUMATOID ARTHRITIS Department of Genetics, Cell and Immunobiology, Department of Rheumatology, 3rd Department of Internal 16:10-16:25 Viktor Müller A NEW ROLE FOR EXOSOMES IN CANCER: A RADICAL HYPOTHESIS Institute of Biology, Eötvös Loránd University, Budapest, Evolutionary Systems Research Group, MTA Centre for 16:25-17:00 COFFEE BREAK & POSTER VIEW 16:50-17:00 General assembly 1. 17:00-18:25 Session II. EXTRACELLULAR VESICLES II. Session chairs: Attila Mócsai, György Nagy 17:00-17:25 Erzsébet Ligeti DISTINCT MOLECULAR PATHWAYS IN BIOGENESIS OF DIFFERENT TYPES OF EXTRACELLULAR VESICLES FROM NEUTROPHILIC GRANULOCYTES Semmelweis University, Budapest 17:25-17:40 Ákos Lőrincz CALCIUM SIGNALING IN THE BIOGENESIS OF NEUTROPHIL DERIVED EV Semmelweis University, Budapest 17:40-18:10 Francisco Sánchez Madrid, EFIS Award Lecture IMMUNE CELL-CELL COMMUNICATION: TRANSFER OF GENETIC INFORMATION THROUGH THE IMMUNOLOGICAL SYNAPSE Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Servicio de Inmunología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Universidad Autónoma de Madrid, CIBER de Enfermedades Cardiovasculares, ISCIII (CIBERCV), Madrid, Spain 18:10-18:20 EFIS Award ceremony 18:20-18:25 Wrap up of the session 18:25-18:40 OPENING CEREMONY: Zoltán Prohászka and Péter Balogh 20:00-22:00 DINNER

2 THURSDAY, 18 th OCTOBER :30-09:30 Session III. AUTOIMMUNITY, CHRONIC INFLAMMATION AND TUMORS I. Session chairs: Tímea Berki, Éva Rajnavölgyi 08:30-08:45 Árpád Ferenc Kovács IMMUNOMODULATORY EFFECTS OF BEWO TROPHOBLASTIC CELL-DERIVED EXTRACELLULAR VESICLES ON HUMAN LYMPHOCYTES 08:45-09:00 Benjamin Tamás Papp HLA-II HOMOZYGOZITY PROTECTS FROM BRONCHIAL ASTHMA Department of Dermatology and Allergology, University of Szeged, Hungary 09:00-09:15 Éva Boros INTERDEPENDENT GENE- AND MICRORNA-EXPRESSION PATTERN CONTRIBUTES TO THE EPITHELIAL TO MESENCHYMAL TRANSITION IN INFLAMMATORY BOWEL DISEASE Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged 09:15-09:30 Barbara Érsek MELANOMA ASSOCIATED FIBROBLAST DERIVED ARGINASE REGULATES CD8+ T CELL IMMUNE CHECKPOINT RECEPTOR EXPRESSION 09:30-09:45 Shaun Peterson Microsatellite Instability (MSI) Biomarker for Immunotherapy Promega Corporation 09:45-10:00 Zoltán Hegyi ImageXpress Pico: the new generation of automated cell imaging and image analysis systems Bio-Science Kft. 10:00-11:15 POSTER SESSION I. & EXHIBITION WITH COFFEE Chairs: László Cervenak, Árpád Lányi & BIO-SCIENCE WORKSHOP 11:15-12:15 Session IV. AUTOIMMUNITY, CHRONIC INFLAMMATION AND TUMORS II. Session chairs: Anna Erdei, Péter Németh 11:15-11:30 Gergő Mihály Balogh EFFECT OF HLA PROMISCUITY ON ANTITUMOR IMMUNITY Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged 11:30-11:45 Gábor J. Szebeni COMPLEX IMMUNOPHENOTYPING BY SINGLE CELL MASS CYTOMETRY Biological Research Centre, Hungarian Academy of Sciences, Szeged 11:45-12:00 Zoltán Szekanecz DEVELOPMENT OF SECONDARY MALIGNANCIES IN AUTOIMMUNE-RHEUMATIC DISEASES AND AFTER TARGETED IMMUNOTHERAPY OF ARTHRITIS Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen 12:00-12:15 Éva Szekanecz AUTOIMMUNE PHENOMENA DUE TO CHECKPOINT INHIBITION IN ONCOLOGY Department of Oncology, Faculty of Medicine, University of Debrecen 12:15-12:30 Sonja Balk ForteBio BLI Systems for Versatile and Rapid Biomolecular Kinetics and Quantitation FortéBio LLC 12:30-12:45 BREAK

3 12:45-13:30 Session V. HOST-MICROBE INTERACTIONS Session chairs: Peter Antal-Szalmás, Imre Kacskovics 12:45-13:00 Beáta Szilvia Bolla CUTIBACTERIUM ACNES CONTRIBUTES TO THE MAINTENANCE OF SKIN BARRIER AND HOMEOSTASIS Department of Dermatology and Allergology, University of Szeged 13:00-13:15 Lilla Erdei THE ROLE OF TNFAIP3 IN THE REGULATION OF TLR SIGNALING EVENTS IN HUMAN EPIDERMAL KERATINOCYTES Department of Dermatology and Allergology, University of Szeged 13:15-13:30 Máté Vadovics ELEVATED METASTATIC ACTIVITY, TAM RECEPTOR EXPRESSION AND ERK ACTIVATION OF ORAL SQUAMOUS CELL CARCINOMA CELL LINES UPON MICROBIAL EXPOSURE Department of Microbiology, University of Szeged 13:30-14:30 LUNCH BREAK 14:30-16:00 Session VI. EVOLUTION & IMMUNE COMPARTMENTS Session chairs: István Andó, Krisztina Buzás 14:30-14:45 Kornélia Bodó UNRAVELLING THE HAZARDS OF METAL NANOMATERIALS: COMPARATIVE OBSERVATIONS ON INVERTEBRATE PHAGOCYTES 14:45-15:00 Máté Manczinger PATHOGEN DIVERSITY DRIVES THE EVOLUTION OF GENERALIST ANTIGEN PRESENTATIONIN HUMAN POPULATIONSPRESENTATIONIN HUMAN POPULATIONS Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged 15:00-15:15 Eszter Ágnes Tóth SURFACE CARGO OF BLOOD PLASMA EXTRACELLULAR VESICLES IN INFLAMMATORY AND NON-INFLAMMATORY MICROENVIRONMENTS 15:15-15:30 Ildiko Bodi RELATIONSHIP OF CONGENITAL HEART DISEASE WITH THE STRUCTURE OF HUMAN THYMUS Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest 15:30-15:45 Jia Xinkai CHARACTERIZATION OF THE STROMAL COMPOSITION OF SEROSAL LYMPHOID ORGANOIDS IN MICE 15:45-16:00 Péter Balogh CHEMOKINE-DRIVEN COMPARTMENTALIZATION OF LYMPHOCYTES AND HIGH-GRADE B-CELL LYMPHOMA SUBTYPES IN FOLIATE LYMPHOID AGGREGATES (FLAGS) OF THE SEROSA 16:00-16:15 Eddy van Collenburg Single Cell applications - Every droplet tells a story Bio-Rad Laboratories 16:30-18:00 POSTER SESSION II. & EXHIBITION WITH COFFEE Chairs: Mihály Józsi, Éva Pállinger & BIOCENTER WORKSHOP 18:00-19:00 General assembly 2. 20:00-24:00 GALA DINNER

4 FRIDAY, 19 th OCTOBER :30-10:00 Session VII. COMPLEMENT Session chairs: Zsuzsa Bajtay, Márta Széll 08:30-08:45 Marcell Cserhalmi CHARACTERIZATION OF THE HUMAN FACTOR H-RELATED PROTEIN FHR2 FOR LIGAND INTERACTIONS AND ROLE IN COMPLEMENT ACTIVATION Complement Research Group, Department of Immunology, Eötvös Loránd University, Budapest 08:45-09:00 László Cervenak A NEW LABEL-FREE METHOD REVEALS NOVEL MECHANISMS OF INNATE IMMUNITY 3 rd Department of Internal Medicine, Semmelweis University, Budapest 09:00-09:15 Dóra Bencze HUMAN PLASMACYTOID AND MONOCYTE-DERIVED DENDRITIC CELLS DISPLAY DISTINCT METABOLIC PROFILE UPON RIG-I ACTIVATION 09:15-09:30 Tünde Fekete REGULATORY NLRS CONTROL THE RLR-MEDIATED TYPE I INTERFERON AND INFLAMMATORY RESPONSES IN HUMAN DENDRITIC CELLS 09:30-09:45 Zsolt I. Komlósi THE NUMBER OF CIRCULATING IMMATURE TRANSITIONAL B CELLS CORRELATES WITH THE TYPE 3 INNATE LYMPHOID CELLS IN HEMATOPOIETIC STEM CELL-TRANSPLANTED PATIENTS WITH ACUTE GRAFT-VERSUS-HOST DISEASE 09:45-10:00 Bianca Brandus FHR1 AND FHR5 COMPETE WITH FACTOR H FOR BINDING TO BACTERIAL PROTEINS AND ENHANCE COMPLEMENT ACTIVATION Department of Immunology, Eötvös Loránd University, Budapest 10:00-10:15 COFFEE BREAK 10:15-11:15 Session VIII. IMMUNITY OF EPITHELIA (SKIN, MUCOSAE) AND IMMUNOPATHOLOGY I. Session chairs: Zoltán Szekanecz, Zoltán Pós 10:15-10:30 Zoltán Kellermayer PROTECTION FROM COLITIS IN MICE IN THE ABSENCE OF NKX2.3 TRANSCRIPTION FACTOR IS INDEPENDENT OF IL-22 10:30-10:45 Attila Gábor Szöllősi THE ROLE OF TRANSIENT RECEPTOR POTENTIAL VANILLOID 4 ON MONOCYTE-DERIVED LANGERHANS CELLS 10:45-11:00 Zsolt Dajnoki CONNECTION BETWEEN BARRIER ALTERATIONS AND ADAPTIVE IMMUNE ACTIVITIES IN TOPOGRAPHICALLY DIFFERENT SKIN AREAS Division of Dermatological Allergology, Faculty of Medicine, University of Debrecen 11:00-11:15 Anikó Göblös CARD14 GENE VARIANTS AND NUCLEAR FACTOR κb (NFκB) ACTIVATION IN PITYRIASIS RUBRA PILARIS MTA-SZTE Dermatological Research Group, University of Szeged 11:15-11:30 COFFEE BREAK 11:30-12:15 Session IX. IMMUNITY OF EPITHELIA (SKIN, MUCOSAE) AND IMMUNOPATHOLOGY II. Session chairs: Attila Bácsi, Zoltán Prohászka 11:30-11:45 Márta Széll PRINS LONG NON-CODING RNA REGULATES INTERLEUKIN EXPRESSION IN KERATINOCYTES MTA-SZTE Dermatological Research Group, university of Szeged 11:45-12:00 Tareq Abu-Dakah ORAL TOLERANCE AND REGULATORY T CELL FUNCTION IS IMPAIRED IN MADCAM-1-/- MICE BUT NOT IN NKX2.3-/- MICE 12:00-12:15 Dóra Vojkovics DIFFERENTIAL EFFECTS OF THE ABSENCE OF NKX2-3 AND MADCAM-1 ON THE DISTRIBUTION OF INTESTINAL ILC3 CELLS AND POSTNATAL SILT FORMATION IN MICE

5 12:15-13:00 Presentations of the BioLegend Abstract Award Winners 13:00 Closing ceremony 13:00-14:30 LUNCH

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