COMET CLINICAL TRIALS CONSORTIUM. June 2016 Newsletter Volume 4 Issue 6. PG 3 Member and Trials Snapshot. Letter from Dr. Brezden-Masley, Founder

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1 COMET CLINICAL TRIALS CONSORTIUM June 2016 Newsletter Volume 4 Issue 6 PG 1 Trials of the Month PG 3 Member and Trials Snapshot PG 4 Website Functions Trials of the Month Type Trial Site Breast IMpassion 130 Lakeridge Letter from Dr. Brezden-Masley, Founder This has been a great year for COMET and we hope that you are enjoying the website and all the services it offers. Since its launch in 2011, COMET has grown in popularity and is a central hub for over 130 clinical trials in Ontario! CNS CNS MRI pseudopro -gression We are always making improvements to make COMET better for our users! If you have any suggestions, please do not hesitate to contact us at comettrials@smh.ca and we are more than happy to assist. GU BRIGHTER Mount Sinai, St.Micheal s Haem HBV St. Michael s GYNE IND.221 Lung Mel GI IMpower 131 Melanoma Neoadjuva -nt NCIC CO. 21 Royal Victoria Odette Kingston, Mount Sinai, Odette, Southlake, Trillium Sincerely, Dr. Christine Brezden-Masley Founder, COMET Clinical Trials Consortium Letter from Suruthi Senthilvel, Project Manager April showers bring May flowers! And with that, we can say spring is here! We hope that CCTC has been helpful in transitioning the gap between patient referrals and newly emerging clinical trials. We are open to feedback from all our members to better COMET s features for all out members! Our main goals are to make the CCTC more user-friendly by incorporating your continued input to better it! For any inquiries, please contact me at comettrials@smh.ca! Many thanks, Suruthi Senthilvel Project Manager, CCTC June 2016 Newsletter 1

2 TRIALS OF THE MONTH Type Acronym Study Title Description Site(s) Breast IMpassion130 A Phase III, Multicenter, Randomized Placebo-Controlled Study of Atezolizumab (MPDL3280A) (Anti-PD-L1 Antibody) in Combination With Nab Paclitaxel Compared With Placebo With Nab Paclitaxel for Patients With Previously Untreated Metastatic Triple Negative Breast Cancer - Any HER2 - Metastatic (1st, 2nd, 3rd or 4th Lakeridge Health Corporation CNS CNS MRI pseudoprogression Differentiation of Pseudoprogression and True Progression Through High Field Susceptibility Weighted Imaging and R2* - Imaging Study Sciences GU BRIGHTER A Study of BBI608 Plus Weekly Paclitaxel to Treat Gastric and Gastro-Esophageal Junction Cancer (BRIGHTER) Haem HBV A Multi-centre Phase III Study to Evaluate Preemptive Tenofovir for Prevention of Hepatitis B Virus Reactivation in HBsAg Negative/Anti-HBc Positive Individuals Undergoing Rituximab-based Chemotherapy for Non-Hodgkin s Lymphoma GYNE IND.221 Dose-Ranging Study of IPH2201 in Patients With Gynecologic Malignancies Lung IMpower 131 A Phase III, Open-label, Multicenter, Randomzed Study Evaluating the Efficacy and Safety of MPDL3208A (Anti-PDL-1 Antibody) in Combination With Carboplatin + Paclitaxel or MPDL3208A in Combination With Carboplatin + Nab-paclitaxel Versus Carboplatin + Nab-paclitaxel in Chemotherapy-naive Patients With Stage IV Squamous Non-small Cell Lung Cancer - Gastric/Stomach Cancer - Metastatic (1st, 2nd, 3rd or 4th - Non-Hodgkin's Lymphoma - Prevention - Ovarian Cancer - Metastatic - Non-Small Cell Lung Cancer - Metastatic (1st Mount Sinai, St. Michael s St. Michael s Sciences Royal Victoria Regional Health Mel Melanoma Neoadjuvant Study of Neo-adjuvant Use of Vemurafenib Plus Cobimetinib for BRAF Mutant Melanoma With Palpable Lymph Node Metastases - Tumour Stage III Odette Cancer GI NCIC CO.21 A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (CHALLENGE) - Colon Cancer - Tumour Stage II/III - Prevention Study Kingston General, Sciences, Mount Sinai, Odette, June 2016 Newsletter Southlake, 2 Trillium

Trials Snapshot Trial Type Breast CNS GI GU GYNE H&N HEME Lung Melanoma NETs Total Trials Imaging Study 2 1 3 6 Prevention 1 1 1 3 Radiation 2 2 6 6 17 Supportive Care 1 1 Surgical Therapy 2 2 1 1 1

3 Trials Snapshot Trial Type Breast CNS GI GU GYNE H&N HEME Lung Melanoma NETs Total Trials Imaging Study Prevention Radiation Supportive Care 1 1 Surgical Therapy Systemic Therapy Therapeutic Total Trials Registered Members and Trials Per Institution Institution Members Trials Cambridge Memorial 3 2 Grand River 8 1 Hamilton Health Sciences 6 - Humber River Regional 6 - Kingston General 3 8 Juravinski Cancer 6 1 Lakeridge Health CorporaDon Science 7 63 Mackenzie Health 4 - Markham Stouffville 1 - Institution Members Trials Southlake Regional Health 12 6 St. Joseph s Healthcare (Hamilton) 4 - St. Joseph s Health (Toronto) 6 1 St. Michael s 11 3 Thunder Bay Regional 2 - Toronto General 3 1 Toronto East General 8 1 Trillium Health Partners 16 1 William Osler Health Systems 2 - Windsor Regional 1 - Mount Sinai 2 4 North York General 9 1 OdeMe Cancer / Sunnybrook Ontario InsDtute for Cancer Research 2 - OMawa 1 - Princess Margaret Cancer 19 3 Rouge Valley Health System 2 - Royal Victoria Regional Health Scarborough General 1 - COMET Summary 200+ Members 28 Institutions 130 accruing trials Newest Initiative One of the main features of COMET is its referrals process and we want to hear from you! All your feedback will be integrated to better our referrals process for physicians across the province! Send us a at comettrials@smh.ca. June 2016 Newsletter 3

erefer Patients If you see a trial that your patient might be eligible for, click Email PI &CRC on the trial s page to open the erefferal window.

4 Website Functions: Part 1 Search Clinical Trials Once logged in, click Search Trials on the top bar. Then use the drop down menus or Search by Keyword for clinical trials matching your patient;s specifications. erefer Patients If you see a trial that your patient might be eligible for, click PI &CRC on the trial s page to open the erefferal window. Simply state your interest in referring a patient and click send. Post Clinical Trials When on your Account page, click Post Trial tab to post a new clinical trial at your institution,. The statue of your posted trials will appear on the right. Edit posted trials by clicking their titles. Trial will be reviewed and posted by the end of the day. June 2016 Newsletter 4

Website Functions: Part 2 Add Your Institution See a trial that

page and click the Add my Institution to This Trial button.

Click their email addressed to open a window to email them.

educational grants form the following supporters: Contact Us If

5 Website Functions: Part 2 Add Your Institution See a trial that is already posted but you are not listed as an available institution? Choose the PI and CRC of that trial at the bottom of the trial page and click the Add my Institution to This Trial button. Membership Directory Thinking about collaborating with other institutions? Go to the Membership Directory tab to view all the CCTC members. Click their addressed to open a window to them. Acknowledgements The CCTC has been funded by unrestricted educational grants form the following supporters: Contact Us If you have any questions please do not hesitate to contact us: 30 Bond Street Toronto, ON Canada M5B 1W8 E: comettrials@smh.ca T: (416) June 2016 Newsletter 5

Ontario s Initiatives in Surgical Quality- The Successes & Where We are Going

Ontario s Initiatives in Surgical Quality- The Successes & Where We are Going Robin S. McLeod Professor of Surgery and Health Policy, Management and Evaluation University of Toronto Lead, Quality Improvement