Melanoma, o status da imunoterapia e o futuro próximo
|
|
- Cornelia Nichols
- 6 years ago
- Views:
Transcription
1 III International Symposium on Immuno-Oncology Saturday, October 7 th 9:3 1: am Melanoma, o status da imunoterapia e o futuro próximo Antoni Ribas, M.D., Ph.D. Professor of Medicine, Surgery, Molecular and Medical Pharmacology Director, Tumor Immunology Program, Jonsson Comprehensive Cancer Center (JCCC) Director, Parker Institute for Cancer Immunotherapy (PICI) Center at UCLA University of California Los Angeles (UCLA) Chair, Melanoma Committee at SWOG
2 Overall Survival: Metastatic Melanoma Phase III Studies 1-year OS 25 35% 1 46% 2 47% 4 56% 6 7% 7 71% 8 71% 1 Pembrolizumab 74% 11 Dab + tram d 75% 12 Vem + cobi 73% 13 Nivo + ipi % 1 24% 2 29% 4 Ipi 3% 6 45% 7 58% Nivo 8 53% 11 Dab + tram 48% 12 Vem + cobi 55% 14 Pembrolizumab 2-year OS 64% 13 Nivo + ipi 3-year OS 22% 3 44% 15 Dab + tram 37% 16 Vem + cobi 5-year OS 18% 5 Ipi 35% 9 Nivo (ph I) Georgina V Long, MIA 1. M. Middleton Ann Oncol 27;18: Hodi FS et al NEJM 21;363: Schadendorf D et al JCO 215:33: Robert C et al NEJM 211;364: Maio M et al. JCO 215; 33: Chapman PB et al Poster presentation SMR Hauschild A et al Poster presentation ESMO 214. Abstract Atkinson V et al Poster presentation SMR Hodi FS et al Oral presentation AACR 216. Abstract CT1. 1. Carlino M et al Oral presentation AACR 216. Abstract CT Long GV Lancet Oncol Ascierto PA et al Lancet Oncol 216:17: Larkin J et al AACR 217: Schachter J et al Oral presentation ASCO 216. Abstract Flaherty K et al Oral presentation ASCO 216. Abstract MacArthur GA et al. Poster presentation SMR 216
3 PFS, probability High LDH High tumour volume More metastatic sites Brain metastases PD-L1 negative/lack of immune signature 5% 45-5% 43% Normal LDH Low tumour volume Fewer metastatic sites CR to treatment % 39% 3% 24%. Georgina V Long, MIA Time from randomisation, months Dabrafenib + trametinib 1 (n = 352) Vemurafenib + cobimetinib 5 (n= 247) Nivolumab 2 (n = 21) Nivolumab 3 (n = 316) a Pembrolizumab 4 (n = 279) Nivo + ipi 3 (n = 314) 1. Robert C Oral ESMO Atkinson et al Poster SMR Larkin J et al Oral AACR Schachter J et al Oral ASCO Ascierto PA et al Lancet Onc 216.
4 CTLA-4 and PD-1 Checkpoint Blockade Abril-Rodriguez and Ribas, Snapshot, Cancer Cell 217
5 Progression-free Percentage Survival of PFS (%) Checkmate 67: Progression-Free Survival Median PFS, mo (95% CI) HR (95% CI) vs. IPI HR (95% CI) vs. NIVO NIVO+IPI (N=314) NIVO (N=316) IPI (N=315) 11.7 ( ).42 (.34.51).76 (.62.94) 6.9 ( ).54 (.45.66) 2.9 ( ) % 43% Grade 3/4 tox: 59% 21% 43% 37% 2 1 NIVO+IPI NIVO 18% IPI Months Patients at risk: NIVO+ IPI NIVO IPI Larkin et al. AACR 217, Wolchok et al. NEJM % 12% Database lock: Sept 13, 216, minimum f/u of 28 months
6 Overall Percentage Survival of PFS (%) Checkmate 67: Overall Survival NIVO+IPI NIVO IPI 73% 74% 67% Median OS, mo (95% CI) HR (98% CI) vs. IPI HR (95% CI) vs. NIVO Months Patients at risk: NIVO+IPI NIVO IPI % 59% 45% NIVO+IPI (N=314) NIVO (N=316) IPI (N=315) NR.55 (.42.72)*.88 ( ) NR (29.1 NR).63 (.48.81)* 2. ( ) *P<.1 Larkin et al. AACR 217, Wolchok et al. NEJM 217 Database lock: Sept 13, 216, minimum f/u of 28 months
7 CTLA-4 and PD-1 Checkpoint Blockade Abril-Rodriguez and Ribas, Snapshot, Cancer Cell 217
8 Melanoma response to PD-1 blockade is mediated by pre-existing infiltrates of CD8s inhibited by reactively expressed PD-L1 PD1/PDL1 1 Anti-PD-1 Anti-PD-L1 Melanoma cell or tumor macrophage IFN-g Tumeh et al., Nature 214
9 PD-1 blockade induces responses by inhibiting adaptive immune resistance CD8 PD-1 PD-L1 Response Progression Melanoma cell or tumor macrophage Melanoma cell or tumor macrophage Interferon gamma Hypothesis formulated based on quantitative IHC analyses of 46 cases from UCLA Adapted from Tumeh et al. Nature 214 Patient #1 Patient #2
10 What differentiates anti-pd-1-responsive from non-responding melanomas? ORR: 33% ORR in previously untreated: 45% Pembrolizumab Keynote 1 trial. Central radiology review by RECIST v1.1 Ribas et al. JAMA 216
11 What differentiates anti-pd-1-responsive from non-responding melanomas? Ayers et al, JCI 217 Pembrolizumab Keynote 1 trial. Central radiology review by RECIST v1.1 Ribas et al. JAMA 216
12 What differentiates anti-pd-1-responsive from non-responding melanomas? Mutational load and response to anti-pd-1 in NSCLC Mutational load and response to anti-pd-1 in MSI high colon cancer Mutational load and response to anti-pd-1 in melanoma Rizvi et al, Science 215 Le et al, NEJM 215 Hugo et al, Cell 216 McGranahan et al. Science 216 Pembrolizumab Keynote 1 trial. Central radiology review by RECIST v1.1 Ribas et al. JAMA 216
13 What differentiates anti-pd-1-responsive from non-responding melanomas? Hugo, Zaretsky et al. Cell 216 Willy Hugo, PhD Jesse Zaretsky IPRES (Innate anti-pd-1 Resistance) signature Roger S. Lo, MD, PhD Pembrolizumab Keynote 1 trial. Central radiology review by RECIST v1.1 Ribas et al. JAMA 216
14 The Cancer Immunogram Tumor foreignness Mutational load Tumor sensitivity to immune effectors MHC expression IFN-g sensitivity General immune status Lymphocyte count Absence of inhibitory tumor metabolism LDH, glucose utilization Immune cell infiltration Intratumoral T cells anti-pd-1/l1 Absence of soluble inhibitors IL6->CRP/ESR Absence of Checkpoints PD-L1 Blank, Haanen, Ribas, Schumacher. Science 216
15 Desmoplastic melanoma: Defined by a dense collagenous fibrous tissue a) DM1 DM2 b) Baseline 2-3 months later Tumor (S1) S1 Trichrome Collagen (Trichrome) a) a) S1 S1 Trichrome Trichrome S1 S1 A rare subtype of melanoma (less than 4%) S1 A dense fibrous reaction Trichrome Trichrome DM1 CM1 A known relationship to UV light damage High NF1 mutation rate and no known actionable genes for targeted therapies. ome CM1 CM2 DM2 CM2 blue collagenous stroma, red cytoplasm and brown nucleus CASE 1 b) b) CASE CASE 1 CASE CASE 2 CASE 2 CASE CASE 3 SE 3 Baseline Baseline 2-3 months after anti-pd1 2-3 months therapy later Zeynep Eroglu Siwen Hu-Lieskovan Jesse Zaretsky (submitted)
16 High response rate and high mutational load in Desmoplastic melanoma 7% overall response rate 18% complete response rate n=57 (out of 154 cases Reviewed*) 1 siiic 3 M1a 2 M1b 35 M1c *Retrospective Review o s e (M o n th s ) B) E s tim a te d O v e ra ll S u r v iv a l (% ) % Overall survival (OS), median not reached Estimated 2 year OS 73% (CI 62-88) Time (months) T im e S in c e F irs t d o s e (M o n th s ) Non-Desmoplastic Melanoma Desmoplastic Melanoma = Progressive Disease = Response (RECIST1.1) Zeynep Eroglu Siwen Hu-Lieskovan Jesse Zaretsky (submitted)
17 Response, % Primary and Acquired Resistance to PD-1 Blockade Waterfall plot of RECIST responses in 51 patients treated with pembrolizumab in the Keynote 1 trial KM of duration of response in patients treated with pembrolizumab or ipilimumab in the Keynote 6 trial Primary resistance Acquired resistance No. at risk Pembrolizumab Ipilimumab Time, months Ribas et al. JAMA 216 Robert et al. ASCO 217
18 How does the cancer sense IFN-gamma and reactively expresses PD-L1? PD1/PDL1 1 Melanoma cell or tumor macrophage Interferon gamma Tumeh et al., Nature 214
19 Interferon gamma receptor pathway regulating reactive PD-L1 expression Melanoma cell IRF-1 PDL1 Promoter PD-L1 Adapted from Shin et al. Cancer Discovery 217 and Garcia-Diaz et al. Cell Reports 217
20 Primary resistance to PD-1 blockade by disabling PD-L1 adaptive expression Would be useless to try to inhibit PD-1:PD-L1 Melanoma cell IRF-1 PDL1 Promoter PD-L1 Adapted from Shin et al. Cancer Discovery 217 and Garcia-Diaz et al. Cell Reports 217
21 Is JAK loss associated with primary resistance to PD-1 blockade? Responders Non-Responders JAK1 homozygous all heterozygous JAK1 homozygous 1/23 melanoma cases with high-allele frequency JAK1 mutation 1/16 colorectal cases with high-allele frequency JAK1 mutation data from Le DT et al. NEJM 215 Shin et al, Cancer Discovery 217
22 Lesion Size (mm 2 ) Case #1 2 4 Days on Therapy Lesion Size (mm 2 ) Case # Days on Therapy Non-Synonymous Mutations Non-Synonymous Mutations Baseline Baseline CNV Relapse CNV * Baseline CNV Relapse CNV Baseline (M42) CN Total CN Total Relapse >=4 CN Minor Allele (LOH) Baseline Relapse 1/ /6 >6 CN Minor Allele 1 (LOH) New mutation * Relapse (Tumor) Jesse Zaretsky UCLA MSTP JAK1 Q53* * Relapse (M464) JAK2 F547_splice
23 Interferon-gamma Sensitivity Model: Initially, benefits of PD-L1 suppression outweigh immune sensitizing effects. PD-L1 expression is of no benefit after PD-1/L1 blockade; selective pressure is flipped. The cancer has an incentive to lose INF-γ sensitivity, avoid apoptosis, enhanced antigen presentation. Acquired Resistance JAKs Melanoma cell Growth inh/apoptosis PD-L1 APM Adapted from Zaretsky et al. NEJM 216
24 How prevalent are JAK and B2M loss-of-function mutations? 2 2 Neither 8 IFNGR, JAK/STAT pathway mutations B2M mutations n=12 In 8 additional paired biopsies: One additional B2M LoF mutation No additional JAK1/2, IFNGR, IRF1 or STAT1/3/5 LoF mutations Jesse Zaretsky, Antoni Ribas (unpublished)
25 Confirmation of B2M and JAK as genetic mechanisms of resistance to anti-pd-1 using CRISPR/Cas9 knock out sublines MC38 wild-type MC38 B2M knockout MC38 JAK2 knockout tumor volume (mm3) MC38 WT untreated MC38 WT apd-1 tumor volume (mm3) B2M untreated B2M apd-1 tumor volume (mm3) JAK2 untreated JAK2 apd days after tumor injection days after tumor injection days after tumor injection Davis Torrejon, Gabriel Abril Rodriguez, Siwen Hu-Lieskovan (unpublished)
26 Defects in the IFNγ pathway induce resistance Genome-wide CRISPR mutagenesis reveals essential genes for the effector function of T cells in a target cell. Loss of Ptpn2 increases IFNγ sensing by tumour cells Functional loss of APLNR reduces efficacy of cancer Immunotherapy, which IPs with JAK1
27 Conclusions Inhibiting adaptive immune resistance is the mechanistic basis of the antitumor activity of PD-1 blockade therapies Combination therapies aimed at increasing T cell infiltration in tumors may improve the antitumor activity of PD-1 blockade Loss of function mutations in IFN-gamma receptor signaling or antigen presenting machinery mediate some cases of primary resistance and acquired resistance to PD-1 blockade therapy
28 Intervalo
29 III International Symposium on Immuno-Oncology Saturday, October 7 th 1:3 1:5 am Combinação em Imunoterapia: Deve ser o standard? Qual o melhor parceiro para combinar com imunoterapia? Antoni Ribas, M.D., Ph.D. Professor of Medicine, Surgery, Molecular and Medical Pharmacology Director, Tumor Immunology Program, Jonsson Comprehensive Cancer Center (JCCC) Director, Parker Institute for Cancer Immunotherapy (PICI) Center at UCLA University of California Los Angeles (UCLA) Chair, Melanoma Committee at SWOG
30 Intrinsic or primary resistance to immune checkpoint therapies- cellular microenvironment Cold tumors- induce TILs? Alternate immune suppressive mechanisms? Teng, Ngiow, Ribas, Smyth. Cancer Research, 215
31 Intrinsic or primary resistance to immune checkpoint therapies- cellular microenvironment 41% 45% 12% 2% Teng et al., Can Res, 215; Taube et al., Sci Trans Med, 212
32 2 out of 48 melanoma cell lines had JAK1/2 LOF mutations and did not respond to IFN-gamma by expressing PD-L1 PD-L1 baseline surface expression M395: JAK1 chr1: c>t, Exon 17 D775N M368 : JAK2 chr9: G>A, Exon 8 D313_Splice JAK1 5 # Mutations D775N JAK2 5 Pkinase_Tyr Pkinase_Tyr aa # Mutations D313_splice SH2 Pkinase_Tyr Pkinase_Tyr aa Daniel Shin, MD Shin et al. Cancer Discovery 217, 7,
33 Management of cancer in the anti-pd-1/l1 era Anti-PD-1/anti-PD-L1 Bring T cells into tumors: Generate T cells: + anti-ctla4 + immune activating antibodies or cytokines + TLR agonists or oncolytic viruses + IDO or macrophage inhibitors + targeted therapies Vaccines TCR engineered ACT CAR engineered ACT Modified from Ribas, Cancer Discovery 216
34 PD-1 / PD-L1 and IDO in the T cell inflamed phenotype T cell T cell mediated INFγ release triggers both PD-L1 expression IDO expression in tumor cells and in the µ-environment PD-1 INFγ INFγ - IDO STAT PD-L1 Tumor cell TCR MHC Kynurenine Tryptophan - +
35 Efficacy data: ECHO-22, Keynote-6, Checkmate 67 Response ECHO-22 Epacadostat + Pembro 1 PD-1 single agent Checkmate 67 2 / Keynote-6 3 Ipi + Nivo Checkmate 67 2 ORR (CR+PR) 56% 44% / 42% 58% CR 14% 16% / 13% 19% PR 41% 3% / 29% 42% SD 16% 1% / 21% 11% PD 29% 38.6 / 29% 23.6 Not evaluable 3% 7% / - 6% Median PFS 12.4 months 6.9 / 8.3 months 11.5 months 18 months 52% 43% / - 5% Grade 3/4 toxicity 2% 21% / 17.5% 59% 1 Hamid, ESMO 217; 2 Larkin, AACR 217 and Wolchok, NEJM 217; 3 Robert, ASCO 217 (2 pembro arms pooled). Note: data not randomized head to head, comparison only for indication
36 Double immune checkpoint inhibition: PD-1 plus LAG-3 CTLA-4 Blockade PD-1 Blockade + LAG-3 Blockade Dendritic cell MHC B7 TCR CD B7 CTLA T cell T cell MHC TCR ++ + PD1 PD-L anti-pd1 LAG Tumor cell anti-ctla-4 anti-lag-3 MHC c II ASCO 217-Ascierto et al Nivolumab + BMS (anti-lag3) Patients refractory or resistant to anti-pd-1
37 Best Percent Change in Sum of Target Lesion Diameters From Metastatic Melanoma with Prior-IO Cohort LAG-3 1% a n = 22 ORR, 2% LAG-3 <1% a n = 12 ORR, 7.1% LAG-3 Unknown n = 8 ORR, LAG-3 expression enriched for responses in IO-experienced patients Baseline b Nearly a 3-fold increase in ORR was observed in patients with LAG-3 1% vs LAG-3 <1% (2% vs 7.1%) Overall response rate was 13% PRs: 2 prior PD; 3 prior PR; 1 unk DCR, disease control rate; ORR, objective response rate. a LAG-3 expression (percent of positive cells within invasive margin, tumor, and stroma) evaluated using immunohistochemistry (IHC) assays on formalin-fixed, paraffin-embedded tumor sections. Immune cell LAG-3 expression ( 1% or <1%) determined using mouse antibody clone 17B4. b Response-evaluable patients (n = 48; all progressed on prior anti PD-1/PD-L1 therapy). Six patients had clinical progression prior to their first scan and are not included in the plot. One patient with best change from baseline >3% had an unconfirmed best response of SD. Ascierto et al. ASCO 217
38 Adding intralesional therapies to anti-pd-1/l1 Anti-PD-1/anti-PD-L1 IT injection oncolytic virus TLR agonist STING agonist + Anti-PD-1/anti-PD-L1 Then the benefit should only be in the patients who were unlikely to respond to anti-pd-1/l1 alone because their T cells were not in the tumor
39
40 Kaplan-Meier Percent Kaplan-Meier Percent Percentage Change from Baseline Patient 2 MASTERKEY-265: T-Vec + pembrolizumab T-VEC Intralesional Pembrolizumab Wk:1 6 3 Baseline (Week -5) Week Week N = 21 Stage IIIB (N = 1) Stage IIIC (N = 6) Stage IV M1a (N = 2) Stage IV M1b (N = 4) Stage IV M1c (N = 8) % objective response rate 33% complete response rate PFS OS T-VEC plus pembrolizumab (N = 21) Median (95% CI) Study Month Number of Patients at Risk: T-VEC plus pembrolizumab(n = 21) Median (95% CI) Study Month Number of Patients at Risk: Ribas et al. Cell 217
41 T-VEC increases tumor CD8 and PD-L1 in patients responding to combination with pembrolizumab Pt #1 Baseline Week 6 Week 3 Pt #2 CD8 antibody with red chromogen T-VEC T-VEC+ pembro T-VEC T-VEC+ pembro
42 Adding BRAF targeted therapies to anti-pd-1/l1 Anti-PD-1/anti-PD-L1 BRAFi+MEKi Wilmott et al. CCR 213 Frederick et al. CCR 213 BRAFi+MEKi + anti-pd-1/l1
43 Combination of BRAFi+MEKi+Anti-PD-1 NIH Director s Blog* Knocking Out Melanoma: Does This Triple Combo Have What It Takes? Posted on March 31, 215 by Dr. Francis Collins Comment on: Hu-Lieskovan S, et al. Sci Transl Med. 215;7:279ra41. Hu-Lieskovan et al. Sci Transl Med. 215 Mar 18;7(279):279ra41 *Available at: Accessed on August 18, 216.
44 Change from Baseline, % Clinical trials combining BRAFi+MEKi+anti-PD-1/L1 dabrafenib+trametinib +durvalumab dabrafenib+trametinib +pembrolizumab vemurafenib+cobimetinib +atezolizumab * * * * * Time, months * * Ribas et al. J Clin Oncol 33, 215 (suppl, abstr 33 ASCO) * Time, months Ribas et al. ESMO, 217 Hwu et al. Annals of Oncology 27; 216 (supp 6; abstr 119PD ESMO)
45 Conclusions Inhibiting adaptive immune resistance is the mechanistic basis of the antitumor activity of PD-1 blockade therapies Combination therapies aimed at increasing T cell infiltration in tumors may improve the antitumor activity of PD-1 blockade Loss of function mutations in IFN-gamma receptor signaling or antigen presenting machinery mediate some cases of primary resistance and acquired resistance to PD-1 blockade therapy
New biomarkers for response to immunotherapy
WIN Paris, 14:15-14:40, June 26, 2017 New biomarkers for response to immunotherapy Antoni Ribas, M.D., Ph.D. Professor of Medicine, Surgery, Molecular and Medical Pharmacology Director, Tumor Immunology
More informationImmunotherapy of Melanoma Sanjiv S. Agarwala, MD
Immunotherapy of Melanoma Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer Center, Bethlehem, PA Overview Metastatic Melanoma
More informationCombination Approaches in Melanoma: A Balancing Act
Combination Approaches in Melanoma: A Balancing Act Antoni Ribas, MD, PhD Jonsson Comprehensive Cancer Center University of California Los Angeles Los Angeles, California Advances in the Treatment of Metastatic
More informationImmunotherapy for the Treatment of Melanoma. Marlana Orloff, MD Thomas Jefferson University Hospital
Immunotherapy for the Treatment of Melanoma Marlana Orloff, MD Thomas Jefferson University Hospital Disclosures Immunocore and Castle Biosciences, Consulting Fees I will be discussing non-fda approved
More informationAdvances in the biology and treatment of malignant melanoma 2018
Advances in the biology and treatment of malignant melanoma 2018 GF Y-P RTK Y-P Ras GTP P BRAF V600 MEK BRAFi P ERK Cyclin D Cell cycle (Ki67) Baseline Day 15 Toxicity Dabrafenib Dabrafenib + trametinib
More informationNew paradigms for treating metastatic melanoma
New paradigms for treating metastatic melanoma Paul B. Chapman, MD Melanoma Clinical Director Melanoma and Immunotherapeutics Service Memorial Sloan Kettering Cancer Center, New York 20 th Century Overall
More informationMELANOMA METASTASICO: NUEVAS COMBINACIONES. Dr Ana Arance MD PhD Oncología Médica Hospital Clínic Barcelona
MELANOMA METASTASICO: NUEVAS COMBINACIONES Dr Ana Arance MD PhD Oncología Médica Hospital Clínic Barcelona Summary of OS accross clinical trials in patients with metastatic melanoma Ugurel et al. Eur J
More informationBiomarkers for immunotherapy. John Haanen MD PhD
Biomarkers for immunotherapy John Haanen MD PhD Clear value of mobilizing endogenous tumor-specific T cell responses 1. TIL therapy J. Haanen, NKI-AVL 1. Checkpoint blockade C. Robert, NEJM 2015 Where
More informationImmunotherapy, an exciting era!!
Immunotherapy, an exciting era!! Yousef Zakharia MD University of Iowa and Holden Comprehensive Cancer Center Alliance Meeting, Chicago November 2016 Presentation Objectives l General approach to immunotherapy
More informationTreatment and management of advanced melanoma: Paul B. Chapman, MD Melanoma Clinical Director, Melanoma and Immunotherapeutics Service MSKCC
Treatment and management of advanced melanoma: 2018 Paul B. Chapman, MD Melanoma Clinical Director, Melanoma and Immunotherapeutics Service MSKCC Disclosure Paul B. Chapman, MD Nothing to disclose. Off
More informationUpdate on Immunotherapy in Advanced Melanoma. Ragini Kudchadkar, MD Assistant Professor Winship Cancer Institute Emory University Sea Island 2017
Update on Immunotherapy in Advanced Melanoma Ragini Kudchadkar, MD Assistant Professor Winship Cancer Institute Emory University Sea Island 2017 1 Outline Adjuvant Therapy Combination Immunotherapy Single
More informationMedical Treatment for Melanoma Sanjiv S. Agarwala, MD
Medical Treatment for Melanoma Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer Center, Bethlehem, PA Disclosures None Overview
More informationImmunoterapia e melanoma maligno metastatico: siamo partiti da li. Vanna Chiarion Sileni Istituto Oncologico Veneto
Immunoterapia e melanoma maligno metastatico: siamo partiti da li Vanna Chiarion Sileni Istituto Oncologico Veneto Vanna.chiarion@iov.veneto.it Metastatic Melanoma Available Treatment: 197 217 Zelboraf
More informationAdvances in Cancer Immunotherapy for Solid Tumors Expert Perspectives on The New Data Sunday, June 5, 2016
Advances in Cancer Immunotherapy for Solid Tumors Expert Perspectives on The New Data Sunday, June 5, 2016 Supported by an independent educational grant from AstraZeneca Not an official event of the 2016
More informationImmunotherapy for Melanoma. Caroline Robert, MD, PhD Gustave Roussy and Université Paris Sud Villejuif, France
Immunotherapy for Melanoma Caroline Robert, MD, PhD Gustave Roussy and Université Paris Sud Villejuif, France Overall Survival for Metastatic Melanoma Proportion Alive 1.0 0.8 0.6 0.4 0.2 Survival data
More informationCurrent Trends in Melanoma Theresa Medina, MD UCD Cutaneous Oncology
Current Trends in Melanoma Theresa Medina, MD UCD Cutaneous Oncology Overview Melanoma incidence and prevention Approach to surgical management of early melanoma Landscape of Advanced Melanoma Therapy
More informationTreatment of Tumors Resistant to PD-1 inhibitors
Treatment of Tumors Resistant to PD-1 inhibitors Harriet Kluger, MD Professor of Medicine (Medical Oncology), Yale School of Medicine Deputy Section Chief, Medical Oncology Associate Cancer Center Director
More informationImmunotherapy in Unresectable or Metastatic Melanoma: Where Do We Stand? Sanjiv S. Agarwala, MD St. Luke s Cancer Center Bethlehem, Pennsylvania
Immunotherapy in Unresectable or Metastatic Melanoma: Where Do We Stand? Sanjiv S. Agarwala, MD St. Luke s Cancer Center Bethlehem, Pennsylvania Overview Background Immunotherapy clinical decision questions
More informationMelanoma: From Chemotherapy to Targeted Therapy and Immunotherapy. What every patient needs to know. James Larkin
Melanoma: From Chemotherapy to Targeted Therapy and Immunotherapy What every patient needs to know James Larkin Melanoma Therapy 1846-2017 Surgery 1846 Cytotoxic Chemotherapy 1946 Checkpoint Inhibitors
More informationBiomarkers for immunotherapy. John Haanen MD PhD
Biomarkers for immunotherapy John Haanen MD PhD Clear value of mobilizing endogenous tumor-specific T cell responses 1. TIL therapy J. Haanen, NKI-AVL 1. Checkpoint blockade C. Robert, NEJM 2015 Where
More informationMelanoma: Immune checkpoints
ESMO Preceptorship Programme Immuno-Oncology Siena, July 04-05, 2016 Melanoma: Immune checkpoints Michele Maio Medical Oncology and Immunotherapy-Department of Oncology University Hospital of Siena, Istituto
More informationWhat we learned from immunotherapy in the past years
What we learned from immunotherapy in the past years Paolo A. Ascierto, MD Unit Melanoma, Cancer Immunotherapy and Innovative Therapies Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Italy Disclosure
More informationNews from ASCO. Niven Mehra, Medical Oncologist. Radboud UMC Institute of Cancer Research and The Royal Marsden Hospital
News from ASCO Niven Mehra, Medical Oncologist Radboud UMC Institute of Cancer Research and The Royal Marsden Hospital Disclosures Speaker fees: Merck, Bayer Advisory boards: Janssen-Cilag Research and
More informationMelanoma. Il parere dell esperto. V. Ferraresi. Divisione di Oncologia Medica 1
Melanoma Il parere dell esperto V. Ferraresi Divisione di Oncologia Medica 1 MELANOMA and ESMO 2017.what happens? New data and updates ADJUVANT THERAPY with CHECKPOINT INHIBITORS (CA209-238 trial) AND
More information6/7/16. Melanoma. Updates on immune checkpoint therapies. Molecularly targeted therapies. FDA approval for talimogene laherparepvec (T- VEC)
Melanoma John A Thompson MD July 17, 2016 Featuring: Updates on immune checkpoint therapies Molecularly targeted therapies FDA approval for talimogene laherparepvec (T- VEC) 1 Mechanism of ac-on of Ipilimumab
More informationFocus on Immunotherapy as a Targeted Therapy. Brad Nelson, PhD BC Cancer, Victoria, Canada FPON, Oct
Focus on Immunotherapy as a Targeted Therapy Brad Nelson, PhD BC Cancer, Victoria, Canada FPON, Oct 18 2018 Disclosures I have nothing to disclose that is relevant to this presentation. Immunology @ Deeley
More informationRenal Cell Carcinoma: Systemic Therapy Progress and Promise
Renal Cell Carcinoma: Systemic Therapy Progress and Promise Michael B. Atkins, M.D. Deputy Director, Lombardi Comprehensive Cancer Ctr Georgetown University Medical Center Everolimus Rini, Campbell, Escudier.
More informationIMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS
IMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS Dr Elizabeth Smyth Cambridge University Hospitals NHS Foundation Trust ESMO Gastric Cancer Preceptorship Valencia 2018 DISCLOSURES Honoraria for advisory role
More informationBasic Principles of Tumor Immunotherapy. Ryan J. Sullivan, M.D. Massachusetts General Hospital Cancer Center Boston, MA
Basic Principles of Tumor Immunotherapy Ryan J. Sullivan, M.D. Massachusetts General Hospital Cancer Center Boston, MA Disclosures Consulting Fees: Biodesix, Novartis Pharmaceuticals Other: Boehringer
More informationOut of 129 patients with NSCLC treated with Nivolumab in a phase I trial, the OS rate at 5-y was about 16 %, clearly higher than historical rates.
6th Meeting on external quality assessment in molecular pathology, Naples, May 12-13, 2017 Overview of clinical development of checkpoint inhibitors in solid tumors Pr Jaafar BENNOUNA University of Nantes
More informationNew Systemic Therapies in Advanced Melanoma
New Systemic Therapies in Advanced Melanoma Sanjay Rao, MD FRCPC Medical Oncologist (BCCA-CSI) Clinical Assistant Professor, UBC Faculty of Medicine SON Fall Update October 22, 2016 Disclosures Equity
More informationUpdate on Melanoma Treatment. Tara C Mitchell, MD
Update on Melanoma Treatment Tara C Mitchell, MD Overview Immune therapy update Targeted therapy update New concepts in treating melanoma What is the immune system? A complex network of protective cells
More informationPTAC meeting held on 5 & 6 May (minutes for web publishing)
PTAC meeting held on 5 & 6 May 2016 (minutes for web publishing) PTAC minutes are published in accordance with the Terms of Reference for the Pharmacology and Therapeutics Advisory Committee (PTAC) and
More informationPriming the Immune System to Kill Cancer and Reverse Tolerance. Dr. Diwakar Davar Assistant Professor, Melanoma and Phase I Therapeutics
Priming the Immune System to Kill Cancer and Reverse Tolerance Dr. Diwakar Davar Assistant Professor, Melanoma and Phase I Therapeutics Learning Objectives Describe the role of the immune system in cancer
More informationIII Sessione I risultati clinici
10,30-13,15 III Sessione I risultati clinici Moderatori: Michele Maio - Valter Torri 10,30-10,45 Melanoma: anti CTLA-4 Vanna Chiarion Sileni Vanna Chiarion Sileni IOV-IRCCS,Padova Vanna.chiarion@ioveneto.it
More informationASCO Annual Meeting 2017 Bart Neyns MD PhD, UZ Brussel. 20th Post-ASCO Meeting, 24th June 2016
IMMUNOTHERAPY @the ASCO Annual Meeting 2017 Bart Neyns MD PhD, UZ Brussel 20th Post-ASCO Meeting, 24th June 2016 FAS-L Cancer Testis Ag Differentiation Ag Neo-antigens PD-1 CTL CD8+ Tcell CTLA-4 CD28 B7.1/B7.2
More informationMelanoma: What else beyond Checkpoint Inhibitor pathway?
Melanoma: What else beyond Checkpoint Inhibitor pathway? Jose Lutzky MD, FACP Director, Mount Sinai Melanoma Program Miami Beach, Florida Clinical Associate Professor, Wertheim School of Medicine, FIU,
More informationRole of the Pathologist in Guiding Immuno-oncological Therapies. Scott Rodig MD, PhD
Role of the Pathologist in Guiding Immuno-oncological Therapies Scott Rodig MD, PhD Department of Pathology, Brigham & Women s Hospital Center for Immuno-Oncology, Dana-Farber Cancer Institute Associate
More informationASCO 2014: The Future is Here. What I Will Talk About. George W. Sledge MD Stanford University School of Medicine
ASCO 214: The Future is Here George W. Sledge MD Stanford University School of Medicine What I Will Talk About Two paths to a Cure Slicing the pie MelMng the snowflake The Past Isn t Dead Improving PaMent
More informationImmunotherapy for Metastatic Malignant Melanoma. Dr Daniel A Vorobiof Sandton Oncology Centre Johannesburg
Immunotherapy for Metastatic Malignant Melanoma Dr Daniel A Vorobiof Sandton Oncology Centre Johannesburg Survival in Melanoma by Stage Proportion Surviving 1.0 0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 Stage
More informationNew treatments in melanoma
New treatments in melanoma Paolo A. Ascierto, MD Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy Meta-analysis of Phase II cooperative group trials in metastatic stage IV melanoma to determine
More informationO DESAFIO DA INOVAÇÃO EM ONCOLOGIA EM PORTUGAL The Challenges of innovative oncology care in Portugal. Gabriela Sousa Oncologia Médica IPO Coimbra
O DESAFIO DA INOVAÇÃO EM ONCOLOGIA EM PORTUGAL The Challenges of innovative oncology care in Portugal Gabriela Sousa Oncologia Médica IPO Coimbra Incidência aumenta 3% ao ano Envelhecimento populacional
More informationCheckpoint regulators a new class of cancer immunotherapeutics. Dr Oliver Klein Medical Oncologist ONJCC Austin Health
Checkpoint regulators a new class of cancer immunotherapeutics Dr Oliver Klein Medical Oncologist ONJCC Austin Health Cancer...Immunology matters Anti-tumour immune response The participants Dendritc cells
More informationEmerging Tissue and Serum Markers
Emerging Tissue and Serum Markers for Immune Checkpoint Inhibitors Kyong Hwa Park MD, PhD Medical Oncology Korea University College of Medicine Contents Immune checkpoint inhibitors in clinical practice
More informationThe Immunotherapy of Oncology
The Immunotherapy of Oncology The 30-year Overnight Success Story M Avery, BIOtech Now 2014 Disclosures: Geoffrey R. Weiss, M.D. None The History A. Chekov: It has long been noted that the growth of malignant
More informationImmunotherapy for dmmr metastatic colorectal cancer. Prof.dr. Kees Punt Dept. Medical Oncology AUMC
Immunotherapy for dmmr metastatic colorectal cancer Prof.dr. Kees Punt Dept. Medical Oncology AUMC Active specific immunotherapy (ASI) in stage II-III colon cancer Vaccination with autologous tumor + BCG
More informationCheckpoint Regulators Cancer Immunotherapy takes centre stage. Dr Oliver Klein Department of Medical Oncology 02 May 2015
Checkpoint Regulators Cancer Immunotherapy takes centre stage Dr Oliver Klein Department of Medical Oncology 02 May 2015 Adjuvant chemotherapy improves outcome in early breast cancer FDA approval of Imatinib
More informationReview of immunotherapy in melanoma
Review of immunotherapy in melanoma Surein Arulananda, 1,2,3 Elizabeth Blackley, 1 Jonathan Cebon 1,2,3 1. Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia. 2. Cancer Immunobiology
More informationASCP Immuno-Oncology Scientific Updates Liquid Biopsies: Current Limitations and Potential Applications
ASCP Scientific Updates: Liquid Biopsies: Current Limitations and Potential Applications December 2018 Faculty Alexander J Lazar MD, PhD Professor Departments of Pathology, Genomic Medicine, & Translational
More informationOptimizing Immunotherapy New Approaches, Biomarkers, Sequences and Combinations Immunotherapy in the clinic Melanoma
Optimizing Immunotherapy New Approaches, Biomarkers, Sequences and Combinations Immunotherapy in the clinic Melanoma Dr. J.L.Manzano S. Oncología Médica H. Germans Trias i Pujol, ICO-Badalona PRBB Auditorium,
More informationCancer Immunotherapy Patient Forum. for the Treatment of Melanoma, Leukemia, Lymphoma, Lung and Genitourinary Cancers - November 7, 2015
Cancer Immunotherapy Patient Forum for the Treatment of Melanoma, Leukemia, Lymphoma, Lung and Genitourinary Cancers - November 7, 2015 Biomarkers and Patient Selection Julie R. Brahmer, M.D. Director
More informationMelanoma Clinical Trials and Real World Experience
Melanoma Clinical Trials and Real World Experience Paul Lorigan University of Manchester Manchester, UK www.christie.nhs.uk/melanoma Melanoma Bridge, Naples 214 New Benchmarks for Phase II Trials OS at
More informationImmune Checkpoints. PD Dr med. Alessandra Curioni-Fontecedro Department of Hematology and Oncology Cancer Center Zurich University Hospital Zurich
Immune Checkpoints PD Dr med. Alessandra Curioni-Fontecedro Department of Hematology and Oncology Cancer Center Zurich University Hospital Zurich Activation of T cells requires co-stimulation Science 3
More informationLargos Supervivientes, Tenemos datos?
Largos Supervivientes, Tenemos datos? Javier Puente, MD, PhD Medical Oncology Department. Hospital Clinico San Carlos Associate Professor of Medicine. Complutense University of Madrid. Summary Snapshot
More informationBest Practices in the Treatment and Management of Metastatic Melanoma. Melanoma
Best Practices in the Treatment and Management of Metastatic Melanoma Philip Friedlander MD PhD Director of Melanoma Medical Oncology Program Assistant Professor Division of Hematology Oncology Assistant
More informationNew Frontiers in Metastatic Melanoma: A Closer Look at the Role of Immunotherapy
New Frontiers in Metastatic Melanoma: A Closer Look at the Role of Immunotherapy Philip Friedlander MD PhD Director of Melanoma Medical Oncology Program Assistant Professor Division of Hematology Oncology
More informationOverview: Immunotherapy in CNS Metastases
Overview: Immunotherapy in CNS Metastases Manmeet Ahluwalia, MD, FACP Miller Family Endowed Chair in Neuro-Oncology Director Brain Metastasis Research Program Cleveland Clinic Disclosures Consultant- Monteris
More informationImmuno-Oncology - How it all got started. Christian Blank The Netherlands Cancer Institute EUFEMED Meeting London, May 19, 2017
Immuno-Oncology - How it all got started Christian Blank The Netherlands Cancer Institute EUFEMED Meeting London, May 19, 2017 DISCLOSURES Advisory role: BMS, MSD, Novartis, Roche, GSK, Pfizer Honoraria:
More informationWHY LOOK FOR ADDITIONAL DATA TO ENRICH THE KAPLAN-MEIER CURVES? Immuno-oncology, only an example
WHY LOOK FOR ADDITIONAL DATA TO ENRICH THE KAPLAN-MEIER CURVES? Immuno-oncology, only an example YIDOU ZHANG Health Economics and Payer Analytics Director Oncology Payer Evidence and Pricing, AstraZeneca
More informationMelanoma: Therapeutic Progress and the Improvements Continue
Melanoma: Therapeutic Progress and the Improvements Continue David W. Ollila, MD Professor of Surgery Jesse and James Millis Professor of Melanoma Research May 20, 2016 Disclosures: NONE Outline 2016 Therapeutic
More informationIl ruolo di PD-L1 (42%) tra la prima e la seconda linea di trattamento
Il ruolo di PD-L1 (42%) tra la prima e la seconda linea di trattamento Alessia Pochesci Divisione di Oncologia Toracica Istituto Europeo di Oncologia, Milano Tutor: Prof.ssa Silvia Novello Dott.ssa Chiara
More information2/16/2018. The Immune System and Cancer. Fatal Melanoma Transferred in a Donated Kidney 16 years after Melanoma Surgery
C007: Immunology of Melanoma: Mechanisms of Immune Therapies Delphine J. Lee, MD, PhD Chief and Program Director, Dermatology, Harbor UCLA Medical Center Principal Investigator, Los Angeles Biomedical
More informationBiomarkers in Imunotherapy: RNA Signatures as predictive biomarker
Biomarkers in Imunotherapy: RNA Signatures as predictive biomarker Joan Carles, MD PhD Director GU, CNS and Sarcoma Program Department of Medical Oncology Vall d'hebron University Hospital Outline Introduction
More informationImmunotherapy Treatment Developments in Medical Oncology
Immunotherapy Treatment Developments in Medical Oncology A/Prof Phillip Parente Director Cancer Services Eastern Health Executive MOGA ATC Medical Oncology RACP www.racpcongress.com.au Summary of The Desired
More informationTHE FUTURE OF IMMUNOTHERAPY IN COLORECTAL CANCER. Prof. Dr. Hans Prenen, MD, PhD Oncology Department University Hospital Antwerp, Belgium
THE FUTURE OF IMMUNOTHERAPY IN COLORECTAL CANCER Prof. Dr. Hans Prenen, MD, PhD Oncology Department University Hospital Antwerp, Belgium DISCLAIMER Please note: The views expressed within this presentation
More informationApproaches To Treating Advanced Melanoma
Approaches To Treating Advanced Melanoma Suraj Venna, MD Medical Director, Melanoma and Cutaneous Oncology Inova Schar Cancer Institute Associate Professor, VCU Fairfax VA Disclosures No relevant disclosures
More informationCheckMate 012: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer
CheckMate 12: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer Abstract 31 Hellmann MD, Gettinger SN, Goldman J, Brahmer J, Borghaei H, Chow LQ, Ready NE,
More informationImmunotherapy for Melanoma. Michael Postow, MD Melanoma and Immunotherapeutics Service Memorial Sloan Kettering Cancer Center
Immunotherapy for Melanoma Michael Postow, MD Melanoma and Immunotherapeutics Service Memorial Sloan Kettering Cancer Center Conflicts of Interest Bristol-Myers Squibb: -Research support -Participated
More informationMariano Provencio Servicio de Oncología Médica Hospital Universitario Puerta de Hierro. Immune checkpoint inhibition in DLBCL
Mariano Provencio Servicio de Oncología Médica Hospital Universitario Puerta de Hierro Immune checkpoint inhibition in DLBCL Immunotherapy: The Cure is Inside Us Our immune system prevents or limit infections
More informationReflex Testing Guidelines for Immunotherapy in Non-Small Cell Lung Cancer
Reflex Testing Guidelines for Immunotherapy in Non-Small Cell Lung Cancer Jimmy Ruiz, MD Assistant Professor Thoracic Oncology Program Wake Forest Comprehensive Cancer Center Disclosures I have no actual
More informationMELANOMA: THE BEST OF THE YEAR Dott.ssa Silvia Quadrini UOC Oncologia ASL Frosinone
MELANOMA: THE BEST OF THE YEAR 2018 Dott.ssa Silvia Quadrini UOC Oncologia ASL Frosinone The Best of the Year 2018: MELANOMA CHIRURGIA TERAPIA ADIUVANTE TERAPIA PER MALATTIA AVANZATA The Best of the Year
More informationImmunotherapy in Colorectal cancer
Immunotherapy in Colorectal cancer Ahmed Zakari, MD Associate Professor University of Central Florida, College of Medicine Medical Director, Gastro Intestinal Cancer Program Florida Hospital Cancer Institute
More informationImmunotherapy for the Treatment of Head and Neck Cancers. Robert F. Taylor, MD Aurora Health Care
Immunotherapy for the Treatment of Head and Neck Cancers Robert F. Taylor, MD Aurora Health Care Disclosures No relevant financial relationships to disclose I will be discussing non-fda approved indications
More informationImmunotherapy in head and neck cancer and MSI in solid tumors
Immunotherapy in head and neck cancer and MSI in solid tumors Brian Hunis, MD, MBA Associate Medical Director, Memorial Cancer Institute. Hollywood, FL »No disclosures Objectives»Discuss the role of immunology
More informationUpdate on Targeted Therapy in Melanoma
Update on Targeted Therapy in Melanoma Seville June 2013 James Larkin FRCP PhD London UK Overview What are the targets in melanoma? BRAF / KIT / NRAS / GNAQ / MEK DNA / microtubules CTLA4 / PD1 / PDL1
More informationThe PD-1 pathway of T cell exhaustion
The PD-1 pathway of T cell exhaustion SAMO 18.3.2016 Overview T cell exhaustion Biology of PD-1 Mechanism Ligands expressed on tumor cell and on non-tumor cells other receptor pairs Biomarkers for apd-1/pd-l1
More informationCutaneous melanoma: new developments for 2018
Cutaneous melanoma: new developments for 2018 and beyond KIM MARGOLIN, M.D., FASCO CITY OF HOPE MEDICAL ONCOLOGY CORONADO, CALIFORNIA SEPTEMBER 20, 2018 DISCLOSURE Consultant for ImaginAb, Nektar Therapeutics,
More informationKombination von Checkpointinhibitoren beim malignen Melanom
Kombination von Checkpointinhibitoren beim malignen Melanom Dirk Jäger Medizinische Onkologie Nationales Centrum für Tumorerkrankungen Universitätsklinikum Heidelberg Ipilimumab beim metastasierten Melanom
More informationPersonalized Treatment Approaches for Lung Cancer
Personalized Treatment Approaches for Lung Cancer California Thoracic Society 2018 Annual Carmel Conference January 27, 2018 Matthew Gubens, MD, MS Associate Professor of Medicine Chair, Thoracic Oncology
More informationImmunotherapy for the Treatment of Head and Neck Cancers. Barbara Burtness, MD Yale University
Immunotherapy for the Treatment of Head and Neck Cancers Barbara Burtness, MD Yale University Disclosures AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim, Bristol-Myers Squibb, Merck & Co., Inc.,
More informationBrain mets under I.O.
Brain mets under I.O. Bernard Escudier Gustave Roussy, Villejuif, France Disclosure Honorarium received from BMS, Novartis, Pfizer, Bayer, Roche, Exelixis, Ipsen, Eisai, Calithera Travel Grant from BMS,
More informationIl Futuro dell Immunoterapia
Attualità e Prospettive in Immuno-oncologia Istituto Superiore Di Sanità Roma 4 Novembre, 2016 Il Futuro dell Immunoterapia Anna Maria Di Giacomo Medical Oncology and Immunotherapy-Department of Oncology
More informationConversations in Oncology. November Kerry Hotel Pudong, Shanghai China
Conversations in Oncology November 12-13 Kerry Hotel Pudong, Shanghai China Immunotherapy of Lung Cancer Professor Caicun Zhou All materials are for scientific exchanges. Afatinib and nintedanib are not
More informationIMMUNOTHERAPY IN THE TREATMENT OF CERVIX CANCER. Linda Mileshkin, Medical Oncologist Peter MacCallum Cancer Centre, Melbourne Australia
IMMUNOTHERAPY IN THE TREATMENT OF CERVIX CANCER Linda Mileshkin, Medical Oncologist Peter MacCallum Cancer Centre, Melbourne Australia Distinguishing self from non-self T cells trained in the thymus as
More informationLung Cancer Update 2016 BAONS Oncology Care Update
Lung Cancer Update 2016 BAONS Oncology Care Update Matthew Gubens, MD, MS Assistant Professor Chair, Thoracic Oncology Site Committee UCSF Helen Diller Family Comprehensive Cancer Center Disclosures Consulting
More informationIMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS
IMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS Dr Elizabeth Smyth Royal Marsden Hospital ESMO Colorectal Cancer Preceptorship Valencia 2018 DISCLOSURES Honoraria for advisory role Servier, Celgene, BMS, Five
More informationLESSONS LEARNT Melanoma Academic Perspective
LESSONS LEARNT Melanoma Academic Perspective Paolo A. Ascierto, MD Unit Melanoma, Cancer Immunotherapy and Innovative Therapies Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Italy Disclosures
More informationPhase 1 Study Combining Anti-PD-L1 (MEDI4736) With BRAF (Dabrafenib) and/or MEK (Trametinib) Inhibitors in Advanced Melanoma
Phase 1 Study Combining Anti-PD-L1 (MEDI4736) With BRAF (Dabrafenib) and/or MEK (Trametinib) Inhibitors in Advanced Melanoma Abstract #3003 Ribas A, Butler M, Lutzky J, Lawrence D, Robert C, Miller W,
More informationONCOS-102 in melanoma Dr. Alexander Shoushtari. 4. ONCOS-102 in mesothelioma 5. Summary & closing
ONCOS-102 in melanoma Dr. Alexander Shoushtari 4. ONCOS-102 in mesothelioma 5. Summary & closing 1 Preliminary data from C824 Activating the Alexander Shoushtari, MD Assistant Attending Physician Melanoma
More informationUpdates in Immunotherapy for Urothelial Carcinoma
Updates in Immunotherapy for Urothelial Carcinoma Andrew J Armstrong MD ScM FACP DUA 2018 Copyright 2006 SciMed. Talk Outline Immunotherapy progress in 2017: 5 new approved PD-1/PD-L1 inhibitory agents
More informationWeitere Kombinationspartner der Immunotherapie
1 Weitere Kombinationspartner der Immunotherapie Rolf Stahel University Hospital of Zürich Zürich, 9.12.216 2 Immunotherapy in a multimodality approach NSCLC Advanced disease Checkpoint inhibitors for
More informationCancer immunotherapy with oncolytic viruses: more than just lysis
Cancer immunotherapy with oncolytic viruses: more than just lysis Dmitriy Zamarin MD PhD Assistant Attending, Immune Therapeutics Center Memorial Sloan-Kettering Cancer Center New York, NY BCAN Think Tank
More informationLung Cancer Immunotherapy
Lung Cancer Immunotherapy Luis E. Raez MD FACP FCCP Chief of Hematology/Oncology & Medical Director Memorial Cancer Institute/Memorial Health Care System Clinical Professor of Medicine Herbert Wertheim
More informationNew Therapeutic Approaches to Malignant Melanoma
2018 Master Class for Oncologists New Therapeutic Approaches to Malignant Melanoma F. Stephen Hodi, M.D. Dana-Farber Cancer Institute, Boston, MA Disclosure I have nothing to disclose. Off Label/Investigational
More informationImproving Immunotherapy for Melanoma
Improving Immunotherapy for Melanoma David McDermott, MD Beth Israel Deaconess Medical Center Dana Farber/ Harvard Cancer Center Harvard Medical School Immunotherapy Improvement Model All patients All
More informationEvolving Treatment Strategies in the Management of Metastatic Melanoma: Novel Therapies for Improved Patient Outcomes. Disclosures
Evolving Treatment Strategies in the Management of Metastatic Melanoma: Novel Therapies for Improved Patient Outcomes Fall Managed Care Forum November 11, 2016 Matthew Taylor, M.D. Disclosures Consulting/Advisory
More informationImmunotherapy Experience in Melanoma Integrating IO into Clinical Practice Sanjiv S. Agarwala, MD
Immunotherapy Experience in Melanoma Integrating IO into Clinical Practice Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer
More informationIMMUNOTHERAPY IN THE TREATMENT OF CERVIX CANCER
Gynecologic Cancer InterGroup Cervix Cancer Research Network IMMUNOTHERAPY IN THE TREATMENT OF CERVIX CANCER Linda Mileshkin, Medical Oncologist Peter MacCallum Cancer Centre, Melbourne Australia Cervix
More informationLA QUARTA ARMA CONTRO IL CANCRO
LA QUARTA ARMA CONTRO IL CANCRO Paolo A. Ascierto, MD Unit Melanoma, Cancer Immunotherapy and Innovative Therapies Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Italy Disclosure Employment or
More informationPatient Selection: The Search for Immunotherapy Biomarkers
Patient Selection: The Search for Immunotherapy Biomarkers Mark A. Socinski, MD Executive Medical Director Florida Hospital Cancer Institute Orlando, Florida Patient Selection Clinical smoking status Histologic
More information