Danylo Halytsky Lviv National Medical University
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1 Danylo Halytsky Lviv National Medical University Collaboration opportunities for advanced animal research Prof. Rostyslav Bilyy Department of Histology, Cytology and Embryology
2 Danylo Halytsky Lviv National Medical University (LNMU, web site: The biggest medical university in Western Ukraine, ~ students, 6 Faculties, 75 departments. Big clinical base and research facilities.
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5 Our expertise: Cell death and immune interactions Advanced animal research Micro and nanocomposites in the immune response
6 Joint UA Bavarian Projects: 1. Joint research project Smart amplifiers of reactive oxygen species (ROS) for treatment of inflammatory diseases and cancer Friedrich Alexander Universität Erlangen Prof. Dr. Andriy Mokhir 2. Volkswagenstiftung Grant Sugar coated killers how immunoglobulin glycosylation modifies immunity and autoimmunity Universitätsklinikum Erlangen, Medizinische Klinik 3 Klinikum der Universität München 3. Horizon 2020 project MSCA RISE 2015, Nr Pathogenes and Graphen Partner Universitätsklinikum Erlangen, Medizinische Klinik 3
7 Friedrich Alexander Universität Erlangen Prof. Dr. Andriy Mokhir Smart amplifiers of reactive oxygen species (ROS) for treatment of inflammatory diseases and cancer Collaboration started in 2016 as a result of casual meeting No specific funding ROS-Responsive N-Alkylaminoferrocenes for Cancer-Cell-Specific Targeting of Mitochondria. Reshetnikov V, Daum S, Janko C, Karawacka W, Tietze R, Alexiou C, Paryzhak S, Dumych T, Bilyy R, Tripal P, Schmid B, Palmisano R, Mokhir A. Angew Chem Int Ed Engl Jul 23. doi: /anie Lysosome Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs. Daum S, Reshetnikov MSV, Sisa M, Dumych T, Lootsik MD, Bilyy R, Bila E, Janko C, Alexiou C, Herrmann M, Sellner L, Mokhir A. Angew Chem Int Ed Engl Dec 4;56(49): doi: /anie
8 Universitätsklinikum Erlangen, Medizinische Klinik 3 Prof. Martin Herrmann Dr. Luis Munoz Acquainted in 2003 when both published the similar finding in the same journal Close collaboration since 2007 Joint papers in: Science Nature Medicine PNAS others
9 Klinikum der Universität München Prof. Hans Joachim Anders Joint VW Project Topic editors of special Research Topic in Frontiers in Immunology Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis. Mulay SR, Desai J, Kumar SV, Eberhard JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Bräsen JH, Romagnani P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ. Nature Communication Jan 28;7: doi: /ncomms PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling. Desai J, Kumar SV, Mulay SR, Konrad L, Romoli S, Schauer C, Herrmann M, BilyyR, Müller S, Popper B, Nakazawa D, Weidenbusch M, Thomasova D, Krautwald S, Linkermann A, Anders HJ. Eur J Immunol Jan;46(1): doi: /eji Epub 2015 Nov 30.
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11 We offer collaboration opportunities for advanced animal research: EU Standards Ethical approval within 4 6 weeks Mice, rabbits Unique mice models
12 Advance mouse and rabbit models Innate immunity: DTH, Sepsis, Skin infections, Air pouch, others Tumors: alogeneic and syngeneic IHC Advanced histology Microphotography Thermal imaging
13 We propose custome hardware solutions for most complicated experiments!
14 Experience: Angew Chem Int Ed Engl Jul 23. doi: /anie ACS Appl Mater Interfaces. 2017;9(42). Angew Chem Int Ed Engl Dec 4;56(49): Proc Natl Acad Sci USA Oct 4;113(40):E5856 E5865. Frontiers in Immunology. 2014;5(Nov):560. Scientific Reports Dec 5;6(1): RSC Advances. 2016;6(63). Cell Death Differentiation. 2016;23(6): Eur J Immunology 2016 Jan;46(1): Nature Communications. 2016;7: RSC Advances 6 (2), Nature Medicine Apr 28;20(5): others
15 We are looking for long term collaboration in the areas of inflammation, immunity, cancer treatment and related fields.
16 Danylo Halytsky Lviv National Medical University Collaboration opportunities for advanced animal research Prof. Rostyslav Bilyy
PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling
Eur. J. Immunol. 2016. 46: 223 229 DOI: 10.1002/eji.201545605 Leukocyte signaling 223 SHORT COMMUNICATION PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling
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Supplementary fig. 1. Crystals induce necroptosis does not involve caspases, TNF receptor or NLRP3. A. Mouse tubular epithelial cells were pretreated
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