FEBS ADVANCED LECTURE COURSE

Transcription

1 FEBS ADVANCED LECTURE COURSE SUNDAY, August 25 From Registration Opening remarks (organizers) Self-presentation of all participants Welcome reception

2 MONDAY, August 26 Karen Knudsen, Eckardt Treuter Faculty meeting (lecturers & organizers) Lecture 1: Myles Brown (Boston, USA), IUBMB Keynote Speaker Epigenetics of nuclear receptor function in cancer Lecture 2: John Schwabe (Leicester, UK) Regulation of HDAC co-repressor complexes by inositol phosphates Lecture 3: Susanne Mandrup (Odense, Denmark) Transcription factor networks regulating adipocyte differentiation and metabolism Short talks 1-6 (5 min talk + 5 min discussion) Lorenza Pasqualini (Innsbruck, Austria) mirnas: novel members of the androgen receptor transcriptome Marina Suhorutshenko (Tallin, Estonia) The potential role of natural dioxin receptor ligands in prostate cancer and male infertility preliminary study using LNCaP cell line Christopher McNair (Philadelphia, USA) Genome-wide analysis of AR-cell cycle interplay reveals novel functions in cancer Marjolein Droog (Amsterdam, the Netherlands) Tamoxifen-driven endometrium cancer is mediated by pioneer factor FOXA1 Aoife Ward (Heidelberg, Germany) The role of a novel microrna cluster, C19MC, in breast cancer Soleilmane Omarjee (Lyon, France) Involvement of ERα-36 in estrogen mediated non-genomic signaling Lecture 4: Iannis Talianidis (Athens, Greece) Epigenetic regulation of hepatic metabolic pathways Lecture 5: Jorma Palvimo (Kuopio, Finland) SUMOylation-regulated gene programs and stress responses of steroid receptors Poster Session I (lecturer-student teams: presentations)

3 TUESDAY, August 27 Knut Steffensen, Jorma Palvimo Lecture 6: Stefan Herzig (Heidelberg, Germany) Nuclear receptor cofactor complexes in systemic lipid homeostasis Lecture 7: Beatrice Desvergne (Lausanne, Switzerland) Metabolic homeostasis and nuclear receptors networking Lecture 8: Eckardt Treuter (Stockholm, Sweden) Epigenetic control of metabolism and inflammation by nuclear receptor coregulators Short talks 7-12 (5 min talk + 5 min discussion) Zuzanna Drebert (Ghent, Belgium) Glucocorticoid receptor modulation impacts the tumor microenvironment Junaid Ali Khan (Paris, France) A new strategy for selective targeting of progesterone receptor with passive antagonists Frank Nylén (Stockholm, Sweden) A novel link between thyroid hormone and innate immunity Muriel Smet (Ghent, Belgium) Liver X Receptors in Th2-driven allergic asthma in mice Bence Daniél (Debrecen, Hungary) Cistromic features of liganded RXR s action in macrophages define a distinct, partly hidden enhancer network Milu Cherian (Memphis, USA) New small molecule inhibitors of Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) action Poster Session II (odd numbers) Poster Session III (even numbers) Lecture 9: Jan-Åke Gustafsson (Houston, USA) Novel roles of LXR beta and ER beta in the central nervous system Tutorial group dinner

4 WEDNESDAY, August 28 Adriana Maggi, Jan-Åke Gustafsson Lecture 10: Barbara Demeneix (Paris, France) Thyroid hormones a link between stem cell renewal and longevity? Lecture 11: Karin Dahlman-Wright (Stockholm, Sweden) Modulation of estrogen signaling in breast cancer cells Lecture 12: Jason Carroll (Cambridge, UK) Understanding estrogen receptor transcription in breast cancer Short talks (5 min talk + 5 min discussion) Fabiana Arieti (Geneva, Switzerland) A SHARP (SMRT/HDAC1 Associated Repressor Protein) look into RNA recognition Tatsiana Sushko (Minsk, Republic of Belarus) The role of microsomal steroid hydroxylases in δ7-steroid biosynthesis Athanasios Stergiopoulos (Athens, Greece) Nuclear receptor NR5A2 regulates proliferation and differentiation of neural stem cells during development via distinct mechanisms Sari Toropainen (Kuopio, Finland) PIAS1 functions as a target gene and pathway selective androgen receptor coregulator in prostate cancer cells Qiong Fan (Oslo, Norway) Interaction of LXR and O-GlcNAc transferase - a bridge between glucose and lipid metabolism? Isabel Forss (Odense, Denmark) The role the transcription factor PPARγ in browning of human adipocytes Beach Workshops (2 x 1 hour: each student chooses two workshops) (1) NRs & metabolic diseases (Desvergnes, Herzig, Maggi, Mandrup, Talianidis) (2) NRs & neurodegenerative diseases (Demeneix, Gustafsson, Heneka) (3) NRs & breast/prostate cancer (Brown, Carroll, Dahlman-Wright, Knudsen) (4) NRs & coregulators: structures, epigenomics, PTMs (Schwabe, Palvimo, Treuter) Lecture 13: Karen Knudsen (Philadelphia, USA) AR signaling and regulation in advanced cancer

5 THURSDAY, August 29 Barbara Demeneix Lecture 14: Michael Heneka (Bonn, Germany) Role of nuclear receptors PPARγ and LXR in neurodegenerative disorders Lecture 15: Adriana Maggi (Milan, Italy) Metabolism and reproduction: an ancestral balance unsettled by aging 11:15-12:00 Last expert opinions (Q/A): How to publish? How to obtain grants (EU/NIH)? Moderators: Barbara Demeneix, Knut Steffensen, Karen Knudsen 12: Concluding remarks, poster and short talk awards, course evaluation, certificates. Individual activities Farewell dinner FRIDAY, August 30 Departure day