Address: AFR-202, Block-A, University School of Biotechnology Guru Gobind Singh Indraprastha University Sector 16C, Dwarka Delhi India

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1 Name: Dr. Rinu Sharma Designation: Assistant Professor School: University School of Biotechnology Address: AFR-202, Block-A, University School of Biotechnology Guru Gobind Singh Indraprastha University Sector 16C, Dwarka Delhi India Phone No. (Office): id: Educational Qulification: Ph.D Specialization: Cancer Molecular Biology Dr. Rinu Sharma obtained her master's degree in Biotechnology and Ph.D. in Biochemistry from All India Institute of Medical Sciences, New Delhi. She carried out her doctoral research on the identification and characterization of differentially expressed genes in human esophageal cancer. Subsequently, she pursued her postdoctoral research in Department of Biochemistry AIIMS, as Research Scientist. The salient features of her work have been published in reputed international journals, including Int.J.Cancer, Plos One, BMC Cancer and Genomics. She has extramural grants from various funding agencies viz. DBT, DST, UGC etc. She has also guided the research work of Ph.D, postgraduate and undergraduate students at G.G.S. I.P. University and AIIMS. Her current areas of interest are identification of non-invasive blood based biomarkers for early diagnosis of esophageal cancer and functional analysis of significantly altered genes using gene silencing and proteomic approaches. Her group is also interested in deciphering the clinical as well as functional significance of mirnas in esophageal cancer. Awards and Achievements RAMNATH HIRALAL JAJU AWARD for the best oral presentation by mid-level scientist in 35th Annual Convention of Indian Association for Cancer Research (IACR) Best Poster Award : International Symposium on Recent Advances in Cancer Research: Therapeutics to Chemoprevention, Gandhinagar, 8th 9th February, Sitaram Joglekar Award for best oral presentation by young scientist during XXIV Annual Convention of Indian Association for Cancer Research (IACR) 2005

2 SCHOLAR OF THE YEAR AWARD Mata Prasad Award B.Sc. (Hons.) Microbiology Part III awarded by Ram Lal Anand college GOLD MEDAL 1 st position in B.Sc. (Hons.) Microbiology awarded by University of Delhi Best Poster of The Day award: 9th Asian Pacific Federation of Clinical Biochemistry and 28th annual Conference of Association of Clinical Biochemists of India, March, Senior Research Fellowship from Council for Scientific and Industrial Research, Government of India. Junior Research Fellowship from Council of Scientific and Industrial Research, Government of India. Gate Examination cleared. PUBLICATIONS: PEER REVIEWED JOURNALS Prediction of recurrence free survival for esophageal cancer patients using a protein 2 signature based risk model. Md. Raghibul Hasan, Gunjan Srivastava, Akram Alyass, Rinu Sharma, Anoop Saray, Tushar K. Chattopadhyay, Siddartha DattaGupta, Paul G. Walfish, Shyam S. Chauhan, Ranju Ralhan. Oncotarget, 2016 (In Press). Priyanka Sharma, Anoop Saraya, Rinu Sharma. Evaluation of a mirna-mrna panel for esophageal cancer detection. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr B43 Priyanka Sharma and Rinu Sharma. mirna-mrna Crosstalk in Esophageal Cancer: From Diagnosis to Therapy. Critical Reviews in Oncology/Hematology, 2015 Jul 16. pii: S (15) Priyanka Sharma, Anoop Saraya, Rinu Sharma. Potential diagnostic implications of mir-144 overexpression in human esophageal cancer. Indian Journal of Medical Research, 2015, In press. Shivam Singh, Anoop Saraya, Rinu Sharma. Increased levels of sperm protein 17 mrna and circulating antibodies in periampullary carcinoma patients. Int. J. Clin. Oncol Aug;20(4): doi: /s Epub 2014 Oct 29. PubMed PMID: Hasan R, Sharma R, Saraya A, Chattopadhyay TK, DattaGupta S, Walfish PG, Chauhan SS, Ralhan R. Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early

3 event in esophageal tumorigenesis and is a predictor of poor disease prognosis. BMC Cancer Jan 2;14:2. doi: / MIR107 (MicroRNA 107) Priyanka Sharma, Rinu Sharma. Atlas of Genetics and Cytogenetics in Oncology and Haematology. December 2013 Md.Raghibul Hasan, Rinu Sharma, Anoop Saraya, Tushar K. Chattopadhyay, Siddartha DattaGupta, and Ranju Ralhan. Slug is a predictor of poor prognosis in esophageal squamous cell carcinoma patients. PLoS One Dec 18;8(12):e Priyanka Sharma, Anoop Saraya, Prerna Gupta, Rinu Sharma. Decreased levels of circulating and tissue mir-107 in human esophageal cancer. Biomarker, 2013, Jun;18(4): Md. Raghibul Hasan, Shyam S. Chauhan, Rinu Sharma*, Ranju Ralhan*.RNA-interference mediated down-regulation of TC21 sensitizes esophageal cancer cells (TE13) to Cisplatin. World Journal of Gastroenterology, 2012, Volume 18, Issue 31 *Corresponding author. Kriti Bahl, Anoop Saraya and Rinu Sharma. Increased levels of circulating and tissue mrnas of Oct-4, Sox-2, Bmi-1 and Nanog is ESCC patients: Potential tool for Minimally Invasive Cancer Diagnosis. Biomarker Insights, 2012, 7: Epub 2012 Mar 26. Tasneem Kausar*, Rinu Sharma*, Md. Raghibul Hasan, Tushar K. Chattopadhyay, Siddartha Datta Gupta, Ranju Ralhan. Overexpression of a splice variant of oncostatin M receptor beta in human esophageal squamous carcinoma. Cellular Oncology 2011, Volume 34, Number 3, Pages *Equal Contribution Kausar T, Sharma R, Hasan MR, Tripathi SC, Saraya A, Chattopadhyay TK, Gupta SD, Ralhan R. Clinical significance of GPR56, transglutaminase 2, and NF-κB in esophageal squamous cell carcinoma. Cancer Invest Jan;29(1):42-8. Epub 2010 Urmi Bajpai, Rinu Sharma, Tasneem Kausar, Siddharth Datta Gupta, Tushar Kant Chattopadhayay and Ranju Ralhan. Clinical Significance of zeta In Human Esophageal Squamous Cell Carcinoma. International Journal of Biological Markers, 2008,Vol. 23 no. 4 Garima Gupta, Rinu Sharma, T.K.Chattopadhyay, Siddharth Dutta Gupta and Ranju Ralhan. Differential Expression of SP17 in human esophageal cancer. International Journal of Cancer, 2007 Apr 15;120(8): Neetu Sud, Rinu Sharma, TusharKant Chattopadhyay, Ranju Ralhan. Differential Expression of GPCR 56 in human esophageal cancer. Cancer Letters ; 233(2): Rinu Sharma, Neetu Sud, Tushar Kant Chattopadhyay and Ranju Ralhan. TC21/R-Ras2 upregulation in Esophageal Tumorigenesis: Potential Diagnostic Implications. Oncology, 2005; 69(1):10-8. Epub Rinu Sharma, N.K.Shukla, Meera Mathur and Ranju Ralhan. Prognostic significance of Stromelysin-3 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Esophageal cancer. Oncology,Basel,2004,67: Neetu Sud, Rinu Sharma, Riju Ray, TusharKant Chattopadhyay, Ranju Ralhan. Differential Expression of. International Journal of Cancer, 2004 Vol..112,pg

4 Sharmishtha Samantaray, Rinu Sharma, T.K.Chattopadhyay, Siddharth Dutta Gupta and Ranju Ralhan. MMP-2and MMP-9 Expression in Esophageal Squamous Cell Carcinoma. Journal of Cancer Research and Clinical Oncology, 2004, 130(1): Rinu Sharma, Sharmishtha Samantaray, Nootan Kumar Shukla and Ranju Ralhan. Transcriptional Gene Expression Profile Of Human Esophageal Squamous Cell Carcinoma. Genomics, 2003 May; 81(5): Robin Mathew, Sonia Arora, Rinu Khanna, Meera Mathur, T.K.Chattopadhyay, Nootan K. Shukla and Ranju Ralhan. Alterations in p53 and prb pathways and their prognostic significance in esophageal cancer. European Journal of Cancer, 2002, 38, Mathew R, Khanna R, Kumar R, et al. Stromelysin-2 Overexpression In Human Esophageal Squamous Cell Carcinoma: Potential Clinical Implications. Cancer Detect Prev 2002;26(3):222-8 Mathew R, Arora S, Khanna R, Shukla NK, Mathur M, Ralhan R. Alterations in Cyclin D1 expression in Esophageal Squamous Cell Carcinoma in Indian population. Journal of Cancer Research and Clinical Oncology, 2001, 127, Papers Presented in Conferences International: 1. Priyanka Sharma, Anoop Saraya and Rinu Sharma. Evaluation of a mirnamrna panel for esophageal cancer detection Noncoding RNAs and Cancer: Mechanisms to Medicines. 4 th December-7 th December, Boston, MA, USA. 2. Priyanka Sharma, Anoop Saraya and Rinu Sharma. Exploring diagnostic relevance of mirna signature in esophageal cancer. Global Cancer Summit, International Collaborative Conference. 18th-20th November, J.N.TATA Auditorium, IISC, Bengaluru. 3. Shivam Singh, Anoop Saraya and Rinu Sharma. Expression of MARCH8 in esophageal cancer and prediction of putative mircornas regulating its expression. Global Cancer Summit-2015, an International Collaborative Conference on Frontiers in Oncology: Genetics, Diagnostics and Therapeutics", Bengaluru, 18th-20th November, Rinu Sharma. Diagnostic implications of altered mirna profiles in esophageal cancer. 6 th International conference on Biomarkers and Clinical Research. 31 st August-2 nd September, 2015, Toronto Canada. 5. Priyanka Sharma, Anoop Saraya, Rinu Sharma. Aberrant expression of PIM1 in esophageal cancer and In-silico prediction of its putative transcription-factors. Indraprastha International Conference on Biotechnology. 22 to 25 October, GGSIPU, New Delhi. 6. Shivam Singh, Anoop Saraya, Rinu Sharma. Clinical significance of NY-ESO-1 in periampullary carcinoma. Indraprastha International Conference on Biotechnology. October 22-25, Guru Gobind Singh Indraprastha University, New Delhi. 7. Renu Verma, Priyanka Sharma, Rinu Sharma, P. C. Sharma. In-Silico study of Wnt signaling pathway genes as potential targets of microsatellite instability associated carcinoma. Indraprastha International Conference on Biotechnology. October 22-25, Guru Gobind Singh Indraprastha University, New Delhi.

5 8. Priyanka Sharma, Anoop Saraya, Rinu Sharma. Prediction of putative micro RNAs and their potential targets implicated in Esophageal cancer: Integration of In-silico and Experimental Approaches. 3rd International Conference on Stem Cells and Cancer (ICSCC-2012): Proliferation, Differentiation and Apoptosis. 27th to 30th October, RML Hospital, New Delhi. 9. Surendra Yadav, Shivam Singh and Rinu Sharma. Chemopreventive effect of Ocimum sanctum in esophageal cancer cell line (TE-13). International Symposium on Recent Advances in Cancer Research: Therapeutics to Chemoprevention, Gandhinagar, 8th 9th February, Kriti Bahl, Sakshi Kohli, Yenna Malhotra, Anjali, Anoop Saraya and Rinu Sharma. Expression analysis of splice variants of stem cell marker Oct-4 in Human Esophageal Squamous Cell Carcinoma. International Symposium on Recent Advances in Cancer Research: Therapeutics to Chemoprevention, Gandhinagar, 8th 9th February, Priyanka Sharma, Anoop Saraya, Prerna Gupta, Rinu Sharma. Expression of differentially expressed mirnas in human esophageal cancer patients: potential minimally invasive biomarkers for diagnosis and prognosis. New Horizons in Cancer Research: Biology to Prevention to Therapy, December 13-16, 2011, Gurgaon, Delhi (NCR), India. 12. Kriti Bahl, Anoop saraya and Rinu Sharma. Elevated levels of circulating and tissue mrna of Oct- 4,Sox-2, Bmi-1 and Nanog in ESCC patients: Potential tool for Non Invasive Cancer Diagnosis. New Horizons in Cancer Research: Biology to Prevention to Therapy, December 13-16, 2011, Gurgaon, Delhi (NCR), India. 13. Md. Raghibul Hasan, Rinu Sharma, Tasneem kausar, Shyam S. Chauhan, Ranju Ralhan. TC21 downregulation induces cisplatin sensitivity in esophageal cancer cells. 2nd AACR International Conference on "Advances in Cancer Research: From the Laboratory to the Clinic" March 7-10, 2010 in Jordan. 14. Md. Raghibul Hasan, Rinu Sharma, T. K. Chattopadhayay, Siddhartha Datta Gupta, Shyam S.Chauhan, RanjuRalhan. Clinical significance of E-Cadherin and Slug in esophageal squamous cell carcinoma. RGCON 2009, 8th International Conference Focus: Lung & Esophageal Cancers, 27th -29th March 2009 organized by Rajiv Gandhi Cancer Institute & Research Centre, Delhi, INDIA. 15. Garima Gupta, Rinu Sharma, T.K.Chattopadhyay and Ranju Ralhan. International Symposium on Translational Research: Adoptosis & Cancer, Trivandrum, 18 th 21 st December, Differential Expression of Sperm Protein 17 in Human Esophageal Squamous cell Carcinoma. 16. Tasneem Kausar, Rinu Sharma, T.K.Chattopadhyay, Sidharth Datta Gupta and Ranju Ralhan. International Symposium on Translational Research: Adoptosis & Cancer, Trivandrum, 18th 21st December, Differential Expression of Oncostatin Receptor-β in Human Esophagal Squamous Cell Carcinoma. 17. Rinu Khanna, Sonia Arora, Meera Mathur, N.K.Shukla and Ranju Ralhan. ASCO Pan Asia Cancer Conference (A-PACC) February, 24-26, 2002, New Delhi. 18. Rinu Khanna, Sonia Arora, Robin Mathew,Meera Mathur, N.K.Shukla and Ranju Ralhan. Cyclin D1 Overexpression An Adverse Prognosticator In Esophageal Squamous Cell Carcinomas On Indian Population. 9th Asian Pacific Federation of Clinical Biochemistry and 28th annual Conference of Association of Clinical Biochemists (APCC) of India, March,9-14, R. Khanna, N.K. Shukla, T.K. Chattopadhya and R. Ralhan. Molecular Cloning Of Messenger RNAs Differentially Expressed In Human Esophageal Normal And Malignant Tissues International Conference on Emerging Trends in Cancer Research. March, 14-16, 2002 School of Life Sciences, J.N.U., New Delhi.

6 National: 1. Priyanka Sharma, Anoop Saraya and Rinu Sharma. Clinical and functional implications of mirnas and their targets in esophageal cancer. 35th Annual Convention of Indian Association for Cancer Research (IACR) th-10th April, Hotel Ashoka, Chanakyapuri, New Delhi. 8th-10th April, Shivam Singh, Anoop Saraya, Prasenjit Das and Rinu Sharma. Increased expression of MARCH E3 Ligase in human esophageal squamous cell carcinoma. 35th Annual Convention of Indian Association for Cancer Research (IACR) th-10th April, Hotel Ashoka, Chanakyapuri, New Delhi. 8th-10th April, Priyanka Sharma and Rinu Sharma. Tumor suppressor role of mir-107 in esophageal squamous cell carcinoma 35th Annual Convention of Indian Association for Cancer Research (IACR) th-10th April, Hotel Ashoka, Chanakyapuri, New Delhi. 8th-10th April, Priyanka Sharma, Anoop Saraya, Rinu Sharma. Clinical significance of PUR-alpha in human esophageal squamous cell carcinoma. 34 th Annual Convention of Indian Association for Cancer Research (IACR) th -21 st February, Hotel Clarks Amer, Jaipur. 5. Shivam Singh, Anoop Saraya and Rinu Sharma. Elevated circulating levels of anti-sp17 antibody in Periampullary cancer patients. 34th Annual Convention of Indian Association for Cancer Research: Cancer Research: from Bench to the Bedside, Jaipur, 19th-21st February, Priyanka Sharma, Anoop Saraya, Rinu Sharma. Clinical significance of mir-144 in human esophageal squamous cell carcinoma. 32nd Annual Convention of Indian Association for Cancer Research (IACR) & International Symposium on "Infection & Cancer. 13th to 16th February, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi. 7. Rinu Sharma, T.K.Chattopadhayay and Ranju Ralhan. Unraveling Novel Molecular Targets in Esophageal Cancer by Gene Expression Profiling. 24 TH Annual Convention of Indian Association for Cancer Research, February 2005 (Sitaram Joglekar Award for best oral presentation ) 8. Rinu Khanna, N.K.Shukla And Ranju Ralhan. Transcriptional Gene Expression Profiling Of Human Esophageal Squamous Cell Carcinoma. Biotechon-2001, October 4-6, 2001,Vallabhbhai Patel Chest Institute, University of Delhi, Delhi. 9. Rinu Khanna. Differential gene expression profile analysis of human esophageal squamous cell carcinoma. 21st Annual convention of Indian Assocoiation for Cancer Research Bangalore, India Mathew, S Arora, R Khanna, M Mathur, NK Shukla, R Ralhan. Putative molecular markers for esophageal squamous cell carcinoma. The Impact of Biotechnology on Predictive Oncology and Therapy, October 2000 Geneva. Research Projects: o : DBT sanctioned project entitled Functional analysis and target identification of c-mir/marchviii (E3 ubiquitin ligase) in human esophageal cancer using RNAi and quantitative proteomics approach

7 o o o : DST sanctioned project entitled Expression of Cancer Testis Antigens in Periampullary Carcinomas: Potential Noninvasive Biomarkers for Diagnosis/Prognosis : UGC sanctioned project entitled Clinical Significance of Stem Cell Markers in Esophageal Cancer: Potential Blood Based Markers : DBT sanctioned project entitled Circulating mirnas in Esophageal Cancer Patients and Healthy Subjects: Potential Blood Based Biomarkers for Diagnosis and Prognosis Membership: Indian Association of Cancer Research (IACR), Life member American Association of Cancer Research (AACR): Active Member European Society for Medical Oncology (ESMO): Member Reviewer for Journals: Cancer Biomarkers European Journal of Surgical Oncology Students supervised /Under Supervision Ph.D: Three (3) JRF: One(1) Ph.D: Scholar Co- Supervision : One (1) Research Associate: One (1) M.Tech: Five (5) B.Tech: More than 30

Dr. Hem C Jha. AWARDS AND FELLOWSHIP Ramanujan fellowship award from Department of Science and Technology (DST), India (2016).

Dr. Hem C Jha. AWARDS AND FELLOWSHIP Ramanujan fellowship award from Department of Science and Technology (DST), India (2016). Dr. Hem C Jha EDUCATION Ph. D., Birla Institute of Technology, Pilani, 2010. M.Sc., Devi Ahilya Vishwavidyalaya, Indore, 2003. B.Sc., University of Rajasthan, Jaipur, 2001. WORK EXPERIANCE Ramanujan Fellow: