Human Papillomavirus
|
|
- Joel Newton
- 6 years ago
- Views:
Transcription
1 Human Papillomavirus
2 Alberto Rosenblatt Homero Gustavo de Campos Guidi Human Papillomavirus A Practical Guide for Urologists
3 Alberto Rosenblatt, MD Hospital Israelita Albert Einstein Av. Albert Einstein 627/701 São Paulo-SP Brazil Homero Gustavo de Campos Guidi, MD, PhD Rua Teodoro Sampaio 744 São Paulo-SP 14th Floor Brazil ISBN: e-isbn: DOI: / Library of Congress Control Number: Springer-Verlag Berlin Heidelberg 2009 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: estudiocalamar, Figueres/Berlin Printed on acid-free paper springer.com
4 This book is dedicated to our beloved parents Agostinha and Mayer Rosenblatt Isaura Guidi and Domingos Guidi and to Sophie and Fernanda for their constant support in every step of our lives.
5 Foreword The award of the Nobel Prize in Medicine to Professor Harald zur Hausen in 2008 represented one of the most auspicious recognitions in the field of cancer prevention. Zur Hausen s pioneer work unleashed an entire domain of research on the molecular biology of human papillomavirus (HPV) and on its interaction with the human host. His work permitted the characterization of HPV infection as the cause of the vast majority of cervical cancers and of a large proportion of anogenital and upper aerodigestive tract malignancies. Understanding the unequivocal role of HPV infection in carcinogenesis led to two new fronts in cervical cancer prevention, namely, (i) the development of diagnostic assays for HPV DNA, which are now being incorporated into cervical cancer screening programs worldwide, and (ii) the regulatory approval of the first prophylactic HPV vaccines to prevent HPV infections with the genotypes of HPV that cause most cases of cervical cancer. The burden of morbidity and mortality from cancers associated with HPV infection is greatest in developing cancers. Cervical cancer is the second most common cancer in women worldwide and the most common in many developing countries in Latin America, equatorial Africa, and in Southeast Asia. These countries now have a renewed hope in controlling a disease that has been very difficult to prevent via traditional Pap cytology screening, an undertaking that has worked well only in highresource countries. One of the new vaccines also prevents the HPV types that cause the majority of genital warts and low-grade lesions of the lower genital tract. Such HPV types are also responsible for laryngeal papillomatosis. Collectively, these diseases, albeit classified as benign, are responsible for much suffering and loss of quality of life throughout the world. In all, the spectrum of malignant and benign diseases that can be prevented by the new prophylactic HPV vaccines affects women, men, and children everywhere, and leads to major healthcare expenditures related to diagnosis, management, and treatment. In this book, Drs. Alberto Rosenblatt and Homero Gustavo de Campos Guidi have devoted considerable care in providing a comprehensive overview of the pathogenesis, diagnosis, treatment, and prevention of diseases causally associated with HPV infections. In many chapters, the authors also summarize the literature about diseases in which HPV seems to be an incidental finding and whose specific role has not yet been elucidated. As experienced, practicing urologists, Drs. Rosenblatt and Guidi provided a richly illustrated guide that clinicians will find very useful as an easy to navigate, yet authoritative reference to the diagnosis and treatment of HPVassociated diseases. Although the emphasis is on the urologist s approach to disease management, this book will also be appreciated by gynecologists, dermatologists, vii
6 viii Foreword pediatricians, and infectious disease specialists. The authors also enlisted the contribution of two renowned colleagues, Drs. Luisa Villa and Simon Horenblas, for two chapters on laboratory detection methods and penile neoplasia, respectively. Clinical and sub-clinical HPV infections are the most common sexually transmitted diseases. Although there is justifiable enthusiasm in the public health community with the novel prophylactic vaccines and sensitive screening tools, many challenges lie ahead. The science on preventive and therapeutic approaches to curb the burden of HPV diseases has grown exponentially in recent years. Clinicians need a practical guide to allow them to sift through the new methods that have passed the scrutiny of evidence-based medicine and can thus be used in the care of their patients. The authors, Drs. Rosenblatt and Guidi, and Springer, the publisher, are to be commended for Human Papillomavirus A Practical Guide for Urologists, a contribution that fills this need with high scholarly value. Montreal, Canada Eduardo L. Franco
7 Preface We are what we repeatedly do. Excellence, then, is not an act, but a habit. Aristotle Human papillomavirus infection is a globally widespread disease that affects young people and adults without sexual distinction. The sexually transmitted virus is responsible for the development of benign anogenital lesions as well as several premalignant and malignant anogenital and nongenital disorders. Although obstetricians/gynecologists, urologists, and dermatologists are the medical specialists most often involved in the management of HPV-related diseases, practitioners in general ought to have a comprehensive understanding of the challenges caused by this infective agent. The interested reader will find in the chapters of this practical guide all the current information concerning HPV and associated anogenital diseases, with particular emphasis on the management of the infected male. Premalignant and malignant penile neoplasias as well as current management of anal and cervical intraepithelial disease are also reviewed in this book, providing the readers with an authoritative wealth of updated data. The addition of practically oriented tables and numerous colored figures provides quick access to the objective information, which is supported with over 800 references. It is expected that the burden of HPV infection and associated diseases will certainly be reduced with the advent of current prophylactic vaccines. However, HPV infection is a recurrent disorder and this book will enable practitioners in general to understand and manage the male s most common genital-related disorders. São Paulo, Brazil Alberto Rosenblatt Homero Gustavo de Campos Guidi ix
8 Acknowledgments The authors acknowledge with deep appreciation Prof. Simon Horenblas and Dr. Luisa Lina Villa for their valuable contribution to this book. Prof. Horenblas s vast expertise in penile cancer and Dr. Villa s acclaimed investigative work with human papillomavirus provide us with two key chapters where updates on penile neoplasia and the current laboratory investigation of human papilloma virus are presented. We express our gratitude to Dr. Carlos Walter Sobrado Jr., Dr. Sidney Roberto Nadal, Dr. Maricy Tacla, Dr. Marcia Jacomelli, Dr. Reinaldo J. Gusmão, Dr. Toshiro Tomishige, Dr. Monica Stiepcich, Dr. Rubens Pianna de Andrade, Dr. Libby Edwards, Prof. Robert A. Schwartz, Prof. Gerd Gross, and Prof. Gino Fornaciari for their generous contribution providing the innumerous and valuable figures that illustrate the chapters of the book. We also specially thank Prof. Filomena Marino Carvalho for her significant insights regarding the nomenclature of genital squamous intraepithelial lesions as well as the illustrative cytology and histopathology slides, and Dr. Nadir Oyakawa, a pioneer in the field of HPV-related diseases in women and who prematurely left us at the height of her scientific career. We thank the publishers who kindly gave us copyright permissions for the use of figures in this book. Finally, we are deeply grateful to all the staff at Springer involved in the creation of this book, in particular, Ute Heilmann (Editorial Director, Clinical Medicine), Annette Hinze (Editor, Clinical Medicine), Wilma McHugh (Project Coordinator), and Dörthe Mennecke-Bühler (Assistant Editor, Clinical Medicine) for their professionalism, friendship, and guidance along the path to publication. We also thank Nandini Loganathan and the staff at SPi for their excellent job with the production of this book. xi
9 Contents Part I Human Papillomavirus Facts and Novel Detection Methods 1 Human Papillomavirus History and Epidemiology Introduction Historical Perspective Epidemiology HPV in Women HPV in Men HPV Transmission Modes Prevention References Laboratory Methods for Detection of Human Papillomavirus Infection Introduction HPV DNA Methods HPV RNA Methods Serological Assays Detecting HPV Infection in Men References Part II Human Papillomavirus and Urological-Associated Diseases 3 Human Papillomavirus and External Genital Lesions Introduction Overview Clinical Manifestations Differential Diagnosis Detection Methods Treatment Other Treatment Modalities Management of Latent and Subclinical HPV Infection Circumcision and HPV Follow-Up Prevention References xiii
10 xiv Contents 4 Human Papillomavirus-Associated Lesions of the Urinary Tract Introduction Overview Clinical Manifestations Differential Diagnosis Detection Methods Treatment Follow-Up Prevention The Role of HPV in Urethral, Bladder, Renal, and Prostate Cancer Development References Human Papillomavirus and Penile Intraepithelial Neoplasia Introduction Terminology Overview Multifocal Intraepithelial Neoplasia (Bowenoid Papulosis) Bowen s Disease Erythroplasia of Queyrat (Unifocal Intraepithelial Neoplasia) Penile Lichen Sclerosus Penile Horn Genital Paget s Disease Kaposi s Sarcoma PIN Prevention References Human Papillomavirus and Squamous Cell Carcinoma of the Penis Introduction Natural History of HPV in Male Subjects Etiology of Squamous Cell Cancer of the Penis Molecular Pathogenesis Prevention of HPV Infection HPV as a Prognostic Indicator in Penile Cancer Conclusion References Part III Human Papillomavirus and Other Anogenital Premalignant Diseases 7 Human Papillomavirus and Anal Intraepithelial Neoplasia Introduction Overview Clinical Manifestations Differential Diagnosis Diagnosis Treatment for Anogenital Warts and AIN Surveillance Anal Disease Screening Prevention of HPV-Related Anal Warts and AIN References
11 xv Contents 8 Human Papillomavirus and Cervical Intraepithelial Neoplasia Introduction Overview Terminology and Grading of Cervical Dysplastic Lesions Risk Factors for Cervical Cancer Development Natural History of Cervical Dysplastic Lesions Clinical Manifestations Diagnosis Treatment for HSIL and CIN Treatment Modalities Post-treatment Follow-Up Prevention Screening References Part IV Human Papillomavirus Infection and Immunosuppression 9 Human Papillomavirus Infection in HIV-Infected Individuals Introduction Overview HPV Infectious Cycle Effects of Host Immune Status on the Risk of HPV Infection Host Immune Evasion Methods of HPV HPV Infection in Immunosuppressed Individuals Relationship Between Declining CD4 + Levels, HPV Infection, and Anogenital Cancers Relationship Between HIV/HPV Coinfection and CIN/Cervical Cancer Relationship Between HIV/HPV Coinfection and AIN/Anal Cancer HAART in HPV-Associated Neoplasias HAART in HPV-Associated Cervical Disease HAART in HPV-Associated Anal Disease HAART in HPV-Associated Oral Disease Surveillance Considerations Regarding HPV Prophylactic and Therapeutic Vaccines in HIV-Infected Individuals References Part V Human Papillomavirus - Laser Treatment and Prevention 10 Human Papillomavirus and CO 2 Laser Treatment Introduction Historic Background CO 2 Laser Components CO 2 Laser Beam CO 2 Laser Indications Personal Laser Technique References Human Papillomavirus Vaccines Introduction HPV: An Overview
12 xvi Contents 11.3 A Short Introduction to Papillomavirus Biology Significance of HPV Proteins in the Generation of Prophylactic and Therapeutic HPV Vaccines Natural History of HPV Antibodies Prophylactic HPV Vaccination HPV Vaccination: Issues to Be Addressed Prophylactic HPV Vaccines in Men Therapeutic HPV Vaccination and Future Vaccine Developments References Index
Urinary Tract Infection
Urinary Tract Infection Abhay Rané Ranan Dasgupta Editors Urinary Tract Infection Clinical Perspectives on Urinary Tract Infection Editors Abhay Rané, MS, FRCS, FRCS (Urol) Department of Urology Surrey
More informationCone Beam CT of the Head and Neck
Cone Beam CT of the Head and Neck Chung How Kau Kenneth Abramovitch Sherif Galal Kamel Marko Bozic Cone Beam CT of the Head and Neck An Anatomical Atlas Professor Chung How Kau University of Alabama Birmingham
More informationImaging of Urinary Tract Diverticula
Imaging of Urinary Tract Diverticula Vladimir M. Builov Imaging of Urinary Tract Diverticula Vladimir M. Builov Department of X-Ray and MRI RailWay Clinical Hospital Yaroslavl Russia ISBN 978-3-319-05382-0
More informationDermatological Diseases of the Nose and Ears
Dermatological Diseases of the Nose and Ears Can Baykal K. Didem Yazganoğlu Dermatological Diseases of the Nose and Ears An Illustrated Guide Prof. Dr. Can Baykal Dr. K. Didem Yazganoğlu Istanbul University
More informationAlexander N. Sencha Elena V. Evseeva Mikhail S. Mogutov Yury N. Patrunov. Breast Ultrasound
Breast Ultrasound Alexander N. Sencha Elena V. Evseeva Mikhail S. Mogutov Yury N. Patrunov Breast Ultrasound Alexander N. Sencha Department of Ultrasound Diagnostics Yaroslavl Railway Clinic Yaroslavl
More informationDifferential Diagnosis of Movement Disorders in Clinical Practice
Differential Diagnosis of Movement Disorders in Clinical Practice Abdul Qayyum Rana Peter Hedera Differential Diagnosis of Movement Disorders in Clinical Practice Abdul Qayyum Rana Parkinson's Clinic
More informationMEDICAL RADIOLOGY Diagnostic Imaging
I MEDICAL RADIOLOGY Diagnostic Imaging Editors: A. L. Baert, Leuven K. Sartor, Heidelberg II Contents Springer Berlin Heidelberg New York Hong Kong London Milan Paris Tokyo III A. Adam R. F. Dondelinger
More informationSPRINGER BRIEFS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. Gerhard Bauer Joseph S. Anderson. Gene Therapy for HIV From Inception to a Possible Cure
SPRINGER BRIEFS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY Gerhard Bauer Joseph S. Anderson Gene Therapy for HIV From Inception to a Possible Cure 123 SpringerBriefs in Biochemistry and Molecular Biology For
More informationRadiology Illustrated
Radiology Illustrated For further volumes: http://www.springer.com/series/11755 In-One Kim Editor Radiology Illustrated: Pediatric Radiology Editor In-One Kim, M.D. Department of Radiology Seoul National
More informationVaricella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus
Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus Helena M. Tabery Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus In Vivo Morphology in the Human Cornea
More informationINTRODUCTION HUMAN PAPILLOMAVIRUS
INTRODUCTION HUMAN PAPILLOMAVIRUS Professor Anna-Lise Williamson Institute of Infectious Disease and Molecular Medicine, University of Cape Town National Health Laboratory Service, Groote Schuur Hospital
More informationIn Clinical Practice
In Clinical Practice Taking a practical approach to clinical medicine, this series of smaller reference books is designed for the trainee physician, primary care physician, nurse practitioner and other
More informationHuman Papillomavirus
Human Papillomavirus Dawn Palaszewski, MD Assistant Professor of Obstetrics and Gynecology University of February 18, 2018 9:40 am Dawn Palaszewski, MD Assistant Professor Department of Obstetrics and
More informationAdvances in Anatomy Embryology and Cell Biology
Advances in Anatomy Embryology and Cell Biology Vol. 175 Editors F. Beck, Melbourne B. Christ, Freiburg W. Kriz, Heidelberg E. Marani, Leiden W. Kummer, Gießen R. Putz, München Y. Sano, Kyoto T. H. Schiebler,
More informationF.C. Shakhtatinskaya, L.S. Namazova-Baranova, V.K. Tatochenko, D.A. Novikova, T.E. Tkachenko
F.C. Shakhtatinskaya, L.S. Namazova-Baranova, V.K. Tatochenko, D.A. Novikova, T.E. Tkachenko Scientific Center of Children s Health, Moscow, Russian Federation Human Papilloma Virus. Prevention of HPV-Associated
More informationCongenital Hip Disease in Adults
Congenital Hip Disease in Adults George Hartofilakidis George C. Babis Kalliopi Lampropoulou-Adamidou Congenital Hip Disease in Adults George Hartofilakidis, MD, FACS Orthopaedic Department Medical School
More informationRadiation Therapy for Skin Cancer
Radiation Therapy for Skin Cancer Armand B. Cognetta Jr. William M. Mendenhall Editors Radiation Therapy for Skin Cancer Editors Armand B. Cognetta Jr. Dermatology Associates of Tallahassee Chief, Division
More informationRespiratory Medicine Series Editor: Sharon I.S. Rounds. Marc A. Judson Editor. Pulmonary Sarcoidosis A Guide for the Practicing Clinician
Respiratory Medicine Series Editor: Sharon I.S. Rounds Marc A. Judson Editor Pulmonary Sarcoidosis A Guide for the Practicing Clinician Respiratory Medicine Series Editor: Sharon I.S. Rounds For further
More informationErrors. Uroradiology. Manuel Viamonte Jr. Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Manuel Viamonte Jr. Errors In Uroradiology With 148 Figures (41 Cases) in 173 Separate Illustrations Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Prof. Manuel
More informationIntraoperative Ultrasound Imaging in Neurosurgery
Ludwig M.Auer Vera Van Velthoven Intraoperative Ultrasound Imaging in Neurosurgery Comparison with CT and MRI With 466 Figures in 547 Separate Illustrations Springer-Verlag Berlin Heidelberg New York London
More informationLouise Grech Alan Lau Editors. Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis. From Hospital to Community
Louise Grech Alan Lau Editors Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis From Hospital to Community Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis Louise Grech
More informationMonographs. Series Editor: U. Veronesi
Monographs Series Editor: U. Veronesi The European School of Oncology gratefully acknowledges financial support for the production of this monograph received from Farmacia (Hellas) SA, Schering-Plough
More informationAtlas of Lymph Node Anatomy
Atlas of Lymph Node Anatomy Mukesh G. Harisinghani Editor Atlas of Lymph Node Anatomy This publication was developed through an unrestricted educational grant from Siemens. Editor Mukesh G. Harisinghani
More informationJohn Papadopoulos David R. Schwartz Consulting Editor. Pocket Guide to Critical Care Pharmacotherapy Second Edition
John Papadopoulos David R. Schwartz Consulting Editor Pocket Guide to Critical Care Pharmacotherapy Second Edition 123 Pocket Guide to Critical Care Pharmacotherapy John Papadopoulos Author David R. Schwartz
More informationFerrozzi. Garlaschi. Bova CT of Metastases
Ferrozzi. Garlaschi. Bova CT of Metastases Springer Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Singapore Tokyo F. Ferrozzi. G. Garlaschi. D. Bova CT of Metastases With a Foreword
More informationWhite Coat Hypertension
White Coat Hypertension Giuseppe Mancia Guido Grassi Gianfranco Parati Alberto Zanchetti White Coat Hypertension An Unresolved Diagnostic and Therapeutic Problem Giuseppe Mancia Emeritus Professor University
More informationMR Mammography (MRM) Werner A. Kaiser. Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Werner A. Kaiser MR Mammography (MRM) With 648 Figures and 25 Tables Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Priv.-Doz., Dr. med., Dipl.-Chem. Werner
More informationPharmaceutical Care Issues of Patients with Rheumatoid Arthritis
Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis Louise Grech Alan Lau Editors Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis From Hospital to Community Editors Louise
More informationPractical Case Studies in Hypertension Management. Series editor: Giuliano Tocci Rome Italy
Practical Case Studies in Hypertension Management Series editor: Giuliano Tocci Rome Italy The aim of the book series Practical Case Studies in Hypertension Management is to provide physicians who treat
More informationIndirect Questioning in Sample Surveys
Indirect Questioning in Sample Surveys Arijit Chaudhuri Tasos C. Christofides Indirect Questioning in Sample Surveys 123 Arijit Chaudhuri Applied Statistics Unit Indian Statistical Institute Kolkata,
More informationCristina Nanni Stefano Fanti. PET-CT: Rare Findings and Diseases
Cristina Nanni Stefano Fanti PET-CT: Rare Findings and Diseases Cristina Nanni Stefano Fanti PET-CT: Rare Findings and Diseases Dr. Cristina Nanni Ospedale S. Orsola-Malpighi Dept. of Nuclear Medicine
More informationMRI of Rectal Cancer
MRI of Rectal Cancer Arnd-Oliver Schäfer Mathias Langer MRI of Rectal Cancer Clinical Atlas Prof. Dr. Arnd-Oliver Schäfer Department of Diagnostic Radiology Freiburg University Hospital Hugstetter Straße
More informationExercises in Radiological Diagnosis
Exercises in Radiological Diagnosis Michel Runge Bones and Joints 170 Radiological Exercises for Students and Practitioners With 407 Illustrations Springer-Verlag Berlin Heidelberg New York London Paris
More informationAbdominal & Small Parts Sonography
i ii SOUNDWAY, INCORPORATED P.O. Box 126 Media, PA 19063 Abdominal & Small Parts Sonography A Comprehensive Study ISBN 978-1-4951-0847-1 Copyright 2014, SoundWay, Incorporated. All rights reserved. No
More informationRadiation Therapy for Head and Neck Cancers
Radiation Therapy for Head and Neck Cancers Murat Beyzadeoglu Gokhan Ozyigit Ugur Selek Editors Radiation Therapy for Head and Neck Cancers A Case-Based Review Editors Murat Beyzadeoglu, MD Professor
More informationEfim Benenson. Rheumatology. Clinical Scenarios. Syndrome or disease?
Rheumatology Efim Benenson Rheumatology Clinical Scenarios Syndrome or disease? Author Efim Benenson, MD Professor of Medicine Department of Internal Medicine University of Cologne Cologne Germany The
More informationMedical and Surgical Complications of Sickle Cell Anemia
Medical and Surgical Complications of Sickle Cell Anemia Ahmed Al-Salem Medical and Surgical Complications of Sickle Cell Anemia Ahmed Al-Salem Department of Surgery Dar A lalafia Medical Company Qatif
More informationPlanning and Care for Children and Adolescents with Dental Enamel Defects
Planning and Care for Children and Adolescents with Dental Enamel Defects Etiology, Research and Contemporary Management Bernadette K. Drummond Nicola Kilpatrick Editors 123 Planning and Care for Children
More informationNeurobiological Bases of Abnormal Aggression and Violent Behaviour
Neurobiological Bases of Abnormal Aggression and Violent Behaviour . József Haller Neurobiological Bases of Abnormal Aggression and Violent Behaviour József Haller Department of Behavioral Neurobiology
More informationPost-Transplant Lymphoproliferative Disorders
Post-Transplant Lymphoproliferative Disorders Vikas R. Dharnidharka Michael Green Steven A. Webber (Eds.) Post-Transplant Lymphoproliferative Disorders Vikas R. Dharnidharka, MD, MPH Associate Professor
More informationHandbook for Venous Thromboembolism
Handbook for Venous Thromboembolism Gregory Piazza Benjamin Hohlfelder Samuel Z. Goldhaber Handbook for Venous Thromboembolism Gregory Piazza Cardiovascular Division Harvard Medical School Brigham and
More informationMorphological Aspects of Inner Ear Disease
Morphological Aspects of Inner Ear Disease Yasuya Nomura Morphological Aspects of Inner Ear Disease Yasuya Nomura President The Society for Promotion of International Oto-Rhino-Laryngology Tokyo, Japan
More informationSmall Supernumerary Marker Chromosomes (ssmc)
Small Supernumerary Marker Chromosomes (ssmc) . Thomas Liehr Small Supernumerary Marker Chromosomes (ssmc) A Guide for Human Geneticists and Clinicians With contributions by Unique (The Rare Chromosome
More informationNon-Idiopathic Spine Deformities in Young Children
Non-Idiopathic Spine Deformities in Young Children Muharrem Yazici Editor Non-Idiopathic Spine Deformities in Young Children Editor Muharrem Yazici, MD Department of Orthopedics Hacettepe University Faculty
More informationThomas Reinhard Frank Larkin Editors. Corneal Disease. Recent Developments in Diagnosis and Therapy
Corneal Disease Thomas Reinhard Frank Larkin Editors Corneal Disease Recent Developments in Diagnosis and Therapy Editors Prof. Dr. med. Thomas Reinhard University Eye Hospital Freiburg Germany Dr. Frank
More informationEvidence-Based Forensic Dentistry
Evidence-Based Forensic Dentistry Balwant Rai Jasdeep Kaur Evidence-Based Forensic Dentistry Authors Balwant Rai Earth and Life Sciences Vrije Universiteit Amsterdam and ILEWG Amsterdam The Netherlands
More informationProgress in Social Psychiatry in Japan
Progress in Social Psychiatry in Japan Yoshibumi Nakane Progress in Social Psychiatry in Japan An Approach to Psychiatric Epidemiology Yoshibumi Nakane Department of Neuropsychiatry Nagasaki University
More informationLocal Flaps in Facial Reconstruction
Local Flaps in Facial Reconstruction Velupillai Ilankovan Madan Ethunandan Tian Ee Seah Local Flaps in Facial Reconstruction A Defect Based Approach Velupillai Ilankovan Poole Hospital NHS Foundation
More informationSurgical Techniques for Kidney Cancer
Surgical Techniques for Kidney Cancer Rakesh V. Khanna Gennady Bratslavsky Robert J. Stein Editors Surgical Techniques for Kidney Cancer 123 Editors Rakesh V. Khanna Department of Urology SUNY Upstate
More informationAtlas of Bone Scintigraphy in the Developing Paediatric Skeleton
Klaus Hahn Sibylle Fischer Isky Gordon Atlas of Bone Scintigraphy in the Developing Paediatric Skeleton The Normal Skeleton, Variants and Pitfalls In Collaboration with J. Guillet, A. Piepsz, I. Roca and
More informationTadaaki Kirita Ken Omura Editors. Oral Cancer. Diagnosis and Therapy
Oral Cancer Tadaaki Kirita Ken Omura Editors Oral Cancer Diagnosis and Therapy Editors Tadaaki Kirita Department of Oral and Maxillofacial Surgery Nara Medical University Nara, Japan Ken Omura Oral Cancer
More informationMorbid Obesity in Adolescents
Morbid Obesity in Adolescents ThiS is a FM Blank Page Kurt Widhalm Gerhard Prager Editors Morbid Obesity in Adolescents Conservative Treatment and Surgical Approaches Editors Kurt Widhalm Department of
More informationProgressive Multiple Sclerosis
Progressive Multiple Sclerosis Alastair Wilkins Editor Progressive Multiple Sclerosis Editor Alastair Wilkins, M.A., M.B., B.Chir, Ph.D., FRCP Department of Neurology Frenchay Hospital Bristol UK ISBN
More informationAtlas of Peripheral Nerve Ultrasound
Atlas of Peripheral Nerve Ultrasound Siegfried Peer Hannes Gruber Editors Atlas of Peripheral Nerve Ultrasound With Anatomic and MRI Correlation Editors Siegfried Peer CTI GesmbH Klostergasse 4 Innsbruck
More informationPractical Case Studies in Hypertension Management. Series editor Giuliano Tocci Rome, Italy
Practical Case Studies in Hypertension Management Series editor Giuliano Tocci Rome, Italy The aim of the book series Practical Case Studies in Hypertension Management is to provide physicians who treat
More informationCytologyin Gynecological Practice
P. Stoll G. Dallenbach-Hellweg Cytologyin Gynecological Practice An Atlas of Phase-Contrast Microscopy Second Edition with 149 Figures Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong
More informationBenign Breast Diseases
Catherine N. Chinyama Benign Breast Diseases Radiology Pathology Risk Assessment Second Edition 123 Benign Breast Diseases Catherine N. Chinyama Benign Breast Diseases Radiology - Pathology - Risk Assessment
More informationApplications. in Oncology
Kewal K. Jain Applications of Biotechnology in Oncology Applications of Biotechnology in Oncology Applications of Biotechnology in Oncology Kewal K. Jain, MD, FRACS, FFPM Jain PharmaBiotech, Basel, Switzerland
More informationInteraction Between. Mental and Physical. Needed Areas of Research. Edited by R. Ohman H. L. Freeman A. Franck Holmkvist S.
Interaction Between Mental and Physical Illness Needed Areas of Research Edited by R. Ohman H. L. Freeman A. Franck Holmkvist S. Nielzen In Collaboration with Members of the EMRC Study Group on Mental
More informationSpringerBriefs in Cancer Research
SpringerBriefs in Cancer Research For further volumes: http://www.springer.com/series/10786 Natalia Aptsiauri Angel Miguel Garcia-Lora Teresa Cabrera MHC Class I Antigens In Malignant Cells Immune Escape
More informationMusculoskeletal Health in Women
Musculoskeletal Health in Women Elinor Mody Elizabeth Matzkin Editors Musculoskeletal Health in Women Editors Elinor Mody, MD Department of Rheumatology Gretchen and Edward Fish Center for Women s Health
More informationQuality Assurance Program on Stereotactic Radiosurgery
Quality Assurance Program on Stereotactic Radiosurgery Springer Berlin Heidelberg New York Barcelona Budapest Hong Kong London Milan Paris Tokyo Gunther H. Hartmann Quality Assurance Program on Stereotactic
More informationMuscle Pain: Understanding the Mechanisms
Muscle Pain: Understanding the Mechanisms Siegfried Mense l Editors Robert D. Gerwin Muscle Pain: Understanding the Mechanisms Editors Prof. Dr. Siegfried Mense Universität Heidelberg Medizinische Fakultät
More informationTemperature Regulation in Humans and Other Mammals
Temperature Regulation in Humans and Other Mammals Springer Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Singapore Tokyo Claus Jessen Temperature Regulation in Humans and Other Mammals
More informationEmerging Concepts of Tumor Exosome Mediated Cell Cell Communication
Emerging Concepts of Tumor Exosome Mediated Cell Cell Communication Huang-Ge Zhang Editor Emerging Concepts of Tumor Exosome Mediated Cell Cell Communication 2123 Editor Huang-Ge Zhang University of Louisville
More informationSexually Transmissible Infections in Clinical Practice
Sexually Transmissible Infections in Clinical Practice Alexander McMillan Sexually Transmissible Infections in Clinical Practice A Problem-Based Approach 123 Alexander McMillan, MD, FRCP Formerly, Consultant
More informationTrauma Biomechanics. Third Edition
Trauma Biomechanics Third Edition Kai-Uwe Schmitt Peter F. Niederer Markus H. Muser Felix Walz Trauma Biomechanics Accidental Injury in Traffic and Sports Third Edition 123 PD Dr. Kai-Uwe Schmitt Prof.
More informationMastering Rhinoplasty: A Comprehensive Atlas of Surgical Techniques with Integrated Video Clips. Rollin K. Daniel
Mastering Rhinoplasty: A Comprehensive Atlas of Surgical Techniques with Integrated Video Clips Rollin K. Daniel Rollin K. Daniel Mastering Rhinoplasty A Comprehensive Atlas of Surgical Techniques with
More informationPsychopharmacology Series 8
Psychopharmacology Series 8 Methodology of the Evaluation of Psychotropic Drugs Edited by O. Benkert, W. Maier, and K. Rickels With 19 Figures Springer-Verlag Berlin Heidelberg New York London Paris Tokyo
More informationGynecologic Oncology
Gynecologic Oncology Ramez N. Eskander Robert E. Bristow Editors Gynecologic Oncology A Pocketbook Editors Ramez N. Eskander, M.D. Assistant Professor Division of Gynecologic Oncology Department of Obstetrics
More informationMinimally Invasive Gynecological Surgery
Minimally Invasive Gynecological Surgery O l av Is t re Editor Minimally Invasive Gynecological Surgery Editor Olav Istre, MD, PhD Fredriksberg Denmark ISBN 978-3-662-44058-2 ISBN 978-3-662-44059-9 (ebook)
More informationKai-Uwe Schmitt. Peter F. Niederer Felix Walz. Trauma Biomechanics. Introduetion to Aecidentallnjury. ~ Springer
Trauma Biomechanics Kai-Uwe Schmitt. Peter F. Niederer Felix Walz Trauma Biomechanics Introduetion to Aecidentallnjury ~ Springer PD Dr. KAI-UWE SCHMITT Prof. Dr. sc. techno PETER F. NIEDERER Prof. Dr.
More informationMark W.J. Strachan Brian M. Frier. Insulin Therapy. A Pocket Guide
Insulin Therapy Mark W.J. Strachan Brian M. Frier Insulin Therapy A Pocket Guide Mark W.J. Strachan, MD, FRCP (Ed) Metabolic Unit Western General Hospital Edinburgh United Kingdom Brian M. Frier, MD,
More informationIatrogenic Effects of Orthodontic Treatment
Iatrogenic Effects of Orthodontic Treatment Roberto Justus Iatrogenic Effects of Orthodontic Treatment Decision-Making in Prevention, Diagnosis, and Treatment Roberto Justus Department of Orthodontics
More informationHPV AND CERVICAL CANCER
HPV AND CERVICAL CANCER DR SANDJONG TIECHOU ISAAC DELON Postgraduate Training in Reproductive Health Research Faculty of Medicine, University of Yaoundé 2007 INTRODUCTION CERVICAL CANCER IS THE SECOND
More informationVulvovaginal Candidosis
Werner Mendling Vulvovaginal Candidosis Theory and Practice Foreword by H. Rieth With 168 Figures, Most in Color Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Dr. Werner Mendling Frauenklinik
More informationCerebral Blood Flow, Metabolism, and Head Trauma
Cerebral Blood Flow, Metabolism, and Head Trauma Christian W. Kreipke Editors Jose A. Rafols Cerebral Blood Flow, Metabolism, and Head Trauma The Pathotrajectory of Traumatic Brain Injury Editors Christian
More informationCytology and Surgical Pathology of Gynecologic Neoplasms
Cytology and Surgical Pathology of Gynecologic Neoplasms Current Clinical Pathology ANTONIO GIORDANO, MD, PHD SERIES EDITOR For further titles published in this series, go to http://www.springer.com/springer/series/7632
More informationAIDS Testing Methodology and Management Issues
AIDS Testing Gerald Schochetman J. Richard George Editors AIDS Testing Methodology and Management Issues Foreword by Walter R. Dowdle With 38 Illustrations Springer-Verlag New York Berlin Heidelberg London
More informationRecurrent Erosion Syndrome and Epithelial Edema
Recurrent Erosion Syndrome and Epithelial Edema Helena M. Tabery Recurrent Erosion Syndrome and Epithelial Edema In Vivo Morphology in the Human Cornea Helena M. Tabery, MD Malmö Sweden helena.tabery@telia.com
More informationONCOGENIC BALANITIS. G. Tchernev 1, J. Ananiev 2, J. C. Cardoso 3, S. Philipov 4 and U. Wollina 5
ONCOGENIC BALANITIS G. Tchernev 1, J. Ananiev 2, J. C. Cardoso 3, S. Philipov 4 and U. Wollina 5 1 Polyclinic for Dermatology and Venerology, University Hospital Lozenetz, Saint Kliment Ohridski University,
More informationEsthetic and Functional Management of Diastema
Esthetic and Functional Management of Diastema Ugur Erdemir Esra Yildiz Editors Esthetic and Functional Management of Diastema A Multidisciplinary Approach Editors Ugur Erdemir Faculty of Dentistry University
More informationB.M. Henz T. Zuberbier. J. Grabbe E. Monroe (Eds.):
B.M. Henz T. Zuberbier. J. Grabbe E. Monroe (Eds.): URTICARIA Springer Berlin Heidelberg New York Barcelona Budapest Hong-Kong London Milan Paris Santa Clara Singapore Tokyo B.M. Henz T. Zuberbier J. Grabbe
More informationPreface to the Second Edition
Preface to the Second Edition This second edition of Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach follows a number of favorable comments we received about the first edition. As
More informationNeuroblastoma. mibg in its Diagnosis and Management. Judy Moyes' V. Ralph McCready Ann Fullbrook
Judy Moyes' V. Ralph McCready Ann Fullbrook Neuroblastoma mibg in its Diagnosis and Management With 241 Figures Springer-Verlag London Berlin Heidelberg New York Paris Tokyo Judy S.E. Moyes. MA (Cantab).
More informationDiagnostic Imaging of the Liver
S. Sakuma T. Ishigaki T. Takeuchi Diagnostic Imaging of the Liver Biliary Tract and Pancreas Data Analysis and Diagnostic Procedures With 312 Figures in 932 Separate Illustrations Springer-Verlag Berlin
More informationCLINICAL GASTROENTEROLOGY
CLINICAL GASTROENTEROLOGY Series Editor George Y. Wu University of Connecticut Health Center, Farmington, CT, USA For further volumes: http://www.springer.com/series/7672 Elizabeth J. Carey Keith D. Lindor
More informationVasilis Vasiliou. Q. Max Guo. Alcohol and Cancer
Alcohol and Cancer Samir Zakhari Editors Vasilis Vasiliou Q. Max Guo Alcohol and Cancer Editors Samir Zakhari, Ph.D. Director Division of Metabolism and Health Effects National Institute on Alcohol Abuse
More informationMitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy
Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy Dhyan Chandra Editor Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy 1 3 Editor Dhyan Chandra, Associate
More informationDesmond P. Kidd. Neuro-Ophthalmology. Illustrated Case Studies
Neuro-Ophthalmology Desmond P. Kidd Neuro-Ophthalmology Illustrated Case Studies Desmond P. Kidd Department of Clinical Neurosciences Royal Free Hospital London UK ISBN 978-1-4471-2409-2 DOI 10.1007/978-1-4471-2410-8
More informationMedication-Related Osteonecrosis of the Jaws
Medication-Related Osteonecrosis of the Jaws Sve n O t to Editor Medication-Related Osteonecrosis of the Jaws Bisphosphonates, Denosumab, and New Agents Editor Sven Otto, MD, DMD, FEBOMFS Department of
More informationClinician s Manual on Restless Legs Syndrome
Clinician s Manual on Restless Legs Syndrome Mark J. Buchfuhrer Clinician s Manual on Restless Legs Syndrome Second Edition Mark J. Buchfuhrer PIH Health Hospital - Downey Downey, CA USA ISBN 978-3-319-31372-6
More informationPolymyalgia Rheumatica and Giant Cell Arteritis
Jozef Rovenský Burkhard F. Leeb Howard Bird Viera Štvrtinová Richard Imrich Editors Polymyalgia Rheumatica and Giant Cell Arteritis SpringerWienNewYork Editors Prof. Jozef Rovenský, MD, DSc, FRCP, Slovakia
More informationHPV-Associated Disease and Prevention
HPV-Associated Disease and Prevention Odessa Regional Medical Center May 28, 2015 Erich M. Sturgis, MD, MPH Professor Department of Head & Neck Surgery Department of Epidemiology Christopher & Susan Damico
More informationWorld Health Organization
World Health Organization The series International Histological Classification of Tumours consists of the following volumes. Each of these volumes - apart from volumes 1 and 2, which have already been
More informationIntelligence and Artificial Intelligence
Intelligence and Artificial Intelligence Springer-Verlag Berlin Heidelberg GmbH U. Ratsch M. M. Richter 1.-0. Stamatescu (Eds.) Intelligence and Artificial Intelligence An Interdisciplinary Debate With
More informationPediatric Endodontics
Pediatric Endodontics Anna B. Fuks Benjamin Peretz Editors Pediatric Endodontics Current Concepts in Pulp Therapy for Primary and Young Permanent Teeth Editors Anna B. Fuks Department of Pediatric Dentistry
More informationHuman papillomavirus and vaccination for cervical cancer
Human papillomavirus and vaccination for cervical cancer Dorothy Machalek Department of Microbiology and Infectious Diseases Royal Women s Hospital, Melbourne, Australia VIRUSES AND CANCER Responsible
More informationReal-life challenges in implementing public strategies for HPV vaccination in developing countries, and strategies to increase immunization coverage
Real-life challenges in implementing public strategies for HPV vaccination in developing countries, and strategies to increase immunization coverage Prof. Charbell Miguel Haddad Kury, MD Pediatrician Infectious
More information